Rajiv Gandhi University of Health Sciences, Karnataka ‘ShSorester PhamoageeBainion~ 10-00-20) Tine: Treetoure ‘Mc Marks: 75M [BIOPHARMACEUTICS ANDPHARMACOKINETICS ‘QP.CODE:5026 ‘Youranswersshouldbe speciicothequestonsashed Drawneatlabeled diagrams hereverecessay LONGESSANS Arora) 2x10=200Aae 1 Ust te various proceses trough whch chugs can ros theological membrane Descibeabsoption of ge romnonperorlenra-ascusrrotes Explainvaiousmethodstoenhancetedissolstonrate of porysohible drugs. Exlsindeterinatonal phamacokineticparaeters rom plasma concentration datatteradmiieationo! uglVbolus SHORTESSAYS (fosweray/Sever) 7x35 Detinebuphamacesis end dlscueste allo formulation develoment. Witeindetataboutpotenbindngarditssgnfiance ete anotecntenalexcrebonot args Explainbiceqivalencestuies. Discuss abouttrebloodlevelcuvesofaugadmiisteredbyLV nfusionandoralroues. \tarepharmacokneticmode? Explinvarcustypes withthe signfcance Estmateonecompartmentmodelparametersbyusng the methodofresls ErplainabouMichaeks Merten’ sequaton? 12, WeteanoteondeterminatonofknandVqy dt steady stateconcentration SHORTANSHERS (ener A) 10x220Ne 13, Whatishepatctest passetfect? 14, Whatiote infuenceofGigH ondrugabserpton? 15, Enlstojectnesofbioavalabary studies. 16. _Detineclesrance. Whatistsunt? 17, DefineCuand AUC. 18. _Defineapparentvkumeo stibatonandgivethemathemticalequtiontcalelatet 18. _Definoloading doseandmaintenancedose 20. Whatdoyoureanbycentaandperpheralcorpartnentintwocerpartmentmodel? 21. _Detinedosedependortietics. 22. Compacetheconceptotineaandnonlinearpharmacokiebos a Q 0 G Q Rotate screen Fit Export Share SearchRajiv Gandhi University of Health Sciences, Karnataka ‘Sach SemesterB Pharm Degree Examination 24-Mar-2021 ‘Time: Three Hous Mx Marks: 75 Marks ‘BIOPHARMACEUTICS ANDPHARMACOKINETICS QP.coDE: 5026 Youranswersshouldbespecitcto the questionsasked Dramneat beled diagrams wherevernecessary. ‘Althe Questions arecompulsory LoNcessars axa 1. What are the assumptions made in developing pH pation hypothesis? What are the kitations of pH pattiontypetesis? on Epiain diferent pharmacokinetic models. What are the important pois to be considered in developing equatonforatwecomparment model? 2. Bplandiferentmethodstoenhance the cstolutonol poorly sokbledtugs. SHORTESSAYS 7xS=35Maks 3. Whatdoyoumeanbytheterm clearanceandhow wilyoudeteminernaelesance Witetheadvantagesandiitaionofmulipledosestudy 4. xplainvanious methods to detomine Michaots Merten Discuss bouterteraforabtanngavald uineexcretondata Desveanequatontodeternineconcentatonofduggivenbyivbokisroutefotowing 1 CEMKinet Explain therolofplasmaproteinsincrugestibuton. \Whatis compartment made” Mscussthevarioustypesofcompartment models. Explain apparentvolumeofdstabuion and dstrbutioncoficent Explain thefactrsatfecting dug dtbution SHORTANSHERS 10x2=20Nks 10. Dugdissolutonrateandbiavalabity. 11, DefineSotd dspesion. 12, Maximumsafe concentration Midmumetfectve concentration. 13, Loadingdoseandmainenancedose 14, _DiferencebetweenBepharmaceuts end pharmacokinetis 15. Whynominearkineics recalled dose dependenkintcs? 16. Pharmaceutical equvalenceand therapeuticequivalenc. 