LHALA Doctor

Medical Skincare
Ulva Linza Carbon Quantum Dots and Their Manufacturing Method (KR: 10-2019-0025669)
Metal-Organic Composite Particles and Compositions Containing Metal-Organic Composite Particles (KR: 10-2021-0192388)
Chemical Composition for Skin Peeling Agents with Anti-inflammatory and Skin Barrier Improvement Functions (KR: 10-2024-0109462)

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor

Breaking the limits of peeling once again.

5th generation peeling, LHALA Doctor

INCUBE 501 INCUBE 701(PLLA) Calcium QPT

LHA Lipid H2sol

Volume : 10ml / 0.35fl.oz

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor, Filling, not Pilling

Remove(-) & Add(+) 5th generation peeling, LHALA Doctor

－ INCUBE 501 ＋ INCUBE 701 PLLA

remove the inflammatory triggers
－ INCUBE 501 Collagen-filling

LHALA Doctor

① Cytokine ② Fibroblast ③ Wound healing

absorption migration

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor Core Technology

1. INCUBE Patented 2. QPT patented 3. INCUBE

technology technology PLLA manufacturing
technology

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – 1. INCUBE Patented Technology

InCube Technology InCube Key features of the technology

Selective absorption Controlled release

(selective separation/removal) (controlled amount, rate of
release)

Definition of INCUBE technology

- Platform technology that can selectively store, protect, and control the release of desired substances (ingredients) and materials using it
- As an apartment-type carrier made through intermolecular distance control technology, it holds and releases various substances such as drugs, proteins, viruses, and cells.

Main functions of INCUBE

Selectively store the substances (ingredients) you want, protect them from the environment, and design their release in the way you want

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – 1. INCUBE Patented Technology

Active substance concentration 58 mM Active substance concentration 60mM Active substance concentration 63mM

Active substance absorption (mg/g)

Active substance absorption (mg/g)

Active substance absorption (mg/g)

Metal Organic Metal-Organic Metal Organic Metal-Organic Metal Organic Metal-Organic
Composite Particles Framework Composite Particles Framework Composite Particles Framework
기존 물질 기존 물질
INCUBE Conventional substances INCUBE Conventional substances INCUBE Conventional substances

Patent details of INCUBE technology (Proof of INCUBE’s drug loading capabilities)

- INCUBE has the characteristic of controlling the concentration of active substances and regulating absorption, compared to conventional drug delivery systems.
- Active substances in INCUBE are absorbed and protected in the internal pores to preserve the titer of the active substance
- Depending on the design and application method of the material, INCUBE enables immediate release, delayed release, sustained release, and stimulus-
responsive release.

Patent Information
- Metal-Organic Framework Particles and Compositions Containing Metal-Organic Framework Particles (KR:10-2021-0192388, PCT: KR2022/000539)
- Metal-Organic Framework Particles Capable of Adsorbing, Storing, or Releasing Two or More Functional Substances, and Compositions Containing Them
(KR: 10-2022-0089639, PCT: KR2023/009884)

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor – 2. QPTTM Patent Technology

5th generation QPT - Ulva Linza Carbon Quantum Dot

Unlike other quantum dots, marine CQDs absorb and react to different UV protection tests using PVA film
Carbon quantum dots (CQDs)
organism (Ulva Linza) based CQDs color properties depending on their and polydiacetylene solution
are nm-sized carbon
are non-toxic and safe to use on all wavelength. LHALA Dr. contains confirmed that CQDs have UV
nanoparticles that show
skin types. CQDs based on marine organisms protection properties.
promising results in the
CQD photothermal therapy helps to (Ulva Linza), which absorb and Prevent UV sensitivity after peeling
medical field.
achieve a fast, effective and painless transmit energy and work best when treatments.
procedure. combined with a laser or LED device.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – 3. INCUBE 701 - PLLA Particle Manufacturing Technology

PLLA raw material scanning electro microscpe (SEM) analysis LHALA DOCTOR (PLLA raw material) SEM analysis

Possesses technology for manufacturing uniform spherical PLLA particles (30-80µm)

- Setting the particle size to 30-80µm to prevent inflammation(phagocytosis) caused by macrophages and the formation of nodules/granulomas.
- Uniformly manufactures spherical PLLA with a size of 30-80㎛ through in-house developed manufacturing equipment.
- Excellent uniformity of particle size and shape compared to other PLLAs.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – 3. PLLA Particle Manufacturing Technology

Reference-1: PLLA particle shape and particle size setting rationale (30-80μm)

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – 3. PLLA Particle Manufacturing Technology

Reference-2: PLLA particle shape

and particle size setting rationale
(30-80μm)

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – 3. PLLA Particle Manufacturing Technology

