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E!ects of Water Pollution on Human Health and Disease

Heterogeneity: A Review

Li Lin1 Haoran Yang (https://www.frontiersin.org/people/u/1780953)1

Xiaocang Xu (https://www.frontiersin.org/people/u/1039891)2*

1
Research Center for Economy of Upper Reaches of the Yangtse River/School of Economics, Chongqing
Technology and Business University, Chongqing, China
2 School of Economics and Management, Huzhou University, Huzhou, China

Background: More than 80% of sewage generated by human activities is

Background: More than 80% of sewage generated by human activities is
discharged into rivers and oceans without any treatment, which results in
environmental pollution and more than 50 diseases. 80% of diseases and 50%
(/articles/10.3389/fenvs.2022.880246/pdf?
of child deaths worldwide are related to poor water quality.
isPublishedV2=False)

Methods: This paper selected 85 relevant papers finally based on the keywords
of water pollution, water quality, health, cancer, and so on.
Results: The impact of water pollution on human health is significant, although
there may be regional, age, gender, and other di!erences in degree. The most
common disease caused by water pollution is diarrhea, which is mainly
transmitted by enteroviruses in the aquatic environment.
Discussion: Governments should strengthen water intervention management
and carry out intervention measures to improve water quality and reduce water
pollution’s impact on human health.

Introduction

Water is an essential resource for human survival. According to the 2021 World
Water Development Report released by UNESCO, the global use of freshwater
has increased six-fold in the past 100 years and has been growing by about 1%
per year since the 1980s. With the increase of water consumption, water quality
is facing severe challenges. Industrialization, agricultural production, and urban
life have resulted in the degradation and pollution of the environment, adversely
a!ecting the water bodies (rivers and oceans) necessary for life, ultimately
a!ecting human health and sustainable social development (Xu et al., 2022a).
Globally, an estimated 80% of industrial and municipal wastewater is discharged
into the environment without any prior treatment, with adverse e!ects on
human health and ecosystems. This proportion is higher in the least developed
countries, where sanitation and wastewater treatment facilities are severely
lacking.

Sources of Water Pollution

Water pollution are mainly concentrated in industrialization, agricultural
activities, natural factors, and insu#cient water supply and sewage treatment
facilities. First, industry is the main cause of water pollution, these industries
include distillery industry, tannery industry, pulp and paper industry, textile
industry, food industry, iron and steel industry, nuclear industry and so on.
Various toxic chemicals, organic and inorganic substances, toxic solvents and
volatile organic chemicals may be released in industrial production. If these
volatile organic chemicals may be released in industrial production. If these
wastes are released into aquatic ecosystems without adequate treatment, they
will cause water pollution (Chowdhary et al., 2020). Arsenic, cadmium, and
chromium are vital pollutants discharged in wastewater, and the industrial sector
is a significant contributor to harmful pollutants (Chen et al., 2019). With the
acceleration of urbanization, wastewater from industrial production has
gradually increased. (Wu et al., 2020). In addition, water pollution caused by
industrialization is also greatly a!ected by foreign direct investment. Industrial
water pollution in less developed countries is positively correlated with foreign
direct investment (Jorgenson, 2009). Second, water pollution is closely related
to agriculture. Pesticides, nitrogen fertilizers and organic farm wastes from
agriculture are significant causes of water pollution (RCEP, 1979). Agricultural
activities will contaminate the water with nitrates, phosphorus, pesticides, soil
sediments, salts and pathogens (Parris, 2011). Furthermore, agriculture has
severely damaged all freshwater systems in their pristine state (Moss, 2008).
Untreated or partially treated wastewater is widely used for irrigation in water-
scarce regions of developing countries, including China and India, and the
presence of pollutants in sewage poses risks to the environment and health.
Taking China as an example, the imbalance in the quantity and quality of surface
water resources has led to the long-term use of wastewater irrigation in some
areas in developing countries to meet the water demand of agricultural
production, resulting in serious agricultural land and food pollution, pesticide
residues and heavy metal pollution threatening food safety and Human Health
(Lu et al., 2015). Pesticides have an adverse impact on health through drinking
water. Comparing pesticide use with health life Expectancy Longitudinal Survey
data, it was found that a 10% increase in pesticide use resulted in a 1% increase in
the medical disability index over 65 years of age (Lai, 2017). The case of the Musi
River in India shows a higher incidence of morbidity in wastewater-irrigated
villages than normal-water households. Third, water pollution is related to
natural factors. Taking Child Loess Plateau as an example, the concentration of
trace elements in water quality is higher than the average world level, and trace
elements come from natural weathering and manufacture causes. Poor river
water quality is associated with high sodium and salinity hazards (Xiao et al.,
2019). The most typical water pollution in the middle part of the loess Plateau is
hexavalent chromium pollution, which is caused by the natural environment and
human activities. Loess and mudstone are the main sources, and groundwater
with high concentrations of hexavalent chromium is also an important factor in
surface water pollution (He et al., 2020). Finally, water supply and sewage
treatment facilities are also important factors a!ecting drinking water quality,
especially in developing countries. In parallel with China rapid economic growth,
industrialization and urbanization, underinvestment in basic water supply and
treatment facilities has led to water pollution, increased incidence of infectious
treatment facilities has led to water pollution, increased incidence of infectious
and parasitic diseases, and increased exposure to industrial chemicals, heavy
metals and algal toxins (Wu et al., 1999). An econometric model predicts the
impact of water purification equipment on water quality and therefore human
health. When the proportion of household water treated with water purification
equipment is reduced from 100% to 90%, the expected health benefits are
reduced by up to 96%.. When the risk of pretreatment water quality is high, the
decline is even more significant (Brown and Clasen, 2012).

To sum up, water pollution results from both human and natural factors. Various
human activities will directly a!ect water quality, including urbanization,
population growth, industrial production, climate change, and other factors
(Halder and Islam, 2015) and religious activities (Dwivedi et al., 2018). Improper
disposal of solid waste, sand, and gravel is also one reason for decreasing water
quality (Ustaoğlua et al., 2020).

Impact of Water Pollution on Human Health

Unsafe water has severe implications for human health. According to UNESCO
2021 World Water Development Report, about 829,000 people die each year
from diarrhea caused by unsafe drinking water, sanitation, and hand hygiene,
including nearly 300,000 children under the age of five, representing 5.3 percent
of all deaths in this age group. Data from Palestine suggest that people who
drink municipal water directly are more likely to su!er from diseases such as
diarrhea than those who use desalinated and household-filtered drinking water
(Yassin et al., 2006). In a comparative study of tap water, purified water, and
bottled water, tap water was an essential source of gastrointestinal disease (Pay-
ment et al., 1997). Lack of water and sanitation services also increases the
incidence of diseases such as cholera, trachoma, schistosomiasis, and
helminthiasis. Data from studies in developing countries show a clear
relationship between cholera and contaminated water, and household water
treatment and storage can reduce cholera (Gundry et al., 2004). In addition to
disease, unsafe drinking water, and poor environmental hygiene can lead to
gastrointestinal illness, inhibiting nutrient absorption and malnutrition. These
e!ects are especially pronounced for children.

Purpose of This Paper

More than two million people worldwide die each year from diarrhoeal diseases,
with poor sanitation and unsafe drinking water being the leading cause of nearly
90% of deaths and a!ecting children the most (United Nations, 2016). More than
50 kinds of diseases are caused by poor drinking water quality, and 80% of
diseases and 50% of child deaths are related to poor drinking water quality in the
world. However, water pollution causes diarrhea, skin diseases, malnutrition, and
even cancer and other diseases related to water pollution. Therefore, it is
necessary to study the impact of water pollution on human health, especially
disease heterogeneity, and clarify the importance of clean drinking water, which
has important theoretical and practical significance for realizing sustainable
development goals. Unfortunately, although many kinds of literature focus on
water pollution and a particular disease, there is still a lack of research results
that systematically analyze the impact of water pollution on human health and
the heterogeneity of diseases. Based on the above background and discussion,
this paper focuses on the e!ect of water pollution on human health and its
disease heterogeneity.

Materials and Methods

Search Process
This article uses keywords such as “water,” “water pollution,” “water quality,”
“health,” “diarrhea,” “skin disease,” “cancer” and “children” to search Web of
Science and Google Scholar include SCI and SSCI indexed papers, research
reports, and works from 1990 to 2021.

Inclusion-Exclusion Criteria and Data Extraction Process

The existing literature shows that water pollution and human health are
important research topics in health economics, and scholars have conducted in-
depth research. As of 30 December 2021, 104 related literatures were searched,
including research papers, reviews and conference papers. Then, according to
the content relevancy, 19 papers were eliminated, and 85 papers remained. The
purpose of this review is to summarize the impact of water pollution on human
health and its disease heterogeneity and to explore how to improve human
health by improving water pollution control measures.

Information extracted from all included papers included: author, publication

date, sample country, study methodology, study purpose, and key findings. All
analysis results will be analyzed according to the process in Figure 1.

Figure 1
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FIGURE 1. Data extraction process (PRISMA).

The relevant information of the paper is exported to the Excel database through
Endnote, and the duplicates are deleted. The results were initially extracted by
one researcher and then cross-checked by another researcher to ensure that all
data had been filtered and reviewed. If two researchers have di!erent opinions,
the two researchers will review together until a final agreement is reached.

