05//2/262

Dale

Subject

Paneuteral borodueta
ntspoluctfon i he tehm is dlsrived tMom t o 108ds
Pona meahs u t idle enPnb mCard
inteyt
Emeans that awy dosage fam i d h ane qiven autsiolo
Hho textfnoiccaled Patentenalg
Th aa Steile hxapanaHoa tha ane aiuen dixactHy
Ihn fhe Systenmic ciCtlao
Commaainjechiou fyhe ae tuthaueLOus Cluko avein)
Cubcutah@aux (Lidu ha sku introimesaula Lindounecle
ybe o Paentenal ProDasalien i
DIniectioui fnfeclion coutain Sfedle Sol o Sucbeii&
Poubahed by_dlisColut tao Gctive iugrclieut B
Citaan SUbsfaurel ia LOnle eh injectio oih Sutable
heu-aqeos bae Oh amixtoseot both

2 fosious iThLle Pahentesal

a)roa91aHiouu aa Conapateot
astesile agueno Sol wth udadten q a
CoutinoLs bhase
Porabaahio a nel of bacteial endotoxins o Perogen
No coutaiu Antimicstokaial bresesuntve
3Pooc fos injectie Thule qho Stenile sSeld Porohaia Hie
ihat aro mired ot o COtituted oit a oliloeu Ucealley
57. deytrHOse Col nopaCaliuo bateio Ctatic taate au
Stefle Oale fah inlCctio befaro adminiotatio
wh oGu aro ho Steble
n Sol
Cou Sol ha injecioui hee hoacbhoio ah
Oden m www.remixeducation.in
injeeiio beto they g0 achinsShn eo
your wnting partner
 O TUE
AON D THR
O WED
FRSAT SUN
OOOD
Subjact

h.oueh nittis thjough wtravenou intuci

5 ImblawtsTheLe selid Sfeile babohaho as InSeniel,
fn he 4ssue to caleak the active fgadlieut o_
ouq Peiol Thya Packed th cfesule
COtaiuen fucliidoally

LAduataye atemaal b.abotaliad Prouiclu immecliale

setot acHidu
Nochcure ot issiu doge
this Sttuke auofdhsbale fht Pa effed
Thi du dixactty scolenjed nta blnoo Steam bb
inectioul
No
Ocaa9e

Emitatio
Need a skilled Pensou
Chasce of Paiu add i niun at ste at iujecHe
SteniliaHou ic uised
Need u instunoutl likeSqinge
Reute cf admiuistoaHou

nna muscUla%_

)SuhCutawou
5 at en aclenmal
6Jutra dexal
3)ebduha
67
dna OssCou
nto arkerial_
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your writing partner

 MON TUE WED THR FRI SAT SUN
Subject

|nforoventajection This aroute deliven) clug oliatly

nto tua blond veius
2)ntna-mucculan i n this oule af Hhe daug i que
idotly into te lange Skeletal musele
3)LatnaesitonEal iAdministuouHo af dug nto t
Peutaneal cavik i called iukha- Peitonal
injechio his HDute i tusidlely used in atmal3 fnn
SubcuteneourThe daug i injeched Jut below tha gkiu
Tho oofe f usecd touacefue clisease dg hosis_etc
The ihitakt da mt be quoiclod througla this itate
a t Can be Painul
a DeMajet
6Pelle imblaualio
CSobcutan00uf injecto
5Batna-dehmal injeckiounnthird0uhe Hho doug is
Cue uto the Skin so i t tanm a Cmall bulae
i sbectally ured fo vacc*n cauHio { dauq 9le9y tetiug

6ltnathocali The dung oniuistorucl to the nolval Cond

EbiduUnal The drugA injfcBed noai t Sb{bal Co.d Such
hot italfeoltho nota local noe
Motly ugeol fu qntthsQa duiug Suntay dlelives efe

LntsHaD SSCOuS iTha fniecioIS clouo clisetyuto tao

ntaroQdeual necio- Thux inici6 o g

clisuacHy into guteuy
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your wnting partner
 TUE WED THR FRI SAT SUN
MON O O O O O
O
Subject

