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N N Dimethylacetamide

The document is a Safety Data Sheet for N,N-Dimethylacetamide, detailing its identification, hazards, and safety measures. It highlights the product's classification, health hazards, and emergency procedures, along with first aid measures and firefighting recommendations. The document emphasizes the need for personal protective equipment and safe handling practices in laboratory settings.

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Shameer Hussain
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0% found this document useful (0 votes)
67 views12 pages

N N Dimethylacetamide

The document is a Safety Data Sheet for N,N-Dimethylacetamide, detailing its identification, hazards, and safety measures. It highlights the product's classification, health hazards, and emergency procedures, along with first aid measures and firefighting recommendations. The document emphasizes the need for personal protective equipment and safe handling practices in laboratory settings.

Uploaded by

Shameer Hussain
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 12

SAFETY DATA SHEET

Creation Date Oct-2013 Revision Date Oct-2018 Revision Number 2

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE


COMPANY/UNDERTAKING

1.1. Product identification

Product Description: N,N-Dimethylacetamide


Product Grade: SQ, ER, HPLC, GCHS
Cat No. : Q12365, Q12367, Q123SH, Q18305, Q43496, Q49205, Q49206, Q1236C
CAS-No 127-19-5
EC-No. 204-826-4
Molecular Formula C4 H9 N O
Reach Registration Number 01-2119459339-27

1.2. Relevant identified uses of the substance or mixture and uses advised against

Recommended Use Laboratory chemicals.


Sector of use SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites
Product category PC21 - Laboratory chemicals
Process categories PROC15 - Use as a laboratory reagent
Environmental release category ERC6a - Industrial use resulting in manufacture of another substance (use of intermediates)
Uses advised against No Information available
1.3. Details of the supplier of the safety data sheet

Company Thermo Fisher Scientific India Pvt. Ltd


403-404, B-wing, Delphi, Hiranandani Business Park,
Powai, Mumbai 400076, INDIA.
E-mail address [email protected]

1.4. Emergency telephone number


India Toll Free: 18 00 22 22 30
Chemtrec US: (800)424-9300
Chemtrec EU: 001(202)483-7616

SECTION 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

CLP Classification - Regulation (EC) No 1272/2008

Physical hazards

Based on available data, the classification criteria are not met

Health hazards

Acute dermal toxicity Category 4 (H312)


Acute Inhalation Toxicity - Vapors Category 4 (H332)
Serious Eye Damage/Eye Irritation Category 2 (H319)
Reproductive Toxicity Category 1B (H360D)

Environmental hazards

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Based on available data, the classification criteria are not met

2.2. Label elements

Signal Word Danger

Hazard Statements
H312 - Harmful in contact with skin
H319 - Causes serious eye irritation
H332 - Harmful if inhaled
H360D - May damage the unborn child
Combustible liquid

Precautionary Statements
P201 - Obtain special instructions before use
P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing
P308 + P313 - IF exposed or concerned: Get medical advice/ attention

Additional EU labelling
Restricted to professional users

2.3. Other hazards

No information available

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1. Substances

Component CAS-No EC-No. Weight % CLP Classification - Regulation (EC) No


1272/2008
Dimethyl acetamide 127-19-5 EEC No. 204-826-4 >95 Acute Tox. 4 (H312)
Acute Tox. 4 (H332)
Eye Irrit. 2 (H319)
Repr. 1B (H360D)

Reach Registration Number 01-2119459339-27

Full text of Hazard Statements: see section 16

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SECTION 4: FIRST AID MEASURES

4.1. Description of first aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Immediate medical attention is required.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical
attention is required.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Inhalation Move to fresh air. Do not use mouth-to-mouth method if victim ingested or inhaled the
substance; give artificial respiration with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device. Immediate medical attention is required. If
not breathing, give artificial respiration.

Protection of First-aiders Ensure that medical personnel are aware of the material(s) involved, take precautions to
protect themselves and prevent spread of contamination.

4.2. Most important symptoms and effects, both acute and delayed

Breathing difficulties. Symptoms of overexposure may be headache, dizziness, tiredness,


nausea and vomiting

4.3. Indication of any immediate medical attention and special treatment needed

Notes to Physician Treat symptomatically. Symptoms may be delayed.

SECTION 5: FIREFIGHTING MEASURES

5.1. Extinguishing media

Suitable Extinguishing Media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Cool closed containers exposed to fire with water spray.

