Question Paper

Exam Date & Time: 17-Mar-2023 (02:00 PM - 05:00 PM)

SHRI DHARMASTHALA MANJUNATHESHWARA UNIVERSITY

MBBS Second Professional Year Resit Examination during March-2023

Subject: Pathology Paper I
QP Code: MU0203
Date of Exam: 17/03/2023/ Friday
Time of Exam: 02:00 PM to 05:00 PM
Pathology Paper I [MU0203]
Marks: 100 Duration: 180 mins.

MCQ
Answer all the questions.
1. Draw Neat Labelled diagrams wherever necessary
2. Your answers to be specific to the Questions
3. Read the Questions Carefully before you start writing
4. Please choose only Blue colour ink to write the answers.
5. Other colours from the paint option can be used for drawings only.
6. Choose yellow colour for text highlighting.
7. Choose Ruled page template if you are not able to write in Unruled page properly in a straight line

1 Reversible change in which one differentiated cell type is replaced by another cell type is called (1)
Hyperplasia Metaplasia Dysplasia Anaplasia

2 The wear and tear pigments are (1)

Lipofuscin Melanin Bilirubin Hemosiderin

3 The following is an eicosanoid (1)

Histamine Serotonin Prostacyclin Interleukin-1

4 Fibrinoid necrosis is a type of necrosis seen in (1)

Acute Pancreatitis Chronic Pancreatitis Vasculitis Granuloma

5 Activation of caspases is the mechanism of (1)

All of
Necrosis Apoptosis Necroptosis
these

6 The Governor of the genome (1)

TP 53
RB gene APC gene WTI gene
gene

7 The following is a RNA oncogenic virus (1)

HTLV-1 HPV HBV EBV

8 Disorganized or jumbled up masses of tissue composed of cells usually found at the site of origin (1)
is called
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 Choristoma Hamartoma Teratoma Sarcoma

9 BCR-ABL gene is seen in ____ leukaemia (1)

Chronic Acute
Chronic lymphoid Acute lymphoid
myeloid myeloid

10 Microscopic examination of a gastric ulcer shows angiogenesis, fibrosis, and mononuclear cell (1)
infiltrate with lymphocytes, macrophages, and plasma cells. Which of the following terms
describes the pathologic process?
Acute inflammation Serous inflammation Fibrinous inflammation Chronic inflammation

11 Grenz zone is a typical histopathological finding seen in (1)

Tuberculoid leprosy Tuberculosis Lepromatous leprosy Actinomycosis

12 Lines of Zahn are seen in (1)

Post-mortem clots Thrombus Fat necrosis Infarction

13 Auto-splenectomy is seen in (1)

Thalassemia Sickle cell anaemia Myelofibrosis Megaloblastic anaemia

14 'M' protein elevation in serum is seen in (1)

Hodgkin Acute myeloid Non-Hodgkin
Multiple myeloma
lymphoma leukaemia lymphoma

15 Anaphylaxis is an example of ____hypersensitivity (1)

Type Type
Type II Type III
I IV

16 Amyloidosis associated with clonal plasma cell proliferation is called as____ amyloidosis (1)
Localised Primary Secondary Familial

17 A serum marker that is elevated in hepatocellular carcinoma and non-seminomatous germ cell (1)
tumours of testis
Carcinoembryonic
Alfa-fetoprotein CA-125 CA-19.9
antigen

18 The lacunar variant of Reed Sternberg cell is seen in (1)

Lymphocyte
Lymphocytic predominant Lymphocyte depletion Nodular sclerosis
rich

19 Auer rods are seen in (1)

Lymphoblast Plasmablast Myeloblast Erythroblast

20 White infarct is seen in all except (1)

Heart Spleen Kidneys Lung

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 Long essay
Answer all the questions.

21 A 50 years / male vegetarian on treatment with antiepileptic medications, presented with pallor, (10)
paraesthesia of extremities O/E he had beefy tongue.

a) What is your diagnosis?

b) How will you investigate this patient further and establish the diagnosis.

c) Define and classify pathophysiological causes of anaemia.

