Ssecond - Year - Paper - B - 2 (26-4-24) Zeshan
Ssecond - Year - Paper - B - 2 (26-4-24) Zeshan
Pharmacology
Computer
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PHARMACOLOGY 2023
Distribution: Describes the journey of the drug through the bloodstream to various
Examples
Advantages
Drugs get to the site of action more rapidly, providing a rapid response, which may be required
in an emergency
Disadvantages
These routes are irreversible and may cause pain, fear, and infection
1. Oral Administration: Drugs are typically administered orally in the form of tablets,
capsules, or liquids. The drug formulation must dissolve in the fluids of the GIT before it
can be absorbed.
2. Ingestion: The drug is taken orally and enters the stomach
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3. Dissolution: Once the drug reaches the stomach and intestines, it must dissolve in the
gastrointestinal fluids to be available for absorption. The rate of dissolution can affect
the onset of action of the drug.
4. Ionization: The drug may ionize, depending on its pH sensitivity, which affects
its absorption.
5. Absorption: After dissolution, the drug molecules must cross the gastrointestinal
epithelium to enter the bloodstream. This can occur through various mechanisms,
including passive diffusion, facilitated transport, active transport, and endocytosis.
Passive Diffusion:
Facilitated Transport:
Active Transport:
6. Distribution: Once absorbed into the bloodstream, the drug is distributed to various
tissues and organs based on factors such as blood flow, tissue permeability, and protein
binding.
7. Metabolism and Elimination: The drug may undergo metabolism in the liver or other
tissues to form metabolites that are then excreted from the body through the kidneys
or bile. The rate of metabolism and elimination can affect the drug's duration of action.
8. Systemic circulation: The absorbed drug enters the bloodstream and is
distributed throughout the body.
Factors influencing drug transport from the GIT include:
- pH
- Solubility
- Permeability
- Drug interactions
- Food effects
- Gut motility
- Enzyme activity
SOCIALBEHAVIOR
Qus – 4: - Define communication and what are importance of
communication?
Definition of Communication
Communication is the process of exchanging information, ideas, or messages between
individuals, groups, or organizations through a common system of symbols, signs, or
behavior. It involves the transmission, reception, and interpretation of information,
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and can take many forms, such as verbal (spoken or written), nonverbal (body language,
facial expressions), or visual (images, videos).
The importance of communication lies in its ability to:
1. Convey meaning and understanding
2. Build relationships and trust
3. Facilitate collaboration and teamwork
4. Resolve conflicts and issues
5. Share knowledge and ideas
6. Provide feedback and guidance
7. Enhance productivity and efficiency
8. Promote learning and growth
9. Foster a positive work culture
10. Facilitate effective decision-making
Culture make us different from animals in a way that our dressing,Eating and way of
living is different and much better then animals Which increases the complexity of
human behavior due to the
E.g. The behavior according to way of living,Culture of marriage in our society influences
the human behavior in the following ways.
Environmental Influences These are the factors or influencing stimuli that affect the
human and surround them.
Physical Environment Physical environment is used those environmental factors that can be
seen and visualized.
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Drugs (Narcotics) Drugs especially narcotics effect temporarily and permanently
leading to bad social relations.
TV Television and commercials can change the basic thoughts and views of any
person.
1. Mental Health
Mental health is a state of well-being in which the individual realizes his or her own abilities,
can survive with the normal stresses of life, can work productively and fruitfully, and is able to
make a contribution to his or her community”.
Mental illness can occur when the brain (or part of the brain) is not working well or is working in
the wrong way. When the brain is not working properly, one or more of its 6 functions will be
disrupted
2. Applied Psychology
Applied psychology is the use of psychological principles and theories to overcome problems in
real life situations. Many areas of our lives and society have been influenced and changed by the
often-unnoticed application of psychological principles
1. Any pharmacist exercising their professional role must be registered, safe and
competent to practice.
2. Pharmacist must be aware that the patient is the primary focus.
3. Pharmacist must be trained in respect of their area of operation.
4. Pharmacist must ensure that dispensing is carried out accurately.
5. Each prescription must be critically reviewed before dispensing to ensure that the
medicines are safe and in the best interest of the patient.
6. The pharmacist must contact the prescriber regarding medicines and patient issues if
needed.
7. Patients must be given complete details regarding their medicines at the time of
dispensing, so that they fully understand what the medicine is and what it is for.
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8. Proper information must be given to the patient regarding the safe storage of their
medicine.
9. The medicine dispensed must be of suitable quality, fit for use suitably packaged and
labeled manner.
10. Pharmacists should ensure that the necessary facilities, equipment and materials are
present.
11. Pharmacy should be clean and weighing must be
Qus – 8: - Explain provincial quality control board?
Provincial Quality Control Board
(1) The Board shall consist of the following:
(a) Secretary to the Government, Health Department, ex-officio member and chairperson;
(b) Additional Secretary (Technical) to the Government, Health Department, ex officio member
and vice-chairperson who shall act as chairperson in the absence of the Secretary Health;
(c) Provincial Drugs Controller of the Government or a senior most officer of the Provincial
Drugs Control administration who shall be a pharmacy graduate, Health Department, ex-officio
member;
(d) a pharmacy professional who holds a graduate or higher degree in Pharmacy and has more
than five years professional experience, appointed as a private member by the Government for
a term of four years;
(f) a professor of medicine, appointed as a private member by the Government for a term of
four years;
(g) District Coordination Officer of a district, ex officio member, in respect of cases pertaining
to the district;
(h) Executive District Officer (Health) of a district, ex-officio member, in respect of cases
pertaining to the district; and
(i) a pharmacist of the Government, Health Department, in a district, appointed [ ]by the
Government for a term of four years who shall be the Secretary of the District Board.
