0

D
( (
HEY, WHAT'S THIS
f ORCE PULLING ME ?
IT LOOKS
LIKE A
DENSE
FOR.EST.
 THE RE l S
SOMEONE OVEI'
THE~E ...
=} CUS E ME, SIR, SORR. Y
INTERR.U PT You ...
,,
••

I'M AFR.AID
You WON'T
FIND MANY
GIR.LS AROUND
HER..E, Boy,
 WELL, SHE
WAS HERE
WITH ME,
JUST A
MINUTE
AGO . ..

I NEED To GET BACK.

To HER . IS THER.E A
PATH TO GET our OF
TH IS FOR.EST?

'(ou FOOL) THER.E>s

NO WAY OUT OF HERE!
ou 1 rlE INSIDE THE BRAIN! THE CoR.E oF YOUR. V£R.Y

IN EXISTENCE ...

"7"HESE AR.E Nor TREES,

-nEY AR.E NEURONS:
-=-1E FINELY BRANCHED CELLS
THAT MAKE UP YOU~

NE"-VOUS SYSTEM.
IT ALL BEGINS AND ENDS WITH NEURONS: FROM YOUR.
SE:NSORY RECEPTOR.$ TO THE. NER.V£S THAT CONTROL YOUR
MUSCLES. EVERYTHING YOU FEEL, R.EMEMBEP. 01' DR.EAi"\
IS WRITTEN IN THESE CELLS.

~ ·

~ SOUND
 THIS FOR.EST OF YOUR.S
t ES THE SECRET OF
-:1£ HUr-.1AN MIND ...

I HAVE SPENT MY WHOLE

\..IFE LOOKING AT TH(.SE
NEUP-.ONS 1 TR.YING To SOLVE
THIS Gf\EAT MYSTE~Y.
ALAS, WE HAVE YET
To DISCOV ER. THE
WHOLE TP-.UTH .

...-tia90 Ramon y Cajal (18s2-1n4) was a Spanish neurose1entist

ootl laureclte. His p1oneerH19 mvesb9at1ohS of u.,e structure
! bratr1 have led him to be considered dS the father- of
- :r~sc1 enc.e 1 althou~h he a l wa~s had a 9reat passion for drdWtn9.
 NOT SO FAST, HR. . CAJAL!
YOU CAN'T TAK.E ALL THE
CREDIT, YOU WOULDN'T
HAVE SEEN A SING~E
NEURON WITHOUT ME

I DISCOVER.ED THE
"BLACK REACTION'l
THAT E'NABLED US
TO SEE NEUF\ONS
FOP-. THE FIR.ST TIME .

Carnillo Gol9i ( uli;-19i.') was at\ Italian sc1el'\bst ahd

Nobel laureate who discovered a method which stamed
011l~ a small number of neurons so that their complex
branched structure could be seen l(nder the microscope.
"ES, H~. GOLGI, BUT YOUR ''RETICULAR THEORY ')
IS WR-ONG f

:J PROPOSED THAT NER.VE CELLS ARE FUSED

~OGETHER. To FoR.M A MESHED NETWORK
:- r< RETICULUM,\ WHICH (wtTH A FEW EXC.EPTIONS)

S CERTAINLY NOT THE CASE .. .

HEY, HEY! GENTLEMEN, CALM DOWN.
YOU AR.E SCIENTISTS AFTER ALL. ...

YES, SIR.,
OF COUR.SE ...
I APOLOGISE.
 TO BE FAIR.)
PROF. GOLGf HER.E
WAS RIGHT IN
THINKING THAT
IN FORMAT/ON
WAS FLOWIN~
B£TWEEN NEUR.ONS
IN THE NERVOUS
SYSTEM.

-r..:NK. YOV V~RY MUCH INDEED)

~f R.ESPECTED COLLEAGUE.

