Tndustrial Phamay-1 BP-702 T
lol Plont Seal- Up Considavakon Qobd Dr. Porjonya Shukta
Dr. N. P. Singh Cass4
* The Acaling up d manufacturing þroun d tablats and
caþsulus ,Yrom 'Jaboraty babeh iu to'intarmadiola
and Jorg scal pro dwchon
Qach stoga od oforakond muat bu corafully barfomud.
x Aprow wsing the somu y aouhmart
þerform quita diuundy when thu sisa d squhmant
ond amount d hatanid is ineraassdighiiantly
Tipud Uoit Ohaahona inalad in Scala-up solid
Josagforms
By-Dr.Mah
Pratap
Singh
(4) Moteria Handling:-Ih Jaborakoy maBsvial, a7t
Simbly handud wih sbatula,
scoopas or by honda
bud in intarmadiat1 oy dorge Acal operakionA
hey ora hondled by mothonical mion. like
scYao ed aystem., Dacuum loading systems, and
matevihg pumps
* Th matrial handling sysBam munt daliver acuraba
amount o ingadenb t intendud dustinakion.
() Dry Blanding. Th gnanulatad
bowde foror encabsulakion
bafori tabla ting
or oncapsulation
must bu wll blendad to good drug
disibuhon and contant uniformity.
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God blonding is eusnk al asprually if Dr. Parjanya Saukla
tablet or cahul is small and druq Dr. V.?. Singh Clueo
Content is Hlaively dow.
* Stsbs houl d ao b1 tukun to enAuYA all in gre dianba
ru from umbs and agglomavaf,
er this suning
usually donu.
nd miing brior to tlan ding
3) Gronul ahon ;- T6 Atalu ap o gro nul ahon bros
þraus in
most efiiant mnner, þurpones fo7
gronwakon mest bu clo
Ot import god flow incraast ta g) to chongs þoriel
Ghporant dnsit AiFa disthiauben lor
þoudars imiproving binding
prepity.
* Bindavs wwid in tablt fomulaton
b make fowdar mon comfrmibl and to froduu Singb
mor! HUsiatonu to brakaga duuing handling.
addid in dy state and gives Prokop
heir binding Prepevhus hun (Mohundra
Stmu ar daued gronulah'ng d is addud.
oY d'sbrALd
dsherasd in
granil ahng luid By-Dr.
Duing scal - ub þroblems cauld bu entauntexad will
acdurd solution,
gronulahing by odjus H'ng viscosity o the
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- 3 Dr DKS & D MPS Classes onogla lay ste. Fclos Dr PK Shukla& Or MP Singh Ciasses on elegrar and t e o
* Somu ims duving gronwlakon , when þraborad Dr. Par]anya Shukla
in þroduchon - pid equipmand
Dr, 4.P. Singh lassa
bi coma o dough lik1 consistany and my
may hove
Sub divi ded to mor! gronwor "and þorous mas
to Jalitala dyig
tor at an cscilaing tybe
buitabb Jorq screH i wsld.
gronal abor wih, a
(4) Drying-Thi wet gronulys oa commonly drisd
by cirwoing hot a'r ovar granuls
tor
dying,bdmastdiurcomma74only tray dryr or
Jlwidigd
y The ophimum temberatuxa ugu'TAd tor dying
Oround
60c (lowAY temh. can also bu used)
x f8D oYH more oddiunt for drying granulus
bycawsi they suouiu is tin a comporad to
rg dyar
Duuing Ataa- uf th important dactoYA nuat
be takn into consideration are
flaidiyed bed dyer Tray dryar
* Air ow yate Ajr temperakura
* Thlat and outle ojr temb. Ai do
* Matria Lood. Dah d,granuh sud
Humidit indet a'r. Dying me.
By Dr. Mahen dro Pratab Singh
Copy: ght: Ail rights reseryet th Dr Parjanya Sh:ia &Dr MP Singh Classes (Yoct he Cl apneh)
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3
(5) Reduchon_d farkel S Dr. Parjanga Sthukta
xaYa-orticdu
The ctoctoa, that may otet compaion Dr. M. f. Sngh Caas
size disibaion , low þrobeyhas,
Uni ormity o contend , unifomit ought and
cojnaxibilby
all hest should be set duuing scal -up.
xTo determina þoricl bje dstibuhon d gronuls
Siaving maho.
