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MULTI COMPARTMENT MODELS (TWO COMPARTMENT OPEN MODEL)
A) IV BOLUS B) IV INFUSION C) ORAL ADMINISTRATION
MUHAMMAD FAHEEM
LECTURER
DEPARTMENT OF PHARMACY
UNIVERSITY OF SWABI
TWO COMPARTMENTS
OPEN MODEL-IV BOLUS
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Two compartment Model
The plasma concentration-Time curve decline biexponantionally
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ASSESSMENT OF PK PARAMETERS
Determination of Prime and Hybrid constants
Determination of Volume of Distribution
Determination of Half Life
Determination of Clearance
Determination of Elimination rate constant
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1) Determination of Prime and Hybrid
constants
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Determination of Hybrid constants
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Determination of Prime Constants
Determination of K
Determination of K21
Determination of K12
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2) Determination of Volume of
Distribution
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i) VD of central compartment
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ii) VD of Peripheral (tissue) compartment
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iii) VD at steady State
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iv) Extrapolated VD
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v) VD by Area
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3) Determination of Half Life
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4) Determination of Clearance
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5) Determination of Elimination rate
constant
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TWO COMPARTMENTS
OPEN MODEL:
IV INFUSION
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TWO COMPARTMENTS
OPEN MODEL:
ORAL ADMINISTRATION
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