(2) The Government shall appoint a secretary of the Provincial Board, who holds a graduate or
higher degree in pharmacy and has at least ten years professional experience who shall also be
member of the Provincial Board.
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(3) The Government may appoint a pharmaceutical expert and an expert of medicine as
members of the Provincial Board in respect of a district for a term of four years.
(4) The quorum for a meeting of the Provincial Board shall be five including the chairperson or
vice-chairperson and one member from the concerned district.
(5) No act or proceeding of the Provincial Board shall be invalid merely on the ground of the
existence of any vacancy or any defect in the constitution of the Board concerned.
(6) The Board may co-opt any other qualified expert having formal training and experience in
the pharmaceutical field.
1. Planning
2. Staffing
3. Training
4. Leading
5. Controlling
Planning
Planning includes decisions about goals and activities that an individual or group will perform and
the use of resources needed to achieve the organization's sales goals.
Staffing
It includes hiring the right people to sell and to lead the salespersons.
Training
Educating the sales personnel to satisfy the customers. Pharmaceutical company customers are
usually physicians or other health-care professionals. They required more detail as compare to
the general public. So, the salesman should be well trained.
Leading
Providing guideline or leading the individual or team in the best way so that they can influence
other people toward achieving the organization's sales goals.
Controlling
1. Input Devices
An Input device is any piece of computer hardware equipment used to feeds or store data into a
computer is known as input device, e.g.
1. Key Board
2. Mouse
3. CD Rom
4. Floppy Disk
5. Microphone
6. Scanner
7. Digital Camera
8. Light Pen
9. Flash Drive
10. Joystick
11. Bluetooth
12. Infrared Device
Keyboard
Keyboard is a primary input device for the PC. Standard keyboard has 104 keys.
Mouse
Mouse is also primary input device for the PC. It is used as a pointer. It can perform functions
like selecting menu commands, moving icons, resizing windows, starting programs, and choosing
options.
CD Rom
Compact disk read only memory, meaning that you can only read from the CD but you canÕt write
to the CD It is an optical device. CD Rom is an input as well as an output device.
CD RW, DVD
Floppy Disk:
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A floppy disk is a disk storage medium composed of a disk of thin and flexible magnetic storage
medium. Floppy disks can store up to 1.44 MB of data and are usually 3 1/2 inches in size
Microphone
Microphone is an input device, which takes voice as input. We use it for voice commands or for
voice chat on the internet.
Scanner
Scanner translates printed images into an electronic format that can be stored in a computerÕs
memory.
Digital camera or Web cam is used for video chatting, to take pictures and for
videoconferences.
Light pen
Light pen is used for special purposes like to highlight object on monitor screen.
Flash Drive
Flash drive is used to transfer data from one computer to another computer. It is an input as
well as an output device.
Joystick
Blue-tooth & infrared devices are used to perform many tasks like, Printing Downloading &
uploading information/ documents from a Mobile phone and computer vice versa.
2. Output Devices
An output device is any piece of computer hardware equipment used to communicate the results
of data processed by computer. By using this hardware, we can get output in different formats.
1. Monitor
2. Printer
3. Speaker
4. CD RW, DVD
5. Floppy
6. Flash Drive
7. Bluetooth & Infrared
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Monitor A monitor is the screen on which words, numbers, and graphics can be seen, it is the
most common output device
Printer
A printer produces output on paper or transparencies. The output is referred to as hard copy.
It can print words, numbers, or pictures.
1. Laser Printer
Speakers
Computer speakers are output device. Speakers allow you to listen to voice like music, and
conversation with people.
Note:
CD RW, DVD, Floppy, Flash Drive, Bluetooth & Infrared devices are both input and output
devices.
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10. Record relevant conversations with friends or family
11. Avoid any unnecessary gaps
12. Record the actions agreed with the patient at the time of discharge
13. Record any adverse reactions or problems including drug allergies.
14. Case-notes must not be removed from the hospital or send original case-notes to other
hospitals
15. Laboratory reports
Qus – 12: - Write a Note on major types of computers?
Types of Computers
1. Mainframes Computers
2. Server
3. Microcomputers
4. Supercomputers
1. Mainframes Computers
Mainframes computers are computers used mainly by large organizations for critical
applications. Mainframe computers are large computers often found in businesses and colleges,
where thousands of people are able to simultaneously use the computer to access data. These
computers have much greater memory and storage capacities than other types of computers.
2. Server
Server is an important component of computer networks. These specialized computers manage
networks. These are used by multiple users, but a smaller number than a mainframe (Generally
used to serve up to 300 users).
It is smaller than a mainframe computer, designed originally for use in small organizations.
Mainframes and Servers are the backbone of information system in corporations, universities,
and other organizations.
3. Microcomputers
Microcomputers are designed to be used by individuals. Some of the most common types of
microcomputers include
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4. Mobile devices
4. Supercomputers
Supercomputers are large, powerful computers that perform specialized tasks. Supercomputer
is designed to run fewer programs at one time, but to do so as quickly as possible
Pharmacology 2020
Qus – 1: - Write a short note on drug absorption& distribution? (5)
Drug Distribution: Describes the journey of the drug through the bloodstream to various
tissues of the body.