Extinguishing media which must not be used for safety reasons


No information available.

5.2. Special hazards arising from the substance or mixture

Combustible material. Containers may explode when heated. Keep product and empty container away from heat and sources of
ignition. Thermal decomposition can lead to release of irritating gases and vapors.

Hazardous Combustion Products


Carbon monoxide (CO), Carbon dioxide (CO2), Nitrogen oxides (NOx).

5.3. Advice for firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary
measures against static discharges. Avoid contact with skin, eyes and clothing.

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6.2. Environmental precautions

Avoid release to the environment. See Section 12 for additional ecological information.

6.3. Methods and material for containment and cleaning up

Remove all sources of ignition. Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. Use
spark-proof tools and explosion-proof equipment.

6.4. Reference to other sections

Refer to protective measures listed in Sections 8 and 13.

SECTION 7: HANDLING AND STORAGE

7.1. Precautions for safe handling

Wear personal protective equipment. Keep away from open flames, hot surfaces and sources of ignition. Do not get in eyes, on
skin, or on clothing. Do not breathe vapors or spray mist. Do not ingest. Use spark-proof tools and explosion-proof equipment.

Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do
not eat, drink or smoke when using this product. Remove and wash contaminated clothing before re-use. Wash hands before
breaks and at the end of workday.

7.2. Conditions for safe storage, including any incompatibilities

Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition. Keep under
nitrogen.

7.3. Specific end use(s)

Use in laboratories

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters

Exposure limits
List source(s): EU - Commission Directive 2006/15/EC of 7 February 2006 establishing a second list of indicative occupational
exposure limit values in implementation of Council Directive 98/24/EC and amending Directives 91/322/EEC and 2000/39/EC on
the protection of the health and safety of workers from the risks related to chemical agents at work. UK - EH40/2005 Containing the
workplace exposure limits (WELs) for use with the Control of Substances Hazardous to Health Regulations (COSHH) 2002 (as
amended). Updated by September 2006 official press release and October 2007 Supplement. IRE - 2010 Code of Practice for the
Safety, Health and Welfare at Work (Chemical Agents) Regulations 2001. Published by the Health and Safety Authority.

Component European Union The United Kingdom France Belgium Spain


Dimethyl acetamide TWA: 10 ppm 8 hr STEL: 20 ppm 15 min TWA / VME: 2 ppm (8 TWA: 10 ppm 8 uren STEL / VLA-EC: 20 ppm
TWA: 36 mg/m3 8 hr STEL: 72 mg/m3 15 min heures). restrictive limit TWA: 36 mg/m3 8 uren (15 minutos). STEL /
STEL: 20 ppm 15 min TWA: 10 ppm 8 hr TWA / VME: 7.2 mg/m3 STEL: 20 ppm 15 VLA-EC: 72 mg/m3 (15
STEL: 72 mg/m3 15 min TWA: 36 mg/m3 8 hr (8 heures). restrictive minuten minutos). TWA / VLA-
Possibility of significant Skin limit STEL: 72 mg/m3 15 ED: 10 ppm (8 horas)
uptake through the skin STEL / VLCT: 10 ppm. minuten TWA / VLA-ED: 36
restrictive limit Huid mg/m3 (8 horas)
STEL / VLCT: 36 Piel
mg/m3. restrictive limit
Peau

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Component Italy Germany Portugal The Netherlands Finland


Dimethyl acetamide TWA: 10 ppm 8 ore. TWA: 10 ppm (8 STEL: 20 ppm 15 huid TWA: 10 ppm 8 tunteina
Media Ponderata nel Stunden). AGW - minutos STEL: 72 mg/m3 15 TWA: 36 mg/m3 8
Tempo exposure factor 2 STEL: 72 mg/m3 15 minuten tunteina
TWA: 36 mg/m3 8 ore. TWA: 36 mg/m3 (8 minutos TWA: 36 mg/m3 8 uren STEL: 20 ppm 15
Media Ponderata nel Stunden). AGW - TWA: 10 ppm 8 horas minuutteina
Tempo exposure factor 2 TWA: 36 mg/m3 8 horas STEL: 72 mg/m3 15
STEL: 20 ppm 15 TWA: 10 ppm (8 Pele minuutteina
minuti. Breve termine Stunden). MAK Iho
STEL: 72 mg/m3 15 TWA: 36 mg/m3 (8
minuti. Breve termine Stunden). MAK
Pelle Höhepunkt: 20 ppm
Höhepunkt: 72 mg/m3
Haut

