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Compendia Of World s Medicinal Flora 1st Edition
Amritpal Singh Digital Instant Download
Author(s): Amritpal Singh
ISBN(s): 9781578084302, 157808430X
Edition: 1
File Details: PDF, 3.18 MB
Year: 2006
Language: english
Compendia of
World’s Medicinal
Flora
Compendia of
World’s Medicinal
Flora
Amritpal Singh
Herbal Consultant
Science Publishers
Enfield (NH) Jersey Plymouth
CIP data will be provided on request.
SCIENCE PUBLISHERS
An imprint of Edenbridge Ltd., British Isles.
Post Office Box 699
Enfield, New Hampshire 03748
United States of America
Website: http://www.scipub.net
ISBN 1-57808-430-X
978-1-57808-430-2
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system,
or transmitted in any form or by any means, electronic, mechanical, photocopying or otherwise,
without the prior permission.
This book is sold subject to the condition that it shall not, by way of trade or otherwise be
lent, re-sold, hired out, or otherwise circulated without the publisher’s prior consent in any
form of binding or cover other than that in which it is published and without a similar
condition including this condition being imposed on the subsequent purchaser.
Amritpal Singh
Contents
Preface v
PART A
PART B
1. Medicinal Algae 14
2. Medicinal Fungi 20
3. Medicinal Lichens 24
4. Medicinal Bryophytes 26
5. Medicinal Pteridophytes 28
6. Medicinal Gymnosperms 32
7. Medicinal Angiosperms 37
Further Reading 270
Appendices 315
Taxonomic Index 321
Subject Index 347
1
Introduction to Herbal Medicine
Sushruta are respected names in the fields of medicine and surgery respectively. Both the
texts have dealt in detail with the use of medicinal plants. Chebulic myrobalans (Terminalia
chebula), Arjuna (Terminalia arjuna), Guggul (Commiphora mukul), Shatavari (Asparagus
officinalis) and Ashwagandha (Withania somnifera) are popular medicinal plants targeted for
application in modern science.
The period between 1488-1682 is known as the age of herbals. Otto Brunfels wrote herbal
text in 1488, which was published in 1534. This period produced a number of distinguished
herbalists like Gesner Conard, Leohard Fuchs, Hieronymus Boch, William Turner and John
Parkinson. Friedrich Wilhelm Serturner (1783-1841) isolated morphine from Papaver
sominferum in 1805 and showed the medical world that certain chemical constituents are
responsible for curative actions of plant based remedies. The scientific community will always
remain thankful to Serturner for his great service to the world of medicinal plants.
Felix Hoffman isolated aspirin from willow bark (Salix spp.) His work augmented the
rational use of willow bark by ancient people. The bark was used in the treatment of arthritis
and rheumatism. Aspirin is still prescribed in reducing pain and stiffness associated with
joints. William Withering (1741-1799) reported to the scientific community about separation
of cardiac glycoside, digoxin from foxglove (Digitalis purpurea). The discovery of digoxin
proved to be a milestone in the history of medicine (particularly cardiology) as digoxin was
once upon a time a first line drug in treating cardiac edema.
Klie isolated reserpine from Rauwolfia serpentina and the alkaloid remained as the drug of
choice for the treatment of hypertension for almost 50 years. Jean Robiquet reported the isolation
of antitussive (cough suppressant) alkaloid, codeine from the opium plant. This was not the
end of the story. Clark Noble did a great service for humanity by discovering Vinca alkaloids
from Madagascar periwinkle (Catharanthus roseus). Vinca alkaloids (vinblastine and vincristine)
are priced drugs for treating leukemia. Discovery of taxol from Pacific yew (Taxus brevifolia) by
Mansukh C.Wani and silymarin from milk thistle (Silybum marianum) by Jack Masquelier are
some recent examples of drugs obtained from plants.
Before the discovery of antibiotics (penicillin and streptomycin), analgesics and steroids,
man was completely dependent on medicinal plants as healthcare system. With the discovery
of phytochemicals, the interest of the scientific community shifted to organic synthesis and
several drugs were synthesized. The growing popularity of the allopathic system of medicine
was a major setback for herbal medicine. Emergency treatment and surgical advances are
the gifts of modern healthcare systems to man.
Today we can see the renaissance of the herbal system of medicine. Ayurveda and
Traditional Chinese Medicine (TCM) are popular systems of healing in western countries.
Recent studies have shown that an increasing number of patients are consulting doctors of
alternative systems of healing. Relative safety and cost effectiveness may be factors
responsible for renaissance of the herbal system of medicine.
The European market for herbal supplements is estimated at over US$ 2.7 billion and for
herbal remedies, a further US$ 0.9 billion. Germany is by far the largest market. The market is
growing rapidly at over 4% per annum for herbal remedies and considerably faster for herbal
supplements. The US herbal market is nearing saturation and is expected to peak at US$ 6-8
billion in the next few years. The Traditional Chinese System has achieved major success in
herbal medicine. The Chinese people have preserved their herbal heritage beautifully. They
have explained the chemical constituents present in Chinese medicinal herbs in great detail.
Traditionally medicinal plants are used as powders, decoctions, infusions, tinctures or
fluid extracts. These preparations, although they have surprisingly high curative value, are
considered raw as per pharmaceutical standards. It has been shown in various studies that
herbal products sold in the market are not always pure. Studies done by consumer laboratories
are very significant in improving quality control and assurance of botanical products. Keeping
in mind the demand of the time, companies promoting herbal products are continuously
working on chemical standardization of these products.