Reference-1: PLLA particle shape and particle size setting rationale (30-80μm)

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – INCUBE 501

INCUBE 501
treatment

Source : Zirconium-Based Metal-Organic Framework Capable of Binding Proinflammatory Mediators in Hydrogel Form Pro
motes Wound Healing Process through a Multiscale Adsorption Mechanism. 2023

INCUBE 501 inhibits inflammation by removing excess inflammatory substances (cytokines, reactive oxygen species, NO),
thereby suppressing inflammation, promoting natural regeneration, and aiding in wound healing.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor – INCUBE 501

Inhibit inflammation by removing

Cytokine
Eliminate inflammatory triggers
sorption
Scavenge Nitric oxide inflammation
free radicals uptake When inflammatory substances are produced in
and wound excess, it adsorbs them to suppress
triggers when inflammation and regenerate skin.
overproduced

Promote natural regeneration

Maintains proper levels of cytokines, ROS,

and NO, stimulating natural regeneration

Inhibit wound formation by inhibiting

epithelial cell overproliferation

Inhibit wound formation by removing

substances that trigger epithelial cell
overgrowth

References: Advanced Healthcare Materials, 2024, 13, 7 (IF=10) & In Vivo, 2023, 38,1, 235-245

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor Key ingredients

INCUBE
INCUBE
701 + QPT + H2solTM + Calcium + Lipid LHA
501 + +
(PLLA)

Fibroblast activation,
Inhibits inflammation, Uniform Spherical PLLA, Excellent for Strengthens skin barrier, Protective film for Developed by
Collagen
wound healing, PLLA Particle combined laser and anti-inflammatory, damaged skin L'Oréal
remodeling
Promotes natural Manufacturing LED procedures Reduces fine lines and Exfoliates without
regeneration Technology wrinkles irritation

- LHA, patented ingredient H2sol TM(alkaline natural fermentation product conjugate) and patented technology
- First new 5th generation peeling product combining INCUBE technology with PLLA particle technology

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – INCUBE 501

INCUBE-501 Suppress Fibroblast Promotes

Containing inflamma migration natural
Products tion regeneration

Effectiveness of InCube-501 technology

By removing excessive inflammatory substances (cytokines, free radicals, NO), it inhibits inflammation and promotes natural
regeneration by promoting fibroblast migration
References : Advanced Healthcare Materials, 2024, 13, 7 (IF=10) & In Vivo, 2023, 38,1, 235-245

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor – INCUBE 501

Using the surface charge of INCUBE-501, excess cytokines are absorbed.

INCUBE-501

INCUBE-501 INCUBE-501 INCUBE-501 INCUBE-501 INCUBE-501

References : Advanced Healthcare Materials, 2024, 13, 7 (IF=10) & In Vivo, 2023, 38,1, 235-245
* This material is confidential and any unauthorized use is strictly prohibited.
* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor – INCUBE 501

Using the surface charge of INCUBE-501, excess NO/ROS are absorbed.

w/o INCUBE-501

 INCUBE-501
 INCUBE-501+Nitrite
INCUBE-501

INCUBE-501
INCUBE-501

 INCUBE-501+TMB+H2O2
 w/o INCUBE-501 INCUBE-501 INCUBE-501
 w/o H2O2

INCUBE-501

INCUBE-501

References : Advanced Healthcare Materials, 2024, 13, 7 (IF=10) & In Vivo, 2023, 38,1, 235-245
* This material is confidential and any unauthorized use is strictly prohibited.
* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor – INCUBE 501

Experimental data on INCUBE-501's promotion of fibroblast migration

INCUBE-501 promotes fibroblast migration

(higher concentrations increase fibroblast migration area)
References : Advanced Healthcare Materials, 2024, 13, 7 (IF=10) & In Vivo, 2023, 38,1, 235-245

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor – INCUBE 501

INCUBE 501 Scientific Presentation - Scar Inhibition

In Vivo, 2023, 38,1, 235-245

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party. INCUBE Patent-Holding Company: LabInCube
 LHALA Doctor – INCUBE 501

Publish a paper Patent applications Technology transfer Internationalization

관련특허의 해외 각국진입 of patents
U.S. Patents

European Patent

Chinese patent
Technology PR

Japanese
Patent

Healing skin wounds without antibiotics and Skin wound recovery within 2 weeks... confirmed
without scarring through animal testing

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – INCUBE 701(PLLA)

Uniformly spherical PLLA particle manufacturing technology promotes collagen production and demonstrates excellent skin regeneration
effects

Conventional PLLA INCUBE 701 LHALA Doctor PLLA

1.If the particle size is not uniform, it fails to stimulate surrounding fibroblasts, leading to a reduced effect on collagen synthesis.
2.Since the particle size varies depending on the application area (epidermis, dermis, fat layer, etc.), various size control techniques
are required.
3.Most PLLA fillers are amorphous, and injecting them in a spherical porous form reduces clogging issues.
4.It is in L-FORM, which has a faster biodegradation rate and a greater effect on promoting collagen formation.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – H2solTM Skin peeling composition with anti-inflammatory and skin barrier improvement functions, Patent KR: 10-2024-0109462

ALKALI, H2sol 's patented formulation of natural ingredients has been proven to have high keratin and melanin dissolving capabilities.