(2+4+4= 10 Marks)

22 25 years male RTA victim presented with rapid pulse, cold clammy cyanotic (10)

skin, tachypnoea and landed in emergency ward in unconscious state

a) What is the diagnosis?

b) Classify the disease and write in detail about the pathogenesis and evolution of the disease.
(2+3+3+2= 10Marks)

Short Essay
Answer all the questions.

23 Discuss factors affecting wound healing (5)

24 Describe cellular events of inflammation. (5)

25 Von Willebrand's Disease (5)

26 Tabulate differences between benign and malignant tumours (5)

27 Discuss mechanisms of Type II Hypersensitivity reactions (5)

28 Tabulate differences between transudate and exudate with examples (5)

29 Discuss sequential stages of Chemical Carcinogenesis with an example (5)

30 A friend of yours has been diagnosed with Hodgkin's lymphoma. How will you empathise with (5)
him and his family members & support them?

Short Answers
Answer all the questions.

31 Name four indications for bone marrow aspiration (2)

32 Enumerate four conditions for raised ESR (2)

33 Differences between dry gangrene and wet gangrene (2)

34 Name four opportunistic infections in AIDS (2)

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35 Red Blood Cell Indices with Normal Values (2)

36 Fate of Thrombus (2)

37 Name four examples of Autosomal Dominant Disorders (2)

38 Special Stains used for amyloid (2)

39 Bombay Blood group (2)

40 Uses of Buffy Coat (2)

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Question Paper
Exam Date & Time: 20-Mar-2023 (02:00 PM - 05:00 PM)

SHRI DHARMASTHALA MANJUNATHESHWARA UNIVERSITY

MBBS Second Professional Year Resit Examination during March-2023

Subject: Pathology Paper II
QP Code: MU0204
Date of Exam: 20/03/2023/ Monday
Time of Exam: 02:00 PM to 05:00 PM
Pathology - Paper II [MU0204]
Marks: 100 Duration: 180 mins.

MCQ
Answer all the questions.
1. Draw Neat Labelled diagrams wherever necessary
2. Your answers to be specific to the Questions
3. Read the Questions Carefully before you start writing
4. Please choose only Blue colour ink to write the answers.
5. Other colours from the paint option can be used for drawings only.
6. Choose yellow colour for text highlighting.
7. Choose Ruled page template if you are not able to write in Unruled page properly in a straight line

1 Which testicular tumour demonstrates lymphocytes in the stromal fibrous bands (1)
Embryonal Yolk sac
Seminoma Choriocarcinoma
carcinoma tumour

2 Marker of hepatitis- B carrier state is: (1)

IgM anti-
HBs Ag HBc Ag HBe Ag
HBc

3 Cirrhosis in Wilson 's disease is related to: (1)

Zinc Copper Mercury Iron

4 Pyogenic osteomyelitis is most commonly caused by (1)

E-coli Klebsiella Staphylococcus aureus Streptococci

5 Most common sarcomas of adulthood (1)

Malignant peripheral nerve sheath
Liposarcoma Rhabdomyosarcoma Leiomyosarcoma
tumor

6 Most common site of Medulloblastoma is (1)

Cerebellum Cerebrum Pons Medulla

7 Genes responsible for familial breast carcinomas are: (1)

TP53 BRCA1 BRCA2 All of the above

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8 A patient with chronic pelvic pain undergoes a hysterectomy. The resected uterus is filled with (1)
nodules composed of benign smooth muscle cells. Which of the following terms best describes
these nodules?
Angiosarcoma Leiomyoma Leiomyosarcoma Rhabdomyoma

9 Most important autoantibody produced in Graves' disease is (1)

Anti TPO Anti- Anti TSH receptor (thyroid stimulating None of the

Ab thyroglobulin immunoglobulin) above

10 Which of the following is used to measure control of blood sugar in diabetes mellitus? (1)
HbA
Hb A Hb S Hb A2
1C

11 Most common cause of Abdominal Aneurysm is (1)

Atherosclerosis Trauma Marfan's syndrome Congenital

12 Which type of endocarditis has vegetations on both sides of the valve (1)
Infective endocarditis Libman-Sacks endocarditis Rheumatic fever None of the above