Medicinal herb is considered a chemical factory as it contains a multitude of chemical
compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene lactones
and oils (essential and fixed). Some rare compounds like furanocoumarins,
hydroxycoumarins, napthoquinones, acylphloroglucinols and sterols are also distributed in
the plant kingdom. These have been discussed in the chapter on phytochemicals. The active
constituents are usually secondary metabolites, derived from biosynthetic pathways present
within the plant tissue.
The chemistry of medicinal herbs is very complex. Not all the constituents present in the
plant have therapeutic activity, some are poisonous e.g. pyrrolizidine and tropane alkaloids.
Phytochemistry deals with the study of the chemical composition of the plant material (phyto
refers to plant). Plants are used in various forms varying from powders to extracts. Powder
represents the drug in ground form and these types of preparations are considered to be
crude. The Pharmacopoeia mentions standardized vegetable powders for therapeutic
application.
Herbal systems of medicine have become increasingly popular in recent years. A recent
study from America demonstrated that about 34% of the general population used one or the
other system at least once a year. In India 76% of patients visiting the general medicine OPD
of a tertiary care hospital use alternative therapies. In light of growing demand of herbal
drugs, quality control and assurance is of prime importance. Standardized herbal extracts are
considered more scientific than crude drugs. A commonly employed technique for removal of
active substance from the crude drug is called extraction.
When we talk about research and development in herbal drugs, Germany is foremost on
the list. German Commission monographs on herbal drugs are a significant work on medicinal
plants in German pharmacopoeia. Chemical composition, adverse drug reactions, side effects,
indications and contraindications have been discussed in a manner similar to synthetic
drugs. The United Kingdom is not far behind. Several organizations have been set up to
improve the quality of herbal drugs. British Herbal Medicine Association (BHMA) has
developed monographs on several rare medicinal plants used in Traditional Western Herbal
Medicine. Phytochemical Society of Europe (PCE) is dedicated to promotion of health benefits
of phytochemicals. America is a hot market for the herbal drug industry. American Botanical
Council (ABC) is the primary body in America working on botanicals.
4 Compendia of World’s Medicinal Flora
With the onset of research in plant based medicine, it is becoming crystal clear that herbal
remedies are not always safe and should be consumed after consulting a healthcare
professional. Take the case of pyrrolizidine alkaloids which are toxic to the liver. Some of the
herbal remedies claimed to be hepatoprotective actually are hepatotoxic. Piper methysticum
(Kava kava) and black cohosh have been reported to be hepatotoxic. Hypericum perforatum (St.
John’s wort) has shown drug interaction with several prescription drugs like antidepressants,
antiepileptic and antivirals.
Ephedera is a popular remedy for weight loss. When it was subjected to testing it
demonstrated life treating side effects and now it faces a ban in several countries. Allium
sativum (garlic) if taken with aspirin can lead to bleeding. Aristlochia indica is toxic to the
kidneys and its use in has been banned in Canada. The Italian Regulatory Authority has
recently reported four cases of acute poisoning following ingestion of Coleus forskohlii.
In India, several steps have been taken to improve the quality of Ayurvedic medicines.
Good manufacturing practice (GMP) guidelines have been introduced so as to ensure quality
control. Bacopa monniera, Asparagus racemosus, Withania somnifera, Tribulus terrestris,
Nardotsachys jatamansi and Centella asiatica have shown promising results and have been the
target of research for drug development.
Complementary/Alternative Medicine
They refer to a broad set of health care practices that are not part of that country’s own
tradition and are not integrated into the dominant health care system. In fact both the terms
are interchangeable.
Traditional Medicine
Traditional medicine is the sum total of the knowledge, skills and practices based on the
theories, beliefs and experiences indigenous to different cultures, whether explicable or not,
used in the maintenance of health as well as in the prevention, diagnosis, improvement or
treatment of physical and mental illness.
Herbal Medicines
They include herbs, herbal materials, herbal preparations and finished herbal products,
which are contained as active ingredients in parts of plants, or other plant materials, or
combinations. Traditional use of herbal medicines refers to the long historical use of these
medicines. Their use is well established and widely acknowledged to be safe and effective,
and may be accepted by national authorities.
Introduction to Herbal Medicine 5
Herbal Materials
They include, in addition to herbs, fresh juices, gums, fixed oils, essential oils, resins and dry
powders of herbs. In some countries, these materials may be processed by various local
procedures, such as steaming, roasting, or stir-baking with honey, alcoholic beverages or
other materials.
Herbal Preparations
They are the basis for finished herbal products and may include comminuted or powdered
herbal materials, or extracts, tinctures and fatty oils of herbal materials. They are produced
by extraction, fractionation, purification, concentration, or other physical or biological
processes. They also include preparations made by steeping or heating herbal materials in
alcoholic beverages and/or honey, or in other materials.
Active Ingredients
They refer to ingredients of herbal medicines with therapeutic activity. In herbal medicines
where the active ingredients have been identified, the preparation of these medicines should
be standardized to contain a defined amount of the active ingredients, if adequate analytical
methods are available. In cases where it is not possible to identify the active ingredients, the
whole herbal medicine may be considered as one active ingredient.
Marker Compound
A constituent of a medicinal herb used for quality control and assurance of herbal product.
A marker compound may or may not have therapeutic activity.
FURTHER READING
Anonymous. 1998. Indian Herbal Pharmacopoeia Volume 1. Indian Drug Manufacturers Association, Worli,
Mumbai.
