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1 Dr.Teeth Notes
MYCOTIC TNFECT IONS
CANDIDIASIS
(CANDIDOSIs, MONILIASIS, THRUS)
Because of the gem1s name
Monila, the disese s
called as monilrasis
Image cnedit: gvgle
1t is the most commen fungal sr mycetic infectin
affecaing human being. It sccurs mainly as a
secendaxy infectien in immunscempnomised
patients. It affects skin, mucous membrane, nails and
intexnal vrgans.
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CAUSATIVE ORGANISMS:
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1 eeth Notes
MYCOTIC INFECTIONS
CANDIDIASIS
ANDIDOSIS, MONILIASIS, THRUSH)
Because of the genus name
Monilia, the disease is
called as moniliasis
g
Image cxedit: gaegle
mmom fungal vr mycotic inmfectivn
n being. It vccurs mainly as a
C t i n in immunscomprsmised
Rin, m u c s u s membrane, nails and
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CAUSATIVE ORGANISMS:
Other organisms:
Predominant
causative organism: C. parapsilosis,
C. stellatoidea,
Candida Albicans C.krusic,
C.rugosa
PREDISPOSING FACTORS:
Pensen who is taking medicationms, eg, antibirtics
and immunosuppxessive dxugs.
.RadiatintheraPy
Chrnic illnes.
Systemic diseases, e.g, diabetes, anaemia,
myxredema and Addisen's disease.
.Immunecompnamised patients, e.g, AIDS.
Sevexe debilitatien
A and B6,
Nutnitisnal deficiency, eg, vitamins
inon.
Old age n infants,*
. Pregnancy.
smokens.
.Denture weanex and
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2h Notes
Other organisms:
C. parapsilosis,
. C. stellatoidea,
C.C. krusie,
C. rugosa
ng medications, e.g, antibirti
ssive dxugs.
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Dr.Tee
CAUSATIVE ORGANISMS:
Predominant
causative organism:
.Candida Albicans
PREDISPOSING FACTORS:
.Pensn whs is taking
and immunasupp
Radiation thenapy.
Ch ramic ilness.
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Dentuxe weaxen and smekens.
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CLINICAL FEATURES:
Candidiasis sccurs mestly as the superfleial
inectin f the mucous membrane « x skin, but
deepex stnuctunes like oesaphagus, lungs Gx
endecandium, axe invelved in sevexely
debilitated or immunssuppnessed pexsens.
Onal candidiasis
Onal Patholesy: clinical Pathrlosic Cerrelatiens,
Regezt, Sciubba, Jondan.
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ORAL MANIFESTATION
.classiied inte the fotlewing types
Name the Clinieat Commen Asse ciated
ClinicalTYeAPpearane Sites t Facters
e and Ccunne
Symptems nce
Pseudmembra Creamy Buccal Antibietic
white mucesa, thenapy.
plagues, tngue, immunsuppre
nemavable | palate ssin
nus(thnush) ; burning
sensation,
oul taste
Pasterie Antibietic
Enythemateus Red
macules, x hand thenapy.
burning palate, zexstomia,
sensation buccal immunesuppre
mucesa ssin,
densal idiepathic
tongue
Central Red, Midline | ldiopathic.