BUT OF COUR.SE
PR.OF. CAJA L., S
''NEURONAL THEORY''
TUR.NED OUT TO BE
R.lGHT IN THE END.
 THE AXON:
THE SOMA
WHICH EMERGES Ff\01"1
(oR CELL 80l>Y)
THE SO MA AND CA"RIES
WHERE ALL THE DENDl\ITES
THE NElJl'.ONAL
CONVER&E AND THE
S\~ NAL TO THE
INPUTS AP.E COM61t.Jfl>
DEN l>RITES OF
TOGE THEI\ IN THE
FINAL S\~NAL on-tEP.. NEU~ONS
15.,,T" YOU CAN FIND PRETTY MUCH ANY
S ~APE OF NEURON '/OU CAN ~MAG.INE :

MEET JAY, ONE OF

MY FAVOURITES,
THE SMALL
GR.ANULE CELL.

HE HAS ONLY 4 SHORT

DENDRJTES AND,
DESPITE HI s SM A LL 51ZE 1
HE HAS AN INCREDIBLY
LONG AXON ...
 ... WHICH TRAVELS UP
To THE PUR.KINJE CELLS.
LIKE CHAR.LIE HERE, WHO HAS
SPECTACULAR. DENOR.ITIC TRE-
AND RECEIVES STIMULATIO·
FROM MANY GRANULE"
 t'H, BUT I DON'T UNOEf'STAND: IF NEUR.ONS AR.E
NOT PHYSICAL.LY
CONNECTED , HOW
CAN AXONS A ND
DEN Dfl.-.1 TES
COMMUN I CATE
WI TH E:ACH OTHER.?

-- S Q.UESTt ON, PLEASE,

... J1 ... L HAVE
Go AHEAD ...
- -.:. ~E A LOOK
S ') £ THE
- =ON
~ .'T BE AFR.AID, II fS OF THE
... --ER.MOST SCIENTIFIC INTER.EST!
PHARMACOLOGY
WHE'R.E AM
 WHO AR.E YOU?
. HAT IS THIS PLACE?

-~E NGS, I'M SIP.. (HARL.ES Sc.OTT SttERRfNGTON AND

-- s s SYNAFSE . I NAMED IT MYSELF
A AFTER. THE
E:r< WOR.D syn-apte1n. (To CLASP TOGE1HE~} AN
AW FULLY
CLEVER. NAME,
WOULDN'T YOU
AGR.Ef?

-
THIS IS WHER..E AN AXON AND A DEND~ITE COME
CLOSE CONTACT AND INFOF\MATION IS TR.ANSMITTED
FR.OM ONE' TO THE OTH Ef\..
HE Y! H0 LD ON , l'IVE HAD fNOU4H OF EXPLANATIC
HOLD ON ... ARE YOU SAYIN~ THAT FR.01"
THIS SYNAPSE I CAN GE-
OUT OF THIS

rg>
0

WELL, YES, I ~UESS YOU NO, THAT'S IT! JUST

COULD PUT IT THAT WAY ... TELL ME HOW TO GET 0-
BUT...
,£LL 1 FIP-.ST OF ALL THEN Yov HAVE To
.iou WILL NEED THIS ... GET INSIDE A
VESICLE ...

HI, I ~ M BE~NAR.D .
LET ME EXPLAIN TO You
WHAT'S ABOUT TO HAPPEN ...

-E: .... You ABOUT IT.

-.a. ~ t-IOR.K. TO 00 NOW
 WHEN I WAS WORK I NGi AT
UNIVERSITY COLLE~E LON
IN THE 1950 s, I DISCOVE:
THAT SYNAPTIC TR.ANS MIS~
IS NOT CONTINUOUS .
INSTEAD NEUR.OTR.ANSMIT-:

ARE RELEASED
IN MANY LITTLE PACKS

CALLED "QUANTA,,
ENCLOSED IN A

VESICLE .

EA CH SYNAPSE CONTAINS A POOL OF VESICLES, AND

WHENEVER THE NEURON EMITS A Sl~NAL THE VESICLES
COME CLOSE To THE
NEURON SUR.FACE:

g~
THEY FUSE WITH THE
OUTER. MEMBR.ANE:

-~-
AND NEUR.OTRANSMITTERs
INSIDE THE VESICLE
AR.£ RELEASED OUTSIDE:
 n MOR.E TALKIN~ !
--; ·EUF\ON IS ABOUT TO
- - A NEW S l~NAL ! ~EADY?
LIKE A NEUROlf~. ANSMITTf':
 ~ ARE ALL ANO WE HAVE
EU R.0- SPECIFIC MISSIONS
- -NSMITTER.S TO A Cc O M P L IS H Fo f'
THE NEUR.ON.