17, Fiptopphenomena lagtine 18, Define Trax Cn 19, Pharmacdynaricdrug interaction. Rajiv Gandhi University of Health Sciences, Karnataka a Q 0 G Q Rotate screen Fit Export Share SearchLowsessavs 1 Rajiv Gandhi University of Health Sciences, Karnataka SochSeneserPhamDageeBxaintion~ 23-2021 Time: Treetours Na Marks: 75 Mocs [BIOPHARMACEUTICS ANDPHARMACOKINETICS ‘QP.CODE:5026 ‘Youranswersshouldbe speciicothequestonsashed Drawneatlabeled diagrams hereverecessay ‘Alte question arecompulon, Detinecragateorton Explainvariusmechorismsof dug absorptnttrough GIT eR Detineboavaiabity Osea thedtlerentmethodsormessirementoftoavaiabily 2. Expaindeterinaionofpharmacokinetcparameters rom plasma concentration data after admiistatonof ug Dylintuson StonTESSANS 7aS25Neee 3. Expainthe factosaffectng rte bineingof age. cy ‘rte anoteontissuepemeabatyofdrgs. 4, Detinemetabotsm WiteanoteonGlucrendation wR \Weteanotecnnonrealexcetonotdngs 5 _Whatarepharmacokinetemodels? Whats theimportanceandusityo sichmodels? 6. DiscussaboutteblondlevelcurvesofaugadminstoredbylV.bolusandoralroutes 7. Explaininbvif whatismutcomparimentmodel? 8 ExplainabouMlehaete-Mentent equation? 9. Howdoyouestmetekn and Vn ately. bots admnistationof dugfelowingnonnearknetcs? SHORTANSHERS. 10x2=20Ners| 10. _Definebiophamacewtcsanddugprcteinbindng, 11, Howcomponentsofgasvomtestinaliudatfetsbsoptioncf dugs? 12. _Defineabeolteandreatvebioavaabily 18. WhatkBCSclssitelonot cringe? 14, WhatfotorsatfecthafMeofthe drugs? 18. _Definevsumectdstrbuton Wrtetsimporance 16, _Detneloadingdoseandmeintenancedose 17. Whatisthe sigtcanceotKn.andViai? 18. Compuetheconceptotinearandacnine phamacckinetes 18. _Whyisitimporanttomortordruglevelscarefulyfordose dependency? Rajiv Gandhi University of Health Sciences, Karnataka a Q 0 G Q Rotate screen Fit Export Share SearchRajiv Gandhi University of Health Sciences, Karnataka ‘SehSorester Pramas Banton 22Jur-222 Time: Treetours Na Marks: 75 Mocs [BIOPHARMACEUTICS ANDPHARMACOKINETICS ‘QP.CODE:5026 ‘ouranswersshouibe spectitothequestionsasked Drawneatlabeled diagrams hereverecessay ‘Alte question arecompulon, Lowsessavs 1. Define Biophrmaceutes Oscussindetal netsofratinbindg oR Discussindetaldegmetatolimandmetabobepatwaysolrenstexeetion 12 Define pharmacokinetics. Deve pharmacokinetic parameters of dug administered by intravenous iyecion (eat StonTEssANS 7aS25Nees 3. Witeaneteoananperccalexte vasclarreutesfordragabsortion. oR Explaineinical sigifcanceotprtein bing, 4. Exstinvroseecluatonmodels Explain USPtypel appar on ‘te anoteoni VVC sonelatons, ‘ie nateonphysiloicl model. ‘Snitcanceofcemporment edling Explaintwocomparimentopenmodel Explainfactorscousingnontineanty. \Witetheobjctvesandsignieanceofnontnearpharmacckinetis. ‘SHORTANSHERS 1ox2-20Nee 10. Detneabsomptonandestrbunenotdugs 11, Enstpyelcochemiel fetorsatecting rugabecrption 12, Enumerate dierent methadstoemnancedsolutenof poof solbledrgs. 13. ObjectvesofBeavalaity. 14, _Detinenravenousinfusion. 15. _Potplaemaconcentationvatime oie, 16. _Detineinravenourbotsiyecton 17. Petmtple dosageregimens. 