Absorption is transfer of a drug from its site of administration to the bloodstream. The rate
and efficiency of absorption depend on the route of administration. For IV delivery, absorption
is complete, that is the total dose of drug reaches the system circulation.
Qus – 2: - Explain the factors modifying the action and dosage of drug?
Factors Modifying the Action and Dosage of Drug
Many factors influence the dosage and action of drug. If the drug is too small, the drug will not
produce the desired action. If it is too large it will produce toxic effects, which are not
desirable.
Following are important factors, which influence the action and dosage of drug.
1. Age
2. Body weight
3. Sex
4. Routes of administration
5. Time of administration
6. Dosage form
7. Absorption, Distribution and excretion of drug
8. Pathological condition
9. Tolerance
10. Combination of drugs (synergism, antagonism)
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Age
Adult dose is for a person between the ages of 18-60years. Children are given small dose. We
use youngÕs formula and ClarkÕs formula to calculate dose for children and infant. Above 60years
of age the dose should be decreased 3/4th of adult dose.
Body Weight
For abnormal body weight the dose of the drug should be suitably adjusted according to the
weight of the patient
Sex
Doses for the women should be less than man because women are usually having more effect
than men. Pregnancy, menstruation and lactation periods should keep in mind while adjusting
dosage.
Routes Of Administration
When drug is given intravenously onset of action is rapid orally given drug have slow onset
action. Oral dose of drug always greater than when it is given parenterally and dose for
subcutaneous or intramuscular injection is greater than intravenous.
Time Of Administration
Presence of food in stomach delays the absorption of drug onset action is slow some drugs can
cause irritant, nausea and vomiting while given in empty stomach. Hypnotics are more effective
when given at bedtime.
Pathological Condition
When liver or kidneys are not functioning properly the dose should be decreased to avoid toxic
effects.
Tolerance
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It is unusual resistance to ordinary dose of the drug-increased dose is often required to obtain
desired therapeutic effects
Combination Of Drugs
When two or more than two drugs are given together action may be increased or decreased
Action of Acetylcholine
It has following major actions
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Allergic rhinitis is a condition characterized by inflammation of the nasal passages due to an
allergic reaction to airborne particles like pollen, dust mites, or pet dander. Symptoms include
sneezing, itching, nasal congestion, and a runny nose. Treatment options may include
antihistamines, nasal corticosteroids, and allergen avoidance measures.
Social behavior represents a continual interaction between the person and the situation.
The goals of our social behaviors function at different levels e.g. day-to-day, current, long-term
Psychotherapy aims to increase the individual's sense of his/her own wellbeing. Usually, it is
provided by a mental health professional such as a clinical psychologist.
Definition Of Communication
The word communication means the act or process of giving or exchanging of information,
signals, or messages as by talk, gestures (movement of part of the body), or writing.
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Verbal And Non-Verbal Communications
1. Verbal Communication
These are vital skills for the doctors and can be mastered through practice. Verbal
communication is a technique used by the doctor to give all the information and advices in the
language of the patient that can be easily understand by the patient.
2. Non-Verbal Communication
The communication other than verbal language is non -verbal communication. It involves the
body movements, face expressions, postural moves to express and communicate with the people.
It is called non-verbal communication.
Powers of Inspectors
(1) Subject to the provisions of section 19 and of any rules made in this behalf, an
Inspector may, within the local limits for which he is appointed, and in any other area
within the permission of the licensing authority,-
(a) inspect any premises-wherein any drug is manufactured, the plant and process of
manufacture, the means employed for standardizing and testing the drugs and all
relevant records and registers;
(b) inspect any premises wherein any drug is sold or is stocked or exhibited for sale or
is distributed, the storage arrangements and all relevant records and registers;
(c) take samples of any drug which is being manufactured, or being sold or is stocked
or exhibited for sale or is being distributed;
(d) enter and search, with such assistance, if any, as he considers necessary, any
building, vessel or place, in which he has reason to believe that an offence under this
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Act or any rules has been or is being committed or may continue to be committed;
(e) call any person to be present as witness in the course of search or seizure or in
connection with any other matter where the presence of witnesses is necessary;
(f) seize such drug and all materials used in the manufacture thereof and any other
articles, including registers, cash memos, invoices and bills, which he has reason to
believe may furnish evidence of the commission of an offence punishable under this
Act or any rules;
(g) require any person to appear before him at any reasonable time and place to give
statement, assistance or information relating to or in connection with the
investigation of an offence under this Act or the rules:
Provided that the exemptions under Sections 132 and 133 of the Code of Civil
Procedure, 1908 (Act V of 1908), shall be applicable to requisitions for attendance
under this Clause;
(h) lock and seal any factory, laboratory, shop, building, store-house or go down, or a
part thereof, where any drug is or is being manufactured, stored, sold or exhibited
for sale in contravention of any of the provisions of this Act or the rules;
(i) forbid for a reasonable period, not exceeding four weeks or such further period,
which shall not be more than three months, as the Inspector may, with. the approval
of the Provincial Quality Control Board, the Central Licensing Board, the Registration
Board, or the licensing authority, as the case may be, specify, any person in charge of
any premises
from removing or dispensing of any drug, article or other thing likely to be used in
evidence of the commission of an offence under this Act or the rules; and
(j) exercise such other powers as may be necessary for carrying out the purposes of
this Act or any rules:
Provided that the powers under causes (f) to (j) shall be exercisable only by an
Inspector specifically authorized in this behalf, by an order in writing, by the
Government appointing him, subject to such conditions as may be specified in such
order:
Provided further that the power under clause (h) may be exercised by an Inspector
not authorized as aforesaid where the contravention is of a provision which requires a
license to be obtained for the manufacture, storage or sale of a drug.