Component Austria Denmark Switzerland Poland Norway


Dimethyl acetamide Haut TWA: 10 ppm 8 timer Haut/Peau STEL: 70 mg/m3 15 TWA: 10 ppm 8 timer
MAK-KZW: 20 ppm 15 TWA: 36 mg/m3 8 timer STEL: 20 ppm 15 minutach TWA: 35 mg/m3 8 timer
Minuten Hud Minuten TWA: 35 mg/m3 8 STEL: 10 ppm 15
MAK-KZW: 72 mg/m3 15 STEL: 70 mg/m3 15 godzinach minutter.
Minuten Minuten STEL: 35 mg/m3 15
MAK-TMW: 10 ppm 8 TWA: 10 ppm 8 minutter.
Stunden Stunden Hud
MAK-TMW: 36 mg/m3 8 TWA: 35 mg/m3 8
Stunden Stunden

Component Bulgaria Croatia Ireland Cyprus Czech Republic


Dimethyl acetamide TWA: 10 ppm kože TWA: 10 ppm 8 hr. Skin-potential for TWA: 30 mg/m3 8
TWA: 36 mg/m3 TWA-GVI: 10 ppm 8 TWA: 36 mg/m3 8 hr. cutaneous absorption hodinách.
STEL : 20 ppm satima. STEL: 20 ppm 15 min STEL: 20 ppm Potential for cutaneous
STEL : 72 mg/m3 TWA-GVI: 36 mg/m3 8 STEL: 72 mg/m3 15 min STEL: 72 mg/m3 absorption
Skin notation satima. Skin TWA: 10 ppm Ceiling: 60 mg/m3
STEL-KGVI: 20 ppm 15 TWA: 36 mg/m3
minutama.
STEL-KGVI: 72 mg/m3
15 minutama.

Component Estonia Gibraltar Greece Hungary Iceland


Dimethyl acetamide Nahk Skin notation skin - potential for STEL: 72 mg/m3 15 STEL: 20 ppm
TWA: 10 ppm 8 TWA: 10 ppm 8 hr cutaneous absorption percekben. CK STEL: 72 mg/m3
tundides. TWA: 36 mg/m3 8 hr STEL: 20 ppm TWA: 36 mg/m3 8 TWA: 10 ppm 8
TWA: 36 mg/m3 8 STEL: 20 ppm 15 min STEL: 72 mg/m3 órában. AK klukkustundum.
tundides. STEL: 72 mg/m3 15 min TWA: 10 ppm lehetséges borön TWA: 36 mg/m3 8
STEL: 20 ppm 15 TWA: 36 mg/m3 keresztüli felszívódás klukkustundum.
minutites. STEL: 72 Skin notation
mg/m3 15 minutites. Ceiling: 20 ppm
Ceiling: 72 mg/m3

Component Latvia Lithuania Luxembourg Malta Romania


Dimethyl acetamide skin - potential for TWA: 10 ppm IPRD Possibility of significant possibility of significant Skin notation TWA:
cutaneous exposure TWA: 36 mg/m3 IPRD uptake through the skin uptake through the skin 10 ppm 8 ore TWA:
STEL: 20 ppm Oda TWA: 10 ppm 8 TWA: 10 ppm 36 mg/m3 8 ore
STEL: 72 mg/m3 STEL: 20 ppm Stunden TWA: 36 mg/m3 STEL: 72 mg/m3 15
TWA: 10 ppm STEL: 72 mg/m3 TWA: 36 mg/m3 8 STEL: 20 ppm 15 minuti minute
TWA: 36 mg/m3 Stunden STEL: 72 mg/m3 15 STEL: 20 ppm 15
STEL: 20 ppm 15 minuti minute
Minuten
STEL: 72 mg/m3 15
Minuten

Component Russia Slovak Republic Slovenia Sweden Turkey


Dimethyl acetamide TWA: 1 mg/m3 0715 Ceiling: 72 mg/m3 TWA: 10 ppm 8 urah Binding STLV: 20 ppm Deri
Skin notation Potential for cutaneous TWA: 36 mg/m3 8 urah 15 minuter TWA: 10 ppm 8 saat
STEL: 3 mg/m3 0715 absorption Koža Binding STLV: 70 TWA: 36 mg/m3 8 saat
TWA: 10 ppm STEL: 20 ppm 15 mg/m3 15 minuter STEL: 20 ppm 15
TWA: 36 mg/m3 minutah LLV: 10 ppm 8 timmar. dakika
STEL: 72 mg/m3 15 LLV: 35 mg/m3 8 STEL: 72 mg/m3 15

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minutah timmar. dakika
Hud

Biological limit values


List source(s): UK - Biological Monitoring Guidance Values provided by the UK's Health and Safety Executive (HSE) Control of
Substances Hazardous to Health Regulations (COSHH) 2002 (as amended) and EH40/2005.