13 Tuberculosis can occur due to all except (1)

Inhalation of airborne Exposure to contaminated Drinking milk contaminated Fetomaternal

organism in aerosols secretion of infected persons with mycobacterium bovis transmission

14 Asbestosis refers to (1)

Asbestos exposure with Asbestoses bodies are copper Begins in
Pleural plaques are the
smoking causes lung containing proteinaceous lower lobe of
most common findings
cancer material lungs

15 Histopathological difference between Barret's epithelium and gastric mucosa (1)

Barret's mucosa is Barret's mucosa is Barret's mucosa is alcian Gastric mucosa is

acidic and stains with alkaline and stains with blue negative, because it alkaline and stains

alcian blue prussian blue is neutral with alcian blue

16 Hirschsprung's colon is due to (1)

Muscle atrophy in muscularis Loss of intrinsic enteric Loss of extrinsic nerve Mucosal

mucosa plexus supply atrophy

17 Most common site for Carcinoma Colon is (1)

Transverse Ascending
Cecum Rectosigmoid colon
Colon Colon

18 Most common tumor of Salivary Gland (1)

Pleomorphic
Adenoid Cystic Carcinoma Warthin Tumor Mucoepidermoid Carcinoma
Adenoma

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 19 Adenocarcinoma are: (1)
Atypical adenomatous
Peripheral Histologically neoplastic cells show All of the
hyperplasia is the precursor
located lesion acinar and papillary pattern of growth above
lesion

20 Histomorphological features of Hashimoto's thyroiditis: (1)

Diffusely enlarged Mononuclear infiltrate with germinal center Presence of Hurthle All of the

gland formation cells above

Long essay
Answer all the questions.

21 55 years old patient presented with retrosternal pain radiating to the left arm, dyspnoea and (10)
sweating of sudden onset. Patient is a known smoker for last 20 years. (2+3+3+2= 10 marks)

a) What is the provisional diagnosis?

b) Write in detail about the morphological changes of the organ involved?

c)Write the biochemical markers indicative of the condition?

d) Mention the complication of the disease?

22 Describe the aetiology of hepatitis. Describe the etiopathogenesis and laboratory findings in viral (10)
hepatitis. Enumerate the complications and consequences of Hepatitis. (2+6+2=10 Marks)

Short Essay
Answer all the questions.

23 Mention four premalignant lesions of skin. Explain the gross and microscopy of Squamous cell (5)
carcinoma.

24 Pathogenesis and microscopy of retinoblastoma (5)

25 8years old male, Complains of fever, pain, tenderness in the right lower limbs -2weeks. O/E (5)
Multiple discharging sinuses. Laboratory test: Leucocytosis and Blood culture is positive. Identify
the disease.? Mention the etiopathogenesis of this lesion?

26 Discuss the complications of type 2 Diabetes mellitus (5)

27 Describe the prognostic and predictive factors for breast carcinoma (5)

28 Distinguish the features of Ulcerative colitis and Crohn's disease (5)

29 Mention the differences between Nephrotic syndrome and Nephritic syndrome. (5)

30 Pathogenesis and microscopy of Benign Prostatic hypertrophy. (5)

Short Answers
Answer all the questions.

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31 Mention four complications of peptic ulcer (2)

32 Differences between direct and indirect Hyperbilirubinemia. (2)

33 Mention the stages of pneumonia (2)

34 Draw and label Aschoff's nodules of Rheumatic heart disease (2)

35 Mention the types of kidney stones (2)

36 Draw and label the microscopy of lipoma. (2)

37 Endometriosis (2)

38 Draw the microscopy of fibroadenoma (2)

39 Mention types of thyroid carcinoma (2)

40 Mention four causes of meningitis. (2)

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