RANDOMIZED CONTROLLED
STUDY, META-ANALYSIS AND
SYSTEMATIC REVIEW
The use of evidence-based practices developed by experts and institutions and nurses prevents loss of
time and energy
Randomized controlled studies, systematic reviews and meta-analyses are also
Used in nursing practice as the "gold standard"
• A randomized controlled study is a study model in which people with similar
Characteristics are divided into experimental and control groups
In order to determine the effectiveness of the research results, the number of participants
must be large.
In addition, when designing the study, the question to be answered should not cause any
Insecurity for the participants.
In internal validity; The findings obtained in the study are related to
the intervention being investigated, rather than showing variability
between the control and experimental groups depending on factors
such as age, gender or weight.
External validity is used to show how adaptable a randomized
controlled trial is to the general population.
• If internal validity is achieved but external validity is not achieved,
this may reduce the suitability of the study
It can prove a cause-effect relationship, but the most important feature of
randomized controlled trials that reduces the level of evidence is that they are
not adaptable to the general population.
• In addition, the data obtained from the study should be
published objectively, regardless of whether it is important or
unimportant.
Meta-analysis is a method of combining the results of multiple,
independent
studies on a specific subject and performing statistical analysis
of the resulting
research findings. Meta-analysis provides clinicians and
medical researchers with quantitative
methods that summarize the results of various studies and allows
them to reach a
common conclusion by combining the results.
s is a method of combining the findings of separate
studies and reviewing criticisms.
• What Types of Studies Can Meta-analysis Be Applied to?
Meta-analysis can be applied to any type of quantitative studies:
• Studies aiming to explain causal or non-causal relationships,
such as controlled
clinical studies, quasi-experiments, observational studies
(cohort, case-control
studies, ...), descriptive studies, screening studies, validity and
reliability studies
of diagnostic methods, cost-effectiveness studies ( 8).
What are the Application Stages of Meta-analysis? Defining the
problem,
• Determining the criteria for including individual studies in the
meta-analysis,
• Obtaining individual research,
• Coding and classifying each study according to characteristics
relevant to the metaanalysis,
• Combining the findings of individual studies,
• Relating the combined findings to the characteristics of the
meta-analysis,
• Reporting the findings of your meta-analysis.