Poro tonmlatien tactani

IStuely a bout Phycica Chaical Pornbek e
o Suhstriste Psuio.
dou foma Ltalo, j alled
Putonpaulaion
Pro tohmulalisa develabmouc Stoolue savel ho
CLeue lobmnu scieuist boh time8 aftant
DE Tucluls pH SolubiliyPkacombotabrliyctoaio
FTLROSC PaLicle Si3e-
Main chall eng o all fuo E Parcudal docege
tosp s fo achfve a ghnd combat1y o tho dsu
wth u Pxcioieutf
ho boooet a Oell aushould be comboHble o/
ho beumay_COweuH
Th Slabli of Hhe dtug suh sauce 1 auoie
Colicalbolut hat a fatmala bam can face t
oleuelobruq o fomulaliou

Po muHou o Potredpral babahalb1Ln Ho

Po banaiou ot PanauctralPocuci) actiue_dsuug
vehicle o solveut & h Sobstaace je adjonud
Qro used
Active dsug ho ackve du should haue Suflicet
agueou olobtlity
2 vv ehicle act a mecliomdusiuq tuo foimulatio
oEaruleral Sol SUSbenLOu 8 emoleious
may be Coueoy O non-QuCouR

af
Agvenos 1ebhicle itolen ot Shecto hodo is Seleote
dosiugtbmulaio- ot bataffral because
Safe alkó atll Holeratecl by bcdy Djptuhe af
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q e ODUEhicle Uged a
your writing partner
 Wceen fom injecHo
t e n fon injechen foottosm (o0
discolved ai
'Wten fon injecion foua fobm
Beccteuosfalfc cOad en ton injec tion

3) AdclHves
alconol, Phene
Antmico0bialBengu
Anioxidaul 9- ThioUdea. AscOnbi c acio
A cetede! citnate
BoPfen Oisooliom calciom
clelaAug ageuts Tetoacodium edelale,
eclentee

Sfabilize -lyceúu, Cuatinins

Solbbil3(u qeut i-ethyl alcohol G11ycesdu

Asu th Sol having samo admotc Abteruna

LSotouic Soli
a bloocd
Dn meclictuo tem isetonic I Uredivtn chauqably Orty

IS00S omotiC
ud blopo cell one Mixed wth a Sol Coutaiuinq 0.9
hejd
gm o Nacl ldMl atn Y WLD ho cels Jutajy
,

noonma 83e
The solhavtug Sam Salt Con h ence ttue Sqme ogMOHC
Poesgoda a the RBC 1s knaun a fso toic Sol

LA ho Cel have on oSmoHc bbuor gouaten Hhown that of

9 Soliom chl0oricle aa kuou, a Hypentouic sor
on Coof
the rSsOe ¥
The 1sofoiC gok do not cauge Swellig
dowet bsrodue, olis omfoo injedec ndo tha eye haal
toat, blood oh othe boly Hcgoe

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6
Poiocluc fo of Pcrsuteral d

tdalhing of couketjue)

Pabanaho compoundiug
Piltcta Steiligclie

Pillig
Sealtuy
S+euacion
Packiug & abeli

nshe ctien
aro
Osed
I) Walhing ef coolaitun closuul Delehgeuls

fon whug
Steam fs alo Used to Jumove clebods e ffe-fvely z fua
unges is doue tth Walen fon tnjeciet
h Colaiuw 8 closUw shoold be Sfeulized aHe cleaui"