' r- ONE OF US CARRIES

TYPE or KEY ...

WHICH OPENS A
MATCHING TRAPDOOR..
CALLED A RECEPTOR.
 LET ME INTRO:'
YOU TO OUR. -~

MY NAME IS
DOPA MIN
AND I PLAY t.
IMPORTANT R~
IN R.EWAf'D
ANP LEARN!~

IN THE BR.t-

SEROTO N f N IS MY
SISTEI' AND LIKE
ME MEDIATES
PLEASANT SENSATIONS·,
MOSTLY INVOLVED
IN THE R.EGULATION
Of Mooo, APPETITE'
AND SLEEP.

ACETYLCHOL
SoMETIMES Hf_
US IN THE 5:
8UT SHE IS A-.
R.ESPONS/BLE ~

THE CONT1'0L
MUSCLES IN -
PEl'IPHEF\.AL
NE"R.VOU.S S'fST';
 U T AM ATE
: -HE MAIN
:xc TATORY
- _ <:CTR.ANSMITTE'~
- : HUMAN BRAIN.
: 5 INVOLVED IN
-- SOR.TS OF='
o=... ANTTASKS 1
: _ - :: CI A LL Y IN
NG & MEMOR.Y.

f I N A L. L. )' THE RE"' 5

G.A.B.A. 1

THE ST RAN GEST

OF US ALL.
HE'S AeLE TO

BOTH INHIBIT
AND EXCITE
NEU ~ONS IN THE
B FZA IN.

E AND GIVE
: J. HAND ...
- 5: CAREFUL~
... THER.E ARE
WHICH INTER.FER.E WtTH THE
NO~MAL ACTIVITY OF Tl1f:
NE UR.O Tf'.A NS Ml TTER.S.
HOWEVE~, SoME VSEFUL DRUG.5 LIKE ANTIDEPRESSANTS
AR.£ ON OU~ TEAM ...

OFTEN IN BRAIN DISORDE.RS

NEUR.ONS DON'T
MAKE ENOUGH
NE lJ RO TR.ANS Ml TTE R.S
To OPEN THE
SYNAPTIC R.t:CEPTOR.S
(So, FOR EXAMPLE, THE BRAIN
IS UNABLE To F£EL. PLEAS\J"'E:).

t-----_ _ '"'-e=:>_- c=:::> ~

THAT., S wHEN ~
WE CALL Fo~ A ~ ~
LITTLE: HELP!
 : tiAD ~NOUGH Or THESE Now THAT I'M OUT OF THE
: UR.OTP-.A NS Ml TTER.S. NEURON, IT SHOULDN'T 8E Too
: ~ ~ETTE:P-. GET our DIFFICULT TO FIND A WAY
Too LAT£! OUT OF THE' 8RAI N ...

~E, SIP..,
YOU SHOW
TO Gf:T
 0 0
0 0
0 0

~::> Qo 00
__, 0

0
0

'::> 0
0 0
....,, 0
ELECTROPH YSIOLOGY
 OH NOf ALL
iHE RECEPTORS
AR.E CLOSED.
I'M Tf{APPED
INSIDE
THE CELL.!
 c?lv.1£. -
0 -------

@@

--- - -- -
0
0
0
0
~

0
WELL, LOOK.. AT WHAT
WE FISHED OUT ...

WELCOME
ABOAR.D.
 ARE You OK?.

NO! I'M NOT OK.! I'VE BEEN FOR.EST,

LOST IN A
SWALLOWED BY A NEURON, PARACHUTED
INTO A SWAl'M Of MONSTEl\.S AND NoW
I'VE ALMOST DROWNED ...
WHAT ELSE IS GOING To .
HAPPEN I?.
WHO AR.E YOU ANYWAY?
WHAT'S GOING ON IN THIS SUBMAR\NE?
- X, MY Fl'IEND, YOU'RE SAFE.
: ,"ALAN HODGKJN AND
- IS MY PAl\.TNER. S1R.. ANDRfW
_f.Y. TOGETHER. WE HAVE
STUDYING How A
- _:;oNAL SIGNAL

LOOK: ELEC: TRICI TY!