Quality Assessment of the Literature

The JBI Critical Appraisal Checklist was used to evaluate the quality of each
paper. The JBI (Joanna Briggs Institute) key assessment tool was developed by
the JBI Scientific Committee after extensive peer review and is designed for
system review. All features of the study that meet the following eight criteria are
included in the final summary:1) clear purpose; 2) Complete information of
sample variables; 3) Data basis; 4) the validity of data sorting; 5) ethical norms;
(6); 7) E!ective results; 8) Apply appropriate quantitative methods and state the
results clearly. Method quality is evaluated by the Yes/No questions listed in the
JBI Key Assessment List. Each analysis paper received 6 out of 8.

Results

The quality of drinking water is an essential factor a!ecting human health. Poor
drinking water quality has led to the occurrence of water-borne diseases.
According to the World Health Organization (WHO) survey, 80% of the world’s
diseases and 50% of the world’s child deaths are related to poor drinking water
quality, and there are more than 50 diseases caused by poor drinking water
quality, and there are more than 50 diseases caused by poor drinking water
quality. The quality of drinking water in developing countries is worrying. The
negative health e!ects of water pollution remain the leading cause of morbidity
and mortality in developing countries. Di!erent from the existing literature
review, this paper mainly studies the impact of water pollution on human health

according to the heterogeneity of diseases. We focuses on diarrhea, skin

diseases, cancer, child health, etc., and sorts out the main e!ects of water
pollution on human health (Table 1).

Table 1

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TABLE 1. Major studies on the relationship between water pollution and health.

Water Pollution and Diarrhea

Diarrhea is a common symptom of gastrointestinal diseases and the most
common disease caused by water pollution. Diarrhea is a leading cause of illness
and death in young children in low-income countries. Diarrhoeal diseases
account for 21% of annual deaths among children under 5 years of age in
developing countries (Waddington et al., 2009). Many infectious agents
associated with diarrhea are directly related to contaminated water (Ahmed and
Ismail, 2018). Parasitic worms present in non-purifying drinking water when is
consumed by human beings causes diseases (Ansari and Akhmatov., 2020) . It
was found that treated water from water treatment facilities was associated with
a lower risk of diarrhea than untreated water for all ages (Clasen et al., 2015). For
example, in the southern region of Brazil, a study found that factors significantly
associated with an increased risk of mortality from diarrhoea included lack of
plumbed water, lack of flush toilets, poor housing conditions, and overcrowded
households. Households without access to piped water had a 4.8 times higher
risk of infant death from diarrhea than households with access to piped water
(Victora et al., 1988)
Enteroviruses exist in the aquatic environment. More than 100 pathogenic
viruses are excreted in human and animal excreta and spread in the environment
through groundwater, estuarine water, seawater, rivers, sewage treatment plants,
insu#ciently treated water, drinking water, and private wells (Fong and Lipp.,

2005). A study in Pakistan showed that coliform contamination was found in

some water sources. Improper disposal of sewage and solid waste, excessive use
of pesticides and fertilizers, and deteriorating pipeline networks are the main
causes of drinking water pollution. The main source of water-borne diseases
such as gastroenteritis, dysentery, diarrhea, and viral hepatitis in this area is the
water pollution of coliform bacteria (Khan et al., 2013). Therefore, the most
important role of water and sanitation health interventions is to hinder the
transmission of diarrheal pathogens from the environment to humans (Wadding-
ton et al., 2009).

Meta-analyses are the most commonly used method for water quality and
diarrhea studies. It was found that improving water supply and sanitation
reduced the overall incidence of diarrhea by 26%. Among Malaysian infants,
having clean water and sanitation was associated with an 82% reduction in infant
mortality, especially among infants who were not breastfed (Esrey et al., 1991).
All water quality and sanitation interventions significantly reduced the risk of
diarrhoeal disease, and water quality interventions were found to be more
e!ective than previously thought. Multiple interventions (including water,
sanitation, and sanitation measures) were not more e!ective than single-focus
interventions (Fewtrell and Colford., 2005). Water quality interventions reduced
the risk of diarrhoea in children and reduced the risk of E. coli contamination of
stored water (Arnold and Colford., 2007). Interventions to improve water quality
are generally e!ective in preventing diarrhoea in children of all ages and under 5.
However, some trials showed significant heterogeneity, which may be due to the
research methods and their conditions (Clasen et al., 2007).

Water Pollution and Skin Diseases

Contrary to common sense that swimming is good for health, studies as early as
the 1950s found that the overall disease incidence in the swimming group was
significantly higher than that in the non-swimming group. The survey shows that
the incidence of the disease in people under the age of 10 is about 100% higher
than that of people over 10 years old. Skin diseases account for a certain
proportion (Stevenson, 1953). A prospective epidemiological study of beach
water pollution was conducted in Hong Kong in the summer of 1986–1987. The
study found that swimmers on Hong Kong’s coastal beaches were more likely
than non-swimmers to complain of systemic ailments such as skin and eyes.
than non-swimmers to complain of systemic ailments such as skin and eyes.
And swimming in more polluted beach waters has a much higher risk of
contracting skin diseases and other diseases. Swimming-related disease
symptom rates correlated with beach cleanliness (Cheung et al., 1990).

A study of arsenic-a!ected villages in the southern Sindh province of Pakistan

emphasized that skin diseases were caused by excessive water quality. By
studying the relationship between excessive arsenic in drinking water caused by
water pollution and skin diseases (mainly melanosis and keratosis), it was found
that compared with people who consumed urban low-arsenic drinking water,
the hair of people who consumed high-arsenic drinking water arsenic
concentration increased significantly. The level of arsenic in drinking water
directly a!ects the health of local residents, and skin disease is the most
common clinical complication of arsenic poisoning. There is a correlation
between arsenic concentrations in biological samples (hair and blood) from
patients with skin diseases and intake of arsenic-contaminated drinking water
(Kazi et al., 2009). Another Bangladesh study showed that many people su!er
from scabies due to river pollution (Hanif et al., 2020). Not only that, but water
pollution from industry can also cause skin cancer (Arif et al., 2020).

Studies using meta-analysis have shown that exposure to polluted Marine

recreational waters can have adverse consequences, including frequent skin
discomfort (such as rash or itching). Skin diseases in swimmers may be caused
by a variety of pathogenic microorganisms (Yau et al., 2009). People (swimmers
and non-swimmers) exposed to waters above threshold levels of bacteria had a
higher relative risk of developing skin disease, and levels of bacteria in seawater
were highly correlated with skin symptoms.

Studies have also suggested that swimmers are 3.5 times more likely to report
skin diseases than non-swimmers. This di!erence may be a “risk perception bias”
at work on swimmers, who are generally aware that such exposure may lead to
health e!ects and are more likely to detect and report skin disorders. It is also
possible that swimmers exaggerated their symptoms, reporting conditions that
others would not classify as true skin disorders (Fleisher and Kay. 2006).

Water Pollution and Cancer

According to WHO statistics, the number of cancer patients diagnosed in 2020
reached 19.3 million, while the number of deaths from cancer increased to
10 million. Currently, one-fifth of all global fevers will develop cancer during
their lifetime. The types and amounts of carcinogens present in drinking water
will vary depending on where they enter: contamination of the water source,
water treatment processes, or when the water is delivered to users (Morris,
1995).

From the perspective of water sources, arsenic, nitrate, chromium, etc. are
highly associated with cancer. Ingestion of arsenic from drinking water can
cause skin cancer and kidney and bladder cancer (Marmot et al., 2007). The risk
of cancer in the population from arsenic in the United States water supply may
be comparable to the risk from tobacco smoke and radon in the home
environment. However, individual susceptibility to the carcinogenic e!ects of
arsenic varies (Smith et al., 1992). A high association of arsenic in drinking water
with lung cancer was demonstrated in a northern Chilean controlled study
involving patients diagnosed with lung cancer and a frequency-matched hospital
between 1994 and 1996. Studies have also shown a synergistic e!ect of smoking
and arsenic intake in drinking water in causing lung cancer (Ferreccio et al.,
2000). Exposure to high arsenic levels in drinking water was also associated with
the development of liver cancer, but this e!ect was not significant at exposure
levels below 0.64 mg/L (Lin et al., 2013).

Nitrates are a broader contaminant that is more closely associated with human
cancers, especially colorectal cancer. A study in East Azerbaijan confirmed a
significant association between colorectal cancer and nitrate in men, but not in
women (Maleki et al., 2021). The carcinogenic risk of nitrates is concentration-
dependent. The risk increases significantly when drinking water levels exceed
3.87 mg/L, well below the current drinking water standard of 50 mg/L. Drinking
water with nitrate concentrations lower than current drinking water standards
also increases the risk of colorectal cancer (Schullehner et al., 2018).

Drinking water with high chromium content will bring high carcinogenicity
caused by hexavalent chromium to residents. Drinking water intake of
hexavalent chromium experiments showed that hexavalent chromium has the
potential to cause human respiratory cancer. (Zhitkovich, 2011). A case from
Changhua County, Taiwan also showed that high levels of chromium pollution
were associated with gastric cancer incidence (Tseng et al., 2018).

There is a correlation between trihalomethane (THM) levels in drinking water and

cancer mortality. Bladder and brain cancers in both men and women and non-
Hodgkin’s lymphoma and kidney cancer in men were positively correlated with
THM levels, and bladder cancer mortality had the strongest and most consistent
association with THM exposure index (Cantor et al., 1978).