Arturo, C. 1941. A History of Medicine; Alfred A. Knopf, New York, chapter 6.
Asimov, I. 1982. Asimov’s Biographical Encyclopedia of Science and Technology (2nd Revised Edition).
Doubleday, Garden City, New York.
Bone, K. 1996. Clinical Applications of Ayurvedic and Chinese Herbs: Monographs for the Western Herbal
Practitioner. Phytotherapy Press, Warwick, Qld.
Charles, L. 1976. Asian Medical Systems: A Comparative Study. University of California Press, Berkeley.
Debus, A.G. 1968. World Who’s Who In Science: A Biographical Dictionary of Notable Scientists from
Antiquity to the Present. Marquis, Chicago.
6 Compendia of World’s Medicinal Flora
Ducourthial, G. 2005. Dioscorides: in the beginning of the Materia Medica. Rev Prat. 55(6): 689–693.
Kapoor, L.D. 1990. CRC Handbook of Ayurvedic Medicinal Plants. CRC Press, Boca Raton.
Logan, C. 1942. Source Book of Medical History. Dover Publications, New York.
Mark Kline, D. 1997. Nicholas Culpeper Biography. Indiana University School of Medicine.
McCarl, M.R. 1996. Publishing the works of Nicholas Culpeper, astrological herbalist and translator of Latin
medical works in seventeenth-century London. Can Bull Med Hist. 13(2): 225–276.
Porter, R. 1994. The Biographical Dictionary of Scientists. Second Edition. Oxford University Press, New York.
Rajasekharan, P.E. Medicinal plants and the pharmaceutical industry Division of PGR, Indian Institute of
Horticultural Research, Banglore.
Tierra M. Why Herbal Standardised Extracts? An Herbalist’s Perspective.
Web reference: http://www.who.int/mediacentre/factsheets/fs134/en/
2
Herbal Pharmacy
Herbal drugs are often in an impure state. In order to make them fit for therapeutic
administration, they are subjected to various treatments which have been described below:
Decoction
Decoction is the process of boiling in water coarsely comminuted vegetable drugs for a definite
period. Before preparing a decoction the drug should be sliced before it is boiled in water for
five minutes or longer. If the comminution is too fine some sediment deposits will appear. The
decoction should be stored in sterile bottles.
Before pouring into bottles, the decoction should be strained instead of filtering. The
decoction should be discarded if there is a change in colour or small white blobs appear on
the surface. Medicinally, decoctions are used externally for washing wounds and internally
for curing ailments. Decoctions are therapeutically more active as they extract the virtues of
medicinal plants, roots, twigs, barks and seeds.
Infusion
Infusion is comparable to a cup of tea. Boling or cold distilled water is poured on the drugs in
a covered vessel and kept for fifteen minutes and then strained. Sometimes boiling is done for
hours to prepare strong infusion. Hot infusion is stronger than cold as it extracts the active
principle more effectively. Every drug has a fixed time at which it imparts its property to water.
For preparing cold infusion boiling water is not required. Coarsely powered drug is kept
in a closed vessel containing water for twenty-four hours. The powdered drug imbibes some
liquid and a mass is formed. The mass is pressed to obtain liquid, which is collected in a
measuring flask and mixed with water left in vessel and the quantity is measured.
The infusions should be used within twelve hours unless a preservative has been added.
Sometimes infusions are prepared with weak alcohol which acts as a preservative. Shelf-life
of alcohol based infusions has not been determined but it has an advantage over water-based
infusions. Water used in preparing infusions should be distilled. Hard water should not be
used as uniform colour is not obtained and it is not able to extract all the virtues of medicinal
herbs.
8 Compendia of World’s Medicinal Flora
Powders
Powders are mixtures of dry substances reduced to fine powder and intimately mixed together.
The drug to be powdered is thoroughly washed with water and dried. Properly dried drug is
reduced to powder in a pestle and mortar. Powders may be of a single substance and more
often of several (compound powders). The different ingredients finely powdered separately
and then weighed so that the required amounts are carefully mixed with a spatula on a slab
or with a small pestle and mortar and made in to fine, nearly impalpable form.
Powders should be mixed in a very clean mortar. The method of mixing greatly affects
the miscibility of powders. A powerful constituent should be first triturated with some bland
substance and then slowly mixed with the rest of the lot. It should be packed in white glazed
paper. Hygroscopic drugs should be stocked in accurately fitting glass stoppered phials
and dispensed wrapped in waxed or paraffin paper and preferably covered with tin foil.
A powered drug is made to pass through a sieve containing parallel wires. Powders of
differing consistency are produced by altering the sieve mesh. By repeated sifting and shaking
in a bottle the ingredients are thoroughly incorporated and a uniformity of colour is obtained.
Expression
It is the process of pressing juice or oil from medicinal or aromatic plant.
Bruising
It is the process of smashing up the different parts of a medicinal plant either by a pounding
machine or pestle and mortar.
Extracts
Extracts are prepared by separating the soluble matter from vegetable tissues by application
of a suitable solvent like alcohol, water or ether. The resultant liquid is concentrated by
evaporation to obtain liquid extract or concentrated nearly to dryness to obtain solid extract.
Depending on the solvent used, the extracts are classified as alcoholic, etheral or aqueous.
The solid and liquid extract classification is based on method of preparation. The alcoholic,
aqueous and etheral extract classification is based on type of solvent used. A standardized
herbal extract is a preparation which contains a certain fixed proportion of the active
constituent.
