0 ratings0% found this document useful (0 votes) 300 views23 pagesUnit-4 Multicompartment Models
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content,
claim it here.
Available Formats
Download as PDF or read online on Scribd
Mal Mul Keomborhert 1) etm jodels
MalBesmbar tren mode are a CONOR ne) aaa.
© Whe |plama ard Aighly pepwied Hewes auch or Henne such os brain,
Hers y Sang _ tre ca edoey conakhite Cento Combar tment,
© Ofer Haw with Aimllar dtshibulien chevactersh ane peel eat tegetton
te consi vte peripheras compuctment Harun.
S Trtovemsly admitted gedication one tahedeed dire inte
Central combur nent.
© Trreeuible dea eliqinghon , ¢/ en by Fapatie biotrens Jormebien or
Wert exeveting » taker pee onlg fey cenbed combartments
© Reveuible diibuti, occur behwsin central and peuphers2 comparbnod
te de ibe b rr be. the d: 7
ry odfocen the drag and the Lenihteral combactmests
secede” pea ae “Tyg bet
© A vate prea invelue forage 4 doy i, ond ool fetes fie ovter fuauu.
Sate eoipheed Comparten % an Fraceeusble to dived
messarergent ave rob tite of eag Aiqinndion ov cfervernces
ches,
‘Scanned with CamScanner re —Geaparingent Oey Mou
TR foe compar trent mou! ernigiedt into 2 cw ‘
in Cental Compaov trent oy Combartment x — Semprit ing. 7) oc!
anol Righty porpused tena Whe
liver, Sumga Kidnegs ede. Hee egeitthonh ith the deus
Wopelty - 7
2 Leriphereh or TTysuucempactnict 07 Combor beet a —erh'g
opal eee
eguilies ng tse ues such ad rpuste , akin, osbipor
Ted Combartment= Open Medel
“Ly tra venous Bolus. Adminis hakion,
=
Peripheral
Day Combos ba ent
‘Scanned with CamScanner ini Kel rabrol cledine. chia bs butiom
low Fermine® dedine igi
—> te
Changes tn de coneenfeabing tm He cen herb anol periphewl conpertonct
after iv belus para, tat bits tee compertmenk adel”
Lek ky ond Ky be fut evden cbabibution Yate constant tepid
drug travsfen betioern cobra 200 peripheral compertment- and bt
¢“ond po define centred anol pee era compar tnen b.
Re rake of change ih dtu Conceneabiey Te cane aL Cowpactmend
lies akiG Kut —ke@ ——@
‘Scanned with GamScanner pee = REVI © Hea cate pip
de Kar,
beeen aaah Ka,
aes Se Me KX —®
Ve Ve. VY
Fe = Proven ch ag te condead compartment °
a sunk oy by in eripherek com fear traent>
Ps = Apparent vole. 4 ae com por tment —
a Apparel —velage prophere compa brent
THe tobe of cha te teas, coneentabiog fn He Pevifeboel
Combar tment — t4 given a
Soe = Kec Kn Cp = — ©
AG 2 KeXe Ky X%
dt Ve Vie ~~
Tote grotion % equation QB ad O Ges —
oy)
‘Scanned with CamScanner Cc. =
- 7 Xe] flat en" 4 (tet Je] og
Cp =e] (Ken jew" -#]
P Ge, nud Sy —O
whe —
Ko = iv. bel dose
A and 6 =
Rybed fib - orden constant
in ak me” 3
Won is ne aertlshom he nae come. 0), pirk dom fate reve Hen
Wee was fe Co for send case 14° tame oh Habe rte dese
a fe re det, nceuimaBihin fy fleima
Scanned with CamScanner ° padi lee fh (gir cite, thee | Snvewer: 2), time 40 Bate
° ee 3 if e i * ars fen dng iY check de cecumudate
wed ite ya “ky gene wile feonk dase
ard wife get Righen enh Joon cditebtowat does ty Hereecll
Ta summation of conaantra ten
Pricciple 0}, Soper posite
ses
Concentrah'on —_>
Ce
Lineor bleb 07 Concenhrabing Vouws “Times shew
Complete eliminating a, Hee previews doris
7 di
@ “re vate of eLininatinn 44 ual fo amount oo B
phi piel ‘y xate coustt) gor fiat orden cliginabion,
Joma gin be
Sn bey
‘Scanned with GamScanner Tneveues hee amowrt— 9) olay,
concen bak
As plormea ade
bhi minateol laren closing Intewwel M40 fneveata
Thu of: eeeyrmiba ie vaitk each close iLL conkinush anh somnnd®)
oF Living teal dune weech alos tatenval is epust te amen 4, dem.