Poupdatietn & Combooudi:g -Tho broclset shoolo be Pspend

&(ompound wnduh asebtic bnoceK°
Tho udividoa part of t Pal borodut ou geutally
Subjecfed to vasíoos Ctedrizakio panoced
Hebatifehy ara mo&tly bouard at compoonoig atod
3) FHaHo 2 stesilizadio!- The þoeperd sel most be flsud
8 then steulize
Thay aro used to JuMOve bactes-iq mouldl but not vionorey
Myto blasma) Such
Than boo dvet is than Subjecteo to a steilizajo braceK
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aj heat Om naolqfoy
 otliquid rupabatio is doua by vaccUm
u Pl The fillg
Abugu Hlig o qaiy Plli
The qravrty
The qaury
fllng boroee i: s/ow £ Used fo Pfg
l g fooe
frae

flou9borodrta
is vsed fon flu
Tty MAinly tuoo tybe method
a)Amboul e fillug fechnologre
b)vfal #tllg technoloqje
Should be oloue Undur lanua
5Sealhq-The fAng s ealiq uwlt
Houd Oonk Stecho sealed
sealed by eithu bul
ampoule a fte linq
ard

Onts eal method

TP Seals ar cemmou în 1fauid |leo a moo ulel

Seo arre Used fon cevceiusry / l ed wrtn poue

he neak is hoaleo usth a bune Uul| the glak

6) Steuligaton Steiligalion is nocc of amova o M0

a o Marytypel
a) Meist heat steligcuio
b) Dy hoat steulgation
pilteraio thooqn bacteisia þoroof Pte
d) Radiako Stesdlgakio-
CChamical Mehod of sterdligecioe

odose
PacKagg labellfug - hi ection aho backed ehhI Sihg
Motple -cdoge codeiut
voliug tue
The backage should orou? clo acutale in fanmalio
Potoduct to useh
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camlo0geHo
b Cat of Co Sol label chssld indlicaBe holh
olfujate to he caoued aut betoa ust
CUSvwHy PauutaMAuufectoro also U am be-euicu
Packaq, vial Ure) cap& 0 Seal3 to Secou ubbe Stobbey
(n t o COuteduOY

antera Ponmu|aion
of dosage taym
njectable solh Sti most com mow type in a
he dsu exicibfe
i s bowfeorod by olissolblug
membsaul
veicle h in 022. Um
lteod hor0
Tho ralhu
PH
fltes s acljut pu Pareutal
ParoutOal
volume
Pa en vakves can be used Fon smal
wthMuHble dose
Wuch
a r e hu fo
hmulaHo in
Tee
7 njttab/e
Susbenion-
qruolieut is susbended tn
acHve in
vaives Sushendig
aq veeus veitle ceulaniug autiminobjal, Pous

0geus a Sunfactaut buffen

bxovicle poiolonged dsu9 ecHo
S U S p e i o a r foImUlated
to

Sos peiou are neven injec ted by SV Joutt

a r qdmuni stend by DM, Subcukantous taadomal
TThy
BUte

3 Bnjeable emul4ions Enavl{e (onist of ageeoos bho

otly bhak g emutsipyiug ageit
Some doug Showl mo stablliky,efPlcacy Oc SaPtely n
t emd |o fom
Tho auW - inflammaBax ac4ity of d i amefh ozOne Palutee

Paro teaemulsr 5 - 6 tind) of claxametago sol

Paranertal
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 boolthParentenal Mau do are fo mulaled fn þovcb
Dou to be o (OvdtYtoted Porio to a dministochon in poucls

be due fo Hid flabilfky fn wate

to Ju (oustitoted
stesuile dateh foornje Ho
Penici llre, brdibîtsutel, ben30e aju-
soluHies Dc sespeasioy
s supblfed uth dsy bouwdl to make
feun in jec Homd
Ditertut method owpasiug a Steile dou bouoolu ane

IS than
a) Steule oucy Stalleto ASFeoile auH- solvew wdch is
,added to Cytelige tue doug baHi cl
HHead dsied aseb Hoally
b) tyobhiligalie Í s a bocen of sePcoatiug a setid svbsece
rom
solby fruezu tra solveut
e
&
evahonaH
fce uduh yaccum

S r a y dsuyg The So" oftuedsug s shayed into a doy

Chambe wue: t come fn coudact uwin a hot
Steam of a Steile qa 60-/oo C
Coutaiw1g g cloçurdi-
he Covutaiue FOcn Parunteal
Aoduet Shovld nuaiutaisd tuo
i ntegsuy of hu boocuct aya sle,ile Pydo9 e foaehigh
Posuty boubasalio tl t uged
The Codamey shoold also be attaclive Stroug eh ought

