https://www.inosr.
net/inosr-applied-sciences/ Nyakairu
INOSR APPLIED SCIENCES 12(3):20-23, 2024 ISSN: 2705-165X
©INOSR PUBLICATIONS INOSR12.3.2023.000
International Network Organization for Scientific Research
https://doi.org/10.59298/INOSRAS/2024/12.3.2023
The Burden of Malaria in East Africa: Epidemiology and
Health Impact
Nyakairu Doreen G.
Faculty of Science and Technology Kampala International University Uganda
ABSTRACT
Malaria remains a significant public health challenge in East Africa, disproportionately affecting the region due to
diverse ecological conditions, socioeconomic factors, and variable healthcare infrastructure. This review provides
an overview of the epidemiological landscape and health impact of malaria in East African countries, including
Kenya, Tanzania, Uganda, Rwanda, Burundi, and Ethiopia. The prevalence and distribution of malaria vary
widely, with high transmission rates in specific regions and vulnerable groups, particularly children under five and
pregnant women. The disease's health impacts are profound, contributing to high morbidity and mortality,
economic loss, and educational deficits, while placing a substantial burden on healthcare systems. Despite progress
in malaria control efforts, challenges such as drug resistance, inadequate healthcare infrastructure, and the need
for sustained funding persist. The methodology for this review involved a comprehensive analysis of existing
literature and epidemiological data on malaria in East Africa. Addressing these challenges requires a multifaceted
approach that includes improved surveillance, targeted interventions, and community engagement to reduce the
burden of malaria and improve health outcomes in the region.
Keywords: Malaria Epidemiology, East Africa, Health Impact, Socioeconomic Burden, Malaria Control Strategies.
INTRODUCTION
Malaria, a mosquito-borne infectious disease caused and incidence rates across different geographic
by Plasmodium parasites, remains one of the most regions. Coastal areas, highlands, and river basins
significant public health challenges in East Africa present distinct transmission patterns, influenced by
[1, 2]. Despite global efforts to control and factors such as altitude, climate, and human
eliminate the disease, East Africa continues to bear a activities[8, 9]. Understanding these regional
disproportionate share of the malaria burden [3]. differences is crucial for implementing targeted
The region's diverse ecology, socio-economic malaria control strategies. The health impact of
conditions, and varying levels of healthcare malaria in East Africa is profound, contributing to
infrastructure contribute to the persistent and high high morbidity and mortality rates. The disease not
transmission rates of malaria. This review aims to only causes severe illness and death but also imposes
provide an overview of the epidemiological a heavy socioeconomic burden on families,
landscape of malaria in East Africa and to highlight communities, and national economies[10, 11].
its profound health impacts on the region's Recurrent malaria episodes lead to absenteeism from
populations. East Africa, comprising countries such work and school, reduced productivity, and
as Kenya, Tanzania, Uganda, Rwanda, Burundi, and increased healthcare costs, perpetuating a cycle of
Ethiopia, experiences some of the highest malaria poverty and disease. Efforts to combat malaria in
transmission rates globally[4, 5]. The disease affects East Africa have yielded some progress, with
millions of people annually, with children under five increased access to preventive measures, diagnostic
and pregnant women being the most vulnerable tools, and effective treatments. However, numerous
groups. Malaria's endemic nature in these countries challenges remain, including the emergence of drug-
is driven by a combination of favorable resistant malaria strains, inadequate healthcare
environmental conditions for mosquito breeding, infrastructure, and the need for sustained political
widespread poverty, and challenges in healthcare and financial commitment. Addressing these
delivery[6, 7]. The epidemiology of malaria in East challenges requires a comprehensive approach that
Africa reveals significant variations in prevalence combines scientific research, public health initiatives,
20
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
https://www.inosr.net/inosr-applied-sciences/ Nyakairu
and community engagement. In this article, we will elimination in the region. By understanding the
delve deeper into the epidemiological trends of complexities of malaria in East Africa, we can better
malaria in East Africa, examine its health impacts on address this enduring public health challenge and
different populations, and discuss the ongoing efforts improve the lives of those affected by the disease.