Portie siie uduchon, d driud gronuly is corrizd
out by pasing all th malarial Vkrough
Dscillabing gronulator,hommar mill, and muchanical sievu
* Duuing Ayu sudu chon ubvicanta or ghdants wd
in Jaboraoy aho addid to final Vblund.
(6) Bundngi Duuing inad blanding pablama bke
Oirigahon, froduchion exeniva ines, and
Vþortie
pari abraton may occuns.
* Th d blanding,equibmunt used duing sal
yA.naan
ub or pro duchon dilnt
oduct'davaloþmunt labovafoy
nt from uatd in Singh
otenhon shauld ba þaid to scali -up and 0.
M.
ught duign By-r.
blnding"orJod, mixing shud and
þropaTly establshad mixing ime
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ind r APP Dr PKS &Dr MPS Classes on G00gle laystore. Hollow Dr P KShukla & Dr MPSingh Classes on Telegram and Facehook.
* matorial
Athrough to undistonding d charocaviahs d
blndod helb to maki scal 'up or. rorjanga Shukla
buceu and mors
mor oliuant. Dr. N.P. Slngh aasA
() Grenudalion Honding and fand ystamai
* Ih Jabaary ’ iniahud gronualu,
into pra hopþar.
is scoopud from drum
Th Jorg sau ’ sopbiak alsd , auomabad hondling
Aysfems liku vocuum or machanical yahns
Duwi'ng va cuum oy ma chanical handlin g AqA qahon may
ocCuT duu to stotic charqas
hia may Jad to þrohlam% wik mabzyvial Jlous and
Causs ditialty to control tablat wught, Rickn,
hardnum and ontont uniformity
MorA
added
sophisieaad matarial honding syatema Causes
concYn d clanabiity.
(8) Combrnion i- Comprnijon d gronals to formwated
tablata on hih 'spud tablu prsn
handing,takon
ond comþauion charaByviahcA must ba
in connidaration
ó datzrmina Comprasion charackaviktia By- Or
trial ar! mada to spd
m.p
eqwvalunt to und Singk
in
þroduchon and þroblems like capping, wUht yariahon,
þicking,chiþing tab lat hardhuws ate. ond solva Hkom.
ihea doctors" lak d to comþMion modhi'ng ane
loading xàte, il Hmu, dwl ine, and cenbitugal fora..
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(9) Tablat Coating i Dr. Porlanya Shukla
Coahing is o shaiaind þrous inyalving .w.r.
M. P. singh Ca
abþlicahion and dehoihon o othin dm oround
tablats.
* is comikd oud by þan sþray or irdiyed Aud mulhcd.
Duning scau -uf jorametas must be sst ane--
Coating Pand Spray Drying air
ParameYerS PavametaYA PatameteYA.
Design and abacity ’ Shay stals -
’ Mahod d sþraying imp d air
’Dittanu blw hrayer ’ Rats d aur low
otaion ond tablet bed
codhing'soluhon
By-Dr. (Mahndraratap Singh
Cabua- PiJot lont:
*Hard alahin, cabsuley has Aimilar þroducion asach
tablata oxupt comprasion and coahing.
Encabuwaion:- Hard qolain cabsuls au commonly
ilud wth dny dag subaBanus
-lhi þoader i Jad into dong discs from hobper
Externally adjustabl þiston or tomþing þins comþu
tho pouday with th comþion Joru.
tormad þluq ia trans<orrd into empBy cabsul1 body
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illad cafaub body is closd oih cap and sucdad. Dr.be mayayg
Parjanya Shukla
Th common broblam toih Hes Avstem is WughtDr. N.P. Sirgh Cla
voriakon
which ari sLA du to þoor ow properhis
Poor OccuYA du to
buk damit, þarhda se distibuhon, and
inods quat ubricaton.
Hard qelahn capauus when sxpossd to high humidity
Condihion iab to sdtaning
adhesion and Josing shabe.
&xpoud to Jow humidty and
xtrem dry (ondihion hy
bicomu hard and bLak won
obplicahon d sightest þrau.
Minimum ’ 357. RH, IS°C
Best bosiblu ’ 50 7. RH, goC
Maximum ’ 6s. RH,25°c.
By -Or. Mahandra haot Singk
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