3
Phytochemicals
The word phytochemical is derived from phyto or plant. Its study involves understanding
the chemical composition of plants used in medicine. Phytochemicals produced in plants
are secondary compounds responsible for metabolic activities and defense purposes.
Phytochemicals are produced by specific biochemical pathways, which occur inside the
plant cells. Phytochemicals can range from medicinally useful agents to deadly poisons. A
number of phytochemicals isolated from plant material are used in the pharmaceutical drug
industry today.
Alkaloids
Alkaloids are basically nitrogen bases. The amino acids act as building blocks for biosynthesis
of alkaloids. A majority of alkaloids contain a pyridine, quinoline, and isoquinoline or tropane
nucleus and are responsible for physiological effects in man or in animal. The side chains in
alkaloids are derived from terpene or acetate. Alkaloids have basic properties and are alkaline
in reaction, turning red litmus paper blue.
Alkaloids combine with acids to form crystalline salts without the production of water.
A majority of alkaloids exist in solid form like atropine and they contain oxygen. Some
alkaloids like lobeline or nicotine occur in liquid from and contain carbon, hydrogen and
nitrogen. Alkaloids have one peculiarity regarding solubility in organic solvents. They are
readily soluble in alcohol and sparingly soluble in water.
The salts of alkaloids are usually soluble in water. In nature, alkaloids exist in many
plants: in larger proportion in the seeds and roots often in combination with vegetable acids.
Alkaloid solutions are intensely bitter. The names of alkaloids ends in the suffix—ine. The
salts of alkaloids are official. Codeine, atropine, morphine, ergotamine and ephedrine are
common examples. Alkaloids are responsible for physiological effects in man or animals.
The physiological effects are due to secondary metabolites arising from bio-chemical
pathways operating in the plant cell. Alkaloids constitute the largest group of secondary
chemical constituents.
Alkaloids are a significant source of pharmaceutical drugs. More than 12,000 alkaloids
are known to exist in green flora and only a few have been exploited for medicinal purpose.
With the help of scientific procedures like chromatography and mass spectroscopy it is now
possible to determine the molecular formulas and chemical structures of active constituents
of medicinal herbs.
10 Compendia of World’s Medicinal Flora
Bitters
Bitter principles are basically glycosides and are found commonly in plants of Genitiaceae.
They are chemically unrelated but possess the common property of an intensely bitter taste.
Although this group of drugs is not used today, once upon a time they were given to promote
appetite and aid digestion. The bitters act on gustatory nerves, which results in increased
flow of saliva and gastric juices. From a chemistry point of view, the bitter principles contain
lactone group. They may be diterpene lactones e.g., Andrographolide or Triterpenoids e.g.,
Amarogentin. The bitters have no action in general.
Some bitter principles are known to be astringent due to the presence of tannic acid.
Gentiana lutea is the plant known to contain astringent bitter principles. They should not be
prescribed with metals, as they are known to cause gastro-intestinal upset. Bitters have no
detailed account in Herbal Materia Medica and are of not much historic importance. Some
like Amarogentin have recently received some importance because of antiprotozoal activity.
Andrographolide is being investigated for Anti-Aids activity. Bitter also possesses aromatic
properties due to the presence of volatile oils, e.g.; Citrus aurantium (orange peel). They are
sometimes used as flavoring agents.
Quassinoids
They are triterpenes with a pentacyclic ring system having lactone and methylene-oxygen
ring bridge linking C8 and C13.
Limonoids
They are modified triterpenes with or derived from a precursor with a 4, 4,-8- trimethyl-17-
furanylsteroid skeleton.
Isoflavones (Phyto-estrogens)
Isoflavones are found in Glycine max (soybean). Clinical research has demonstrated soy
isoflavones to be effective in menstrual diseases. They have antioxidant activity also.
Isoflavones belong to a group of compounds known as phyto-estrogens.
Furanocoumarins
Furanocoumarins are photosensitizing agents used in the treatment of pigment disorders.
Ayurveda, the ancient science of India, has described the use of bawachi (Psoralia corylifolia)
Phytochemicals 11
for the treatment of leucoderma. Psoralens isolated from the medicinal herb, are reputed
drugs in the field of dermatology.
Furanocoumarins are formed when furor ring is joined with coumarins. The plants of
Rutaceae, Leguminosae and Apiaceae are rich sources of furanocoumarins. Depending upon
the structure, the furanocoumarins are divided into linear and angular types.
Furanocoumarin containing preparations are used externally as well as internally for
treatment of leucoderma, psoriasis and skin carcinoma.
Furochromones
They are group of coumarins, derived from benzopyrone. They are related to
furanocoumarins and are present in plants of family Apiaceae and Rutaceae.
Hydroxycoumarins
They represent another group of coumarins, which are widely distributed in Apiaceae and
Gramineae.
Glycosides
They are water-soluble constituents, found in the cell sap. They are colourless, crystalline
substances containing carbon, hydrogen and oxygen. Some glycosides are peculiar in having
nitrogen and sulphur. Glycosides are neutral in reaction. Chemically, glycosides contain a
carbohydrate (glucose) and a non-carbohydrate part (aglycone or genin). Alcohol, glycerol
or phenol represents aglycones. A glycoside can be readily hydrolysed into its components
with ferments or mineral acids.
Glycosides differ in their solubility in water. Some are soluble in ether and alcohol.
Amygdalin found in almonds is a familiar example of a glycoside. Benzeldehyde is the
decomposition product of amygdalin, responsible for odour and taste of almonds. Glycosides
are optically active and are levorotatory.