How, plums drag concentrating approaches A tealy ttete or Platuu.
Ka At stahe condition’ whan rate a chug, entenis ual vehe
Sb ang O Laing” cystem, a
Precumulatiny “Factor ov Peeumulatiy Inder (Ro. )
Te ts defined os robo bebooen Reghasb , taibial concen bration
at 4 Bhabe ,Cmay ancl Fight plinc_ concentration aflen
Jat — ee _ Sifu oe
C
Ra = im
tee
Rx salle
[a ek
‘Scanned with CamScanner Steady State Drug Levels Levels
Stedy Store or Pl Petoesble
Oo], elminakon ts equal to te amour» drag tn
bedy, © mud plied by vate Constant i Fiak order” eli inabi nl ),
Tre vate,
oe ee Concertvalion Increases empount— of, dug, Liminaded
during dosing tot Q. iner :
a ing iobivak ales coder
“Ta, de
accumulation with each dose eit be coo knuscl
Ort2 amok ©) dy elininated obs Rach desis ietewoh ig oquaQ
Se a d
chee!
Kew , plosme— drug, concentration “pp reaches a Study state ov Platen.
Tha, Steady state condilton ae ction when wate 9} a
enteric “fren epol rote dng, St iy Aystey oro ne jo ter
deagy accamulaten octute.
Chonging dete ov desing, inboved pt concenhation attained 2
AteteS bak not tige’ ar ach ene. Ate stole
The. steed) Atite (Platesw) t veackel im afpronimabs pine Rol
ot “Y ‘t y
‘Scanned with GamScanner © At Ateady stote He d concanbvaim (Css) , te pert Cmax)
and rouge (Oma) oF one time chewing, ong or interval Jiniler.
Time —>
Concenkation—tine profile auociated wile mmalliple “Dv. bolus
od ming wating to stanly State,
@ Under Condi: ion gp mbbple Kev. belay adminiehahion 7Bepilatme
Comcenheabon at taely tate lu cluates (peak and t thoy )
wheat under Fnfusi — condition, olaame. Concentration
Kenain Constant.
‘Scanned with CamScanner Elect of Dose (Xe) on stedy tbabe —
Te Roker dose, He figher steady — state levide. Tre Llu chualk
in ¢, a ancl Cay Oe gtr ws Righer doses ae . 7
W\ Higher dove
max
Tatecmediate dose
o—
~ Low dose
Tine fo nee Nn?
5 te : teady thal
Tine prefree of, enwd ple “Lav. elas administiaHen Yeaching, 4 wadp tthe
wing,” dfbount= seeee
Elle sp Dose Tetoad (1) om sted tobe
— “The deqr acey mualah 35 gaeaten ie
© ren TS ty ey Da aja a Ro
ve Yay flachalin tm Cage a7 Cin.
