FACULTY OF PHARMACY | B.
Pharmacy
SYLLABUS | Semester-7
Subject code: 13PH0704
Subject name: Novel Drug Delivery Systems
Scope: This subject is designed to impart basic knowledge in the area of novel drug delivery
systems.
Objective: Upon completion of the course the student shall be able to
1. To understand various approaches for the development of novel drug delivery systems.
2. To understand the criteria for the selection of drugs and polymers for the development of
novel drug delivery systems, their formulation and evaluation.
Teaching and assessment scheme:
Teaching Scheme (Hours) Theory/ Tutorial Marks Practical Marks Total
Credits
Theory Tutorial Practical CSE IA (I) ESE (E) TW Viva (V) Marks
3 1 0 4 10 15 75 0 0 100
Theory syllabus: Teaching hours: 45 Hours
Unit-1 10 Hours
Controlled drug delivery systems: Introduction, terminology/definitions and rationale,
advantages, disadvantages, selection of drug candidates. Approaches to design controlled
release formulations based on diffusion, dissolution and ion exchange principles.
Physicochemical and biological properties of drugs relevant to controlled release formulations.
Polymers: Introduction, classification, properties, advantages and application of polymers in
the formulation of controlled release drug delivery systems.
Unit-2 10 Hours
Microencapsulation: Definition, advantages and disadvantages, microspheres/ microcapsules,
microparticles, methods of microencapsulation, applications. Mucosal Drug Delivery system:
Introduction, Principles of bioadhesion/ mucoadhesion, concepts, advantages and
disadvantages, transmucosal permeability and formulation considerations of buccal delivery
systems. Implantable Drug Delivery Systems: Introduction, advantages and disadvantages, the
concept of implants and osmotic pump.
Unit-3 10 Hours
Transdermal Drug Delivery Systems: Introduction, Permeation through the skin, factors
affecting permeation, permeation enhancers, basic components of TDDS, formulation
approaches. Gastro retentive drug delivery systems: Introduction, advantages, disadvantages,
approaches for GRDDS – Floating, high-density systems, inflatable and gastroadhesive systems
and their applications. Nasopulmonary drug delivery system: Introduction to Nasal and
Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose),
nasal sprays, nebulizers.
Unit-4 8 Hours
Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction
to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications.
Unit-5 7 Hours
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Ocular Drug Delivery Systems: Introduction, intraocular barriers and methods to overcome –
Preliminary study, ocular formulations and ocuserts Intrauterine Drug Delivery Systems:
Introduction, advantages and disadvantages, development of intrauterine devices (IUDs) and
applications.
Tutorials will be based on the above syllabus. Teaching hours: 15 Hours
Recommended References (Latest edition):
1. Y. W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded, Marcel Dekker,
Inc., New York, 1992.
2. Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York,
1992.
3. Encyclopaedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley Interscience
Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim
4. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi,
First edition 1997 (reprint in 2001).
5. S.P. Vyas and R.K. Khar, Controlled Drug Delivery -concepts and advances, Vallabh Prakashan,
New Delhi, First edition 2002.
Journals
1. Indian Journal of Pharmaceutical Sciences (IPA)
2. Indian Drugs (IDMA)
3. Journal of Controlled Release (Elsevier Sciences)
4. Drug Development and Industrial Pharmacy (Marcel & Decker)
5. International Journal of Pharmaceutics (Elsevier Sciences)
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