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(2) The provisions of the Code of Criminal Procedure, 1898 (Act V of 1898), in so far
as they are not inconsistent with the provisions of this Act, shall apply to searches
and seizures made under this Act.
Fundamental Computer 2020
It is smaller than a mainframe computer, designed originally for use in small organizations.
Mainframes and Servers are the backbone of information system in corporations, universities,
and other organizations.
5. Microcomputers
Microcomputers are designed to be used by individuals. Some of the most common types of
microcomputers include
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Supercomputers are large, powerful computers that perform specialized tasks. Supercomputer
is designed to run fewer programs at one time, but to do so as quickly as possible.
1. Science
Scientists have been using computers to develop theories and to analyze and test the data. The
high speed and accuracy of the computer allow different scientific analyses to be carried out.
2. Education
Computers are very helpful in education sector. Currently, the classrooms, libraries and
museums are efficiently utilizing computers to make the education much more interesting.
4. Engineering/Architecture/Manufacturing
The architects and engineers are extensively using computers in designing and drawings.
Computers can create objects that can be viewed from all the three dimensions. The
manufacturing factories are using computerized robotic arms to perform hazardous jobs.
Computers help in coordinating the entire manufacturing process.
5. Entertainment
Computers are also used for entertainment purpose. They are used to control the images and
sounds. The special effects would not have been possible without the computers. In addition,
computerized animation and colorful graphics have modernized the film industry.
6. Communication
E-mail or electronic mail is one of the communication media in which computer is used. Through
e-mail, messages and reports are passed from one person to one or more persons with the aid of
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computer and telephone line. The advantage of this service is that while transferring the
messages it saves time, avoids wastage of paper and so on. Moreover, the person who is
receiving the messages can read the messages whenever he is free and can save it, reply it,
forward it or delete it from the computer.
7. Business Application
This is one of the important uses of the computer. There are various concerns where computers
are used such as in business forecasting, to prepare pay bills and personal records, in banking
operations and data storage. Businesses are also using the networking of computers, where a
number of computers are connected together to share the data and the information. Use of e-
mail and the Internet has changed the ways of doing business.
8. Publishing
Computers have created a field known as desktop publishing (DTP). In DTP, with the help of
computer and a laser printer one can perform the publishing job all by oneself.
9. Banking
Computers are extensively used in the field of banking and finance. People can use the ATM
(automated teller machine) services 24 hours a day to deposit and withdraw cash. When
different branches of the bank are connected through computer networks.
Modem Applications
Modems were originally used for connecting users to the Internet or for sending faxes, but a
majority of the modems are used by businesses in a variety of different applications.
1. Performance
2. Privacy
3. Recovery
1. Performance
We can use following tools under the performance menu to enhance the performance of your
computer system
2. Privacy
Computer saves history of all events whenever we use computer for general purpose like,
working on files or surfing Internet. This function allows us to clean and manage the
1. Document History
2. Find and Search History
3. Scan Disk Temporary Files
4. Clipboard Contents
5. Run History
6. Temporary Files Directory
7. Recycle Bin
8. Browser History
9. Third-Party Software Traces
3. Recovery
With the help of “Recovery” option, Norton Utilities Recover Deleted Files. This tool can also
find duplicate files so that we can manage the capacity of our hard disk, we can also repair
drivers and uninstall the unused or unwanted software.
Branches of Pharmacology
1. Pharmacokinetics
Study of effects the body has on drugs, includes absorption, distribution, metabolism and
excretion is called Pharmacokinetics.
2. Pharmacodynamics
Study of effects of drugs on the body is called Pharmacodynamics.
2. Drug
It refers to any substance that brings about a change in biological function through its chemical
action.
3. Pro-Drug
It refers to compounds that, on administration, must undergo chemical conversion by
metabolic processes before becoming an active pharmacological agent. (Levodopa into dopamine)
4. Placebo
It refers to an inactive substance or preparation given to satisfy the patients symbolic need
(psyche need) for drug therapy, and used in controlled studies to determine the efficiency of
medicinal substance.
Qus – 3: - Define Neuron and explain the types of nerve cell (5)
Neuron
Neuron is defined as the basic structural and functional unit of the nervous system.
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Neuron is like any other cell in the body having nucleus and all the organelles in the cytoplasm.
Phase I
Phase-I reaction function to convert lipophilic molecules into more polar molecules by the
exposing a polar functional group. Mainly it is oxidation, but sometimes there is reduction or
hydrolysis.
Phase II
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This phase consists of conjugation reactions. If the metabolites from Phase I metabolism is
sufficiently polar, it can be excreted by the kidneys, However, many Phase I metabolites are
too lipophilic to be retained in the kidneyÕs tubules. A subsequent conjugation reaction
with an endogenous substrate such as sulfuric acid, acetic acid, or amino acid result in polar and
more water-soluble compounds, that excreted by the kidney
Social behavior represents a continual interaction between the person and the situation.