From the perspective of water treatment process, carcinogens may be

From the perspective of water treatment process, carcinogens may be
introduced during chlorine treatment, and drinking water is associated with all
cancers, urinary cancers and gastrointestinal cancers (Page et al., 1976).
Chlorinated byproducts from the use of chlorine in water treatment are

associated with an increased risk of bladder and rectal cancer, with perhaps
5,000 cases of bladder and 8,000 cases of rectal cancer occurring each year in
the United States (Morris, 1995).

The impact of drinking water pollutants on cancer is complex. Epidemiological

studies have shown that drinking water contaminants, such as chlorinated by-
products, nitrates, arsenic, and radionuclides, are associated with cancer in
humans (Cantor, 1997). Pb, U, F- and no3- are the main groundwater pollutants
and one of the potential causes of cancer (Kaur et al., 2021). In addition, many
other water pollutants are also considered carcinogenic, including herbicides
and pesticides, and fertilizers that contain and release nitrates (Marmot et al.,
2007). A case from Hebei, China showed that the contamination of nitrogen
compounds in well water was closely related to the use of nitrogen fertilizers in
agriculture, and the levels of three nitrogen compounds in well water were
significantly positively correlated with esophageal cancer mortality (Zhang et al.,
2003).

In addition, due to the time-lag e!ect, the impact of watershed water pollution
on cancer is spatially heterogeneous. The mortality rate of esophageal cancer
caused by water pollution is significantly higher downstream than in other
regions due to the impact of historical water pollution (Xu et al., 2019). A study
based on changes in water quality in the watershed showed that a grade 6
deterioration in water quality resulted in a 9.3% increase in deaths from digestive
cancer. (Ebenstein, 2012).

Water Pollution and Child Health

Diarrhea is a common disease in children. Diarrhoeal diseases (including cholera)
kill 1.8 million people each year, 90 per cent of them children under the age of
five, mostly in developing countries. 88% of diarrhoeal diseases are caused by
inadequate water supply, sanitation and hygiene (Team, 2004). A large
proportion of these are caused by exposure to microbially infected water and
food, and diarrhea in infants and young children can lead to malnutrition and
reduced immune resistance, thereby increasing the likelihood of prolonged and
recurrent diarrhea (Marino, 2007). Pollution exposure experienced by children
during critical periods of development is associated with height loss in
adulthood (Zaveri et al., 2020). Diseases directly related to water and sanitation,
combined with malnutrition, also lead to other causes of death, such as measles
and pneumonia. Child malnutrition and stunting due to inadequate water and
sanitation will continue to a!ect more than one-third of children in the world

(Bartlett, 2003). A study from rural India showed that children living in
households with tap water had significantly lower disease prevalence and
duration (Jalan and Ravallion, 2003).

In conclusion, water pollution is a significant cause of childhood diseases. Air,

water, and soil pollution together killed 940,000 children worldwide in 2016,
two-thirds of whom were under the age of 5, and the vast majority occurred in
low- and middle-income countries (Landrigan et al., 2018). The intensity of
industrial organic water pollution is positively correlated with infant mortality and
child mortality in less developed countries, and industrial water pollution is an
important cause of infant and child mortality in less developed countries (Jor-
genson, 2009). In addition, arsenic in drinking water is a potential carcinogenic
risk in children (García-Rico et al., 2018). Nitrate contamination in drinking water
may cause goiter in children (Vladeva et al.., 2000).

Discussions

This paper reviews the environmental science, health, and medical literature,
with a particular focus on epidemiological studies linking water quality, water
pollution, and human disease, as well as studies on water-related disease
morbidity and mortality. At the same time, special attention is paid to
publications from the United Nations and the World Health Organization on
water and sanitation health research. The purpose of this paper is to clarify the
relationship between water pollution and human health, including: The
relationship between water pollution and diarrhea, the mechanism of action, and
the research situation of meta-analysis; The relationship between water
pollution and skin diseases, pathogenic factors, and meta-analysis research; The
relationship between water pollution and cancer, carcinogenic factors, and types
of cancer; The relationship between water pollution and Child health, and the
major childhood diseases caused.

A study of more than 100 literatures found that although factors such as country,
region, age, and gender may have di!erent influences, in general, water
pollution has a huge impact on human health. Water pollution is the cause of
many human diseases, mainly diarrhoea, skin diseases, cancer and various
childhood diseases. The impact of water pollution on di!erent diseases is mainly
childhood diseases. The impact of water pollution on di!erent diseases is mainly
reflected in the following aspects. Firstly, diarrhea is the most easily caused
disease by water pollution, mainly transmitted by enterovirus existing in the
aquatic environment. The transmission environment of enterovirus depends on
includes groundwater, river, seawater, sewage, drinking water, etc. Therefore, it is
necessary to prevent the transmission of enterovirus from the environment to
people through drinking water intervention. Secondly, exposure to or use of
heavily polluted water is associated with a risk of skin diseases. Excessive
bacteria in seawater and heavy metals in drinking water are the main pathogenic
factors of skin diseases. Thirdly, water pollution can pose health risks to humans
through any of the three links: the source of water, the treatment of water, and
the delivery of water. Arsenic, nitrate, chromium, and trihalomethane are major
carcinogens in water sources. Carcinogens may be introduced during chlorine
treatment from water treatment. The e!ects of drinking water pollution on
cancer are complex, including chlorinated by-products, heavy metals,
radionuclides, herbicides and pesticides left in water, etc., Finally, water pollution
is an important cause of children’s diseases. Contact with microbiologically
infected water can cause diarrhoeal disease in children. Malnutrition and
weakened immunity from diarrhoeal diseases can lead to other diseases.

This study systematically analyzed the impact of water pollution on human

health and the heterogeneity of diseases from the perspective of di!erent
diseases, focusing on a detailed review of the relationship, mechanism and
influencing factors of water pollution and diseases. From the point of view of
limitations, this paper mainly focuses on the research of environmental science
and environmental management, and the research on pathology is less involved.
Based on this, future research can strengthen research at medical and
pathological levels.

In response to the above research conclusions, countries, especially developing

countries, need to adopt corresponding water management policies to reduce
the harm caused by water pollution to human health. Firstly, there is a focus on
water quality at the point of use, with interventions to improve water quality,
including chlorination and safe storage (Gundry et al., 2004), and provision of
treated and clean water (Khan et al., 2013). Secondly, in order to reduce the
impact of water pollution on skin diseases, countries should conduct
epidemiological studies on their own in order to formulate health-friendly
bathing water quality standards suitable for their specific conditions (Cheung et
al., 1990). Thirdly, in order to reduce the cancer caused by water pollution, the
whole-process supervision of water quality should be strengthened, that is, the
purity of water sources, the scientific nature of water treatment and the
e!ectiveness of drinking water monitoring. Fourthly, each society should prevent
e!ectiveness of drinking water monitoring. Fourthly, each society should prevent
and control source pollution from production, consumption, and transportation
(Landrigan et al., 2018). Fifthly, health education is widely carried out. Introduce
environmental education, educate residents on sanitary water through

newspapers, magazines, television, Internet and other media, and enhance

public health awareness. Train farmers to avoid overuse of agricultural chemicals
that contaminate drinking water.

Author Contributions

Conceptualization, XX|; methodology, LL; data curation, HY; writing and editing,
LL; project administration, XX|.

Funding

This article is a phased achievement of The National Social Science Fund of

China: Research on the blocking mechanism of the critical poor households
returning to poverty due to illness, No: 20BJY057.

Conflict of Interest

The authors declare that the research was conducted in the absence of any
commercial or financial relationships that could be construed as a potential
conflict of interest.

Publisher’s Note

All claims expressed in this article are solely those of the authors and do not
necessarily represent those of their a#liated organizations, or those of the
publisher, the editors and the reviewers. Any product that may be evaluated in
this article, or claim that may be made by its manufacturer, is not guaranteed or
endorsed by the publisher.
References

Afroz, R., Rahman, A., and Rahman, A. (2017). Health Impact of River Water Pollution in
Malaysia. Int. J. Adv. Appl. Sci. 4 (5), 78–85. doi:10.21833/ijaas.2017.05.014

CrossRef Full Text (https://doi.org/10.21833/ijaas.2017.05.014) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Health+Impact+of+River+Water+Pollution+in+Malaysia&btnG=
)

Ahmed, S., and Ismail, S. (2018). Water Pollution and its Sources, E!ects and Management: a
Case Study of Delhi. Int. J. Curr. Adv. Res. 7 (2), 10436–10442 (tel:10436–10442).
doi:10.24327/ijcar.2018.10442.1768

CrossRef Full Text (https://doi.org/10.24327/ijcar.2018.10442.1768) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Pollution+and+its+Sources,+E!ects+and+Manage-
ment:+a+Case+Study+of+Delhi&btnG=)

Ansari, Z. Z., and Akhmatov, S. V. (2020). Impacts of Water Pollution on Human Health: A
Case Study of Delhi.
Google Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Impacts+of+Water+Pollution+on+Hu-
man+Health:+A+Case+Study+of&btnG=)

Arif, A., Malik, M. F., Liaqat, S., Aslam, A., Mumtaz, K., and Afzal, A. (2020). 3. Water Pollution
and Industries. Pure Appl. Biol. (PAB) 9 (4), 2214–2224 (tel:2214–2224).
doi:10.19045/bspab.2020.90237