Mateyal used toh (oueinu- Grla Seem to be tue maieial

OF chofce of couclouuns fon
Patunderal ibduet
Sodalint qla BodO slicae qlais a e mostly brofe
Tho t n Hlm of sticoo aro qbbliel to cout tu fugfdt fare susr

O HO vial3 s ambouls to bouvet tutacion of thsproddc L

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 is cqlled silicogaten
1 Hh qla Sontace Thuis berocey
to Iv futd3
Plaxte couteiuth are also vsed

Used fon closue Rubbeh ís tu maleial otchotce

Mateta vial,IV
tou closudel fo mott- eloce
bolB toc
sysúng3
oid botel Pls foon olisbosable
o thalmic ipefes oFa needle nto
Rubbe closuu allbo eaje rn ubo duc tieu
amuti- dose vial usea
Jwbbei are
h2Synhuhc
vai efy of nakural bolymey
inteacHo,
te cavse eachiug OT Chemi cal
SObSteCe may
to t e susfece
Thww foo cqUe blattfc coali apblied
oen
altopes meho
TO fa Swbbeh closurel to raduce leachiug

Cuntity couterol tet aruhafoamtd en Sfei/e

n Steri7e

coutaol tert- wwch

3a qualty Padonteral boooll tuclole

t Stedtity text
Pysroq cn texts
3leaken fe
4) Paiculale mate fertfug

concenin
1) Sfesúlity tegtu- Stevúlity tert is majoon boiut of
Case of aonteal Poroddc

a) Dfect fuoculalien metod

b) Memhrous ftltralion mehod

Pyoge tot Puoge ae mele he lt berodoctd ot 0 Chemically

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ey aba tio ly 8acchides ? head Stable
 a body hDy bUocluce a
ton uJoge ano eutenednto
ponse of feveh uwith body
ache yajo coudd icto with fu an

on se of 1h
The (o Judente rof Py09e Sobghuct
Qge aose MaLy Cause odeatn:
nauntenal bJabaratiod aro dletehmiuad by
ay Rabhit fert
b) CAL felt
in comblete(y
The leaken fertis dous to doteet
3) leakes feet 1- Coack bu3et aed
is
seoled camp 0tle on if twe
awy

Seal
4) Pasticolade matten tetfug-Parlicvlale matten
boumaouy is
by
Concehn ih he pajenteal onocuct3 9rveh
RouHe
Route
Tho visual inshectiotn Is doua by tua holdiug tue amboule
by fts neak agaiutt hghly llumnaded scouen
black
Wute ScO Fo tus oleteciou of b lack bauicle
SCOOns toh to detec Hoy of wite basHiclel

Obhthaluc bce baratiou obhthalmic boabarais.d o eye

selfd pöopahaHo,
porebatcHond aw Steúle 1foufcl, seiselo o
P'ceHcctqroolieudg
hat mou COutein One o mode active
thal au
abblíed to eye
inf/ed in blu eye 1os
Te ophelmic bo haoalioy aw

eye ball

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 1
Tyex of oAhaImfc pcthaakis
obhtha.lhic o eye solohb
Eye Susbeio
3 Eye doebs
4) ye o thtmads
5 Eye lotfeu

oimuaHo (ousidhaos of obhhallnic dosegetoim

toJum
All obhthalmic brcbataiod most be steile F o
Fooneign þricles , iberu 8 Hlamouel).
k wt th (a chY m a
bè jsofo
o PhHa lnic bModvet choedd
g futa HO
S E t o u to aveid liscomfott
vauoa
93) Pioloug
To dug in t e eye
fue (ouctact tme of tue bobarocHeul
to obhthalmic
thickiniq ageud a u added n
ha majoc drole t 1
Tea have a b a bout . T u e PH
9Comfos totuepakicd
HehapbeHC activit, solobilfty stability
adoled in
Hence ome SoPacteu on wEtng aqeud aA

o pthalmic brocdoet8

emol4iod
e dvop4 tye dechs axo Stesile toaudeh& oly Sol
o Sesbede of eue o moe ective inqneclieutk meat fo)
Instellaion fno euewih surable clsrobbe
o phthalmic dso Should be s Fesile,