The goals of our social behaviors function at different levels e.g. day-to-day, current, long-term
1. What we do
2. Finding own identity
3. Devotion
6. Young Adulthood (18 Years To 35 Years)
1. Affiliation
2. Love
3. Marriage
4. Job
5. Management skill
6. Expand relation
7. Isolation
8. Rage
9. Grudge
10. Leg pulling
7. Middle Adulthood (35 Years To 55/65 Years)
1. Verbal Communication
These are vital skills for the doctors and can be mastered through practice. Verbal
communication is a technique used by the doctor to give all the information and advices in the
language of the patient that can be easily understand by the patient.
2. Non-Verbal Communication
The communication other than verbal language is non -verbal communication. It involves the
body movements, face expressions, postural moves to express and communicate with the people.
It is called non-verbal communication.
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Qus – 8: -: - Write some codes of ethics for pharmacists. (5)
Pharmacists are health professionals who assist individuals in making the best
use of Medications. This Code, prepared and supported by pharmacists, is
intended to state publicly The principles that form the fundamental basis of the
roles and responsibilities of pharmacists.
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4. A pharmacist acts with honesty and integrity in professional relationships.
5. A pharmacist maintains professional competence.
6. A pharmacist respects the values and abilities of colleagues and other health
Professionals.
7. Pharmacist serves individual, community, and societal needs.
8. A pharmacist seeks justice in the distribution of health resources.
Fundamental Computer 2019
The four basic functions of computers are also known as the information processing cycle.
Computer accepts data from an input device, processes it, stores it in a disk and finally displays
it on an output device such as a monitor.
1. Input
2. Process
3. Output
4. Storage
Input
The computer gathers data or allows a user to add data
Process
Data is converted into information
Output
After processing the data, computer shows the result in different format, which is called
output.
Storage
Data or information is stored for future use
2. Software
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Software is the program that is on the computer that allows you to work with the computer, e.g.
M.S Office, Corel Draw etc.
1. Science
Scientists have been using computers to develop theories and to analyze and test the data. The
high speed and accuracy of the computer allow different scientific analyses to be carried out.
2. Education
Computers are very helpful in education sector. Currently, the classrooms, libraries and
museums are efficiently utilizing computers to make the education much more interesting.
4. Engineering/Architecture/Manufacturing
The architects and engineers are extensively using computers in designing and drawings.
Computers can create objects that can be viewed from all the three dimensions. The
manufacturing factories are using computerized robotic arms to perform hazardous jobs.
Computers help in coordinating the entire manufacturing process.
5. Entertainment
Computers are also used for entertainment purpose. They are used to control the images and
sounds. The special effects would not have been possible without the computers. In addition,
computerized animation and colorful graphics have modernized the film industry.
6. Communication
E-mail or electronic mail is one of the communication media in which computer is used. Through
e-mail, messages and reports are passed from one person to one or more persons with the aid of
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computer and telephone line. The advantage of this service is that while transferring the
messages it saves time, avoids wastage of paper and so on. Moreover, the person who is
receiving the messages can read the messages whenever he is free and can save it, reply it,
forward it or delete it from the computer.
7. Business Application
This is one of the important uses of the computer. There are various concerns where computers
are used such as in business forecasting, to prepare pay bills and personal records, in banking
operations and data storage. Businesses are also using the networking of computers, where a
number of computers are connected together to share the data and the information. Use of e-
mail and the Internet has changed the ways of doing business.
8. Publishing
Computers have created a field known as desktop publishing (DTP). In DTP, with the help of
computer and a laser printer one can perform the publishing job all by oneself.
9. Banking
Computers are extensively used in the field of banking and finance. People can use the ATM
(automated teller machine) services 24 hours a day to deposit and withdraw cash. When
different branches of the bank are connected through computer networks.
Qus – 12: - Define Computer network and explain the advantage and
disadvantage of computer networking. (5)
Computer Network
A computer network is a set of two or more computers connected together in order to share
information and other resources. The computers in a network are connected with one another
through cables, satellite or telephone lines.
Advantages Of Networking
1. Computers can communicate with each other easily
2. Computers can share data and files.
3. Computing power and/or storage facilities can be shared.
4. Hardware such as printers can be shared.
5. There is control over which programs, data and hardware a user has access to.
Disadvantages Of Networking
1. A virus can spread more easily.
2. As data is shared there is a greater need for security.
3. If the server fails, all the workstations are affected.
4. The cost of installing the equipmentÕs is greater.
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Pharmacology 2019
Qus – 1: - Write a note on Drug Metabolism. (5)
1. Drug Metabolism
Drugs are most eliminated by biotransformation and/or excretion into the urine or bile. The
process of metabolism transforms lipophilic drugs into more polar readily excretable products.
The liver is the major site for drug metabolism, but specific drug may undergo
biotransformation in other tissues, such as the kidney and the intestine.
3. Phase I
Phase-I reaction function to convert lipophilic molecules into more polar molecules by the
exposing a polar functional group. Mainly it is oxidation, but sometimes there is reduction or
hydrolysis.