1B, StateNtchaelie Menten equation 19, _Ensthedrugsfolowsnantines pharmecokinetcs a Q 0 G Q Rotate screen Fit Export Share SearchRajiv Gandhi University of Health Sciences, Karnataka SoxhSeneser8PhamDageExaintion~ 24-2022 ‘Tie Treetours Na Marks: 75 Mocs [BIOPHARMACEUTICS ANDPHARMACOKINETICS ‘QP.CODE:5026 ‘ouranswersshouibe spectitothequestionsasked Drawneatlabeled diagrams hereverecessay ‘Alte question arecompulon, Lonsessavs 1. Classy factorsifuercing absorption drugs Expainphysicochemiafactrsindetall oR Detineboavalabity, Weteitsoectves Expandiferetmethodsformeasurementofbicaraabaty 2. Datvevarous pharmacokinetic prametesforinravenousinusionbyonecorparimertopenmedel SHORTESSAYS 7xS=35¥eks 2. rtvaronemctanamoldagsbeton Blinsce ands don tea rteetonepreabyo age 4. Wieartenpotwapcenlncetont dogs ce Eplsbiogaencentuseset Detreconrent. Wt pking ona, testo tee pamaccitceprametr. Exleniocpetnpe ota \meartesftoncaangrrineaty alta SHoRTANSHERS. 10x2=20Ner 10. Poreranspetinabsorpton 11, Enlafactorftectngprotenbieding 12. Datnetvve. 18, _Enlstmthodstoenhancethe dasolutonrateofpoary sable drugs 14, _Detnepyscloges! mode andwtetsone application. 15, DetneBiologcathaite 16, Sanicanceolaatingdoseinclitcalseting 17. Definestadystateindrglevlet 18. Detinencninearpharmacckintes 19. _Deinapparenteumecdstibston, a Q 0 G Q Rotate screen Fit Export Share SearchLonsessavs 1 SHORTESSAYS 1 Rajiv Gandhi University of Health Sciences, Karnataka ‘SehSerester PhamDage Banton 06 Jur-228 ‘Tie Treetours Nx Marks 75 Mes [BIOPHARMACEUTICS ANDPHARMACOKINETICS ‘QP.CODE:5026 ‘Youranswersshouldbe speciicothequestonsashed Drawneatlabeled diagrams hereverecessay ‘Alte question arecompulon, Discussindetalthevaiousphysclogicalactorsaffecting rug absorption oR Detiemetabtism Explanphasereactions. Discuss In etal necampariment open made for a druy administered as IV bolus. Ge the schematic representation graphsandequatonsfrthe same a Explainthepassive cision ndactvetansponotiugs oR Explainaparentvokme oftibutonandgiveits sgnifcace Explanthefactorsafectingrnaexcretonot hugs. cy Detineboavalabilty Memon hecbjecivescfbicavalablty studs. ‘Wetethelmportanceot Compatmentmedetng npharmecckinetc study. HowdoyoudetemineKEsingrateofexcretionmethod tom winedata Detineloadingardainteancedose. Give the fomua forte same ExplainMichaets~ Mertenequaton determining nom lineanty. Explainthe vaousfoctorseacngtonomtneany SHORTANSHERS 1ox2-20Nee 33 4 6. 6. v. 8. WhatisPolymorpisn? Detinepreteln binding, Watisclerance™Gvethe frmulaforsame Givethesgificanceot bioequivalence Watiscentalcompartmentandpermeabity? Wie equationtorzerorderhalfeandfistorderhalite Give theschemtirepresertatonofonecompartmentepenmodelV infusion Plotmltple dosageregimens. ‘comparethe concept inearandnominearpharmacoknetics, \inyroniwarkinetescaleddose dependent kinetics. Rajiv Gandhi University of Health Sciences, Karnataka a Q 0 G Q Rotate screen Fit Export Share SearchRajiv Gandhi University of Health Sciences, Karnataka ‘SithSemesterB.PharmDegree Examination - 10-Nov-2023, ‘Time: Three Hous Mx Marks: 75 Marks ‘BIOPHARMACEUTICS ANDPHARMACOKINETICS QP.coDE: 5026 Youranswersshouldbespecitcto the questionsasked Dramneat beled diagrams wherevernecessary. ‘Althe