SANTHIRAM COLLEGE OF PHARMACY

(AUTONOMOUS)
Indo-Caribbean International Conference on
Innovations in Drug Design, Development, Analysis & Patient Care - A Synergizing Science & Practice with Association of Pharmacy Professionals

TITLE OF PRESENTATION: Pharmacogenomics in precise medicine

AUTHORS: M. Pavan naik Conf. Code:
001
DEPT: Pharmacology
COLLEGE NAME: Santhiram college of pharmacy
ABSTRACT: (b) Genotyping: This method analyzes specific genetic markers known to DISCUSSION:
Pharmacogenomics , By identifying genetic influence drug metabolism, such as SNPs (Single Nucleotide Pharmacogenomics is a rapidly evolving
variations that affect drug metabolism, Polymorphisms) in genes like CYP2C19 (which affects clopidogrel field that plays a critical role in the
efficacy, and toxicity, pharmacogenomics metabolism). development of precision medicine, which
enables the development of tailored 2. Ethnogenomics : seeks to tailor medical treatment to the
therapeutic strategies, optimizing drug Ethnic and Population-Specific Variations: Certain genetic variants are individual characteristics of each patient,
treatments for individuals based on their more common in specific populations, influencing drug response. including their genetic makeup. This
genetic profiles. Pharmacogenomic studies that consider ethnicity help identify population- integration of pharmacogenomics into
specific recommendations for drug selection and dosing. clinical practice promises significant
INTRODUCTION : Pharmacogenomics is a
3. Therapeutic Drug Monitoring (TDM) : improvements in drug efficacy, safety, and
field of study that examines how an
Personalized Dosing: By combining genetic testing with TDM, doctors overall therapeutic outcomes.
individual's genetic makeup influences their
can adjust drug dosages based on how a patient's genetic makeup affects
response to drugs. It combines CONCLUSION: By identifying genetic
drug metabolism and response, optimizing treatment and minimizing side
pharmacology (the study of drugs) and variations that affect drug metabolism,
effects.
genomics (the study of genes) to understand efficacy, and safety, pharmacogenomics
the genetic factors that affect drug efficacy, RESULTS: allows clinicians to prescribe the right drug
metabolism, and toxicity. In the context of at the right dose for the right patient, thereby
precision medicine, pharmacogenomics improving therapeutic outcomes and
plays a pivotal role by enabling reducing the risk of adverse drug reactions.
personalized treatment plans tailored to
each patient’s genetic profile This approach REFERENCE:
aims to optimize drug therapy, minimize 1.Roden, D. M., & Van Driest, S. L. (2019).
adverse effects and improve overall clinical Pharmacogenomics and Personalized
outcomes. Medicine.
2. Shah, R. R., & Morgan, M. Y. (2014).
METHOD:
Pharmacogenomics in Clinical Practice:
1.Genetic testing :
The Future of Personalized Medicine.
(a) DNA Sequencing: Technologies like
1.
Next-Generation Sequencing (NGS) enable
detailed analysis of a person's entire ACKNOWLEDGEMENT: I Would like to
genome or exome, identifying specific express sincere gratitude for organinizing
genetic variations that may affect drug this conference
efficacy and safety.
1
Presented at the Indo- Caribbean International Conference held at SRCP, on 7th March 2025