Phenolic Compounds
They are widely distributed in plant flora. They constitute an important part of glycosides
(phenolic glycosides), flavonoids, napthodianthrones and tannins. Acylphloroglucinols are
group of phenolic compounds having significant antidepressant activity.
Phenylpropanoids
They contain a three-carbon side chain attached to phenol. Hyroxycoumarins,
phenylpropenes and lignans are common examples of phenylpropanoids.
Resins
Resins are obtained by oxidization of volatile oils. Resins are brittle, non-volatile, solid
substances. Sometimes resins are among the products of oxidization of terpenes. The chemical
composition of resins is very complex and contains various compounds including acids.
12 Compendia of World’s Medicinal Flora
Resins are soluble in alkalis, alcohol and insoluble in water. They are obtained from plant
exudates and are produced in special ducts.
Oleoresins
They are natural products of resin mixed with volatile oils.
Gum-resins
They are plant exudates and are mixtures of gum and resin and often volatile oils. When gum-
resins are dissolved in water, gum becomes soluble and resin is kept in suspension. Asfoetida
is a familiar example.
Balsams
They are combinations of resins or oleoresins with aromatic acids like benzoic acid or cinnamic
acid or both. They are viscous and obtained from the trunk of certain plants.
Saponins
They are glycosides found in a number of plants. Saponins are regarded as high molecular
weight compounds in which a sugar molecule is combined with triterpene or steroid
aglycone. Saponins have a characteristic feature of frothing. The term saponin is derived
from Saponaria vaccaria; a plant, which abounds in saponins and once upon a time was used
as a soap. Saponins are soluble in water and insoluble in ether. Saponins like glycosides or
hydrolysis give aglycones.
Tannins
They are widely distributed in plant flora. They are phenolic compounds of high molecular
weight. Tannins are soluble in water and alcohol and are found in root, bark, stem and outer
layers of plant tissue. Tannins have a characteristic feature to tan, i.e. to convert the things
into leather. The tannins are acidic in reaction and it is attributed to the presence of phenolic
or carboxylic group. Tannins form complex with proteins, carbohydrates, gelatin and
alkaloids.
Terpenes
They are flammable unsaturated hydrocarbons, existing in liquid form. They are found in
essential oils, resins or oleoresins. They are used as intermediaries for the synthesis of
sesquitrepenes and terpenoids. They are classified as mono, di or triterpenoids.
Sesquiterpenes
They constitute a significant group of phytochemicals. The sesquiterpenes are widely
distributed in plant flora particularly in Compositae.
Phytochemicals 13
Sterols
They are derivatives of steroids. Some chemical constituents present in plant flora resemble
steroids. Modern clinical studies have supported their role as anti-inflammatory and
analgesic agents. Beta-sitosterol is the most commonly studied sterol compound isolated
from a number of medicinal herbs and it has been seen as effective in reducing serum
cholesterol levels.
Withanolides
They are a group of naturally occurring oxygenated ergostane type steroids having lactone
in side chain and 2-en-1-one system in ring A. Withanolides which are considered to be
responsible for various applications of the herb as adaptogen (anti-stress) and
immunomodulator.
Lectins
They are structurally diverse, carbohydrate binding proteins that bind reversibly to specific
mono or oligosaccharides. Abrin and ricin are familiar examples.
FURTHER READING
Alder Wright, Reports on Aconite Alkaloids.
Crozier, A., Lean, M.E.J., Mcdonald, M.S. and Black, C. (1995). Quantitative analysis of the flavonoid content
of commercial tomatoes, onions, lettuce and celery. J. Agric. Food Chem. 45, 590–595.
Evans, W.C. 1989. Trease and Evans’ Pharmacognosy, 13th ed. Baillière Tindall, London, 595–599.
Harper and Row, New York. Medicines Commission (1980a). British Pharmacopoeia. Vol I. HMSO, University
Press, Cambridge.
Hertog, M.G.L., Hollman, P.C.H. and Venema, D.P. (1995). Optimization of a quantitative HPLC determination
of potentially anticarcinogenic flavonoids in vegetables and fruits. J. Agric. Food Chem. 40: 1591–1598.
Kovalskava, N.E. and Sokolova, I.V. (1995). Photophysical Properties of Furocoumarins. Siberian Physical
Technical Institute, 1, Sq. Novo-Sobornaya, Tomsk, 634050, Russia.
Luca, V. and St Pierre, B. 2000. The cell and developmental biology of alkaloid biosynthesis. Trends Plant Sci.
5: 168–173.
MacRae, W.D. and Towers, G.H.N. 1984. Biological activities of lignans. PH. 23(6): 1207–1220.
Manske and Holmes. 1953. The Alkaloids, Vol III, Academic Press.
Schmeller, T. and Wink, M. 1998. Utilization of alkaloids in modern medicine. In: Roberts M, Wink M (eds).
Alkaloids-Biochemistry, Ecology and Medicinal Applications. Plenum Press, New York, 435–459 [review].
The Alkaloids, Vol. 1, R.H.F. 1950. Manske Ed., Academic Press, New York, 33–206.
Watt’s Dict. of Chem., 2nd Ed.
1
Medicinal Algae
SEA WEEDS
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name and name composition onal use research used
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chronic
fatigue,
high cho-
lesterol,
high blood
pressure,
poor imm
immunity,
skin prob-
lems,
allergies,
asthma,
rheuma-
toid dise-
ases and
depres-
sion
Ochromonas Lipids
danica
(Chrysophyceae)
FURTHER READING
Ali, M.S., Saleem, M., Yamdagni, R. and Ali, M.A. 2002 and 2004. Steroid and antibacterial steroidal glycosides
from marine green alga Codium iyengarii.