THIS IS THE
THE BRAIN!

WELL, ACTUALLY
IT WAS NOT
A SECf'ET
AT ALL ...
LONG BEFOR.E GOLGl
STAR.TED TO LOOK AT
2.ooo
NEUR.ONS IN HIS MICROSCOPE,
IT WAS KNOWN THAT
THE NER.VOUS SYSTEM
-
WAS AN EL.ECTR.I C.AL MACHINE.
1900
IN THE X2:I. CENTURY,
ANOTHER.. ITALIAN
SCIENTIST DISCOVER.ED
THAT MUSCLES CAN BE
CONTR..O LLED BY ELEC TR.IC lTY.
1&00
 0 0
0 o o Oo OOoo 0
-~ S IS EXACTLY WHAT HAPPENS oo o 0oo 0 0
0
oO 000 000000
THE NEURON: THERE ARE 0 ° 0
0 0 0 0 0 0 0 00 o 0
0 0
0 0
)IFFERENT NUMBER. OF IONS 0 0 00 0 0 0 0 0 0 0
oO -..0000 00

TH E INSIDE AND OVTSI DE .---~.,~.... ....

......
0 0
0
0
0
0
0
0 0
~ THE CELL, PRODUCED BY 0

ON PUMPS WHICH

- ·-iTAIN AN ELECTR.IC
-~NTIAL ACROSS
--:: CELL MEMBRANE.

NEU ROTR.ANSMITT Ef'S OPEN THE POST-SYNAPTIC REC.EPToR.S,

liiAT ABOUND OUTS IDE QUICKLY FLOW INSIDE THE CELL,
::cr1vELY INJECTIN~ AN ELECTR.f( CURR.ENT INTO THE

"= CN , CHAN~ IN~ THE DIFFER.ENCE JN M£MBR.A NE POTENTIAL.

o 0 O o oo 00
0ooOoo o o
0 0 0 0 0 0 0
o o0 0 0 0 0 0 0 0
00 0
0
o 0 00 o 0 0 0 0 00 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 00 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 00 Oo o 0 0 0 0 0 0 0 0
oooooo ooo ooo - ooo
Oo oo o o o o o o o ooo ooo - Oooo
oo o oooooo o f o
 H MMM, THAT MAKES ME
WONDER WHY NEURONS
EVEN BOTHE~ WITH
ELECTP..IC Sl~NAlS. ISN'T
THE CHEMICAL
Sl~NAL OF THE
NEV 1\0 TRANSMITTERS
ENOU~H?

: NO, THE BRAIN NEEDS BOTH!

_- o F ALL BECAUSE THE ELECTRIC Sl~NAL IS FASTER.
- CAN Q UI CKLY
::-_ OV£ ft LONG,

CES IN THE BODY,

- : - CAN MEAN
- ~ FFERENCE BETWEEN
: .AN D DEATH.

- ALSO BECAUSE TRANS L ATING_ ALL THE DIFFER.ENT

CHEMICAL SIG,NALS
INTO ELECTRIC

CURP-.ENTS ENABLES
THE NEVR.ON TO
COMB! NE THEM
TO~ETHER AND
PER.FORM
COMPUTATIONS
INSIDE THE CELL.
AN ACTION
POTENTIALt
THAT SOUNDS (OOLt
WHAT HAPPENS
NEXT?
 •.• AND BANQ!
THE WHOLE
PR.OC ESS IS
REPEATED IN THE
NEXT NEURON!
HE.Y, WHAT THE HELL WAS THAT ?

WELL, YOU SEE ... _SO, FOR. OUR. £XPEP--IME'

IT WAS ALMOST IMPOSSIBLE WE HAD TO USE SG.U:
TO P-.ECol\.D THESE E'LECTR.IC WHICH HAVE GIANT AY:
OF lh'\rt'I IN DIAM£TE1\.
Cuf\RENT5 Fl\.OM TINY
STf\UC.TUR.ES LIKE NE"UR.ONS.
 IT SE'EMS TO ME
THAT UNDER.STANDING
THE BRAIN IS MOR.£
TROUBLE THAN
IT'S WORTH!
 0 0
oo 0

0
--- 0
00
0 00
0
0

0 0 0
0
PLASTICITY
 \
\ '

I )
j
/

'

.
.

