theHYMedicine.
com
Cytokine Secreted by Activity “Hot T-bone stEAK”
- Inflammation • IL-1: fever (hot)
IL-1 Macrophage - Hypothalamus → Fever
- Liver → Synthesis of acute phase proteins • IL-2: stimulates T cells
• IL-3: stimulates bone marrow
@HY_Medicine
IL-2 All T cells - Growth of NK & T cells
• IL-4: stimulates IgE production
IL-3 All T cells - Growth & Differentiation of Myeloid Progenitor cells
• IL-5: stimulates IgA production
- Differentiation of T cells → TH2 (Suppress TH1)
- Growth of B cells • IL-6: stimulates aKute-phase protein production
IL-4 TH2
- Class switch to IgE & IgG
theHYMedicine.com
- Eosinophil activation - TH1 cells coordinate a cell mediated
IL-5 TH2 - Differentiation of B cells → Plasma cells
(macrophages & CTL) immune response
- Class switch to IgA and inhibit a TH2 stimulated humoral response
Macrophage - TH2 cells coordinate a humoral (B cell)
- Liver → Synthesis of acute phase proteins
IL-6 TH2 - Promotes TH17 Differentiation immune response and suppress a TH1
TH17
stimulated cell mediated immune response
@HY_Medicine
- Growth & Differentiation of Lymphoid Progenitor cells
IL-7 - Prolongs naive & memory T cell lives
IL-8 Macrophage - Neutrophil attraction & adherence to endothelium
- Attenuates Inflammatory response
IL-10 TH2 - Suppress cytokine production by TH1
- Activates NK cells
theHYMedicine.com
IL-12 Macrophage - Differentiation of T cell → TH1
IL-13 TH2 - Class switch to IgE
IL-15 Macrophage - Growth of NK & T cells
theHYMedicine.com
- Pro-inflammatory (stimulates IL-1 & IL-6)
IL-17 TH17 - Recruits neutrophils
- Activated NK cells
IL-18 - - IFN-𝛄 synthesis
- Expression of GM-CSF, TNF, IL-1β
TH17 - Pro-inflammatory
IL-21
@HY_Medicine
TH2 - Work together with IL-22
- Targets epithelial cells; ↑ barrier function
IL-22 TH17 - Production of defensins
IL-23 - - ↑ TH17 activity
- Inflammation
TNF-𝛂 Macrophage
theHYMedicine.com
- Hypothalamus → Fever
- Enhances Phagocytic activity
TH1 - Liver: synthesis of acute phase proteins
TNF-β CTLs (CD8+) - Muscle & Fat Catabolism → Cachexia
IFN-𝛂 Plasmacytoid Dendritic
Cells - Inhibits viral replication
type I Interferon
- ↑ MHC I expression
@HY_Medicine
- Activates NK Cells
IFN-β Plasmacytoid Dendritic
type I Interferon Cells
- Inhibits viral replication
- TH1 -
IFN-𝛄 ↑ MHC I & MHC II expression
- CTLs (CD8+) -
type II Interferon Activates Macrophages
- NK Cells - Inhibits differentiation of T cells → TH2
- Anti-inflammatory
- Pro-inflammatory in presence of IL-6
TGF-β Macrophage - Differentiation of Treg
- Inhibits macrophage activation
- Stimulates Angiogenesis
theHYMedicine.com