and future directions for malaria control and
EPIDEMIOLOGY OF MALARIA IN EAST AFRICA
Prevalence and Distribution: East Africa, highlands, and river basins, creates varying levels of
encompassing countries such as Kenya, Tanzania, malaria risk. According to the World Health
Uganda, Rwanda, Burundi, and Ethiopia, exhibits Organization (WHO), sub-Saharan Africa, including
high malaria transmission rates. The region's East Africa, accounts for approximately 90% of
diverse geography, including coastal areas, global malaria cases and deaths[4, 12, 13].
Regional Variations
Malaria is prevalent in Kenya, Tanzania, Uganda, but still face significant challenges, especially in
Rwanda, Burundi, and Ethiopia. Western regions lowland areas. Ethiopia has a higher malaria
around Lake Victoria and coastal areas experience incidence in the highland areas[14, 15].
perennial transmission, while highlands and arid Demographic Impact: Malaria disproportionately
northern areas have lower rates. Tanzania has the affects specific demographic groups, particularly
highest burden in the northwestern regions and children under five and pregnant women. These
along the coast, while Uganda has the highest groups are more vulnerable to severe malaria due to
transmission in the northern and eastern regions. their lower immunity.
Rwanda and Burundi have lower transmission rates
Children under Five
Children in this age group account for the majority malaria. The WHO estimates that over 260,000
of malaria-related deaths in East Africa. The African children under the age of five die from
immature immune systems of young children make malaria annually, with a significant portion of these
them more susceptible to severe and often fatal deaths occurring in East Africa [16, 17].
Pregnant Women
Pregnant women are at increased [18] risk of severe during pregnancy contributes to adverse birth
malaria, which can lead to maternal anemia, low outcomes, including prematurity and intrauterine
birth weight, stillbirth, and neonatal death. Malaria growth retardation[5, 19].
HEALTH IMPACT OF MALARIA IN EAST AFRICA
Morbidity and Mortality: Malaria is a major cause and school, decreased productivity, and economic
of illness and death in East Africa, imposing a heavy loss. The disease also contributes to the
burden on healthcare systems and communities. overburdening of healthcare facilities, as individuals
High malaria transmission results in recurrent frequently seek treatment for febrile illnesses
episodes of illness, leading to absenteeism from work suspected to be malaria [8, 20].
Mortality
Malaria is a major cause of mortality in East Africa, affects educational attainment, with children missing
particularly among young children and pregnant school due to illness or caring for sick family
women. Despite efforts to reduce deaths, challenges members. Repeated malaria episodes in early
like drug resistance and inadequate healthcare childhood can lead to long-term educational deficits.
infrastructure persist. Malaria has significant The healthcare system is also burdened by the need
socioeconomic impacts, including financial strain on for resources for diagnosis, treatment, and
families and healthcare systems due to the high cost prevention. Seasonal surges in malaria cases can
of treatment and loss of income due to illness and overwhelm health facilities, leading to inadequate
caregiving responsibilities. It also significantly care for other conditions.
CONCLUSION
Malaria continues to be a major public health approach, involving improved surveillance, targeted
challenge in East Africa, with significant interventions, and community engagement. By
epidemiological and health impacts. Efforts to understanding the epidemiology and health impact
combat the disease have made progress, but of malaria, stakeholders can develop more effective
challenges remain, including drug resistance, strategies to reduce the burden of this devastating
healthcare access, and the need for sustained funding disease and improve health outcomes for affected
and political commitment. Addressing the burden of populations.
malaria in East Africa requires a multifaceted
21
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
https://www.inosr.net/inosr-applied-sciences/ Nyakairu
REFERENCES
1. Abossie, A., Yohanes, T., Nedu, A., Tafesse, W., Soroti District, North Eastern Uganda. Malar.
Damitie, M.: Prevalence of Malaria and J. 21, 363 (2022).