They Should be have nevta PH

COm co0ud vsedl iu fabmohsfo of eye odbob& i

T AcHve fvqoclies
21 Boffo
5) Pou sevative
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1) AuR oxi dauts
5) Thitkeiaget
 6Touictty Modl Pen
vehicle
Suy fectaut3
in ee dotob to
al tn COcnþanaleo
HcHve ngJOlieuti- They
pooduce Peologica efect

ex
Pcologicaleffect
MydiaHcs Atrobi
Andi inflammatauy Hyote cosdsoue

Nio4tes Physos gmins

Antl mico bial ChlOrambhanical

The Cotrol of PH o foonm ulaio

oculan
ar imboelaud-
Bultehs of e apete
oetenhnauds sich iufluence th Stabillky
8 +a
aqeu he oculan acce þtab ty of tua Fodmolatio
ab Sanptio of t a dsug hoough tho coJNhat
The noSImal PH .y
CX Baic aid, Sodiom acid bhosphale soolivm cifoate
3) Poasenualivel- oculan foomuladio au Steule but they shuld
Coutain ouevalivel fo avoid micooba Codcmiuojo
Bengalkonium chloale, Ben3etho niUm chlo3ide
u)
4
Anl oxidautsi- Thuy QLo included in Some obthalmic poet
bodmaly those Couteiuiq eptne þhaiue otn oxializdble
olug
ex Sodliom bisol bhale o melabisolbhate
of
5) ThicKeiuq aqeti They adt addod to Aee fha visco sy
that Couctact ime of dsu in tn
eye clovoba so
eye com be
baolovejed
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ex methy cellulose, cabhboRy
methl ell wlose
 be
oP eye dorobl should
6) TOxictty Mocli fe-The toxicity
cotoic h lachyma secrefHe
ex
Nacl, kel, Boffen salt,9yceu
beu fAed
-Ln ebthamic hrobatatloy qenthally
veice-
Ocute UsP o Used a s a solveuc uhichmay
be ebteiuad by JOvese oshmesis olionizulis oListlld

oce
CoStesj otl a a
MDal oi, vegetable e Such aj s e s a sil
Used tn exfemboJNanebUs COmpouuoliue

8) Sonfactaut
20
exi
extBengthonium chlosúde, bolysonbate -

ex Phso gtigniue eye dsops

Fo doa
huso Stqamine O59m
Su bhal

Sodlium metabiso|þhaBe 0 2 gm

Bengal keru om chloide O 2MI

Posu Pied wate

PoeparaHon of eye olob

The vaious steb au invelueol

a Poo boraHo of so
b) clasi Picatlo& filltg
steil8alo
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N a Poebasatiou o tuo solutioud The vasioos adjuwants (

Ponsenasfue, Stabrl3r
auioxiclautSh toxiciy Modiey,
ViSco sty moci Pes o bo Hfen)
aro
dlissoluved t veuice
added tsn veuicle cdded
Than he actuity fngeolient is
fo make tuo veuile

b) Cladfication PFilug sinteacd glak lHe om Omboau

fHess of o'us-t2 micson Pooa Sige o
Used fon 4his
buyboe
fto t e lual
The clt fed solh s ettheh flled cliscctty
hoc stesd li3euHey o
CouteuOl Suich ate sealed i a to
Hlled thto a sutble Coutaiueh bsdosn to talio Steugafo

C)Ste-flzakou is riy
121°c on
)Auto claviuc at |1s'eto 30min 0

9 Duy haat stesulfgaio a (6o fo 2 is embloyed

to ne aqveevt AoebahaHoud Such a lquid ban fu eye
Gob Silicoe Jwbbe fuats must be urecl

labellu
1) Fon extehno Use ouly
Nan 2 co of medicamau
3) Nam co of auntimícresal cge