CrossRef Full Text (https://doi.org/10.19045/bspab.2020.90237) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=3.+Water+Pollution+and+Industries&btnG=)

Arnold, B. F., and Colford, J. M. (2007). Treating Water with Chlorine at Point-Of-Use to
Improve Water Quality and Reduce Child Diarrhea in Developing Countries: a Systematic
Review and Meta-Analysis. Am. J. Trop. Med. Hyg. 76 (2), 354–364.
doi:10.4269/ajtmh.2007.76.354

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/17297049/) | CrossRef Full Text

(https://doi.org/10.4269/ajtmh.2007.76.354) | Google Scholar (https://scholar.google.-
com/scholar?hl=en&as_sdt=0%2C5&q=Treating+Water+with+Chlorine+at+Point-Of-
Use+to+Improve+Water+Quality+and+Reduce+Child+Diarrhea+in+Developing+Coun-
tries:+a+Systematic+Review+and+Meta-Analysis&btnG=)

Bartlett, S. (2003). Water, Sanitation and Urban Children: the Need to Go beyond “Improved”
Provision. Environ. Urbanization 15 (2), 57–70. doi:10.1177/095624780301500220
Provision. Environ. Urbanization 15 (2), 57–70. doi:10.1177/095624780301500220

CrossRef Full Text (https://doi.org/10.1177/095624780301500220) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Water,+Sanitation+and+Urban+Chil-
dren:+the+Need+to+Go+beyond+Improved+Provision&btnG=)
Bessong, P. O., Odiyo, J. O., Musekene, J. N., and Tessema, A. (2009). Spatial Distribution of
Diarrhoea and Microbial Quality of Domestic Water during an Outbreak of Diarrhoea in the
Tshikuwi Community in Venda, South Africa. J. Health Popul. Nutr. 27 (5), 652–659.
doi:10.3329/jhpn.v27i5.3642

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/19902801/) | CrossRef Full Text

(https://doi.org/10.3329/jhpn.v27i5.3642) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Spatial+Distribution+of+Diarrhoea+and+Microbial+Quali-
ty+of+Domestic+Water+during+an+Outbreak+of+Diarrhoea+in+the+Tshikuwi+Commu-
nity+in+Venda,+South+Africa&btnG=)

Boldo, E., MartÍN-Olmedo, P., Medina, S., Pirard, P., Mouly, D., and Beaudeau, P. (2006).
Towards the Quantification of Health Impacts Caused by Drinking-Water Pollution in
European Countries. Epidemiology 17 (6), S447. doi:10.1097/00001648-200611001-01198

CrossRef Full Text (https://doi.org/10.1097/00001648-200611001-01198) | Google Schol-

ar (https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Towards+the+Quantifi-
cation+of+Health+Impacts+Caused+by+Drinking-
Water+Pollution+in+European+Countries&btnG=)

Brown, J., and Clasen, T. (2012). High Adherence Is Necessary to Realize Health Gains from
Water Quality Interventions. PLoS ONE 7 (5), e36735–9. doi:10.1371/journal.pone.0036735

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/22586491/) | CrossRef Full Text

(https://doi.org/10.1371/journal.pone.0036735) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=High+Adherence+Is+Necessary+to+Real-
ize+Health+Gains+from+Water+Quality+Interventions&btnG=)

Cantor, K. P., Hoover, R., Mason, T. J., and McCabe, L. J. (1978). Associations of Cancer
Mortality with Halomethanes in Drinking Water. J. Natl. Cancer Inst. 61 (4), 979
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/702538/) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Associations+of+Cancer+Mortali-
ty+with+Halomethanes+in+Drinking+Water&btnG=)

Cantor, K. P. (1997). Drinking Water and Cancer. Cancer Causes Control CCC 8 (3), 292–308.
doi:10.1023/a:1018444902486 (tel:1018444902486)

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/9498894/) | CrossRef Full Text

(https://doi.org/10.1023/a:1018444902486) | Google Scholar (https://scholar.google.-
com/scholar?hl=en&as_sdt=0%2C5&q=Drinking+Water+and+Cancer&btnG=)

Chen, B., Wang, M., Duan, M., Ma, X., Hong, J., Xie, F., et al. (2019). In Search of Key:
Protecting Human Health and the Ecosystem from Water Pollution in China. J. Clean. Prod.
228, 101–111. doi:10.1016/j.jclepro.2019.04.228
CrossRef Full Text (https://doi.org/10.1016/j.jclepro.2019.04.228) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=In+Search+of+Key:+Protecting+Hu-
man+Health+and+the+Ecosystem+from+Water+Pollution+in+China&btnG=)

Cheung, W. H. S., Chang, K. C. K., Hung, R. P. S., and Kleevens, J. W. L. (1990). Health E!ects
of Beach Water Pollution in Hong Kong. Epidemiol. Infect. 105 (1), 139–162.
doi:10.1017/s0950268800047737

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/2384140/) | CrossRef Full Text

(https://doi.org/10.1017/s0950268800047737) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Health+E!ects+of+Beach+Water+Pollu-
tion+in+Hong+Kong&btnG=)

Cheung, W. H. S., Hung, R. P. S., Chang, K. C. K., and Kleevens, J. W. L. (1991).

Epidemiological Study of Beach Water Pollution and Health-Related Bathing Water
Standards in Hong Kong. Water Sci. Technol. 23 (1-3), 243–252. doi:10.2166/wst.1991.0422

CrossRef Full Text (https://doi.org/10.2166/wst.1991.0422) | Google Scholar

(https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Epidemiologi-
cal+Study+of+Beach+Water+Pollution+and+Health-
Related+Bathing+Water+Standards+in+Hong+Kong&btnG=)

Chowdhary, P., Bharagava, R. N., Mishra, S., and Khan, N. (2020). Role of Industries in Water
Scarcity and its Adverse E!ects on Environment and Human Health. Environ. Concerns
Sustain. Dev., 235–256. doi:10.1007/978-981-13-5889-0_12
CrossRef Full Text (https://doi.org/10.1007/978-981-13-5889-0_12) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Role+of+Industries+in+Water+Scarcity+and+its+Adverse+Ef-
fects+on+Environment+and+Human+Health&btnG=)

Clasen, T. F., Alexander, K. T., Sinclair, D., Boisson, S., Peletz, R., Chang, H. H., et al. (2015).
Interventions to Improve Water Quality for Preventing Diarrhoea. Cochrane Database Syst.
Rev. 10, CD004794. doi:10.1002/14651858.CD004794.pub3
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/26488938/) | CrossRef Full Text
(https://doi.org/10.1002/14651858.CD004794.pub3) | Google Scholar (https://scholar.-
google.com/scholar?
hl=en&as_sdt=0%2C5&q=Interventions+to+Improve+Water+Quality+for+Prevent-
ing+Diarrhoea&btnG=)

Clasen, T., Schmidt, W.-P., Rabie, T., Roberts, I., and Cairncross, S. (2007). Interventions to
Improve Water Quality for Preventing Diarrhoea: Systematic Review and Meta-Analysis. Bmj
334 (7597), 782. doi:10.1136/bmj.39118.489931.be

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/17353208/) | CrossRef Full Text

(https://doi.org/10.1136/bmj.39118.489931.be) | Google Scholar (https://scholar.google.-
com/scholar?hl=en&as_sdt=0%2C5&q=Interventions+to+Improve+Water+Quali-
ty+for+Preventing+Diarrhoea:+Systematic+Review+and+Meta-Analysis&btnG=)

Conroy, R. M., Elmore-Meegan, M., Joyce, T., McGuigan, K. G., and Barnes, J. (1996). Solar
Disinfection of Drinking Water and Diarrhoea in Maasai Children: a Controlled Field Trial.
Lancet 348 (9043), 1695–1697. doi:10.1016/s0140-6736(96)02309-4
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/8973432/) | CrossRef Full Text
(https://doi.org/10.1016/s0140-6736(96)02309-4) | Google Scholar (https://scholar.-
google.com/scholar?
hl=en&as_sdt=0%2C5&q=Solar+Disinfection+of+Drinking+Water+and+Diar-
rhoea+in+Maasai+Children:+a+Controlled+Field+Trial&btnG=)

Dasgupta, P. (2004). Valuing Health Damages from Water Pollution in Urban Delhi, India: a
Health Production Function Approach. Envir. Dev. Econ. 9 (1), 83–106.
doi:10.1017/s1355770x03001098

CrossRef Full Text (https://doi.org/10.1017/s1355770x03001098) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Valuing+Health+Damages+from+Water+Pollution+in+Ur-
ban+Delhi,+India:+a+Health+Production+Function+Approach&btnG=)

Dwivedi, S., Mishra, S., and Tripathi, R. D. (2018). Ganga Water Pollution: A Potential Health
Threat to Inhabitants of Ganga Basin. Environ. Int. 117, 327–338.
doi:10.1016/j.envint.2018.05.015
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/29783191/) | CrossRef Full Text
(https://doi.org/10.1016/j.envint.2018.05.015) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Ganga+Water+Pollution:+A+Potential+Health+Threat+to+In-
habitants+of+Ganga+Basin&btnG=)

