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UNIT-T" NDOS

a
MICROtNCAPSULNT'ion

m
hoadalio
Syllabtu
Cullabt *

Difuufion, -Md osphueA

(Disad). icopar liclea

ar
MeHocde h(oaMulu
of micioenapaulalm, Appliallona
(Iechniu)

MOOtncapsulati

4
Ph
aprous in which Aalucl, iquids ov

vtn 9asu enclosed whin mCvoscopiC

particde such a polymu) by foinng hin Coading
l
(0ading ofF

Ccoading matuial
el

opsu
ew

muvoencapsulahon mCO+ en+ Capaulahm

r

Anall Capsulu
paches
Ca

cdiug enclosud anstdu

-Iha Copsulo( ov opeul ibe)
uch
Conuu two moteia !
COe Coadting mateja
naetal u)

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siz Jim lo mm
Smal sphe hoving
sheloali9

a
Unutovm wall makyol)
Surronding
polm

m
Cocch
COH makaja »

h maic which
enclosed

ar
insida tu poymr
Co Makiol
tontaind main (API) whih
Heponsa.
vomnu, Aspiin, Ph Sodium CMonida, asp ek
ould ba -
t should iqud or Soud
Anould be
dru APT
l
el

Coating Marera
mates ial be Cocttd on th
COe material, Fshould bt polymor.
ew

Shovld ba
should inet Towards tu COH MatU

Ahould b Comptibu withthe CO matehial

r

Aould spbli se Coe matena.

Ca

- Auould he fiexilu, brittle, hovd and in Codw

Cotig

Gums Gum Orahic Sodum alginate Pvotein Gebtin

Albunin
Covohycd
ale Starh dextan Ond AUUoO et-
Caldulesa-Metuylalwlora upids Bes unx, Stcaric ocicd *
phsspholipila -

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hdvantags
masks
Tt th unpleasa Jasje of Somm

a
drug
Ampicillin, aninophyllins ele

m
AIsO mask tu Uvplea sat Or unarca ptable odouy of
Certaun COH maevial. Castor o, cod live oil ek-

ar
Inprove th handling and Aprag F Cestan
drus

avoic incompatiblifjies in drug Comoinathon.

T
Acpirin and dhlorphunjiramnL maleak. ek

h
PhGIT iitatim Ca std by 0om
by
Tndomuthocin ek-
du enous Sulphole, kel, Pava catavmol,

and providus SUstajnd, prolgks,

It inproves h sabill
l
CoholledH eltas of drug.
delayed o
el

Diçadvautagts
ew

expen sie
materials,
COR

not Used or all Codhing

distontinuou Cooing.
to inomplele ad
and
lends
Somutim
r
Ca

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Micopavfices
Ihese h Sphuvicol Anaped (micromutvic) matvy

a
Sy shem which conains h rlic off siz
of 0oo um

m
. Tn this+h dug moletules an dissolrtd, entappid,

ar
encapsulatd, or attachud

. Tn hu , Drug molecul dispersid arol physicalby

and Unifovmy Ph in polymaic ecrhes.

Polymurs DHugs opazides

l
el

iopovtiu myuosphy
ew

M&OCaDsulRy

O iuosphves
r

Amal, spharical, fee-fbwlkg farhices,

J - Jo00 um.
Ca

havinq duamater of

In t, dng disbibuted

throuout th mahiy

-
Otten, uoophts aR emud a mioopaticus

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MoOapsulu
In th, dugs a Unufovm
enclo xd wihin
wau

a
Auvrounding tham.
Cok Maleal

m
thot encloud within a MUoopsu
Hd codting materiathat cloael t COH molerial
Codtivg nokeiss

ar
+ paluyman)

ugs( (o)

Methods
Ph
of miuoencapsuladion trchnigves

Micoencapsulation
l
el

Physical Physio-chmical chumca

Suspnsion
Air sCoacervadion- Polymeization
ew

Mulhorifiu-(edifugal phase sapavodi on

Solvent
pHOCeAs uthods evapovation.