Borgesen, Nat Prod Lett. 16: 407–413. Mar. Drugs 2: 139.
Beltron, E.C. and Nielan, B.A. 2000. Geographical segregation of Neurotoxin-producing Cyanobacterium
Anabaena circinalis. App and Environ Microbiol. 66: 4468–4474.
Cardillina, J.H. II., Marner, F.J. and Moore, R.E. 1979 and 2004. Seaweed dermatitis: structure of lyngbyatoxin
A. Science. 204, 193–195. Mar. Drugs 2: 137.
Carte, B.K. 1996. Biomedical potential of marine natural products. Bioscience. 46: 271–286.
Medicinal Algae 19
Donia, M. and Hamann, M.T. 2003. Marine natural products and their potential applications as anti-infective
agents. The Lancet. 3: 338–348.
Fan Xu, X.L., Song, X., Zhao, F.H., Han, J.L. and Shi, J.G. 2004. A new bromophenol from the brown alga
Leathesia nana. Chinese Chemical Letters. 15(6): 661–663.
Feldman, S.C., Reynaldi, S., Stortz, C.A., Cerezo, A.S. and Damont, E.B. 1999. Antiviral properties of
fucoidan fractions from Leathesia difformis. Phytomedicine 6(5): 335–340.
Gerwick, W.H. and Fenical, W. 1981. Ichthyotoxic and cytotoxic metabolites of the tropical brown alga
Stypopodium zonale. J Org Chem. 46: 21–27.
Gerwick, W.H., Proteau, P.J., Nagh, D.G., Hamel, E., Blobhin, A. and Slate, D.L. 1994. Structure of cruacin A,
a novel antimitotic, antiproliferative and brine shrimp toxic natural product from the marine
cyanobacterium Lyngbya majusula. J Org Chem. 59: 1243–1245.
Idler, D.R. and Atkinson, B. 1976. Seasonal variation in the desmosterol content of dulse from Newfoundland
waters. Comp Biochem Physiol B. (4): 517–519.
Koehn, F.E., Longley, R.E. and Reed, J.K. 1992. Microcolin A and B, new immunosuppressive peptides from
the blue green alga Lyngbya majuscula. J Nat Prod. 55: 613–619.
Kowalowski, P., Zych, M., Burczyk, J., Smietana, B., Mietana, K., Pabis, T. and Stolarczyk, A. 2001. Cell wall-
carotenoids of the alga Botrydium granulatum Visher (Botrydiaceae-Botrydales), p. 11.
Stevenson, C.S., Capper, E.A., Roshak, A.K., Marquez, B., Grace, K., Gerwick, W.H., Jacobs, R.S. and Marshall,
L.A. 2002. Scytomenin—a marine natural product inhibitor of kinases key in hyperproliferative
inflammatory diseases. Inflammation Res. 51: 112–118.
Vadiraja, B.B., Gaikwad, N.W. and Madyastha, K.M. 1998. Hepatoprotective effect of C-phycocyanin
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Xu, S-H, Ding, L-S, Wang, M-K, Peng, S–L and Liao, X. 2002. Studies on the Chemical Constituents of the
Algae Sargassum polycystum, Youji Huaxue (Chinese J Org Chem) 22: 138–140.
2
Medicinal Fungi
YEAST
FURTHER READING
Adachi, K., Nanba, H. and Kuroda, H. 1987. Potentiation of Host-Mediated Antitumour Activity in Mice by
Beta-glucan Obtained from Grifola frondosa (Maitake), Chem. Pharm. Bull. 35: 262–270.
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Fruit Body of Grifola frondosa (Maitake), Chem. Pharm Bull. 36: 1000–1006.
Balon, T.W., Jasman, A.P. and Zhu, J.S. 2002. A fermentation product of Cordyceps sinensis increases whole-
body insulin sensitivity in rats. J Altern Complement Med. 8(3): 315–323.
Bobek, P. 1991. Cholesterol-lowering effect of the mushroom Pleurotus ostreatus in hereditary
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898.
Brauer, D., Kimmons, T. and Phillips, M. 2002. Effects of management on the yield and high-molecular-
weight polysaccharide content of shiitake (Lentinula edodes) mushrooms. J Agric Food Chem. 50(19): 5333–
5337.
Brodziak, L. 1984. Nutritive value of the mushroom Lentinus edodes (Berk.) Sing. (shiitake) compared with
that of other edible mushrooms. Rocz Panstw Zakl Hig 35(1): 59–62.
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Pharm Bull. (Tokyo) 31(3): 1115–1118.
Kanayama, H. et al. 1986. Studies on the antitumour-active polysaccharides from the mycelia of Poria cocos
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Kawagishi, et al. 1994. Erinacines A, B, C, strong stimulators of nerve growth factor synthesis, from the
mycelia of Hericium erinaceum. Tetrahedron Letters 35(10): 1569–1572.
Kiho, T. 1993. Polysaccharides in fungi. XXXII. Hypoglycemic activity and chemical properties of a
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Kiho, T. et al. 1995. Polysaccharides in fungi. XXXV. Anti diabetic activity of an acidic polysaccharide from
the fruiting bodies of Tremella aurantia. Biol Pharm Bull. 18(12): 1627–1629.