papillaxy atxephiccpostexi immunesuppre
mucesal n densa ssin
atnophy
(median aneas; tngue
xhembeid asymptm
slossitis) atic
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Name t the ClinicabCo
Clinical Type APpeananc Si
e e and1
(SymptTms
Pseudomembna Creamy- B
white m
plaques, to
nemavable P
nus (thnush) ;bunning
sensatisn,
oul taste
Enythematous Red Po
4
macules,
bunning P
sensatiosn b
m
d
t
Central Red, Mi
papillany atnophic Po
atnophy mucosal n o
(median aneas; t
rhombeid asymptom
glossitis) atic
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Dr.Teeth Notes
Red axeas, Pesteni« |Immunesuppres
t e n with| x palate, sin,
xemevable| pestenie Ldiepathie
white n donsa
Chenic plaques; tngue,
multijecal buxning angles s
sensatin,} m u t h
asymptom
atic
Red, Angles o¢| Idiepathic,
fissuxed m.vuth immunosuppre
ssin, lss f
lesians;
vextical
innitated,
naw dimensin
Angulax feeling
cheilitis
DentuNe Red, Confined Probably n
stematitis asymptem xuetxueinjectien;|
atic palatal | dentuxe tten
(chxaniic denture is pesitive n
atnephic
candidiasis, beaxingCultune but
mucesa mucesa is n e t
denture sone
mouth)
Whie Antexi ldiepathic,
Hypenplastic
(candidal plaques x buccal| immundsuppxxe
ssien; caxe
leukeplakia) that anee mucsa
must be taken
not
nemavable n t te confuse
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Red aneas, Posteni
t e n with| x palate
nemavable| posteriq
white n donsa
Chnonic
plaques; tongue
multifocal bunning amgles
sensatiTn, | mouth
asymptom
atic
Red, Angles
issuned| mouth
Lesiens;
innitated,
raw
Angula eeling
cheilitis
Dentune Red, CTnfine
Stomatitis asymptom t
(chxonic atic palatal
atnophic dentune
candidiasis, beaning
dentune sexe mucosa
msuth)
Hypenplastic White Anterio
plaques r bucca
(candidal
leukoplakia)| that axe mucesa
nat
remvable
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leutepatia) that anemucea
ww.ww.w
s i n ; caxe
net must be tahen
xemevable n t t e cenfuse
Mere Moke
Mrteethaeademy damgrom edoe eet
PrTeeth Notes
this with
asymptem thex
atic keratetic
lesians with
supeximprsed
candidiasis
MucCutanes White Tngue, Raxe;
us plaaues, buccat inhexited x
sme ot mucosa, sporadic
which palate dirpathie
may be immune
nemavable | dysfunctin
:ned axeas
Endocnine White Tengue, Rane;
buccal endrcxine
candidiasis plagues,
syndnomes mest of mucesa, diserdex
which ane | palate develops aften
not candidiasis
nemovable
Image cnedit:
Onal Patholegy: Clinical Patholosic Caxxelatiens,
Regezi, Sciubba, Jndan.
Textbek vnal pathology. Shajer.
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Dr.Teeth Note
asymptom
atic
MuCoCutaner White Tongue
uS
plaques, bucca
STme ok mucosa
which palate
may be
nemovable
;ned aneas
Endocxine- White TonguAe
candidiasis
plaques, bucca
syndnoTmes mast o mucosa
which are palate
nt
remsvable
6
Image credit:
Onal Pathology: Clinical Pathologic
Regezi, Sciubba, Jardan
Textbrok j oral pathology, Shajer.
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Dr.Teeth Notes
HISTOLOGICAL FEATURES:
.It is diagnesed based on presence of hyphae vr|
pseudshyphae, these a r e vaxying in thein
Length and may shrw bxanthing
The cemmen featuxes axe increased thickness o
paxakeratin on the suntace f the lesien aleng
with elongatisn iepithelial nete nidges.
.The candidal hyphae axe embedded in
parakexatin
.Neutnephilic infiltnation (micnoabcess). Chrenic
inflammatexy cell infiltnate can alse be seen
Fungal pseudehyphae
Onal Patholegy: Clinical Pathslogic Cennelations.
Regezi, sciubba, J«ndan.
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Oxal Patholegy: Clinical Pathologic Correlations,
Regezi, Sciubba, J ndan.
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Dr.Teeth Notes
-Candidal hyphae
Neutrophils
-Epithelium
-Inflammatory cells
Image cxedit: gosgle
TREATMENT:
Remaval oi primaxy etislogical factons and
maintenance oi pxepex vral hygiene
In cenventional cases, tapical apd systemic
oj nystatin is dene.
administratien
I n immunssupPressed patient, systemic
administratien f amphatexicin
B and flucenaz«le may be necessa xy