Pan Coading Tonotropicqelation

r

Spray ding
Ca

fAir Suspen sion echniqua

also known as (Wurser) o
J
fluidi sud bd (00ng

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Tnventd by ale durser
involves disptrsin of soli

a
coe malcrial in an
alr
ApCam and n sphay Coaling of h al

m
SUEpended porticlea.

exhows a

ar
Cooiug
chambys

.Hoy Air Suspunsion

Ph o- poudriclas
echwiqus o

A1/ pallh
Spray Noz2]e3
Bofpm
1
l
Atonizafin air
el

11- Coading Suspension

Talet Ai
ew

Thu Cove maleajal ae upin dud n an Upuward moving

seaun in this paurhides rwlae Kpaatety thvough

hu Coodhing
Zon of t chambe
r

In Z0n COe modevials at appued with

of a spray-
Ca

polymeuc Cooding matevial in tu Olm

on deirtd Coating
tA D of Hpatitions daptndy
hick
muorocapsu les
Chonee dries
ur droducicd in h
forud.

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fAHantas (Mitt) 0itocdvanaqus (de marit)

apto ching nmuhods

- not or huat-sonsitie

a
Casy U U labours aal not Hquired
CO maleiels

m
ony Ustd
suprior cocting qualut fo solus (0e)
equipmnt »
queless Cocding makevial. ot h.

ar
mulhiovnfica - Centifuga proress

Coaing
PhCoadtiug maleijal snlut
naleio ~ Makalgroovu)<|

Cove makrial
|
l
inlu
el

pe
w ,Couhah
ew

disec
CoUnr votahnq
r
Ca

Rolahing (ylinder

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Coodino
Pan

a
T wIdely Ugec and oldusF indusbia muthods

m
prming Amalu codttd
-aly aoristr
pavticle or ablus. ile +(Spha

ar
exkut
,P

Ph
Co CL maklals
maerials
l
el
r ew
Ca

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Drjing and Spra feeermlsl

a
SpraD an Congealing

an

m
Ho
dauo (res)|

Tn i enol n a flud Sprayin9

ar
nozzje2
Spayed mdo a
hot drying udium aud gu DMing
chambn
ansfomd ido a dned
Pavhcwlak
coR matenal is
Ph
disprsad
>oR partics

in a COnc Sol of Wal matenia icroCapsuies

obtun Cn emulsim
l

Spray COnGealing)
el

adzr
ew

Jauk soli dificatimn

micoparhicy
feed pp]-
O (feding
r
Ca

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Coacvadm phau Stpanatimn muthods
liny sphnicol dvoplut in which Vaniass

a
Orgonic moletule CLpid nmolotulu poticwla) a hulol
7gshu by
by hydvophabicfovtA

m
(rom a Pumovndskq
k rnud Q uqwd
(CoacLVale)

ar
Coavat
Orqanic
wale Ph
Molecues

Spanahn Of u fwo phaus ie. Amall dvoplds

of a denso polynu ich pha and a dulule
l
luuid phale, is Temud a Coacavdim.
el

It involvesthRe Aleps-
Soleuy-
ew

O formahin of hee imniscbl chunal

pha vehicle) COre

and Coahing malerjal

Deposition
of Cathng mateual
r

OirOund
th COR mattial
Regidisai o
Ca

handns Cal.

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Core makaial

a
Phase

m
Coowvak
Sepovainm
padid
poy (a)
(b)

ar
nicro-
Capswles
Ph
mum rans
fomathim
Cd)
(poly mesic
umbra u)
l

a) Co maenial dispersu
el

in th sbluthon
Conng polyur

b) Separaha of COacovale fvom Soluchim

ew

mateial by muicrod rophs of

Coahng of COR
Coacva
of mumbrana aromd COK parrtc.
d)ifornahm
r
Ca

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SolvenF Evapovadim »

a
eld to_aqueas

m
Containing (swfatant
whil sHm2z

poym distoled Ong

ar
Solve
OlganicS solen pohics vaponahm
Lo
l Ph Stpanak and_
cy mCIshiRt
el
r ew
Ca

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Ipplicalions

a
lo
J USed deugn (ortrolLu elda Ustan

m
cltas and olmgd heleal dosag torm
Used t mask u bitter Te of urtoin du
CPcm,rgan .

ar
Us4 Td Rduca hu qamc and GIT Mfadm Cawud
CAaln drug
Ustd protect

Separade
Ph COHe

ncomparbla
naeuals. (ca. Vit A).

Subtan
Used too pepa enteuc- côatd design doragfoum
dogagstoum
l
Aqnulfu ra appuohony
el
r ew
Ca

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