Ebenstein, A. (2012). The Consequences of Industrialization: Evidence from Water Pollution

and Digestive Cancers in China. Rev. Econ. Statistics 94 (1), 186–201.
doi:10.1162/rest_a_00150
CrossRef Full Text (https://doi.org/10.1162/rest_a_00150) | Google Scholar (https://schol-
ar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=The+Consequences+of+Industrialization:+Evi-
dence+from+Water+Pollution+and+Digestive+Cancers+in+China&btnG=)

El-Kowrany, S. I., El- Zamarany, E. A., El-Nouby, K. A., El-Mehy, D. A., Abo Ali, E. A., and
Othman, A. A. (2016). Water Pollution in the Middle Nile Delta, Egypt: an Environmental
Study. J. Adv. Res. 7 (5), 781–794. doi:10.1016/j.jare.2015.11.005

CrossRef Full Text (https://doi.org/10.1016/j.jare.2015.11.005) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Pollution+in+the+Middle+Nile+Delta,+Egypt:+an+Envi-
ronmental+Study&btnG=)

Enrique Biagini, R. (1975). Chronic Arsenic Water Pollution in the Republic of Argentina. Med.
Cutan. Ibero Lat. Am. 3 (6), 423
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/132588/) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Chronic+Arsenic+Water+Pollution+in+the+Republic+of+Ar-
gentina&btnG=)

Esrey, S. A., Potash, J. B., Roberts, L., and Shi!, C. (1991). E!ects of Improved Water Supply
and Sanitation on Ascariasis, Diarrhoea, Dracunculiasis, Hookworm Infection,
Schistosomiasis, and Trachoma. Bull. World Health Organ 69 (5), 609

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/1835675/) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=E!ects+of+Improved+Water+Supply+and+Sanitation+on+As-
cariasis,+Diarrhoea,+Dracunculiasis,+Hookworm+Infection,+Schistosomiasis,+and+Tra-
choma&btnG=)

Ferreccio, C., González, C., Milosavjlevic, V., Marshall, G., Sancha, A. M., and Smith, A. H.
(2000). Lung Cancer and Arsenic Concentrations in Drinking Water in Chile. Epidemiology 11
(6), 673–679. doi:10.1097/00001648-200011000-00010
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/11055628/) | CrossRef Full Text
(https://doi.org/10.1097/00001648-200011000-00010) | Google Scholar (https://schol-
ar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Lung+Cancer+and+Arsenic+Concentrations+in+Drink-
ing+Water+in+Chile&btnG=)

Fewtrell, L., and Colford, J. M. (2005). Water, Sanitation and Hygiene in Developing
Countries: Interventions and Diarrhoea-A Review. Water Sci. Technol. A J. Int. Assoc. Water
Pollut. Res. 52 (8), 133–142. doi:10.2166/wst.2005.0244
CrossRef Full Text (https://doi.org/10.2166/wst.2005.0244) | Google Scholar
(https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Water,+Sanita-
tion+and+Hygiene+in+Developing+Countries:+Interventions+and+Diarrhoea-
A+Review&btnG=)

Fitzgerald, E. F., Schell, L. M., Marshall, E. G., Carpenter, D. O., Suk, W. A., and Zejda, J. E.
(1998). Environmental Pollution and Child Health in Central and Eastern Europe. Environ.
Health Perspect. 106 (6), 307–311. doi:10.1289/ehp.98106307
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/9618345/) | CrossRef Full Text
(https://doi.org/10.1289/ehp.98106307) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Environmental+Pollution+and+Child+Health+in+Cen-
tral+and+Eastern+Europe&btnG=)

Fleisher, J. M., and Kay, D. (2006). Risk Perception Bias, Self-Reporting of Illness, and the
Validity of Reported Results in an Epidemiologic Study of Recreational Water Associated
Illnesses. Mar. Pollut. Bull. 52 (3), 264–268. doi:10.1016/j.marpolbul.2005.08.019

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/16212985/) | CrossRef Full Text

(https://doi.org/10.1016/j.marpolbul.2005.08.019) | Google Scholar (https://scholar.-
google.com/scholar?hl=en&as_sdt=0%2C5&q=Risk+Perception+Bias,+Self-
Reporting+of+Illness,+and+the+Validity+of+Reported+Results+in+an+Epidemiolog-
ic+Study+of+Recreational+Water+Associated+Illnesses&btnG=)

Fong, T.-T., and Lipp, E. K. (2005). Enteric Viruses of Humans and Animals in Aquatic
Environments: Health Risks, Detection, and Potential Water Quality Assessment Tools.
Microbiol. Mol. Biol. Rev. 69 (2), 357–371. doi:10.1128/mmbr.69.2.357-371.2005
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/15944460/) | CrossRef Full Text
(https://doi.org/10.1128/mmbr.69.2.357-371.2005) | Google Scholar (https://scholar.-
google.com/scholar?
hl=en&as_sdt=0%2C5&q=Enteric+Viruses+of+Humans+and+Animals+in+Aquatic+Envi-
ronments:+Health+Risks,+Detection,+and+Potential+Water+Quality+Assess-
ment+Tools&btnG=)

Froom, P. (2009). Water Pollution and Cancer in Israeli Navy Divers. Int. J. Occup. Environ.
Health 15 (3), 326–328. doi:10.1179/oeh.2009.15.3.326
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/19650589/) | CrossRef Full Text
(https://doi.org/10.1179/oeh.2009.15.3.326) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Pollution+and+Cancer+in+Israeli+Navy+Divers&btnG=)

Gundry, S., Wright, J., and Conroy, R. (2004). A Systematic Review of the Health Outcomes
Related to Household Water Quality in Developing Countries. J. water health 2 (1), 1–13.
doi:10.2166/wh.2004.0001
doi:10.2166/wh.2004.0001

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/15384725/) | CrossRef Full Text

(https://doi.org/10.2166/wh.2004.0001) | Google Scholar (https://scholar.google.-
com/scholar?

hl=en&as_sdt=0%2C5&q=A+Systematic+Review+of+the+Health+Outcomes+Relat-
ed+to+Household+Water+Quality+in+Developing+Countries&btnG=)

Halder, J., Islam, N., and Islam, N. (2015). Water Pollution and its Impact on the Human
Health. Eh 2 (1), 36–46. doi:10.15764/eh.2015.01005

CrossRef Full Text (https://doi.org/10.15764/eh.2015.01005) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Pollution+and+its+Impact+on+the+Hu-
man+Health&btnG=)

Hanif, M., Miah, R., Islam, M., and Marzia, S. (2020). Impact of Kapotaksha River Water
Pollution on Human Health and Environment. Prog. Agric. 31 (1), 1–9.
doi:10.3329/pa.v31i1.48300
CrossRef Full Text (https://doi.org/10.3329/pa.v31i1.48300) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Impact+of+Kapotaksha+River+Water+Pollution+on+Hu-
man+Health+and+Environment&btnG=)

Haseena, M., Malik, M. F., Javed, A., Arshad, S., Asif, N., Zulfiqar, S., et al. (2017). Water
Pollution and Human Health. Environ. Risk Assess. Remediat. 1 (3), 20. doi:10.4066/2529-
8046.100020

CrossRef Full Text (https://doi.org/10.4066/2529-8046.100020) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Pollution+and+Human+Health&btnG=)

Henry, F. J., Huttly, S. R. A., Patwary, Y., and Aziz, K. M. A. (1990). Environmental Sanitation,
Food and Water Contamination and Diarrhoea in Rural Bangladesh. Epidemiol. Infect. 104
(2), 253–259. doi:10.1017/s0950268800059422

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/2323358/) | CrossRef Full Text

(https://doi.org/10.1017/s0950268800059422) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Environmental+Sanitation,+Food+and+Water+Contamina-
tion+and+Diarrhoea+in+Rural+Bangladesh&btnG=)

Jalan, J., and Ravallion, M. (2003). Does Piped Water Reduce Diarrhea for Children in Rural
India? J. Econ. 112 (1), 153–173. doi:10.1016/s0304-4076(02)00158-6

CrossRef Full Text (https://doi.org/10.1016/s0304-4076(02)00158-6) | Google Scholar

CrossRef Full Text (https://doi.org/10.1016/s0304-4076(02)00158-6) | Google Scholar
(https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Does+Piped+Water+Re-
duce+Diarrhea+for+Children+in+Rural+India?&btnG=)

Jensen, P. K., Jayasinghe, G., Hoek, W., Cairncross, S., and Dalsgaard, A. (2004). Is There an
Association between Bacteriological Drinking Water Quality and Childhood Diarrhoea in
Developing Countries? Trop. Med. Int. Health 9 (11), 1210–1215. doi:10.1111/j.1365-
3156.2004.01329.x

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/15548318/) | CrossRef Full Text

(https://doi.org/10.1111/j.1365-3156.2004.01329.x) | Google Scholar (https://scholar.-
google.com/scholar?hl=en&as_sdt=0%2C5&q=Is+There+an+Association+between+Bac-
teriological+Drinking+Water+Quality+and+Childhood+Diarrhoea+in+Developing+Coun-
tries?&btnG=)

Jorgenson, A. K. (2009). Foreign Direct Investment and the Environment, the Mitigating
Influence of Institutional and Civil Society Factors, and Relationships between Industrial
Pollution and Human Health. Organ. Environ. 22 (2), 135–157.
doi:10.1177/1086026609338163