*
C> ..
0 = .
 ')
,,,--,/
I
\.
 AHA!

You' RE
~O MING ,;

HOME
.. tTH ME, AND
ITTL E FELLA! WHO'S THIS
CHAP?
 I DON,T Oo
KNOW ...
I'M A BIT
CONFUSED.

MAYBE
YOU HAVE
LOST YOUR.
MEMOR. Y.

WELL, THE LAST THIN~ I WHAT ' S THE DIF"FER£NC~.

REMEMBER., I WAS IN THIS DREAM, MEMOR. Y : IT AL_
SUBMARINE , BUT THEN THE HAPPENS IN THE BR.A lf·
k."AKEN ... AND TH I S PRETTY
GIRL. .. OH, BUT IT'.S AL L
So WEIRD . MAYBE IT WAS
ALL JUST A DREAM...

0 0
0
 BUT WHO ARE You?
AND WHAT ARE You
DOING TO THAT Poop,__
... WHATEVE~ Ii 15 .

t'M ERIC KANDEL - ~

AND THIS IS

COME
__, .. _--.
WITH ME, >···..:: -~ ~ - -.
<-;""
I HAVE BEEN
LOOK. I N~ FO~
MEMORY
FOR. A LON~
TI ME ... _
 Fl RST OF ALL:
WHICH KIND
OF MEMORY
DID YOU LOSE ?

ARE Z FUNDAMENTAL TYPES OF MEMORY.

THE FIRST
IS SAFELY
STORED IN
THE BRAIN
BUI CANl T
BE EXPRESSED
··· LEARN IN~ To PLAY AN INSTRUMENT, FOR EXAMPLE.
"'OTOR. MEMORIES THAT EVEN SIMPLER. OR.~ANISMS
- KE APLYS/A CAN L..EAR.N.

THEN THERE IS A SECOND TYPE

OF MEMORY ASSOCIATED WITH
SPECIFIC PLACES OR. DATES,
USUAL-LY WITH A STRONq
£MOTIONAL COMPONENT.
 HEl\E You MAY HAVE'
:'I'\
_.,,, T WILL
·oMETHING THA
- HELP ME To FIND
A WAY our...

I
. --:
 STRAN~E

~---4- -~-
THIS MAP IS
CHAN~I N~ ALL THE Tlf'-AE
- - - .-

How AM I SUPPOSED TO RE~;

1
I
/
/

OF COURSE! THIS IS
THE GR.EAT POWER. OF
THE BRAIN: IT'S PLASTIC!
ONCE YOU LEARN
SOMETH INq IT IS NOT
SET IN STONE, IT'S
CONTINUOUSLY
SHAPED BY
EXPERIENCE.

BUT I HAVE
To FIND A WAY
our OF H£RE !
 THEY' RE PICTURES OF ME ...

OH , DON'T BE SILLY!
HOW CAN THIS BE
YOUR. BRAIN IF
Yo·u,RE INSIDE IT ?

SOMETHINGt SOMEONE IS
IS NOT WATCHIN4 ME •..
~l~HT HERE. I HAVE TO FIND ·
THE MASTER. OF
THIS BRAIN!
 COULD You
PLEASE MMH, THIS IS
SHOW ME HOW THESE KIND OF A DIFFICUL"T"
ME.MOR.IES WERE QUESTION ...
FOR.MED?

OH 1 LISTEN: THE BE LL !
PAVLOV IS CONDUCTIN~
A NEW EXPER.IMENT.

! {)\N~ ?
•
IVAN PAVLOV WAS ONE OF
THE FIR.ST To STUDY MEMORY.
BACK. IN 189;t IN RUSSIA ,
HE PER.FOR.MED
CLASSIC EXPE.R.I MENTS
ON ''CONDI Tl ONIN G'' WITH
THE DIGESTIVE SYSTEMS
of DOGS.
OK., BUT HOW DOES COME AND TAKE
-HE BRAIN ACTUALLY A CLOSEF-. LOOK.
THEM?
 HOW REMARKABLE.!
So, IS THIS HOW
MEMORl£S ARE STORED?

