Zetasizer Advance range

Light Scattering for every application

Welcome to the
Zetasizer Advance
range
Building on the legacy of the industry-leading
Zetasizer Nano Series, the Zetasizer Advance
family of light scattering instruments brings
increased versatility and expertise to your
laboratory. The extensive range of six
Zetasizer Advance systems provides
a perfect fit for every application
and every workflow challenge.

• •
Dynamic Light Scattering (DLS)
Determine the size of particles in your
Adaptive Correlation
Generate robust data quickly and Comprehensive, versatile and cost-effective
sample, from <1 nm to 10 µm increase measurement repeatability
• Electrophoretic Light Scattering (ELS) • ZS Xplorer Software
Zetasizer Lab Zetasizer Pro Zetasizer Ultra
Understand sample stability and Automate even the most complex analysis Our entry-level model, the The Zetasizer Pro utilizes Multi-Angle Dynamic Light
propensity to aggregate without expert knowledge, thanks to Zetasizer Lab, utilizes 90˚ Non-Invasive Back Scatter Scattering (MADLS®)
the sample-centric workflow measurements to generate (NIBS) technology, delivering technology, for the highest
• M3-PALS with Constant Current Mode
high quality particle size a wider range of sample resolution sizing data, makes
Reduce errors in your data associated with • Data Quality System
and zeta potential data, concentration and particle size the Zetasizer Ultra the
electrode polarization at high ion concentrations Get instant feedback and actionable
especially when measuring measurement capabilities. ultimate research model.
advice on how to improve data quality
larger-sized particles.

This feature intelligently identifies and separately Each model is available in

classifies rogue large particles so that they do not either a Blue Label version for
influence the consistently-present particle size result, routine sample investigation or
providing a more representative view of the sample. a Red Label version for use with
more challenging samples.
4 5

A Zetasizer for
every need

Now you’ve been introduced to the Zetasizer

Advance family, how do you find out which
system best fits your requirements?

Here are some application examples

to help you decide:

Colloidal Silica Measurement Z-Average (nm) Proteins

Sizing of colloidal silica is a critical requirement. 1 35.04 For protein researchers, early access to
This is easily and reproducibly measured 2 34.67
characterization data can be a challenge,
using the Zetasizer Lab Blue Label. due to low sample volumes. This is easily
3 34.90
overcome using the Zetasizer Lab Red Label
4 35.44 with the capillary cell to confirm that samples
5 34.97 meet quality requirements and that production
Mean 35.00 and purification processes are optimized.
% RSD 0.80

Titanium Dioxide
Titanium dioxide use is wide-ranging. When used in
Carbon Dots (C-dots)
paints or inks, agglomerate or aggregate formation Photoluminescent C-dots are considered safer
can diminish product performance. alternatives to quantum dots. Measuring fluorescent
samples by DLS can be challenging due to additional
The Zetasizer Pro Blue Label, used alongside the photons emitted by the fluorophore. Available with
MPT‑3 Autotitrator, characterizes the impact of salt NIBS on Zetasizer Pro Red Label, a filter removes this
concentration on the stability of TiO2 and identifies interference to provide accurate and reliable data.
the most stable pH region.

Ceramics Adeno-Associated Virus (AAV)

The strength of ceramics is linked to particle size, Monitoring viral concentration is important during
and the Zetasizer Ultra Blue Label is ideally placed development and production optimization. By
to measure this. Al2O3 samples are often made using the Multi-Angle DLS (MADLS) based particle
of differently-sized particles which can easily be concentration measurement in the Zetasizer Ultra
identified using MADLS. In this 0.1% w/v sample, Red Label, both the size distribution and titer of
the two particle size populations would not be the virus can be measured within a few minutes.
distinguishable with a single angle DLS measurement.
6 7