CrossRef Full Text (https://doi.org/10.1177/1086026609338163) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Foreign+Direct+Investment+and+the+Environment,+the+Miti-
gating+Influence+of+Institutional+and+Civil+Society+Factors,+and+Relationships+be-
tween+Industrial+Pollution+and+Human+Health&btnG=)

Kaur, G., Kumar, R., Mittal, S., Sahoo, P. K., and Vaid, U. (2021). Ground/drinking Water
Contaminants and Cancer Incidence: A Case Study of Rural Areas of South West Punjab,
India. Hum. Ecol. Risk Assess. Int. J. 27 (1), 205–226. doi:10.1080/10807039.2019.1705145

CrossRef Full Text (https://doi.org/10.1080/10807039.2019.1705145) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Ground/drinking+Water+Contaminants+and+Cancer+Inci-
dence:+A+Case+Study+of+Rural+Areas+of+South+West+Punjab,+India&btnG=)

Kazi, T. G., Arain, M. B., Baig, J. A., Jamali, M. K., Afridi, H. I., Jalbani, N., et al. (2009). The
Correlation of Arsenic Levels in Drinking Water with the Biological Samples of Skin
Disorders. Sci. Total Environ. 407 (3), 1019–1026. doi:10.1016/j.scitotenv.2008.10.013

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/19027142/) | CrossRef Full Text

(https://doi.org/10.1016/j.scitotenv.2008.10.013) | Google Scholar (https://scholar.-
google.com/scholar?
hl=en&as_sdt=0%2C5&q=The+Correlation+of+Arsenic+Levels+in+Drinking+Wa-
ter+with+the+Biological+Samples+of+Skin+Disorders&btnG=)

Khan, S., Shahnaz, M., Jehan, N., Rehman, S., Shah, M. T., and Din, I. (2013). Drinking Water
Khan, S., Shahnaz, M., Jehan, N., Rehman, S., Shah, M. T., and Din, I. (2013). Drinking Water
Quality and Human Health Risk in Charsadda District, Pakistan. J. Clean. Prod. 60, 93–101.
doi:10.1016/j.jclepro.2012.02.016

CrossRef Full Text (https://doi.org/10.1016/j.jclepro.2012.02.016) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Drinking+Water+Quality+and+Hu-
man+Health+Risk+in+Charsadda+District,+Pakistan&btnG=)

Kochhar, N., Gill, G. S., Tuli, N., Dadwal, V., and Balaram, V. (2007). Chemical Quality of
Ground Water in Relation to Incidence of Cancer in Parts of SW Punjab, India. Asian J. Water,
Environ. Pollut. 4 (2), 107 doi:10.1086/114154
CrossRef Full Text (https://doi.org/10.1086/114154) | Google Scholar (https://scholar.-
google.com/scholar?
hl=en&as_sdt=0%2C5&q=Chemical+Quality+of+Ground+Water+in+Relation+to+Inci-
dence+of+Cancer+in+Parts+of+SW+Punjab,+India&btnG=)

Kumar, S., Meena, H. M., and Verma, K. (2017). Water Pollution in India: its Impact on the
Human Health: Causes and Remedies. Int. J. Appl. Environ. Sci. 12 (2), 275
Google Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Pollution+in+India:+its+Impact+on+the+Hu-
man+Health:+Causes+and+Remedies&btnG=)

Lai, W. (2017). Pesticide Use and Health Outcomes: Evidence from Agricultural Water
Pollution in China. J. Environ. Econ. Manag. 86, 93–120. doi:10.1016/j.jeem.2017.05.006

CrossRef Full Text (https://doi.org/10.1016/j.jeem.2017.05.006) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Pesticide+Use+and+Health+Outcomes:+Evi-
dence+from+Agricultural+Water+Pollution+in+China&btnG=)

Landrigan, P. J., Fuller, R., Fisher, S., Suk, W. A., Sly, P., Chiles, T. C., et al. (2018). Pollution and
Children's Health. Sci. Total Environ. 650 (Pt 2), 2389–2394 (tel:2389–2394).
doi:10.1016/j.scitotenv.2018.09.375
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/30292994/) | CrossRef Full Text
(https://doi.org/10.1016/j.scitotenv.2018.09.375) | Google Scholar (https://scholar.-
google.com/scholar?hl=en&as_sdt=0%2C5&q=Pollution+and+Children's+Health&btnG=)

Lin, H.-J., Sung, T.-I., Chen, C.-Y., and Guo, H.-R. (2013). Arsenic Levels in Drinking Water
and Mortality of Liver Cancer in Taiwan. J. Hazard. Mater. 262, 1132–1138.
doi:10.1016/j.jhazmat.2012.12.049
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/23352725/) | CrossRef Full Text
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/23352725/) | CrossRef Full Text
(https://doi.org/10.1016/j.jhazmat.2012.12.049) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Arsenic+Levels+in+Drinking+Water+and+Mortality+of+Liv-
er+Cancer+in+Taiwan&btnG=)

Lu, Y., Song, S., Wang, R., Liu, Z., Meng, J., Sweetman, A. J., et al. (2015). Impacts of Soil and
Water Pollution on Food Safety and Health Risks in China. Environ. Int. 77, 5–15.
doi:10.1016/j.envint.2014.12.010

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/25603422/) | CrossRef Full Text

(https://doi.org/10.1016/j.envint.2014.12.010) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Impacts+of+Soil+and+Water+Pollution+on+Food+Safe-
ty+and+Health+Risks+in+China&btnG=)

Marino, D. D. (2007). Water and Food Safety in the Developing World: Global Implications for
Health and Nutrition of Infants and Young Children. J. Am. Dietetic Assoc. 107 (11), 1930–
1934. doi:10.1016/j.jada.2007.08.013
CrossRef Full Text (https://doi.org/10.1016/j.jada.2007.08.013) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Water+and+Food+Safety+in+the+Developing+World:+Glob-
al+Implications+for+Health+and+Nutrition+of+Infants+and+Young+Children&btnG=)

Marmot, M., Atinmo, T., Byers, T., Chen, J., and Zeisel, S. H. (2007). Food, Nutrition, Physical
Activity, and the Prevention of Cancer: a Global Perspective. Nutr. Bull.
Google Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Food,+Nutrition,+Physical+Activity,+and+the+Preven-
tion+of+Cancer:+a+Global+Perspective&btnG=)

Marr, A., and Dasgupta, N. (2009). Industrial Water Pollution in Dhaka, Bangladesh: Strategies
and Incentives for Pollution Control in Small and Medium Enterprises. Int. J. Interdiscip. Soc.
Sci. Annu. Rev. 3 (11), 97–108. doi:10.18848/1833-1882/cgp/v03i11/52752
CrossRef Full Text (https://doi.org/10.18848/1833-1882/cgp/v03i11/52752) | Google
Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Industrial+Water+Pollution+in+Dhaka,+Bangladesh:+Strate-
gies+and+Incentives+for+Pollution+Control+in+Small+and+Medium+Enterprises&btnG=
)

Morris, R. D. (1995). Drinking Water and Cancer. Environ. Health Perspect. 103, 225.
doi:10.2307/3432315

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/8741788/) | CrossRef Full Text

(https://doi.org/10.2307/3432315) | Google Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Drinking+Water+and+Cancer&btnG=)
Moss, B. (2008). Water Pollution by Agriculture. Phil. Trans. R. Soc. B 363 (1491), 659–666.
doi:10.1098/rstb.2007.2176

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/17666391/) | CrossRef Full Text

(https://doi.org/10.1098/rstb.2007.2176) | Google Scholar (https://scholar.google.-
com/scholar?hl=en&as_sdt=0%2C5&q=Water+Pollution+by+Agriculture&btnG=)

Page, T., Harris, R. H., and Epstein, S. S. (1976). Drinking Water and Cancer Mortality in
Louisiana. Science 193 (4247), 55–57. doi:10.1126/science.935854

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/935854/) | CrossRef Full Text

(https://doi.org/10.1126/science.935854) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Drinking+Water+and+Cancer+Mortality+in+Louisiana&btnG=)

Pandey, S. (2006). Water Pollution and Health. Kathmandu Univ. Med. J. (KUMJ) 4 (1), 128.
doi:10.1016/j.crvi.2013.04.013

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/18603885/) | CrossRef Full Text

(https://doi.org/10.1016/j.crvi.2013.04.013) | Google Scholar (https://scholar.google.-
com/scholar?hl=en&as_sdt=0%2C5&q=Water+Pollution+and+Health&btnG=)

Parris, K. (2011). Impact of Agriculture on Water Pollution in OECD Countries: Recent Trends
and Future Prospects. Int. J. Water Resour. Dev. 27 (1), 33–52.
doi:10.1080/07900627.2010.531898

CrossRef Full Text (https://doi.org/10.1080/07900627.2010.531898) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Impact+of+Agriculture+on+Water+Pollution+in+OECD+Coun-
tries:+Recent+Trends+and+Future+Prospects&btnG=)

Payment, P., Siemiatycki, J., Richardson, L., Renaud, G., Franco, E., and Prevost, M. (1997). A
Prospective Epidemiological Study of Gastrointestinal Health E!ects Due to the
Consumption of Drinking Water. Int. J. Environ. Health Res. 7 (1), 5–31.
doi:10.1080/09603129773977