Kiho, T. et al. 1999. Structural features and hypoglycemic activity of a polysaccharide (CS-F10) from the
cultured mycelium of Cordyceps sinensis. Biol Pharm Bull. 22(9): 966–970.
Kim, D.H. et al. 1999. Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.
Biol Pharm Bull. 22(2): 162–164.
Medicinal Fungi 23
Komarova, E.L. and Tolkachev, O.N. 2001. The Chemistry of Peptide Ergot Alkaloids. Pharmaceutical Chemistry
Journal. 35: 504–506.
Kubo, K., Aoki, H. and Nanba, H. 1994. Anti-diabetic activity presents in the fruit body Grifola frondosa
(Maitake). Biol. Pharm. Bull. 17(8): 1106–1110.
Langley, D. 1998. Exploiting the Fungi: Novel Leads to New Medicines. Mycologist 11: 165–166.
Mizuno, T. 1992. Antitumour-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an
edible and medicinal mushroom called yamabushitake or houtou. Biosci Biotechnol Biochem 56(2): 347–
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Mizuno, T., Hagiwara, T., Nakamura, T., Ito, H., Shimura, K., Sumiya, T. and Asakura, A. 1990. Antitumour
activity and some properties of water-insoluble hetero-glycans from “Himematsutake,” the fruiting
body of Agaricus blazei Murill. Agricultural & Biological Chemistry Tokyo 54: 2897–2905.
Takaku, T., Kimura, Y. and Okuda, H. 2001. Isolation of an Antitumour Compound from Agaricus blazei
Murill and Its Mechanism of Action. Journal of Nutrition 131: 1409–1413.
3
Medicinal Lichens
Corsinia Isothiocya-
coriandrina nates
(Corsiniaceae)
FURTHER READING
Asakawa, Y. and Heidelberger, M. 1982. Chemical Constituents of the Hepaticae. Progress in the Chemistry
of Organic Natural Products 42. Wien—New York (Springer).
Basile, A. et al. 1998. Antibiotic effects of Lunularia cruciata. Pharmaceutical Biology 36: 25–28.
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555–566.
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of Hungarian Marchantia polymorpha. Planta Medica. 61: 387–388.
Lorimeres, S.D. et al. 1994. Antifungal Hydroxy acetophenones from the New Zealand liverwort Plagiochila
fasciculata. Planta Medica. 60: 386–387.
Lorimeres, S.D. and Perry, N.B. 1993. An antifungal bibenzyl from the New Zealand liverwort Plagiochila
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Stephan, H. von Reuß and Wilfried A. König. 2005. Olefinic Isothiocyanates and Iminodithiocarbonates from
the Liverwort Corsinia coriandrina. European Journal of Organic Chemistry 6: 1184–1188.
Toyota, M. 2000. Phytochemical study of liverworts Conocephalum conicum and Chiloscyphus polyanthus.
Yakugaku Zasshi. 120(12): 1359–1372.
5
Medicinal Pteridophytes
FERNS
Dicranopteris Flavonoids
pedata
(Gleicheniaceae)
FURTHER READING
Chen, C.C., Huang, Y.L., Yeh, P.Y. and Ou, J.C. 2003. Cyclized geranyl stilbenes from the rhizomes of
Helminthostachys zeylanica. Planta Med. 69(10): 964–967.
Huang, Y.L., Yeh, P.Y., Shen, C.C. and Chen, C.C. 2003. Antioxidant flavonoids from the rhizomes of
Helminthostachys zeylanica. Phytochemistry 64(7): 1277–1283.
Raja, D.P., Manickam, V.S., de Britto, A.J., Gopalakrishnan, S., Ushioda, T., Satoh, M., Tanimura, A.,
Fuchino, H. and Tanaka, N. 1995. Chemical and chemotaxonomical studies on Dicranopteris species.
Chem Pharm Bull. (Tokyo) 43(10): 1800–1803.
Takayama, H., Katakawa, K., Kitajima, M., Seki, H., Yamaguchi, K. and Aimi, N. 2001. A new type of
lycopodium alkaloid, lycoposerramine-A, from Lycopodium serratum Thunb. Org Lett. 3(26): 4165–4167.
Woerdenbag, H.J., Lutke, L.R., Bos, R., Stevens, J.F., Hulst, R., Kruizinga, W.H., Zhu, Y.P., Elema, E.T.,
Hendriks, H., van Uden, W. and Pras, N. 1996. Isolation of two cytotoxic diterpenes from the fern Pteris
multifida. Z Naturforsch [C] 51(9–10): 635–638.
6
Medicinal Gymnosperms
Podocarpus Anti-
totara bacterial
Exploring the Variety of Random
Documents with Different Content
Proper Way to Wrap Papers for Mailing
The Clipped Corners Prevent the Adhesive from Coming in Contact with the
Paper inclosed
A Combination of Pie Tins, Cake Pan, and Stew Pan to Make Temporary Gas-
Stove Oven
A small pie tin was placed in a larger one, as shown; on this was
placed the cake pan filled with the cake batter, and over the whole
was placed the stew pan, which acted as a heat retainer or oven. A
good hot flame was used at first, and was then gradually turned
lower until the cake was finished.—Contributed by Mrs. Anna M. B.
Romig, Allentown, Pa.