Questions arecompulsory LoNcessars 2x10=20eks 1. Witeanoteonabsorpionandvancusmectansmscf rg absorption. oR Define bioavadabtyclasstybio availability and write aboutbioequivalence stud protocol 2. Explain determinationcf phamacckinetc parametesfromplasma concentationdataafteradminitration of rugby iVinusion. SHORTESSAYS 7x5=35Nerks 3. Witeindetalaboutphysologieafactorseffecting dug absorption Wit anoteon appicatonof pharmacckneticmadels 4. Wrteary womethodstodeteminebicavaabily Expain theterminviroinvioconelaton Expain the various factorsleadingtonon nea. Enumerate the kinetic protein ~ dug binding andrepresent ferentplts Witte anoteonmamilayandestemarymodel Expaintwocompartment open mode. How doyouestimateKnandVnaafterVbolusadminisrationof dug{ollowingnon-inearkinetics? SvorraNsHERS 1012-200 10, UstouttheProtensresponsibieforprotanbinding 11. WiteLimitaton of winaryexretiondataforcalelatonof pharmacokinetics. 12, Whatiscnicalpharmacckineticsandwiteits significance. 12, Define apparentvolumeof dstrbutionandwatets ignficance, 14, _Ustoutnon enaloutesofdugescreion 15, _Definenoninearknetis 16, _Defineabsolite andreatvebioavalabty. 17, Whatdoyoureany central andperipheralcompartmentintwocompartmentmadel? 18, _ Whatarethe imitation ofone comparmmentmodel? 19, Whynom-inearkineicsareclled dose dependentkinetcs? Rajiv Gandhi University of Health Sciences, Karnataka a Q 0 G Q Rotate screen Fit Export Share SearchLONG ESSAYS: 2x1 1 2 Rajiv Gandhi University of Health Sciences, Karnataka Sinh Semester 8, Pharm Degree Examination ~ 10-Jun-2024 ‘Time: Tiree Hours ‘Max Marks: 75 Marks BIOPHARMACEUTICS AND PHARMACOKINETICS. ‘QP. cove: 5026 Your answers shouldbe spectc tthe questions asked ‘raw neat labeled diagrams wherever necessary. ‘Al he Questions are compu Classify factors influencing absorption of dugs. Explain physocherica factors in deta ‘OR Deine bioavailability. Explain pharmacokinetic mebods fr assessment of bioavalabily Discuss in deta onecamparment open model or @ drug administered a5 LV. infusion. Give the schematic representation graphs and equations forthe same ‘SHORT ESSAYS 7x8=35 Marks Enis various mechanions of dug absorption trough GIT, explain active vanspont and passvediusion (OR Explain Kets of cg protein binding. Discuss the various study designs forperforming bioeqvalnce tsies oR Explain various factors affecting Btransfomationof drugs. Wat are pharmacokinetic models Explain varius types with the significance. Explain the Non-renal routes of drug excretion Explain two compartment open model in bie. How do you estate Ky at Vn? Explain te causes of nonlneaty SHORT ANSWERS 10x2=20 Marke 10. n 33. 6. 8. WhatisPnocjtoss and phagocytosis? Whatie the tfc of fod on absotion of drug? Dene transformation, ite the formula to eaicuate pate extaction rat, Watis zero order resetion? Draw the loo evel profiles for oral administration Detine dosing frequency. ‘iat re the lntations of one compartment mode? Name tw partes use in austin dosage regimen. ‘Give Michael Menton equation Explain the tems. Rajiv Gandhi University of Health Sciences, Karnataka a Q 0 G Q Rotate screen Fit Export Share Search