‘Scanned with CamScanner @ When Tt, — he degree q aecwpulotion ie fas with
7.7 csa see quester acluahinn fm Cony enol Coin +
® When Tee ty Wen te ne accumiken ob ab &
Crmin abproach Zero. The plasma Gone. ime fete
wilt be reer 23 odminishahen, 4 coal f
Ainge. choses,
VV
a frst
6 (r= *1)
°
« (174
\ >
Tee —>
Fine prfite fov mat hiple ‘Tiy. belua admin ietradhing Veorhice
Stud, state a diferent clowe, Interne (RT)
‘Seanned with GamScanner Te to Reach Steady Ste —
is eS
\ime
Doe eqaiveal do each sk atte determina by
Ahimjnadion vote constart CED gy dg
e Ir is brett Joc portionsl + Pah) Be.
— chute der ret
Time faten to sveach th
and_— number of
dere Aire, besing tnferoe
_—
e The
oleses «
‘Scanned with CamScanner Loading Dese of Primary Dose
d (%)
OTE 8 deficed os fnitial close 9) crvtoin lng, Need “Te yeah
tage Prsme concen bration
© lik loneling dese He atensly tate Yeached rmuch quicker
than eng maintenance close oo
DP Tr repidty ache therapeu Yuponse. and subsequent docs
Mointa‘a t Vapors Jb
© Lanny, doves one Langn Han painter once OG
I Jaintenance Dose
Te a de)inul os Re dete rewlacl te maintosn
Re concentraen within Re Herabeahe- Wat rlow Ks),
Leher Ove Yepeately oF — Constart~ intinrR
‘Scanned with GamScanner ding Sore Oa) + Masatananee Cy)
se
Bera eabte window
oS
- hee
aintenance dost (Xm) only
Tine > #
_Metetenane done wit tn witout lead de =
Calculations a Lending a0 Se Mainterana
Dose
Lentig heres anol ae oles
1) Clearan
2) Veolanee 2 a ere
3 Tica ta biti «
‘Scanned with GamScanner leading Dose Colerlation |
Simple equation fee bedig duce CX) adeinishered os Tv sel
} _ = Cesuy
. > Aven “a take Plame a concentahion te be bedi. |
bpm en vlad 9 Sismbebig. oy “Dea. |
TH Vis nok Kroon Ren leaabne dae CX.) 4 |
a) Tov. Bolus or when Gosepien ia vay vapid
@
ace atl wwe)
Su -
venue) |
b) Ferg ee Tey, ow when Ka 97 Ke
i nen
Trek;
| Xe 7 CR cep
Cyser
‘Scanned with CamScanner Maintenance Dose Calealations —
Aqusher [pt Galata rointenaneee dove (X%q) ore ——
oO |X = Cue:
Be ears = ae age sy te plime sng cont:
cle > Test oy
~ desing af
"Cn gy Mew tone: ab steady sabe
Crnin $6= Min cones ak Abend state
Vo* Apparent volume “0, cbisdtos'tuhim
ie Sey ae
lay xe |
Toe
tu, = Red bie yey
Att extra utluby heeding chien wl jantihenawee. dove Rose to be adjusted oy
Bieovai bide fier
‘Seanned with GamScanner Dose Rake Caladahon «
are dese vaho 4 tquat to Coadinn dos Midd 4:
i close. 7 ae Fd
Bese volio = Xe
Ky
Lehen —
Desig itewal CT) = ty
Bou vate = om
Oe Ga
TE er Dow rahe FOR
Tree caleatahing om appre pr ore compartmen t—
Kinelie not mudticombay tment —= Kineh'es
‘Scanned with CamScanner Clinical Sig nificance of Loading ancl
Maintenane. De
pl stil ca ates ae
“The “Toc phate coring, Cletliog cote + mainhenonee. done) provide
Yapid — HRerapeuve Ger ue long tere ayy:
The cenuebt a leaking, chs ancl mointingnee dete 4 vabiol
ler sheer by, dogs anol iv. aalevaishabing «
emboliem
ed fe treab [on on 7
(. fi Doasiahe Hecapeubie
Hebarin when
alec renal Looing oss. te attain
ely
‘Scanned with CamScanner