WELL, FOR. SURE ...

BUT ALSO ENTIRELY
OH, COME TO
NEW CONN EC TlONS
CAN BE FORMED MY OFFIC~, PLEASE.
SOMETIMES ... WE HAVE: TO
TALK. MOR.E
ABOUT THIS!

PSS SST
HELP ME, PLEASE! WE HAY£
GET OUT OF HERE ... QUIC"'_
THAT'S THE KEY TO MY c,:.:;
WHERE DO
You THINK.
You'R.E ~OING?

HEY~
WHAT'S
HAPPENINq
TO YO\J?
 IT'S THE BELL ...
MY CONDITIONIN ~ ~
I'M STARTIN~ TO
SALIVATE ...

I CAN'T ...
I'M CONDITIONED~

THER.E IS A STEEP
MOUNTAIN ON TOP
OF THIS CAYE.
IF YOU WANT To FIND
A WAY OUT, YOU 1 LL
NEED A BROADER. VIEW.

NOW GO!
BEFORE THEY
R.EACH US~
 HEY! WHY ARE YOU
RUNNIN~ AWAY?

YOU' VE ~OT TO
BE CAREFUL
WH E N YOU' RE
UP THERE!

rr~
~))
----- ---
 0 •

*
PANT
PANT

--
EXCUSE ME., SIR,
COULD YOU ...
STOP, SAY No MOR.E ! r SAW You
COMIN~ A LONG WAY AWAY.
I KNOW WHAT you' R.E

A WAY OUT
OF HERE !

)
OH, HOW DO you KNOW? NO, I M NOT. BUT FR.OM
,.RE You THE ONE IN CHAR.~E VP HERE You CAN SEE
OF THIS BRAIN LAND? TH£ WHOLE BRAIN.
THERE MUST BE" A WAY OUT~ COME
AND
TAKE
A LOOK.
SOME PARTS Of THE BRAIN CONTROL AND RESPOND
To VERY SPECIFIC PARTS OF THE BODY ...

BUT IN OR.DER. To
MOVE AND EXPER IENCE
THE BODY AS
A WHOLE ...
ALL THES E PARTS HAVE TO WORK TOG.ETHER
AND BRAIN WAVES MAY HELP TO coo~D~NATE THEM.

THIS IS WHY WHAT

WAVES WE EXPERIE ~ :!
AS OUR.SELVES
AND SYNCHRONICITY
I S JUST
ARE So IMPORTANT :
THE ~LOBAL
THERE IS NO ACTIVITY OF
CENTRAL THE BP..AI N
CONTROL ! AS A WHOLE .
 BUT SOMETHIN~ OH, THIS IS A QUESTION
SOMEWHERE SC IE NTI S TS AND PHILOSOPHERS
MUST BE IN CONTROL .
HAVE BEEN ASKIN~ FOR. A WHILE.
I MEAN, WHO AM I ?
IT ALL COMES DOWN To THE
IS BRAIN
THE
JUST A MACHINE? So-CALLED DUALISM PROBLEM:

IS MY MIND OR IS THE MIND

SOMETHING JUST A Pl\.ODUC. T
ELSE THAN OF MY BRAIN?
iHE Sf\.AIN?
ARE You TALKIN~ WELL, OF COURSE SCIENTISTS
ABOUT THE MIND DO NOT THINK. OF Ii IN
AS SOME KIND THESE TEr\.MS... BUT THE MIND.
OR. WHATEVER.. MAKES US THI Nt",
OF "SOUL'' ?
AS "OUR.SELVES'', ts THE LAs-
FOR.TREs5 OF THE IRRATIONA1..

FINDING A BIOLOGICAL EXPLANATION FOi' THE MIND

IS REALLY THE HAR.DEST CHALLEN~E OF NEUROSCIENCE .