Associated Risk Factors Among Febrile https://doi.org/10.1186/s12936-022-04396-z
Children Under Five Years: A Cross-Sectional 9. Barabadi, H., Alizadeh, Z., Rahimi, M.T.,
Study in Arba Minch Zuria District, South Barac, A., Maraolo, A.E., Robertson, L.J.,
Ethiopia. Infect. Drug Resist. Volume 13, Masjedi, A., Shahrivar, F., Ahmadpour, E.:
363–372(2020). Nanobiotechnology as an emerging approach
https://doi.org/10.2147/IDR.S223873 to combat malaria: A systematic review.
2. Alum, E., Ugwu, P.-C., Egba, S., Uti, D., Nanomedicine Nanotechnol. Biol. Med. 18,
Alum, B., Extension, K.P.: Climate Variability 221–233(2019).
and Malaria Transmission: Unraveling the https://doi.org/10.1016/j.nano.2019.02.017
Complex Relationship. INOSR Sci. Res. 11, 10. Emmaculate, K., Extension, K.P.: Effects of
16–22(2024). Antimalarial Drugs on the Motor and
https://doi.org/10.59298/INOSRSR/2024/1. Behavioral Programs in Drosophila
1.21622 melanogaster. 3, 17–26 (2024)
3. Bakken, L., Iversen, P.O.: The impact of 11. Kigozi, S.P., Kigozi, R.N., Sebuguzi, C.M.,
malaria during pregnancy on low birth weight Cano, J., Rutazaana, D., Opigo, J., Bousema,
in East-Africa: a topical review. Malar. J. 20, T., Yeka, A., Gasasira, A., Sartorius, B.,
348 (2021). https://doi.org/10.1186/s12936- Pullan, R.L.: Spatial-temporal patterns of
021-03883-z malaria incidence in Uganda using HMIS data
4. Nankabirwa, J.I., Rek, J., Arinaitwe, E., from 2015 to 2019. BMC Public Health. 20,
Namuganga, J.F., Nsobya, S.L., Asua, V., 1913 (2020). https://doi.org/10.1186/s12889-
Mawejje, H.D., Epstein, A., Greenhouse, B., 020-10007-w
Rodriguez-Barraquer, I., Briggs, J., 12. Mitchell, C.L., Ngasala, B., Janko, M.M.,
Krezanoski, P.J., Rosenthal, P.J., Conrad, M., Chacky, F., Edwards, J.K., Pence, B.W.,
Smith, D., Staedke, S.G., Drakeley, C., Mohamed, A., Mhamilawa, L.E., Makene, T.,
Bousema, T., Andolina, C., Donnelly, M.J., Kyaw, T., Molteni, F., Mkali, H., Nyinondi, S.,
Kamya, M.R., Dorsey, G.: East Africa Kabula, B., Serbantez, N., Eckert, E.L., Kitojo,
International Center of Excellence for Malaria C., Reaves, E., Emch, M., Juliano, J.J.:
Research: Summary of Key Research Findings. Evaluating malaria prevalence and land cover
Am. J. Trop. Med. Hyg. 107, 21–32 (2022). across varying transmission intensity in
https://doi.org/10.4269/ajtmh.21-1285 Tanzania using a cross-sectional survey of
5. Anangwe Amimo, F.: Malaria Transmission school-aged children. Malar. J. 21, 80 (2022).
Dynamics in East Africa. In: Eva Amoah, L., https://doi.org/10.1186/s12936-022-04107-8
Kojo Acquah, F., and Kumi Asare, K. (eds.) 13. Sinzinkayo, D., Baza, D., Gnanguenon, V.,
Infectious Diseases. IntechOpen (2024) Koepfli, C.: The lead-up to epidemic
6. Thu, A.M., Phyo, A.P., Landier, J., Parker, transmission: malaria trends and control
D.M., Nosten, F.H.: Combating interventions in Burundi 2000 to 2019. Malar.