0.16

1.
Skin exfoliation Pigmentation Transparency
Improvement Improvement Improvement
The results of evaluating the keratinolytic 0.14
efficacy through the measurement of
keratin degradation ability. 0.12
0.1

2.
The results of evaluating the skin 0.08
transparency improvement efficacy
through the measurement of melanin 0.06
dissolution ability.
0.04
0.02

3. The results of evaluating the keratolytic

efficacy through the measurement of
keratin degradation ability.
0
0% 1% 5% 10%
The results of evaluating the efficacy of improving
skin pigmentation through the measurement of
melanin dissolution ability

It stimulates the epidermis while inducing fibroblast activation with deep penetration. It protects the skin surface and creates a skin barrier of proteins and
lipids, remodeling collagen and connective tissue.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Calcium

Source: "The Effect of Epidermal Calcium Gradient Changes on the Differentiation of Keratinocytes.
Ph.D. Dissertation, Yonsei University Graduate School, 2000. Hwang, Sangmin.

Calcium purity 100%, excellent efficacy.

Calcium inhibits inflammation within the skin, activates skin cells to make skin more resilient and strengthens the skin barrier.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Calcium

Effects of Calcium on the Epidermis in a Skin Organ Culture

Calcium plays a crucial role in the process of

epidermal differentiation.

induces the differentiation of keratinocytes

Research conducted with the support of the Ministry of Health and Welfare's Health and Medical Technology Development Program.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – LHA (Lipo Hydroxy Acid)

LHA improves wrinkles by 137% compared to AHA LHA reduces pigmentation by 135% compared to AHA

(1) LHA is a substance developed by L'Oreal corp.

Capryloyl Salicylic acid, a new substance, slowly and surely penetrates the basal layer to exfoliate (2) Unlike conventional acids that simply forcefully break the
dead skin cells through a process similar to natural exfoliation, while alkali effectively dissolves the bonds of corneocytes, LHA modulates trans-membrane
skin, inducing dermal layer regeneration and protecting and normalizing the skin barrier safely and glycoproteins with its unparalleled lipophilicity and slow
without irritation. penetration rate, allowing for cleaner, more even exfoliation
without irritation.
(3) LHA stimulates epidermal renewal and regeneration of
the extracellular matrix.
(4) LHA reduced the frequency of melanosome clusters and
significantly increased basal epidermal thickness.
(5) LHA has antibacterial effects that improve skin
conditions with high comedo.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor Clinical test completed

Skin safety Exfoliation Antibacterial Skin radiance Skin

Human application improvement Human application Human application brightness
test completed test completed
test completed Human application (tone)
test completed Human application
test completed

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor LHALA Peel VS LHALA Doctor

LHALA Doctor' shows 39.2% better exfoliation effect compared to LHALA Peel.

Before product use After one use of the product

Exfoliation improvement assessment

LHALA
Doctor
(Test group)

LHALA Peel
(Control
Before After one use After one use group)
Before
product use of the product of the product
product use
LHALA Doctor LHALA Peel
Exfoliation improvement result graph Exfoliation improvement image

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor LHALA Peel VS LHALA Doctor

LHALA Doctor shows a 58.6% improvement in radiance compared to LHALA Peel

Table 5. Results and statistical analysis of skin radiance

Before
LHALA product use
Doctor
(Test group) After one use
of the product

Before
LHALA Peel product use
(Control
group) After one use Before After one use Before After one use
of the product product use of the product product use of the product
LHALA Doctor LHALA Peel
¹ If p<0.05, there is a significant difference compared to before
product use. Figure 3. Skin radiance result graph
Deviation,
² An increase in the average value (rate of change ▲) indicates Significance
(Mean
improvement in skin radiance. probability

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor LHALA Peel VS LHALA Doctor

LHALA Doctor shows a 115.7% improvement in brightness compared to LHALA Peel.

