Dr.
Moaaz Wahdan 2024 Biochemistry
Medix Team 1
Dr.Moaaz Wahdan 2024 Biochemistry
Seminars FOMNINU & FOMSCU 2024
1) Cells with long telomeres on their chromosomes could be
a- Cancerous.
b- Young.
c- Old.
d- Have high telomerase activity.
e- Have high DNA polymerase activity.
2) Suppose someone has more telomerase activity than normal, what would this indicate
about that person's cells?
a- They could be cancerous.
b- They may have long telomeres.
c- Their cells could be normal.
d- Their cells would die quickly.
3) Which of the following are the properties of enzyme telomerase?
a) Telomerase is a reverse transcriptase enzyme
b) Telomerase consists of an RNA sequence that serves as a template
c) After completion of each cycle, telomerase translocates to 3'end of DNA to synthesize
repetitive sequence.
d) The enzyme presents in certain cells like stem cell
e) All of the above
4) Which of the following is a characteristic of DNA sequences at telomere?
a- They consist of Guanine and Adenine (or Thymine) nucleotide.
b- They consist of repeated sequences.
c- One strand protrudes beyond the other, creating some single stranded DNA at the
end.
d- All the above
1) B 2) A 3) E 4) D
Medix Team 2
Dr.Moaaz Wahdan 2024 Biochemistry
Seminars FOMNINU 2023
1) The region of repetitive nucleotide sequences at each end of chromatid is:
A. Centromere
B. Telomere
C. Monomer
D. Isomer
2) Telomere is Not related to __________
A. Maintenance
B. Chromosome degradation
C. Division
D. Replication
3) In cancer, telomerase activity ______
A. Increases
B.Decreases
C. Remains constant
D. Plays no role
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Medix Team
1) B 2) C 3) A
Medix Team 3
Dr.Moaaz Wahdan 2024 Biochemistry
Seminars FOMSCU 2023
1) The protective ends of a chromosome are called:
A) Centromere
B) Heterochromatin
C) Telomeres
D) Telomerase
2) Telomere is rich with
A) A
B) C
C) G
D) T
3) All of the following cell types contain the enzyme telomerase except:
A) Cancer cells
B) Germ cells
C) Somatic cells
D) Stem cells
1) C 2) C 3) C
Medix Team 4
Dr.Moaaz Wahdan 2024 Biochemistry
Quizzz
1) Telomerase enzyme is present in all of the following cells except.
A) germ cell
b) somatic cell
c) stem cell
2) Sequence of nitrogenous bases in RNA primer of telomerase enzyme is:
a) AAUCCC
b) TTAGGG
c) ACUGGG
3) Telomerase does which of the following -
a) Joins Okazaki fragments on the lagging strand
b) Catalyzes DNA replication at the ends of chromosome
c) Enhances transcription
d) Requires dCTP
4) Which of the following statements is true about telomeres in vertebrates?
1) It contains tandem repeats of TTAGGG in various species
2) The repeat numbers vary with species , cell types and developmental
stages.
3) In somatic cells, the repeat numbers gradually shorten with age.
4) In cancer cells , the repeat numbers don’t shorten with age.
A) only 1
B) 1,2&3
C) 1,2,3&4
D) 1,3&4
Medix Team 5
Dr.Moaaz Wahdan 2024 Biochemistry
5) One of the following is true about the functions of telomeres
A) Protect DNA ends from degradation
B) Prevent fusion of chromosome ends with other chromosomes
C) Help in replication of telomeres
D) All of the above
6) Shelterin complex is associated with
A) Centromere
B) Telomeres
C) Autonomously replicating DNA sequence
D) All of the above
7) In mammalian cells, the 3’ single stranded overhang of the telomere containing
many Gs may fold over and pair with a short stretch of DNA to form a structure called
A) r-loop
B) s-loop
C) t-loop
D) u-loop
8) Eukaryotic chromosome without telomere is
A) Highly sticky
B) Unstable and may undergo degradation
C) Undergo various types of chromosomal rearrangement such as translocation
D) All of the above
9) Telomere provides stability to the linear chromosomal DNA and helps in
chromosome length maintenance because:
A) Telomere contains t-loop which prevents DNA ends from degradation
B) Telomere contains Shelterin protein complex which prevent nuclease binding
C) Telomere helps in replication of chromosomal ends
D) All of the above
Medix Team 6
Dr.Moaaz Wahdan 2024 Biochemistry
10) What kind of enzyme is the telomerase protein?
A. Terminal transferase
B. DNA polymerase delta
C. Reverse transcriptase
D. RNA polymerase
1) B 2) A 3) B 4) C 5) D
6) B 7) C 8) D 9) D 10) C
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Medix Team
Medix Team 7