multidrug‐resistant Plasmodium falciparum J. 20, 298 (2021).
malaria. Febs J. 284, 2569–2578 (2017). https://doi.org/10.1186/s12936-021-03830-y
https://doi.org/10.1111/febs.14127 14. Minakawa, N., Dida, G.O., Sonye, G.O.,
7. Agyemang-Badu, S.Y., Awuah, E., Oduro- Futami, K., Njenga, S.M.: Malaria Vectors in
Kwarteng, S., Dzamesi, J.Y.W., Dom, N.C., Lake Victoria and Adjacent Habitats in
Kanno, G.G.: Environmental Management Western Kenya. PLoS ONE. 7, e32725 (2012).
and Sanitation as a Malaria Vector Control https://doi.org/10.1371/journal.pone.003272
Strategy: A Qualitative Cross-Sectional Study 5
Among Stakeholders, Sunyani Municipality, 15. Omondi, C.J., Onguru, D., Kamau, L.,
Ghana. Environ. Health Insights. 17, Nanyingi, M., Ong’amo, G., Estambale, B.:
11786302221146890 (2023). Perennial transmission of malaria in the low
https://doi.org/10.1177/11786302221146890 altitude areas of Baringo County, Kenya.
8. Akello, A.R., Byagamy, J.P., Etajak, S., Malar. J. 16, 257 (2017).
Okadhi, C.S., Yeka, A.: Factors influencing https://doi.org/10.1186/s12936-017-1904-y
consistent use of bed nets for the control of 16. Sarfo, J.O., Amoadu, M., Kordorwu, P.Y.,
malaria among children under 5 years in Adams, A.K., Gyan, T.B., Osman, A.-G.,
22
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
https://www.inosr.net/inosr-applied-sciences/ Nyakairu
Asiedu, I., Ansah, E.W.: Malaria amongst of Mozambique. Malar. J. 18, 360 (2019).
children under five in sub-Saharan Africa: a https://doi.org/10.1186/s12936-019-2995-4
scoping review of prevalence, risk factors and 19. Arnaldo, P., Rovira-Vallbona, E., Langa, J.S.,
preventive interventions. Eur. J. Med. Res. 28, Salvador, C., Guetens, P., Chiheb, D., Xavier,
80 (2023). https://doi.org/10.1186/s40001- B., Kestens, L., Enosse, S.M., Rosanas-Urgell,
023-01046-1 A.: Uptake of intermittent preventive
17. Tsegaye, A.T., Ayele, A., Birhanu, S.: treatment and pregnancy outcomes: health
Prevalence and associated factors of malaria in facilities and community surveys in Chókwè
children under the age of five years in Wogera district, southern Mozambique. Malar. J. 17,
district, northwest Ethiopia: A cross-sectional 109 (2018). https://doi.org/10.1186/s12936-
study. PLOS ONE. 16, e0257944 (2021). 018-2255-z
https://doi.org/10.1371/journal.pone.025794 20. Fitri, L.E., Widaningrum, T., Endharti, A.T.,
4 Prabowo, M.H., Winaris, N., Nugraha, R.Y.B.:
18. Alonso, S., Chaccour, C.J., Elobolobo, E., Malaria diagnostic update: From conventional
Nacima, A., Candrinho, B., Saifodine, A., Saute, to advanced method. J. Clin. Lab. Anal. 36,
F., Robertson, M., Zulliger, R.: The economic e24314(2022).
burden of malaria on households and the https://doi.org/10.1002/jcla.24314
health system in a high transmission district
CITE AS: Nyakairu Doreen G. (2024). The Burden of Malaria in East Africa: Epidemiology and Health
Impact. INOSR APPLIED SCIENCES 12(3):20-23.
https://doi.org/10.59298/INOSRAS/2024/12.3.2023
23
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.