Int. J. Drug Res. Tech. 2022, Vol.
11 (4), 1-3 ISSN 2277-1506
International Journal of Drug Research and
Technology
Available online at http://www.ijdrt.com
Commentary
TARGETED DRUG DELIVERY
Selim Azhar*
Department of Pharmacology, SK
Research Institute, Spain
INTRODUCTION
Because of the increased delivery of medications and genes to a tumour site while being
protected from the extracellular environment, Targeted Drug Delivery (TDD) is emerging as a
significant technique for cancer treatment. Stimulus-responsive nanogels (NGs) are three-
dimensional hydrophilic polymer networks that can modify their structural properties in response
to external stimuli. They are made up of covalent bonds or self-assembly processes. Because of
their stability, ease of synthesis, good control over particle size, and ease of functionalization,
these NGs have been extensively studied as smart drug delivery carriers for a variety of
anticancer medicines and genes. They can regulate the size of the particles from 5 to 400 nm, as
well as the polymerization conditions. Drugs with short half-lives (less than 4 hours) benefit
from targeted drug administration because it reduces dose frequency and the intensity of
unwanted effects caused by drug concentration changes. Especially when a therapeutic effect
cannot be maintained overnight due to an inconsistent dose regimen that results in a higher
severity of unwanted effects. Targeting genes with short half-lives to specific RNA binding
proteins is possible. Targeting prolyl isomerase pin1 to RNA binding proteins can control mRNA
genes with short half-lives.
www.irjdt.com 1
.ijdrt.com
Int. J. Drug Res. Tech. 2022, Vol. 11 (4), 1-3 ISSN 2277-1506
Targeted drug delivery via innovative drug delivery systems and nanotechnology intervention is
becoming a major component in medicine's future. Every year, new active pharmaceutical
ingredients (APIs), biologics, novel drug delivery methods, and nanopharmaceuticals are
produced and commercialised around the world following successful clinical studies. These
formulations are expected to capture a significant portion of the present market in the near future.
Regulatory permission is required for the translation of laboratory research to bedside medicine.
Understanding the regulatory requirements for product approval is crucial in this regard. Given
the expensive expense of medicine and the potentially fatal adverse effects of drug therapy,
tailored drug administration is critical in clinical practise. As a result, targeted drug delivery to
solid tumours is a hot topic in research, with the emphasis on better drug formulation and
associated [1,2] optimum delivery methods/devices. Medication-targeting has the potential to
improve drug delivery efficacy, reduce adverse effects, and lower treatment costs significantly.
The vast majority of drug-targeting studies, on the other hand, assume that the drug-particles are
already at or near the target site.
Current issues in pulmonary drug delivery include targeted drug delivery and controlled release.
Oral (pill eating), intravenous (drug injection into a vein), and inhalation are three common
medication delivery methods (breathing into the human lung). In recent years, pulmonary
medication delivery techniques have attracted a lot of attention, with applications ranging from
asthma and Chronic Obstructive Pulmonary Disease (COPD) to lung malignancies and systemic
disorders. When compared to conventional medical therapies, the advantages of pulmonary drug
delivery include increased efficiency due to the huge surface area of the lung (100 m 2) and thin
epithelial layer thickness (0.2 to 0.7 m), lower systemic drug levels with fewer side effects, and
greater convenience. Because the drug aerosol is delivered directly to the target location, a
considerably smaller dose can be employed to provide a therapeutic response with minimal
adverse effects [3]. Inflammation, asthma, COPD, and cystic fibrosis (CF), as well as diabetes
and other systemic disorders, are all treated with pulmonary drug delivery methods. The
aerodynamic dimensions of drug particles/droplets should be in the range of 0.4 dp 7 m for
optimal treatment. The optimization of pulmonary medication delivery (e.g., drug-targeting
administration in lung airways) is difficult due to advanced pharmaceutical aerosol formulations
and the complicated architecture and physiology of human lung airways. The use of physical or
chemical mechanisms, innovative particles or drug carriers, and new drug-delivery device
www.irjdt.com 2
.ijdrt.com
Int. J. Drug Res. Tech. 2022, Vol. 11 (4), 1-3 ISSN 2277-1506
improvements with increased performance are the main research concerns in pulmonary drug
delivery. The following are some of the benefits of pMDIs: portability, precise dosage
management, and a big capacity of medical dosages at a low cost. pMDIs have a number of
drawbacks, including being highly reliant on the patient's inhalation coordination, being limited
to certain drugs that are physically and chemically inert in the propellant mixture, and not being
effective in treating deeper lung conditions due to the strong impaction in the upper respiratory
system caused by the high jet velocity. For example, only around 10% to 20% of the drugs
emitted by CFC-pMDIs are able to enter and deposit in the lungs, while the rest is deposited in
the oropharynx. Furthermore, the deposition of drug formulation material inside the canister can
result in the delivery of an erroneous dose of medication [4,5].
REFERENCES
1. Freeman AI, Mayhew E (1986). Targeted drug delivery. Cancer 58:573-583.
2. Mills JK, Needham D (1999). Targeted drug delivery. Expert Opin Ther Pat 9:1499-
1513.
3. Bae YH, Park K (2011). Targeted drug delivery to tumors: Myths, reality and possibility.
J Control Release 153:198.
4. Singh R, Lillard Jr JW (2009). Nanoparticle-based targeted drug delivery. Exp Mol
Pathol 86:215-23.
5. Kazi KM, Mandal AS, Biswas N (2010). Niosome: A future of targeted drug delivery
systems. J Adv Pharm Technol Res 1:374.
Correspondence Author:
Selim Azhar
Department of Pharmacology, SK Research Institute, Spain
E-mail: [email protected]
Received: 04 April 2022, Manuscript No. IJDRT-22-65980; Editor Assigned: 06 April 2022, PreQC No. P-65980; Reviewed:
19 April 2022, QC No. Q-65980; Revised: 23 April 2022, Manuscript No. R-65980; Published: 30 April 2022, DOI:
10.37421/2277-1506.22.11.346
www.irjdt.com 3
.ijdrt.com
Int. J. Drug Res. Tech. 2022, Vol. 11 (4), 1-3 ISSN 2277-1506
Cite This Article: Azhar S (2022) “Targeted Drug Delivery” International Journal of Drug Research
and Technology Vol. 11 (4), 1-3.
www.irjdt.com 4
.ijdrt.com
