TON DUC THANG UNIVERSITY SOCIALIST REPUBLIC OF VIETNAM

FACULTY OF APPLIED SCIENCES Independence – Freedom – Happiness

DIVISION OF ORGANIC SYNTHESIS

Ho Chi Minh City, December 25, 2023

COURSE SYLLABUS
ORGANIC CHEMISTRY
COURSE CODE: 602035

1. Information:
No of credits: 3(3,0)
Time allocation: Theory 45 Practice 0 Self-study (hours): 90
(hours): (hours):
Prerequisite: No Prerequisite code: No
Prior-Completion: General Chemistry (7520301) Prior-Completion code: 602022 (7520301)
Co-requisite: No Co-requisite code: No
Programme: Have 1 program Programme code: 7520301
2. Course objectives:
No. Course Objectives (COs)
Be able to apply the general principles, laws, and theories of chemistry that were
1
discussed and presented throughout the semester
3 Demonstrate an understanding of chemistry through technological advancement
2 Use critical thinking and logic in the solution of problems
4 Develop independent and cooperative learning skills
5 Recognize and acquire attitudes that are characteristic of the successful worker regardless of the major field of study
3. Course learning outcomes (CLOs):
 No.
1

4. Brief course content:

The course provides student with knowledge of:

 Stereoisomers
 Hydrocarbon: nomenclature, physicochemical properties and reactions of alkane, alkene, alkyne, alkadiene
 Aromatic compounds: nomenclature, physicochemical properties, reactions of aromatic compounds
 Alcohols: nomenclature, physicochemical properties, reactions of alcohol
 Carbonyl compounds: nomenclature, physicochemical properties, and reactions of aldehyde, ketone
 Amine compounds: nomenclature, physicochemical properties, reactions of amines

5. Student’s tasks:

 Require a minimum attendance of 80%.

 Develop self-study and cooperative learning skills to solve the problems and real situation.
 Enthusiastically participate in all the class activities.
 Complete all periodical tests and all mid-term / final exams

6. Teaching materials:
 Textbook:

[1].Phan Thanh Sơn Nam, Trần Thị Việt Hoa, [2007], Hóa Hữu Cơ,NXB Đại học Quốc Gia TPHCM, TpHCM.

 Supplementary Readings:
[2]. L.G.Wade Jr. [2013], Organic chemistry 8 th ed, Pearson, Boston.

[3]. David Klein, [2012], Organic chemistry as a second language : first semester topics, John Wiley & Sons, Hoboken, NJ

 Additional readings:

[4]. Đỗ Đình Rãng, Đặng Đình Bạch, Nguyễn Thị Thanh Phong, [2010], Hóa học hữu cơ, tập 2,NXB Giáo dục, Hà Nội.

[5].Nguyễn Hữu Đĩnh, Đỗ Đình Rẵng, [2010], Hóa học hữu cơ, tập 1, NXB Giáo dục, Hà Nội.

7. Description of Assessment:
Assessment categories Weight (%)
Process evaluation 1 20
Mid-term test 30
Final examination 50
8. Schedule:
Organization of
Self-
Session Content teaching CLOs Requirement Student's tasks
study
T E P D
Chapter 1: Stereoisomers 5 2 0 0 14
1-2 1.1. Geometric Isomers 3 1 0 0 8 [1] At class
1.1.1. Definition Listen to the lecture
1.1.2. Nomenclature Participate in class
1.1.2.1 Cis-trans isomer activities
1.1.2.2. Z-E isomers After class
1.1.3. Properties of Geometric Isomers Homework
1.2. Optical isomers assignment
1.2.1 Definition Reading
1.2.2. Nomenclature of enantiomers [1]: 1-10
1.2.3. Physical, chemical properties and
 biological properties of enantiomers
Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
2 1.3. Conformational Isomers 2 1 0 0 6 [1] At class
1.3.1 Definition Listen to the lecture
1.3.2. Conformations of ethane and butane Participate in class
1.3.3. Conformations of Cyclohexane activities
After class
- Self- constructed
Teaching methods: summary
Lecture - Do the home work
Inquiry-based teaching - Reading books:
Interactive exercises - [1]: 11-19
-[5]: 47-59

Chapter 2: Chemical effects 2 1 0 0 6

3 Chapter 2. Chemical effects 2 1 0 0 6 [2], At class
2.1. Electronic effects [3], Listen to the lecture
2.1.1. Inductive effect [4], Participate in class
2.1.2 Resonance effect [5] activities
2.1.3. Hyperconjugation effect After class
2.2. Prediction of the relative strengths of - Self- constructed
common organic acids and bases summary
Teaching methods: - Homework
Lecture assignment
Inquiry-based teaching - Reading books:
Interactive exercises - [1]: 11-19
- [5]: 47-59