CrossRef Full Text (https://doi.org/10.1080/09603129773977) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=A+Prospective+Epidemiological+Study+of+Gastrointesti-
nal+Health+E!ects+Due+to+the+Consumption+of+Drinking+Water&btnG=)

Rabbani, M., Chowdhury, M., and Khan, N. A. (2010). Impacts of Industrial Pollution on
Human Health: Empirical Evidences from an Industrial Hotspot (Kaliakoir) in Bangladesh.
Asian J. Water, Environ. Pollut. 7 (1), 27
Google Scholar (https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Im-
pacts+of+Industrial+Pollution+on+Human+Health:+Empirical+Evidences+from+an+In-
pacts+of+Industrial+Pollution+on+Human+Health:+Empirical+Evidences+from+an+In-
dustrial+Hotspot+(Kaliakoir)+in+Bangladesh&btnG=)

Rajal, V. B., Cruz, C., and Last, J. A. (2010). Water Quality Issues and Infant Diarrhoea in a
South American Province. Glob. Public Health 5 (4), 348–363.
doi:10.1080/17441690802447267
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/20473801/) | CrossRef Full Text
(https://doi.org/10.1080/17441690802447267) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Quality+Issues+and+Infant+Diar-
rhoea+in+a+South+American+Province&btnG=)

Rampen, F. H. J., Nelemans, P. J., and Verbeek, A. L. (1992). Is Water Pollution a Cause of
Cutaneous Melanoma? Epidemiology 3, 263–265. doi:10.1097/00001648-199205000-
00013

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/1591327/) | CrossRef Full Text

(https://doi.org/10.1097/00001648-199205000-00013) | Google Scholar (https://schol-
ar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Is+Water+Pollution+a+Cause+of+Cuta-
neous+Melanoma?&btnG=)

Royal Commission for Environmental Pollution 1979 Seventh Report. Agriculture and
Pollution. London, UK: H.M.S.O.

Rusiñol, M., Fernandez-Cassi, X., Timoneda, N., Carratalà, A., and Abril, J. F. (2015). Evidence
of Viral Dissemination and Seasonality in a Mediterranean River Catchment: Implications for
Water Pollution Management. J. Environ. Manag. 159, 58–67.
doi:10.1016/j.jenvman.2015.05.019

CrossRef Full Text (https://doi.org/10.1016/j.jenvman.2015.05.019) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Evidence+of+Viral+Dissemination+and+Seasonali-
ty+in+a+Mediterranean+River+Catchment:+Implications+for+Water+Pollution+Man-
agement&btnG=)

Schullehner, J., Hansen, B., Thygesen, M., Pedersen, C. B., and Sigsgaard, T. (2018). Nitrate in
Drinking Water and Colorectal Cancer Risk: A Nationwide Population-Based Cohort Study.
Int. J. Cancer 143 (1), 73–79. doi:10.1002/ijc.31306
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/29435982/) | CrossRef Full Text
(https://doi.org/10.1002/ijc.31306) | Google Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Nitrate+in+Drinking+Water+and+Colorectal+Can-
cer+Risk:+A+Nationwide+Population-Based+Cohort+Study&btnG=)

Schwarzenbach, R. P., Egli, T., Hofstetter, T. B., Von Gunten, U., and Wehrli, B. (2010). Global
Water Pollution and Human Health. Annu. Rev. Environ. Resour. 35, 109–136.
doi:10.1146/annurev-environ-100809-125342
doi:10.1146/annurev-environ-100809-125342
CrossRef Full Text (https://doi.org/10.1146/annurev-environ-100809-125342) | Google
Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Global+Water+Pollution+and+Human+Health&btnG=)

Sliman, N. A. (1978). Outbreak of Guillain-Barre Syndrome Associated with Water Pollution.

Bmj 1 (6115), 751–752. doi:10.1136/bmj.1.6115.751
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/204392/) | CrossRef Full Text
(https://doi.org/10.1136/bmj.1.6115.751) | Google Scholar (https://scholar.google.-
com/scholar?hl=en&as_sdt=0%2C5&q=Outbreak+of+Guillain-
Barre+Syndrome+Associated+with+Water+Pollution&btnG=)

Smith, A. H., Hopenhayn-Rich, C., Bates, M. N., Goeden, H. M., Hertz-Picciotto, I., Duggan, H.
M., et al. (1992). Cancer Risks from Arsenic in Drinking Water. Environ. Health Perspect. 97,
259–267. doi:10.1289/ehp.9297259

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/1396465/) | CrossRef Full Text

(https://doi.org/10.1289/ehp.9297259) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Cancer+Risks+from+Arsenic+in+Drinking+Water&btnG=)

Stephens, J. K. (2002). Deterioration of Stored Domestic Water Quality and Diarrhoea in

Zenu. University of Ghana.
Google Scholar (https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Deterioration+of+Stored+Domestic+Water+Quality+and+Di-
arrhoea+in+Zenu&btnG=)

Stevenson, A. H. (1953). Studies of Bathing Water Quality and Health. Am. J. Public Health
Nations Health 43 (5 Pt 1), 529–538. doi:10.2105/ajph.43.5_pt_1.529
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/13040559/) | CrossRef Full Text
(https://doi.org/10.2105/ajph.43.5_pt_1.529) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Studies+of+Bathing+Water+Quality+and+Health&btnG=)

Team, S. H. (2004). Water, Sanitation and Hygiene Links to Health: Facts and Figures. World
Health Organization.

Google Scholar (https://scholar.google.com/scholar?

hl=en&as_sdt=0%2C5&q=Water,+Sanitation+and+Hy-
giene+Links+to+Health:+Facts+and+Figures&btnG=)

Tondel, M., Rahman, M., Magnuson, A., Chowdhury, I. A., Faruquee, M. H., and Ahmad, S. A.
(1999). The Relationship of Arsenic Levels in Drinking Water and the Prevalence Rate of Skin
Lesions in Bangladesh. Environ. health Perspect. 107 (9), 727–729.
Lesions in Bangladesh. Environ. health Perspect. 107 (9), 727–729.
doi:10.1289/ehp.99107727

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/10464073/) | CrossRef Full Text

(https://doi.org/10.1289/ehp.99107727) | Google Scholar (https://scholar.google.-
com/scholar?

hl=en&as_sdt=0%2C5&q=The+Relationship+of+Arsenic+Levels+in+Drinking+Wa-
ter+and+the+Prevalence+Rate+of+Skin+Lesions+in+Bangladesh&btnG=)

Tseng, C.-H., Lei, C., and Chen, Y.-C. (2018). Evaluating the Health Costs of Oral Hexavalent
Chromium Exposure from Water Pollution: A Case Study in Taiwan. J. Clean. Prod. 172, 819–
826. doi:10.1016/j.jclepro.2017.10.177

CrossRef Full Text (https://doi.org/10.1016/j.jclepro.2017.10.177) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Evaluating+the+Health+Costs+of+Oral+Hexavalent+Chromi-
um+Exposure+from+Water+Pollution:+A+Case+Study+in+Taiwan&btnG=)

Ustaoğlu, F., Tepe, Y., Taş, B., and Pag, N. (2020). Assessment of Stream Quality and Health
Risk in a Subtropical Turkey River System: A Combined Approach Using Statistical Analysis
and Water Quality Index. Ecol. Indic., 113. doi:10.1016/j.ecolind.2019.105815

CrossRef Full Text (https://doi.org/10.1016/j.ecolind.2019.105815) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Assessment+of+Stream+Quality+and+Health+Risk+in+a+Sub-
tropical+Turkey+River+System:+A+Combined+Approach+Using+Statistical+Analy-
sis+and+Water+Quality+Index&btnG=)

Vartiainen, T., Pukkala, E., Rienoja, T., Strandman, T., and Kaksonen, K. (1993). Population
Exposure to Tri- and Tetrachloroethene and Cancer Risk: Two Cases of Drinking Water
Pollution. Chemosphere 27 (7), 1171–1181. doi:10.1016/0045-6535(93)90165-2
CrossRef Full Text (https://doi.org/10.1016/0045-6535(93)90165-2) | Google Scholar
(https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Population+Expo-
sure+to+Tri-
+and+Tetrachloroethene+and+Cancer+Risk:+Two+Cases+of+Drinking+Water+Pollu-
tion&btnG=)

Victora, C. G., Smith, P. G., Vaughan, J. P., Nobre, L. C., Lombard, C., Teixeira, A. M. B., et al.
(1988). Water Supply, Sanitation and Housing in Relation to the Risk of Infant Mortality from
Diarrhoea. Int. J. Epidemiol. 17 (3), 651–654. doi:10.1093/ije/17.3.651

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/3209344/) | CrossRef Full Text

(https://doi.org/10.1093/ije/17.3.651) | Google Scholar (https://scholar.google.com/schol-
ar?
hl=en&as_sdt=0%2C5&q=Water+Supply,+Sanitation+and+Housing+in+Rela-
tion+to+the+Risk+of+Infant+Mortality+from+Diarrhoea&btnG=)
Vladeva, S., Gatseva, P., and Gopina, G. (2000). Comparative Analysis of Results from Studies
of Goitre in Children from Bulgarian Villages with Nitrate Pollution of Drinking Water in 1995
and 1998. Cent. Eur. J. Public Health 8 (3), 179

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/10965445/) | Google Scholar

(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Comparative+Analysis+of+Results+from+Stud-
ies+of+Goitre+in+Children+from+Bulgarian+Villages+with+Nitrate+Pollution+of+Drink-
ing+Water+in+1995+and+1998&btnG=)

Waddington, H., Snilstveit, B., White, H., and Fewtrell, L. (2009). Water, Sanitation and
Hygiene Interventions to Combat Childhood Diarrhoea in Developing Countries. New Delhi
India Global Development Network International Initiative for Impact Evaluation Aug.