4. Phase II
This phase consists of conjugation reactions. If the metabolites from Phase I metabolism is
sufficiently polar, it can be excreted by the kidneys, However, many Phase I metabolites are
too lipophilic to be retained in the kidneyÕs tubules. A subsequent conjugation reaction
with an endogenous substrate such as sulfuric acid, acetic acid, or amino acid result in polar and
more water-soluble compounds, that excreted by the kidney
Qus – 2: - Write the Factor Modifying Action & dosage of drugs? (5)
Factors Modifying the Action and Dosage of Drug
Many factors influence the dosage and action of drug. If the drug is too small, the drug will not
produce the desired action. If it is too large it will produce toxic effects, which are not
desirable.
Following are important factors, which influence the action and dosage of drug .
1. Age
2. Body weight
3. Sex
4. Routes of administration
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5. Time of administration
6. Dosage form
7. Absorption, Distribution and excretion of drug
8. Pathological condition
9. Tolerance
10. Combination of drugs (synergism, antagonism)
Dosage Form Of Drug (Preparation)
Onset action is rapid when the drug is given in liquid or as a powder as compared
to drug Given inform of a tablet of pill.
Following are important factors, which influence the action and dosage of drug .
1. Age
2. Body weight
3. Sex
4. Routes of administration
5. Time of administration
6. Dosage form
7. Absorption, Distribution and excretion of drug
8. Pathological condition
9. Tolerance
10. Combination of drugs (synergism, antagonism)
1. Age
Adult dose is for a person between the ages of 18-60years. Children are given small dose. We
use youngÕs formula and ClarkÕs formula to calculate dose for children and infant. Above 60years
of age the dose should be decreased 3/4th of adult dose.
2. Body Weight
For abnormal body weight the dose of the drug should be suitably adjusted according to the
weight of the patient
3. Sex
Doses for the women should be less than man because women are usually having more effect
than men. Pregnancy, menstruation and lactation periods should keep in mind while adjusting
dosage.
4. Routes Of Administration
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When drug is given intravenously onset of action is rapid orally given drug have slow onset
action. Oral dose of drug always greater than when it is given parenterally and dose for
subcutaneous or intramuscular injection is greater than intravenous
5. Time Of Administration
Presence of food in stomach delays the absorption of drug onset action is slow some drugs can
cause irritant, nausea and vomiting while given in empty stomach. Hypnotics are more effective
when given at bedtime.
8. Pathological Condition
When liver or kidneys are not functioning properly the dose should be decreased to avoid toxic
effects.
9. Tolerance
It is unusual resistance to ordinary dose of the drug-increased dose is often required to obtain
desired therapeutic effects
1. Mechanism Of Action
The depolarizing neuromuscular blocking drug succinylcholine attaches to the nicotinic receptor
and act like acetylcholine. This drug remains attached to the receptor for longer time and
providing a constant stimulation of the receptor.
2. Action
Succinylcholine initially produces short lasting twitching of the muscle (fasciculation) followed
within a few minutes by paralysis. The drug does not produce a ganglionic block except at high
doses.
3. Therapeutic Uses
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Because of its rapid onset and short duration of action, succinylcholine is useful when rapid
endotracheal intubation is required during the anesthesia. For example, if aspiration of gastric
contents is to be avoided during intubations.
4. Pharmacokinetics
Succinylcholine is injected intravenously its duration of action is short therefore usually given
by continuous infusion.
5. Adverse Effects
Hyperthermia, Hyperkalemia
Social behavior represents a continual interaction between the person and the situation.
The goals of our social behaviors function at different levels e.g. day-to-day, current, long-term
1. What we do
2. Finding own identity
3. Devotion
6. Young Adulthood (18 Years To 35 Years)
1. Affiliation
2. Love
3. Marriage
4. Job
5. Management skill
6. Expand relation
7. Isolation
8. Rage
9. Grudge
10. Leg pulling
7. Middle Adulthood (35 Years To 55/65 Years)
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3. Risk acceptance
4. Risk control
5. On-going evaluation
6. Risk Communication
3. Risk Acceptance
In this step we compare risk with acceptance criteria and finalize the acceptance or rejection
or the risk.
4. Risk Control
In the step of risk control, we estimate the costs to control the risk define and take suitable
actions.
5. n-Going Evaluation
This is important step to control upcoming risks; we continuously monitor new harms, risk levels
and update plans and actions accordingly.
6. Risk Communication
It is not enough to learn about risks and control them. One must communicate that information
to health care professionals and patients. If the communication is successful, people will
become aware of the risk and modify their behavior to avoid safety hazards. Without such
communication, there is no hope that patients will change their behavior.
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4. A pharmacist acts with honesty and integrity in professional relationships.
5. A pharmacist maintains professional competence.
6. A pharmacist respects the values and abilities of colleagues and other health
Professionals.
7. Pharmacist serves individual, community, and societal needs.
8. A pharmacist seeks justice in the distribution of health resources.
Computer: - 2018
Qus – 9: - Define Computer and explain the basics four functions of
computer. (5)
The term 'computer' is derived from the word 'compute', which means to calculate.
A computer is a machine that accepts data in digital form and process it for some result based
on a program, which describes how data is to be manipulated or processed
The four basic functions of computers are also known as the information processing cycle.
Computer accepts data from an input device, processes it, stores it in a disk and finally displays
it on an output device such as a monitor.
1. Input
2. Process
3. Output
4. Storage
Input
The computer gathers data or allows a user to add data
Process
Data is converted into information
Output
After processing the data, computer shows the result in different format, which is called
output.