42.
IF Yov WANT TO LOOK.. FOi'.
THESE ANSWER.S, YOU HAVE
To ENTER. THE OLD HAUNTED
CA5TLE OF OUR.
CONSCIOUSNE"SS.

WELL, I'M NOT GOIN~ To

SToP NOW IF I CAN FIND
A WAY OUT IN THER.E !
 /
/
/
/
/
/
/
/
/

OH, MY l.P)
So You WEF\E .. -:-
A HALLUC I NA- •

Q.UEE'N OF Tl-· ';

PLACE?
NO, I'M NOT. WELL, FEAR. NOT, MY DEAR..!
I1M A PRISONEJ\. 1 1 LL FIND THE MASTER OF
JUST LIKE YOU. THIS CR.UE L GAME AND TAKE
You AWAY WITH ME.

AH! GOOD

s
Q
u
E
A
K.
WHO .
AR.E YOU? SHOW YouR. FACE .I
IF IT'S YOU THAT BROU~HT ME
HE.R..E, I M (101N~ To FIND You!
1
 MAYBE
I AM JUST
YOUR.
SOUL.

DON'T FOOL WITH ME!

I WENT THR.OU~H ALL
KINDS OF THIN~S
IN THIS BR.AIN
AND I WANT' YOU
TO SHOW ME A
WAY OVT!

BE CAR.EFUL
WHAT YOU WISH fOfl :
WHEN YOU GO
OUT O~ YOUfl MIND,
THE PER.CEPTION
OF R.EALITY
MAY BECOME
A BIT BLUR.R. Y...
HALLUCINATIONS, PARANOlA
AND DELUSIONS AR..E
SOME SYMPTOMS OF
THE MOST COMPLEX
MENTAL DISORDERS,
L..IK.E SCHIZOPHR.ENIA.

,
IM NOT
THE ON[
HEAR.IN~
DISEMBODIED
VOICES ...
Yol.J THINK.
YoU ARE
So SMART ...

\?
••
WELL, You HAVE FINALLY FOUND

THERE ARE NO GHOSTS, THER.E IS NO SOUL! THE IDEA

OF YOUR.SELF AS "SOMEONE " I NHABtTIN~ YOUR.. BRAIN
IS NOTHIN~ BUT AN ILLUSION; A REFLECTION THAT
THE BRAIN HAS OF ITS OWN BODY AND ACTIONS ...
MAYBE THIS IS
THE REAL SECRET
OF THE HUMAN
BRAIN:
IT'S A GREAT
SToRYTELLE R. .
EPILOQUE
AG.AIN ...
 I DON'T UNDER.STAND ...
so ARE you JUST A PRODUCT
OF MY IMAG.INATION?

DoN'T BE SILLY, YOU HAVE WE ARE JUST Fl CTIONAL

NO IMAGINATION! CHARACTERS IN A BOOK.
OUR. EXISTENCE RELIES ON THE BRAIN OF THE ~EADER. .

WHICH IS ABLE TO SEE

MOTION AND HEAR SovNDS ...

. .. ON A FLAT
SHEET OF
PAPER..
OUR. BRAIN IS INCREDIBLY GOOD AT FINDIN~
PATTERNS AND CONNECTIONS AND LOOK. IN~
BEYOND THE SUR.FACE OF THIN~S ...

... HOWEVER., WE HAVE To BE CAREFUL NOT To MAKE

1
TOO MANY ASSUMPTIONS ABOUT WHAT WE' DON T KNOW,
WHICH IS THE qOLDEN R.ULE OF SCIENCE .
 1
fOR. EXAMPLE 1 WHEN AN ... WE ASSUME IT S THE SAt"'E
OBJECT CHANGES POSITION OBJECT AT Two DIFFERENT
FROM PANEL To PANEL ... MOMENTS IN TIME.

BUT ACTUALLY THEY ARE TWO INDEPENDENT PICTURES ...

THE CONNECTION IS ONLY IN OUR HEAD 1
so, IF You ENJOYED THIS BOOK.,
THANK YOUR. BR.AIN FIR.ST OF ALL 1
BECAUSE NOTHIN~ REALLY
IF NOT INSIDE IT ...
 SO WOULD YOU ~IK~
IO ~o OUT SOMETIME,
EVEN IF" WE. ARE JUST
Fl CTI ONAL CHARACTE~S?

OH, I,M SURE WE CAN

LEAVE SOMETHING TO THEii\
IMA~INATION. THEY' RE
SMART PEOPLE ...