Box Cover without Hinges
Sportsmen are interested in rifles and rifle shooting largely from the
hunting standpoint, although target shooting is a favorite sport
with many of them. This discussion of the sporting rifle will be
concerned, therefore, principally with the hunting aspects, other
forms of shooting being considered as good methods of practice,
and the development of skill in the use of hunting weapons. The
novice, as well as the good shot, must have a suitable weapon, and
should have at least a general knowledge of the types of rifles
available, and their common uses. A number of representative types
of rifles are shown in Fig. 1, and the details of the breech
mechanisms and sights in Fig. 2. Targets and a homemade device
for backing them are shown in Fig. 3. The full-page illustration shows
several positions in the use of the rifle; a moving-target arrangement,
to be constructed by the ambitious shot; a diagram of the trajectory
of a rifle bullet, and several diagrams of the vital shots, in hunting
common big game.
The single-shot rifle, shown at A, Fig. 1, has been largely
supplanted by the repeater and the automatic, so far as hunting is
concerned. For use exclusively in indoor shooting, a heavy rifle of
the “Schuetzen” type is best suited. A high-grade ornamented rifle of
this type is shown in the headpiece of this article.
The most popular type of American rifle is the repeater of the
lever-action variety, shown at B. The lever action embodies many
good points: quickness of fire, ease of operation, freedom from
jamming at a critical moment, strength, and plenty of stopping power.
The mechanism of the lever-action repeating rifle is shown in detail
at J, Fig. 2, and that of the falling-breech-block type of single-shot
rifle, at K. Several other types of lever-action rifles are shown in Fig.
1.
Almost all lever-action repeaters are of the tubular-magazine type,
the magazine extending under the barrel, sometimes the full length
—full magazine; or halfway—half magazine. Rifles of these types are
shown at B and C, and a hammerless repeater at D.
The trombone, or pump-action, repeating rifle, shown at E, has a
mechanism similar to that used in the repeating shotgun, the sliding
forearm loading and ejecting the cartridge. The merit of the military
bolt-action rifle lies in its great strength and simplicity. A weapon of
this type was used by Roosevelt in Africa, and by other big-game
hunters. It is shown at F.
The chief advantages of the automatic rifle, shown at G, which is a
comparatively new weapon, are its speed in firing and its almost
noiseless action. This rifle has a recoil-operated action of the blow-
back type. That shown at H has a box magazine, and the automatic
action is based on the sliding of the barrel within a steel jacket. The
rifle shown at I may be used either as an automatic or as a pump-
action weapon.
The subject of stock and trigger adjustment is one to which every
experienced rifleman devotes considerable attention. The regular
stock rifle is built to standard dimensions, and often the stock is
found a trifle short. For the man of average reach, a 13³⁄₄-in. stock,
with a 1⁷⁄₈-in. drop at the comb, and about 3 in. drop at the heel, will
be found satisfactory.
Fig. 1
Rifle sights are of several types, of which there are in turn many
variations. Only the essentials of the standard types will be
considered. The regulation open sights, with which most rifles are
fitted at the factory, are the buckhorn rear and the Rocky Mountain
front sight. For a hunting rifle the most satisfactory sights are a gold-
bead front sight of about ³⁄₃₂-in. diameter, as shown in Fig. 2 at L; a
folding-leaf rear sight, shown at O, P, and Q, and a combination rear
aperture sight, at M and N, mounted on the tang of the rifle. An arm
so sighted is useful for all kinds of shooting. The combination rear
sight is used in deliberate shots at a target or at game, and the
folding-leaf sight is better than the buckhorn for quick snap shooting.
The sportsman who wishes to master the use of a rifle must have
a knowledge of the trajectory of such weapons, and particularly of
the rifle he uses regularly. He must know, also, how to aline the
sights correctly to get satisfactory results. The trajectory is the path
which the rifle bullet takes in passing from the muzzle of the rifle to
its mark. The force of gravity acts upon the bullet in flight and the
result is that the trajectory is curved, as indicated in the diagram at
the bottom of the page illustration. A relatively low trajectory is, of
course, desirable in a hunting rifle. The black-powder, or slow-speed,
cartridge has a relatively high trajectory, while the high-power
smokeless cartridges have relatively low trajectories.
The adjustment of the sights of a rifle is also of much importance.
Every rifle is targeted at the factory, but this may be done by a fair
shot, using the following method: Arrange three boxes, so that the
rifle barrel may rest upon one, and the arms of the marksman upon
the other two. Place a bag of sand upon the box, so that the barrel
may rest upon it, about 6 in. from the muzzle. Put the target into
place, and adjust the sights for 100 yd. If the sights are properly lined
up, the shots should fall quite regularly within a 10-in. circle. With
peep, or other target, sights, much finer results will be obtained. In
moving the sights it must be remembered that to move the rear sight
to the right will bring the shot to the right, and vice versa, while if the
front sight is moved to the right, the arm will shoot to the left. In
making the test, first adjust the front sight so that it is in exact
alinement with the center of the barrel, and then all corrections may
be made by moving the rear sight.
The proper way to sight a rifle is to hold the front sight just clear of
the notch in the rear sight, with the front bead barely touching the
outer ring of the bull’s-eye, at the extreme bottom. This is shown at
R, Fig. 3. It is the rule of good rifle shot to “see daylight between the
sight and the bull’s-eye.” In any event, do not cover up the front sight
by drawing it down into the notch of the rear sight, so that only the
top of the bead is visible. Another frequent error is to hold the front
sight to cover the bull’s-eye.
The Off-Hand, Knee-Support, and Prone Positions in Shooting should be
Mastered by the Sportsman. The Diagrams Represent Several Vital
Shots, the Moving Target, and the Trajectory of a Rifle Bullet
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