Google Scholar (https://scholar.google.com/scholar?

hl=en&as_sdt=0%2C5&q=Water,+Sanitation+and+Hygiene+Interventions+to+Com-
bat+Childhood+Diarrhoea+in+Developing+Countries&btnG=)

Witkowski, K. M., and Johnson, N. E. (1992). Organic-solvent Water Pollution and Low Birth
Weight in Michigan. Soc. Biol. 39 (1-2), 45–54. doi:10.1080/19485565.1992.9988803

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/1514123/) | CrossRef Full Text

(https://doi.org/10.1080/19485565.1992.9988803) | Google Scholar (https://scholar.-
google.com/scholar?hl=en&as_sdt=0%2C5&q=Organic-
solvent+Water+Pollution+and+Low+Birth+Weight+in+Michigan&btnG=)

Wu, C., Maurer, C., Wang, Y., Xue, S., and Davis, D. L. (1999). Water Pollution and Human
Health in China. Environ. Health Perspect. 107 (4), 251–256. doi:10.1289/ehp.99107251

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/10090702/) | CrossRef Full Text

(https://doi.org/10.1289/ehp.99107251) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Water+Pollution+and+Human+Health+in+China&btnG=)

Wu, H., Gai, Z., Guo, Y., Li, Y., Hao, Y., and Lu, Z. N. (2020). Does Environmental Pollution
Inhibit Urbanization in China? A New Perspective through Residents' Medical and Health
Costs. Environ. Res. 182 (Mar.), 109128–109128.9 (tel:109128–109128.9).
doi:10.1016/j.envres.2020.109128

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/32069743/) | CrossRef Full Text

(https://doi.org/10.1016/j.envres.2020.109128) | Google Scholar (https://scholar.google.-
com/scholar?hl=en&as_sdt=0%2C5&q=Does+Environmental+Pollution+Inhibit+Urban-
ization+in+China?
+A+New+Perspective+through+Residents'+Medical+and+Health+Costs&btnG=)

Xiao, J., Wang, L., Deng, L., and Jin, Z. (2019). Characteristics, Sources, Water Quality and
Xiao, J., Wang, L., Deng, L., and Jin, Z. (2019). Characteristics, Sources, Water Quality and
Health Risk Assessment of Trace Elements in River Water and Well Water in the Chinese
Loess Plateau. Sci. Total Environ. 650 (Pt 2), 2004–2012. doi:10.1016/j.scitotenv.2018.09.322

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/30290343/) | CrossRef Full Text

(https://doi.org/10.1016/j.scitotenv.2018.09.322) | Google Scholar (https://scholar.-
google.com/scholar?
hl=en&as_sdt=0%2C5&q=Characteristics,+Sources,+Water+Quali-
ty+and+Health+Risk+Assessment+of+Trace+Elements+in+River+Water+and+Well+Wa-
ter+in+the+Chinese+Loess+Plateau&btnG=)

Xu, C., Xing, D., Wang, J., and Xiao, G. (2019). The Lag E!ect of Water Pollution on the
Mortality Rate for Esophageal Cancer in a Rapidly Industrialized Region in China. Environ.
Sci. Pollut. Res. 26 (32), 32852–32858 (tel:32852–32858). doi:10.1007/s11356-019-06408-z
CrossRef Full Text (https://doi.org/10.1007/s11356-019-06408-z) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=The+Lag+E!ect+of+Water+Pollution+on+the+Mortali-
ty+Rate+for+Esophageal+Cancer+in+a+Rapidly+Industrialized+Region+in+China&btnG=
)

Xu, X., Wang, Q., and Li, C. (2022b). The Impact of Dependency Burden on Urban Household
Health Expenditure and its Regional Heterogeneity in China: Based on Quantile Regression
Method. Front. Public Health 10, 876088. doi:10.3389/fpubh.2022.876088

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/35602138/) | CrossRef Full Text

(https://doi.org/10.3389/fpubh.2022.876088) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=The+Impact+of+Dependency+Burden+on+Urban+House-
hold+Health+Expenditure+and+its+Regional+Heterogeneity+in+Chi-
na:+Based+on+Quantile+Regression+Method&btnG=)

Xu, X., Yang, H., and Li, C. (2022a). Theoretical Model and Actual Characteristics of Air
Pollution A!ecting Health Cost: A Review. Ijerph 19, 3532. doi:10.3390/ijerph19063532
CrossRef Full Text (https://doi.org/10.3390/ijerph19063532) | Google Scholar
(https://scholar.google.com/scholar?
hl=en&as_sdt=0%2C5&q=Theoretical+Model+and+Actual+Characteristics+of+Air+Pollu-
tion+A!ecting+Health+Cost:+A+Review&btnG=)

Yassin, M. M., Amr, S. S. A., and Al-Najar, H. M. (2006). Assessment of Microbiological Water
Quality and its Relation to Human Health in Gaza Governorate, Gaza Strip. Public Health 120
(12), 1177. doi:10.1016/j.puhe.2006.07.026

PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/17034823/) | CrossRef Full Text

(https://doi.org/10.1016/j.puhe.2006.07.026) | Google Scholar (https://scholar.google.-
(https://doi.org/10.1016/j.puhe.2006.07.026) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Assessment+of+Microbiological+Water+Quality+and+its+Rela-
tion+to+Human+Health+in+Gaza+Governorate,+Gaza+Strip&btnG=)

Yau, V., Wade, T. J., de Wilde, C. K., and Colford, J. M. (2009). Skin-related Symptoms
Following Exposure to Recreational Water: a Systematic Review and Meta-Analysis. Water
Expo. Health 1 (2), 79–103. doi:10.1007/s12403-009-0012-9
CrossRef Full Text (https://doi.org/10.1007/s12403-009-0012-9) | Google Scholar
(https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Skin-related+Symp-
toms+Following+Exposure+to+Recreational+Water:+a+Systematic+Review+and+Meta-
Analysis&btnG=)

Zaveri, E. D., Russ, J. D., Desbureaux, S. G., Damania, R., Rodella, A. S., and Ribeiro Paiva De
Souza, G. (20203). The Nitrogen Legacy: The Long-Term E!ects of Water Pollution on
Human Capital. World Bank Policy Research Working Paper.
Google Scholar (https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=The+Ni-
trogen+Legacy:+The+Long-
Term+E!ects+of+Water+Pollution+on+Human+Capital&btnG=)

Zhang, X.-L., Bing, Z., Xing, Z., Chen, Z.-F., Zhang, J.-Z., Liang, S.-Y., et al. (2003). Research
and Control of Well Water Pollution in High Esophageal Cancer Areas. Wjg 9 (6), 1187–1190.
doi:10.3748/wjg.v9.i6.1187
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/12800221/) | CrossRef Full Text
(https://doi.org/10.3748/wjg.v9.i6.1187) | Google Scholar (https://scholar.google.-
com/scholar?
hl=en&as_sdt=0%2C5&q=Research+and+Control+of+Well+Water+Pollu-
tion+in+High+Esophageal+Cancer+Areas&btnG=)

Zhitkovich, A. (2011). Chromium in Drinking Water: Sources, Metabolism, and Cancer Risks.
Chem. Res. Toxicol. 24 (10), 1617–1629. doi:10.1021/tx200251t
PubMed Abstract (https://pubmed.ncbi.nlm.nih.gov/21766833/) | CrossRef Full Text
(https://doi.org/10.1021/tx200251t) | Google Scholar (https://scholar.google.com/schol-
ar?
hl=en&as_sdt=0%2C5&q=Chromium+in+Drinking+Water:+Sources,+Me-
tabolism,+and+Cancer+Risks&btnG=)

Keywords: water pollution, human health, disease heterogeneity, water intervention, health cost

Citation: Lin L, Yang H and Xu X (2022) E!ects of Water Pollution on Human Health and Disease
Heterogeneity: A Review. Front. Environ. Sci. 10:880246. doi: 10.3389/fenvs.2022.880246
Received: 21 February 2022; Accepted: 09 June 2022;
Published: 30 June 2022.

Edited by:
Ahmed El Nemr (https://loop.frontiersin.org/people/1304299/overview), National Institute of
Oceanography and Fisheries (NIOF), Egypt

Reviewed by:
Behzad Shahmoradi (https://loop.frontiersin.org/people/107193/overview), Kurdistan University of Medical
Sciences, Iran
Atik Kulakli (https://loop.frontiersin.org/people/1769436/overview), American University of the Middle
East, Kuwait

Copyright © 2022 Lin, Yang and Xu. This is an open-access article distributed under the terms of the Cre-
ative Commons Attribution License (CC BY). (http://creativecommons.org/licenses/by/4.0/) The use,
distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright
owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not comply with these
terms.

*Correspondence: Xiaocang Xu, [email protected] (mailto:[email protected])

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily
represent those of their a#liated organizations, or those of the publisher, the editors and the reviewers. Any
product that may be evaluated in this article or claim that may be made by its manufacturer is not
guaranteed or endorsed by the publisher.

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