Storage
Data or information is stored for future use
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Qus – 10: - Explain the difference between hardware and software. (5)
Hardware And Software
1. Hardware
Hardware is physical parts of the computer e.g. keyboard, monitor, mouse etc.
2. Software
Software is the program that is on the computer that allows you to work with the computer, e.g.
M.S Office, Corel Draw etc.
1. Science
Scientists have been using computers to develop theories and to analyze and test the data. The
high speed and accuracy of the computer allow different scientific analyses to be carried out.
2. Education
Computers are very helpful in education sector. Currently, the classrooms, libraries and
museums are efficiently utilizing computers to make the education much more interesting.
4. Engineering/Architecture/Manufacturing
The architects and engineers are extensively using computers in designing and drawings.
Computers can create objects that can be viewed from all the three dimensions. The
manufacturing factories are using computerized robotic arms to perform hazardous jobs.
Computers help in coordinating the entire manufacturing process.
5. Entertainment
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Computers are also used for entertainment purpose. They are used to control the images and
sounds. The special effects would not have been possible without the computers. In addition,
computerized animation and colorful graphics have modernized the film industry.
6. Communication
E-mail or electronic mail is one of the communication media in which computer is used. Through
e-mail, messages and reports are passed from one person to one or more persons with the aid of
computer and telephone line. The advantage of this service is that while transferring the
messages it saves time, avoids wastage of paper and so on. Moreover, the person who is
receiving the messages can read the messages whenever he is free and can save it, reply it,
forward it or delete it from the computer.
7. Business Application
This is one of the important uses of the computer. There are various concerns where computers
are used such as in business forecasting, to prepare pay bills and personal records, in banking
operations and data storage. Businesses are also using the networking of computers, where a
number of computers are connected together to share the data and the information. Use of e-
mail and the Internet has changed the ways of doing business.
8. Publishing
Computers have created a field known as desktop publishing (DTP). In DTP, with the help of
computer and a laser printer one can perform the publishing job all by oneself.
9. Banking
Computers are extensively used in the field of banking and finance. People can use the ATM
(automated teller machine) services 24 hours a day to deposit and withdraw cash. When
different branches of the bank are connected through computer networks.
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same technology. Data transfer speeds over a local area network can from 10 Mbps to1 BPS
(Gigabit Ethernet).
2. MANs
MANs (Metropolitan Area Networks) connect multiple LANs to one another (over an area of up
to a few dozen kilometers) at high speeds.
A MAN is made from switches or routers connected to one another with high-speed links
(usually fiber optic cables).
3. WANs
A WAN (Wide Area Network or extended network) connects multiple LANs to one another over
great geographic distances. The most well-known WAN is the Internet
Pharmacology
Qus – 1: - Briefly Explain the Concept of Toxicity. (5)
Toxicity
Toxicity is defined as the inherent capacity of a chemical to cause injury. All the chemicals,
drugs have some degree of toxicity. All substances are poison there is none, which is not a
poison. The right dose differentiates a poison from a remedy.
Toxicity may occur in three general ways
1. Accidental
2. Intentional
3. Adverse Drug Reactions
Accidental ingestion occurs most commonly in children. Intentional over dosage often with
suicidal attempts, whereas adverse drug reactions occur due to any wrong therapy.
Toxic Actions of Chemicals
Toxic chemicals from the environment may contact the skin or absorbed after ingestion or
inhalation. A chemical toxin can potentially affect any tissue or organ within the body.
Occupational And Specific Environmental Toxin
Occupational and specific environmental toxicity is caused by many types of toxic substances
like Chloroform, Aromatic hydrocarbon, Alcohols, Pesticides, Heavy metals, Gases and inhaled
particles,
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Histamine
Histamine is also an autacoid. It is a chemical messenger that mediates a wide range of cellular
responses including allergic and inflammatory reactions, gastric acid secretion and
neurotransmission in parts of the brain.
Mechanism Of Action
Histamine binds with histamine receptors H1, H2, H3, and H4. Where H1 and H2 receptors are
widely expressed and are targets of clinically useful drugs.
Antihistamines
H1 Antihistamines
These compounds are H1 receptor blockers. They do not influence the formation or release of
histamine. They only block the histamine response at target tissue.
Therapeutic Uses
Allergic And Inflammatory Conditions
H1 receptor blockers are useful in treating allergies caused by antigens.
Motion Sickness and Nausea
Along with the antimuscarinic agents, H1 receptor blockers are the most effective agents for
prevention of the symptoms of motion sickness, nausea.
Somnifacients
Many first-generation antihistamines have strong sedative properties and are used in the
treatment of insomnia.
H2 Antihistamine
These agents block the H2 histamine receptors. The chief clinical use is a inhibitors of gastric
acid secretion in the treatment of ulcers and heartburn.
Many of the antiprotozoal drugs cause serious toxic effects in the host. Most Antiprotozoal
agents have not proved to be safe for pregnant patients.
Anthelmintics Drugs
Anthelmintics are drugs used for eradication of worms from the body. An anthelmintic, which
kills the worm, is called vermicide. If the drug is merely noxious to the worms and causes them
to be expelled from the body, it is called a vermifuge.