Dade a te uich tuu poioluet ht nteuoled to be ured

COutedn Tl Coutaiueh Shoold be feol wrth a ambe

evi oleuet device
To1acli tHeually qla botttes wth
US eol dwbbe)
Useol but nod a day4 blazte botle ( fea odopbeh OaU
LDPE a e wicbly us
ophthal mic doop moy alka be bovioleo f
dose Ceuteint) that sumble sy
uil malutein tte StodlT O tue
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Coytew3
i s stobeo fn well clotel coucleiu

Eye ofutmod ophthaluc oiutmeuk! a e Stedle, grêaty

te cay uet
Semi 9olid bJubatchos hoe a t abblied to
ive o tue eye ltad
Tho olu entenl u eye hough fuw conea by csimple
ffogo,
Aovautage of eye odmo, louge cotact timo qoou eh
tofal doug bio ailabiliy is
with visioy thb vge
Disaduatage fs it tnesfers
bSDaly tinited to bedtmo stetlation

Foon tmelaion of eye oiutmens

oiutnet
ex Aobiue solbhale eye
Foimolo QuoHty
Atoropiue Solbhale O1gm
Wool fat 4gm
faulcd basafftu 1gm
yellod Soft baratt ubfo gm

Theye ingwclieds horodore a tanspa1ed1ubsucatiug

MOISFentg Pllm ou tuu swface of the eyeball

Mehoc of brebobaHoy

oupacuH ou of tho bae met wol fet, qeloo sot

PagHin Cn a dad bath 2 hen add (oui o
Panati
F lt thotovgh Ccanse lHe bab (exi- wnatmo 54)
Placed n hoadedwww.remixeducation.in
tunnel
 Steå liaed at 160 fo 2h
otutmoud baie¥ tLN þack fu tuo
Add mollcameuct wih eqe
Stedle Coutaiut
thQ medicunauk
COSaNakg
The e to0 mehod of n
The OTeprocedure should
be v d n ag epfC coudli tfoud

Casert 1f medicamn eve is woten soloble t it is

Cu ssolued n muutmum uelume o f pusu Hed toctteh tuu
Sol
te steitizeo by autoclaviuq odn tiltoHoy qJecdially
in cOsp0aled fn fue hoavioostly melted steuile base uuich is
SHHoed utill colol
CoseLa
Cose thc n Case of fnsoloble medfcameut Them eoltCams
u a y boucod g toutubate wth Small qauty of
th melted botawiously steitized bage. 'rha micto is 0
nCopos1aded urth tuaneninde of he meHed base
Courtaine-Eye outmaut should be backedtn small sfeillged
collapeible metaaloniniom) e blastic CPolyviny chloside)
tubes ftfed twrth a tambey evidauct apbl fcato
collabeible metal tobes Shoulo be fue fodim dust metal
baricle uich is doe by blowtuq tuo tobes out wit a pourteid
jet oFHltecd dust fo
Cuis
abell fuq -The Boo tsh
he tabel of Pharmacoboef
the
cocax aq iss hat
glesdle þorouided hoe shouldl stle that tue Couteucl
codeed38
u coudefu has not beey obehed.
cye ointmeut Should be Staved in obENfd*
Col blace
Eye loHou l eye lotiovd au Staile agueoUS salutiou appled fo
an
eye bathtoo wolhiof Hho
eye
Thaage
(ange volume of futid to flou qutkely oveh the e
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 16 (fo oSmoHC fo
be sotonic s -

FocTmulationEe lohio shoold

eay tuou
soad tosywJo
Should not be
he bubahd loie
two doy
(ote BP
ex Sodliomchlasiele (Nac) ee

Foomula QvaHly
Sodiom chlosu ole 9m
Pusa Fied dades Fo 00O M
Porodoce

Methoc of tbataHoni
aten
tn bosified
Disso Ne socdtem chlosúde
Wate
of buriPfed
is mede by addiug
mano

he tua volume

qadl
Filten it Hhbieuh Studernd gla ffltes

bothe g Sealed
Tans fe te
e eye lo Fioy to

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