Before product use After one use of the product
Skin brightness (tone) assessment

LHALA
Doctor
(Test
group)

LHALA Peel
Before Before After one use (Control
After one use
product use of the product product use of the product group)

LHALA Doctor LHALA Peel

Figure 4. Skin brightness (tone) result graph

Deviation,
(Mean Significance
probability Skin brightness (tone) image
* This material is confidential and any unauthorized use is strictly prohibited.
* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Usage Order and How to Use
* LHALA Doctor Premium protocols
LHALA Foam → LHALA Ole(LHALA puff) → LHALA Doctor(LHALA puff) → Laser → Mummy (moisture) 10 min + LED → remove → LHALA Triple C+ 라라10(LDM) →
LHALA Gelmask + LHALA 10(LDM) → LHALA Ole → completion

LHALA Foam LHALA Ole(LHALA puff) LHALA Doctor(LHALA puff) laser or procedure

Mummy (moisture) 10 min + LED LHALA Triple C+ 라라10(LDM) LHALA Gelmask + LHALA 10(LDM) LHALA Ole(puff) → completion

* How to Use
Apply appropriate amount (2-3ml) with LHALA puff or peeling brush and wipe with lukewarm water or wet sponges after 10 minutes.
※ Be sure to shake before use
* This material is confidential and any unauthorized use is strictly prohibited.
* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Why use LHALA Ole and LHALA Doctor together?

* LHALA Ole and LHALA Doctor : A Perfect Match

INCUBE 501, sodium hyaluronate in LHALA Ole , helps to reduce inflammation, strengthen the skin barrier, and
promote natural regeneration by protecting the skin from pro-inflammatory factors (such as fine dust, UV rays, free
radicals, and air pollution) prior to all treatments and peels, and helps to safely support the effects of peels and laser
procedures.

* Skin Top Coat ' LHALA Ole'

"Why is it that the skin, which has well-developed sensory receptors, is not given protective
coating? When receiving nail care or hair perm treatments, a base coat is applied before the main
treatment... Why is it that the skin, despite being sensitive, is not given protective coating?"

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Precautions

• Please check if the client has had any other peels or treatments within the last 1-2 weeks.
Pre-treatment
Avoid saunas and at-home peels before and after the procedure.
checklist
•

• Avoid shaving on the day of the procedure, as it may cause irritation.

Be sure to check for any wounds or sensitive areas in the treatment area.
• It is recommended to use Lara Puff and avoid using other sponges or nylon brushes (use the
dedicated brush).

• Recommend washing face with water only until the next morning.
Post-treatment • Immediately after the procedure, it is better to apply nourishment (ampoules, masks) rather
checklist
than makeup as the skin channels are still open.
• Avoid cosmetics containing alcohol (especially perfumes, mists, aftershaves, etc.) as they can
be irritating, especially wiping with cotton pads or home care peels
• As the skin's renewal cycle normalizes, hidden allergies or acne may surface. This is a
completely normal reaction.
• For one week after the procedure, please avoid saunas, Jjimjilbang, alcohol, smoking, and
intense exercise, as they may slow down the regeneration process.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Before & After

after one session of LHALA Doctor

Redness and inflammation improvement

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Before & After

after three sessions of LHALA Doctor

Whitening enhancement,
redness improvement,
skin tone-up,
texture improvement
* This material is confidential and any unauthorized use is strictly prohibited.
* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA Doctor – Q&A

Q. What is the frequency of the treatment?

A. When LHALA Doctor is used alone, treatments are intervals of 1 week. If you combine it with other lasers, you can do it
according to the interval of laser treatment.

Q. I developed more acne after the treatment. Is this a side effect?

A. The treatment helps normalize the skin's exfoliation cycle, and during the process of removing old dead skin cells, acne that
was trapped beneath the surface may come to the surface. This is a natural occurrence.

Q. Why should LHALA Puff be used?

A. LHALA Puff is a dedicated puff specifically designed for LHALA Doctor products. It enhances product absorption and
penetration without irritating the skin, and its porous structure helps deliver the INCUBE technology of LHALA Doctor effectively
to the skin.

Q. Do LHALA Doctor and LHALA Ole need to be used together?

A. LHALA Ole acts as a skin protector and coating before the LHALA Doctor treatment, allowing for better absorption of LHALA Doctor.
It also protects the skin from all inflammatory triggers, making laser and peeling treatments safer. Therefore, the best results can be
expected when used together.

Q. What is the difference between LHALA Peel and LHALA Doctor?

A. LHALA Doctor, a product designed for dermatological use, is an upgraded version of LHALA peel and a 5th-generation peel. It
goes beyond the limits of traditional peels by incorporating innovative technologies such as INCUBE, PLLA, INCUBE 501, and new
ingredients like calcium, along with the existing key components LHA, H2sol , and Lipid.

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.
 LHALA
Doctor
Medical Skincare

* This material is confidential and any unauthorized use is strictly prohibited.

* Any use other than for H2MEDI-related commercial purposes will result in full liability, including damages, to the using party.