Antifungal Drugs
Antifungal drugs are used treat fungal infections. Fungal infections are common. They may
affect mucous membranes, skin hair and nails. Sometimes internal organs may be involved e.g.
lungs, intestine, liver, brain etc. Some antifungal drugs are for local application only. Other
drugs are given orally or may be injected.
Antitubercular Drugs
Antitubercular drugs are used to treat tuberculosis. Tubercular is small rounded swellings or
nodules. Tubercular is an infectious disease caused by the bacillus and characterized by
formation of nodules. In pulmonary tuberculosis, the bacillus is inhaled into the lungs where it
sets up a primary tubercle and spreads to the nearest lymph nodes.
Antileprotic Drugs
These drugs are used to treat leprosy. Leprosy is a chronic disease caused by bacteria that
affect the skin mucous membranes and nerves causing discoloration and lumps on the skin.
Anticancer Drugs
These drugs are used to treat cancer, neoplasia or tumor. Cancer is a disease caused by an
uncontrolled division of abnormal cells in the part of the body that then invade and destroy the
surrounding tissues.
Spread of cancer cells (metastasis) may occur via the blood stream or the lymphatic channels.
Cancer may be treated by surgery, radiotherapy or chemotherapy. Certain tumors are highly
sensitive to chemotherapy but many tumors are not sensitive to such drugs.
Qus – 5: - What are the development stages of life, just name them.?
Answer: Developmental Stages Of Life are:-
Infant (Birth Till 8 Months)
Early Childhood (8 Months To 3 Years)
Play Age (3 Years To 5 Years)
School Age (6 Years To 12 Years)
Adolescence (12 Years To 18 Years)
Young Adulthood (18 Years To 35 Years)
Middle Adulthood (35 Years To 55/65 Years)
Late Adulthood (55/65 Years To
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1. Any pharmacist exercising their professional Role must be registered, safe and
competent to Practice.
2. Pharmacist must be aware that the patient is the Primary focus.
3. Pharmacist must be trained in respect of their Area of operation.
4. Pharmacist must ensure that dispensing is Carried out accurately.
5. Each prescription must be critically reviewed Before dispensing to ensure that
the medicines Are safe and in the best interest of the patient.
6. The pharmacist must contact the prescriber Regarding medicines and patient
issues if Needed.
7. Patients must be given complete details regarding their medicines at the time
of Dispensing, so that they fully understand what the medicine is and
8. what it is for.
9. The medicine dispensed must be of suitable quality, fit for use suitably packaged and
Labeled manner.
10. Pharmacists should ensure that the necessary facilities, equipment and
11. materials are Present.
12. Pharmacy should be clean and weighing must be accurate
13. Proper information must be given to the patient regarding the safe storage
of their Medicn
Qus – 8: - write the note on Rick management plan? (5)
Risk Management Plan
Risk management involves an assessment of the risks a pharmacy faces, followed by the
development of ways to eliminate or control those risks to prevent setbacks from happening.
9. Risk Acceptance
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In this step we compare risk with acceptance criteria and finalize the acceptance or rejection
or the risk.
Criterion for all healthcare providers, given the cost containment Measures in
healthcare budgets. Improving both processes and Patient care outcomes,
With the wide range of solutions for patient Data Collection and Connectivity,
GE Healthcare is at a strong Position to provide the next frontier in data
management: analysis and reporting for care and cost Management.
Qus – 10: - What are the PC tools, name few tools and
define any two?
The Control Panel is full of tools to change the way Windows looks and behaves.
Here we will Discuss the most important tools.
• Add hardware
• Add or remove programs
• Automatic updates
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• Date and time
• Display
• Internet options
• Mouse
• Keyboard
• Network connections
• Regional and language setting
• Sounds and audio devices
• User accounts
1. Windows firewall
1…. Add Hardware
The “Add Hardware” Wizard enables you to add new hardware or troubleshoot any
hardware-Related problems.
3. Automatic Updates
With “Automatic Updates”, Windows checks for updates that can help protect your computer
against the latest viruses and other security threats, it also enhances the performance of your
computer
5. Display
The following tasks are frequently performed when you want to change various display settings
on your computer
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By using Internet option tool, we can change Internet properties. We can change or organize
Security, Privacy, and Connections settings.
7. Mouse
By using mouse tool, we can manage different functions of mouse like clicking speed, movement
of mouse courser etc.
8. Keyboard
By using keyboard tool, we can manage different functions of keyboard.
9. Network Connections
By using this toll we can manage our network connections, we can add or remove or change the
setting of networks.
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• Hardware such as printers can be shared.
• There is control over which programs, data and hardware a user has access to.
Disadvantages Of Networking
• A virus can spread more easily.
• As data is shared there is a greater need for security.
• If the server fails, all the workstations are
affected.
. The cost of installing the equipments is greater
material; we can create reports, medical transcription, memos, business letters and articles.
Microsoft Word allows the medical assistant to produce a document needed quickly and easily.
2. Delete Text
We can erase characters, words, lines, or pages easily.
4. Copy
We can copy any word, line, paragraph or page anywhere else in the file.
5. Spell Check
Spell check is very important feature of most word processing programs. Medical spell checkers
can be added to most word processing programs and can be used to check medical terminology in
word-processed documents.
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7. Page Formatting
In page formatting we can decorate or document by different font style, text size, colors,
highlighting, aligning the text, making text Bold, Italic, underline, or by creating the line numbers
or bullets.
11. Print
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