A Zetasizer you can install yourself Zetasizer advance specifications

Get up and running fast Zetasizer Lab Zetasizer Pro Zetasizer Ultra
with self-install Size Measurement Classical 90° Non-Invasive Back Non-Invasive Back Scatter (NIBS)
Get your new system up and running Principle Dynamic Light Scatter (NIBS) Dynamic Light Scattering
rapidly, when you self-install. There’s no Scattering Dynamic Light Dynamic Light Scattering (90° and 13°)
need to wait for an engineer to visit. Scattering
Multi-Angle Dynamic Light Scattering
(MADLS®)
• Multilingual video installation guides
• 15 months’ access to exclusive Zeta Measurement ELS with M3-PALS ELS with M3-PALS ELS with M3-PALS and Constant
e-learning materials Principle and Constant and Constant Current Current Zeta Mode
Current Zeta Mode Zeta Mode
• Extended 15-month warranty
Molecular Weight and Static Light Static Light Scattering Static Light Scattering
Find out more at: B221 Scattering (173°) (90° and 173°)
(90°)
malvernpanalytical.com/self-install
Optical Filter Wheel No Yes Yes
(Fluorescence/DDLS)

Low Volume Disposable Yes No Yes

Sizing Cell with
Extended Size Analysis
Support

Easy, on-site upgrades MADLS® (High No No Yes

Upgrade your Zetasizer Advance system Resolution DLS)
to a higher specification model at any
time. Upgrades can be performed MADLS® - Particle No No Yes2
Concentration/Titer
onsite* to minimize downtime.

With Zetasizer Advance, you can be 21 CFR Part 11 Optional Optional Optional
confident that, should your needs change, compliant software3
you can upgrade to adapt easily and
improve the value of your system. Size

Range4 0.3 nm to 10 µm 0.3 nm to 10 µm 0.3 nm to 10 µm

21 CFR Part 11 functionality Minimum Volume 3 µL 12 µL 3 µL

Coming soon: Malvern Panalytical’s
Zeta potential
new solution for regulatory compliance,
21 CFR Part 11 and GMP Annex 11. This will
Size Range 3.8 nm to 100 µm 3.8 nm to 100 µm 3.8 nm to 100 µm
provide flexible configuration of roles and
permissions to fit your workflow, supporting Minimum Volume5 20 µL 20 µL 20 µL
electronic records and signatures.
1
Hardware capable; Software support coming soon
2
Red Label only
3
21 CFR Part 11 software features coming soon
4
10 um by default. Option to extend for Zetasizer Lab and Zetasizer Ultra coming soon
5
Patented Diffusion Barrier method in capillary cell

*Upgrades can be performed onsite when you upgrade between

models (Zetasizer Lab, Zetasizer Pro or Zetasizer Ultra); upgrading
from Blue Label to Red Label versions cannot be performed onsite.
Why choose us? Service & Support
When you make the invisible visible, Malvern Panalytical provides the global training, service
and support you need to continuously drive your
the impossible is possible.

of this information and we shall not be liable for errors contained herein or for damages in connection with the use of this material. Malvern Panalytical reserves the right to change the content in this material at any time without notice.
analytical processes at the highest level. We help you

Disclaimer: Although diligent care has been used to ensure that the information in this material is accurate, nothing herein can be construed to imply any representation or warranty as to the accuracy, correctness or completeness
Our analytical systems and services help our increase the return on your investment with us, and
customers to create a better world. Through ensure that as your laboratory and analytical needs
chemical, physical and structural analysis of materials, grow, we are there to support you.
they improve everything from the energies that Our worldwide team of specialists adds value to your
power us and the materials we build with, to the business processes by ensuring applications expertise,
medicines that cure us and the foods we enjoy. rapid response and maximum instrument uptime.
We partner with many of the world’s biggest companies, • Local and remote support
universities and research organizations. They value us
• Full and flexible range of support agreements
not only for the power of our solutions, but also for the
• Compliance and validation support
depth of our expertise, collaboration and integrity.
• Onsite or classroom-based training courses
With over 2200 employees, we serve the world,
• e-Learning training courses and web seminars
and we are part of Spectris plc, the world-
leading precision measurements group. • Sample and application consultancy

Copyright: © 2022 Malvern Panalytical. This publication or any portion thereof may not be copied or transmitted without our express written permission. PN13647
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