Chapter 3: Alkane 1 1 0 0 4
4 3.1. Structure of alkane 1 1 0 0 4 [1], At class
3.2. Nomenclature [2], Listen to the lecture
 3.3.Physical properties [3], Participate in class
3.4.Reaction of alkane [4], activities
3.4.1. Oxidation reaction [5] After class
3.4.2. Craking reaction - Self- constructed
3.4.3. Halogenation reaction summary
- Do the home work
Teaching methods: - Reading books:
Lecture [1]-147-177
Inquiry-based teaching [5]-216-239
Interactive exercises
Chapter 4: Alkene 4 2 0 0 12
5 4.1. Structure of alkene 2 1 0 0 6 [1], At class
4.2. Nomenclature [2], Listen to the lecture
4.3.Preparation of alkene [3], Participate in class
4.3.1. Dehydrohalogenation of alkylhalides [4], activities
4.3.2. Dehydration of alcohol. [5] After class
4.3.3. Dehydrogenation of alkane - Self- constructed
4.3.4. Hydrogenation of alkyne summary
4.4. Physical properties - Do the home work
- Reading books:
Teaching methods:
- [1]: 176-182
Lecture
- [2]:285-327
Inquiry-based teaching
Interactive exercises
6 4.5. Reaction of alkene 2 1 0 0 6 [1], At class
4.5.1 : Electrophilic addition [2], Listen to the lecture
4.5.1.1: Hydrogen halide addition [3], Participate in class
4.5.1.2: Addition of water [4], activities
4.5.1.3. Hydroboration-oxidation of alkene [5] After class
4.5.1.4. Addition of halogen - Self- constructed
4.5.1.5: Oxymercuration-demercuration summary
4.5.2. Elimination of alkene - Do the home work
4.5.3. Oxidation of alkene - Reading books:
4.5.3.1. Oxidation with peracid - [1]: 182-213
 4.5.3.2. Oxidation with cold, dilute solution
of KMnO4
4.5.3.3. Oxidation with KMnO4, heat
4.5.3.4. Oxidation with ozone -[2]: 328-391
Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
Chapter 5: Alkyne 2 1 0 0 6
7 Chapter 5: Alkyne 2 1 0 0 6 [1],
5.1. Structure of alkyne [2],
5.2. Nomenclature [3],
5.3.Preparation of alkyne [4],
5.3.1. From Calcium carbide and CH4 [5] At class
5.3.2.From alkyl dihalides Listen to the lecture
5.3.3. From alkynide ion Participate in class
5.4.Phycical properties activities
5.5. Reaction of alkyne After class
5.5.1. Alkynide ion - Self- constructed
formation summary
5.5.2. hydrogenation - Do the home work
5.5.3. Addition of hydrogen halide - Reading books:
5.5.4. Addition of halogen [1]-252-271
5.5.5. Addition of water [2]: 392-420
5.5.6. Oxidation

Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
Chapter 6: Aromatic compounds 2 1 0 0 6
8 6.1 : Structure of benzene 2 1 0 0 6 [1], At class
6.2: Aromaticity-Hückel’s Rule [2], Listen to the lecture
 6.3: Nomenclature [3],
6.4: Preparation [4],
6.4.1. Dehydrogenation of alkane [5]
6.4.2. Dehydrogenation of cycloalkane
6.4.3. From acetylene
6.5: Physical properties
6.6. Reaction of aromatic compounds
6.6.1. Electrophilic aromatic substitution Participate in class
6.6.1.1: Mechanism activities
6.6.1.2: Effects of substituents on After class
electrophilic aromatic substitution - Self- constructed
6.6.1.3: Nitration reaction summary
6.6.1.4: Sulfonation reaction - Do the home work
6.6.1.5: Halogenation reaction - Reading books:
6.6.1.6: Friedel–Crafts alkylation - [1]: 256-297
6.6.1.7: Friedel–Crafts acylation - [2]: 713-815
6.6.2 Nucleophilic aromatic substitution - [3]: 56-98
6.6.3. Side chain reaction of benzene - [5]: 345-369
deriatives
6.6.3.1. Clemensen reaction
6.6.3.2. Oxidation reaction
6.6.3.3.Halogenation

Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
Chapter 7: Alcohol-Phenol 6 3 0 0 18
9 7.1. Saturated, mono alcohol 2 1 0 0 6 [1], At class
7.1.1. Structure, classification [2], Listen to the lecture
7.1.2. Nomenclature [3], Participate in class
7.1.3. Preparation [4], activities
7.1.3.1. From alkene [5] After class
7.1.3.2. From Grignard reagents - Self- constructed
 7.1.3.3. Reduction of Carbonyl group
7.1.4. Physical properties summary
-Do the home work
- Reading books:
Teaching methods: [1]-378-390
Lecture [2]-425-458
Inquiry-based teaching
Interactive exercises
10 7.1.5. Reaction of alcohol 2 1 0 0 6 [1],
7.1.5.1.Acidity of alcohol [2],
7.1.5.2. Reaction of alcohol with hydro [3],
halic acid [4], At class
7.1.5.3. Reaction of alcohol with [5] -Discussion
phosphorus halides After class
7.1.5.4. Reaction of alcohol with thionyl - Self- constructed
chloride summary
7.1.5.5. Dehydration of alcohol -Do the home work
7.1.5.6. Ether formation - Reading books:
7.1.5.7. Ester formation [1]-391-410
7.1.5.8. Oxidation of alcohol [2]-467-507
Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
11 7.2. Phenol 2 1 0 0 6 [1], At class
7.2.1. Structure [2], Listen to the lecture
7.2.2.Preparation of phenol [3], Participate in class
7.2.2.1.Hydrolysis of aryl halides [4], activities
7.2.2.2. Alkali fustion of sulfonate [5] After class
7.2.2.3.Hydrolysis of Diazonium - Self- constructed
compounds summary
7.2.3.Physical properties -Do the home work
7.2.4. Reaction of phenol - Reading books:
 7.2.4.1.Acidity
7.2.4.2.Wiliiam Ether synthesis
7.2.4.3.Ester formation
7.2.4.4. Electrophilic aromatic substitution [1]-412-433
[4]-159-173
Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
Chapter 8: Aldehyde-Ketone 4 2 0 0 12
12 Chapter 8: Aldehyde-Ketone 2 1 0 0 6 [1],
8.1. Carbonyl compounds [2],
8.2. Nomenclature [3], At class
8.3. Preparation of Aldehyde, ketone [4], Discussion
8.3.1 Oxidation of alcohol [5] After class
8.3.2. Ozonolysis of alkene - Self- constructed
8.3.3. Acylation of Fridel-Crafts summary
8.3.4. Hydration of alkyne -Do the home work
8.3.5. Reaction of Grignard reagents - Reading books:
8.3.6. The Gatterman–Koch formylation -[1]: 387-398
8.4. Physical properties -[4]: 192-205
-[2]: 816- 839
Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
13 8.5. Reaction of aldehyde, ketone 2 1 0 0 6 [1], At class
8.5.1. Nucleophilic addition [2], Listen to the lecture
8.5.1.1. Reaction of hydrogen cyanide [3], Participate in class
8.5.1.2. Hydrate of ketone, aldehydes [4], activities
8.5.1.3. Addition of alcohol [5] After class
8.5.1.4. Addition of NH3 and derivatives - Self- constructed
of amonia summary
8.5.1.5. Addition of NaHSO3 -Do the home work
 8.5.2. Aldol condensation
8.5.3. Cannizzaro reaction
8.5.4. -halogenation reaction - Reading books:
8.5.5. Oxidation rection - [1]- 448-478
8.5.6. Reduction of carbonyl - [2]- 839-870
- [3]- 244-258
Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
Chapter 9: Amines 2 1 0 0 6
14 9.1. Structure, Classification 2 1 0 0 6 [1],
9.2. Nomenclature [2],
9.3. Preparation of amine [3],
9.3.1. Alkylation of amines [4],
9.3.2. Reduction of nitro compounds [5] At class
9.4. Physical properties Listen to the lecture
9.5. Reaction of amine Participate in class
9.5.1.Basicity of amines activities
9.5.2. Electrophilic aromatic substitution of After class
arylamine - Self- constructed
9.5.3.Alkylation of amine summary
9.5.4. Acylation of amine -Do the home work
9.5.5.Reaction of amine with nitrous acid - Reading books:
9.6. Reaction of arenediazonium [1]-529-570
9.6.1. Replacement of diazonium group [2]-879-915
9.6.2. Diazo coupling [3]-281-299

Teaching methods:
Lecture
Inquiry-based teaching
Interactive exercises
Chapter 10: Carboxylic acid 2 1 0 0 6
15 10.1 : Structure 2 1 0 0 6 [1], At class
 10.2 : Nomenclature [2],
10.3 : Preparation [3],
10.3.1: Hydrolysis of ester, amide, nitrile [4], Listen to the lecture
10.3.2: Carboxylation of Grignard reagents [5] Participate in class
10.3.3: Oxidation reaction activities
10.4: Physical properties After class
10.5: Reaction of acid carboxylic - Self- constructed
10.5.1 : Acidity of carboxylic acid summary
10.5.2 : Replacement of -OH group -Do the home work
10.5.3 : Reaction at Cα - Reading books:
[1]-479-526
Teaching methods: [4]-254-300
Lecture
Inquiry-based teaching
Interactive exercises
Total 30 15 0 0 90
9. Date of first approval: December 25, 2023
Course designer Head of Division

Signed Signed

Trần Bội Châu Đỗ Tường Hạ

Reviewer Dean of faculty

Signed Signed

Trần Hoài Khang

10. Date and Up-to-date content

Version: 1.0 - Date issued: 07/26/2020

Version: 1.1 - Date issued: 06/16/2022
Version: 3.0 - Date issued: 12/26/2022

Head of Undergraduate Dean of faculty Instructor

Studies Department (Signed) (Signed)
(Signed)