Component European Union United Kingdom France Spain Germany


Dimethyl acetamide N-methylacetamide: 100 N-Methylacetamide: 30 N-Methylacetamide: 30 N,N-Methylacetamide
mmol/mol creatinine mg/g creatinine urine mg/g Creatinine urine plus
urine post shift end of shift at end of end of workweek N-Hydroxymethyl-N-met
workweek hylacetamide: 30 mg/g
urine (end of shift
measured as mg/g
Creatinine)
N,N-Methylacetamide
plus
N-Hydroxymethyl-N-met
hylacetamide: 30 mg/g
urine (end of several
shifts measured as mg/g
Creatinine;for long-term
exposures)

Component Italy Finland Denmark Bulgaria Romania


Dimethyl acetamide N-Methyl acetamide: 30
µg/g Creatinine urine
end of work week

Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of
exposure to chemical and biological agents.
MDHS70 General methods for sampling airborne gases and vapours

Derived No Effect Level (DNEL) No information available

Route of exposure Acute effects (local) Acute effects Chronic effects Chronic effects
(systemic) (local) (systemic)
Oral
Dermal 42 mg/kg/day 11 mg/kg/day
Inhalation 120 mg/m3 23 mg/m3
Predicted No Effect Concentration No information available.
(PNEC)

Fresh water 0.5 mg/l


Fresh water sediment 2.27 mg/kg dw
Marine water 0.05 ml/l
Marine water sediment 0.227 mg/kg dw
Water Intermittent 5 mg/l
Microorganisms in sewage 458 mg/l
treatment
Soil (Agriculture) 0.159 mg/kg

8.2. Exposure controls

Engineering Measures
Ensure adequate ventilation, especially in confined areas. Use explosion-proof electrical/ventilating/lighting/equipment. Ensure that
eyewash stations and safety showers are close to the workstation location.
Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or
equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to

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control hazardous materials at source

Personal protective equipment


Eye Protection Goggles (European standard - EN 166)

Hand Protection Protective gloves

Glove material Breakthrough time Glove thickness EU standard Glove comments


Butyl rubber > 480 minutes 0.635 mm Level 6 As tested under EN374-3 Determination of
EN 374 Resistance to Permeation by Chemicals
Neoprene gloves > 84 minutes 0.45 mm
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure

Inspect gloves before use.


Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger
of cuts, abrasion.
Remove gloves with care avoiding skin contamination.

Respiratory Protection When workers are facing concentrations above the exposure limit they must use
appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used
and maintained properly

Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits
are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Organic gases and vapours filter Type A Brown conforming to
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Appearance Colorless
Physical State Liquid

Odor Ammonia-like
Odor Threshold No data available
pH 4 200 g/l aq. sol
Melting Point/Range -20 °C / -4 °F
Softening Point No data available
Boiling Point/Range 164 - 166 °C / 327.2 - 330.8 °F @ 760 mmHg
Flash Point 70 °C / 158 °F Method - No information available
Evaporation Rate <0.17 (Butyl Acetate = 1.0)
Flammability (solid,gas) Not applicable Liquid
Explosion Limits Lower 1.7 vol%
Upper 11.5 vol%
Vapor Pressure 1.7 mbar @ 25 °C
Vapor Density 3.02 (Air = 1.0)
Specific Gravity / Density 0.937

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Bulk Density Not applicable Liquid
Water Solubility soluble
Solubility in other solvents No information available
Partition Coefficient (n-octanol/water)
Component log Pow
Dimethyl acetamide 0.8
Autoignition Temperature 490 °C / 914 °F
Decomposition Temperature No data available
Viscosity 1.02 mPa s @ 20 °C
Explosive Properties No information available explosive air/vapour mixtures possible
Oxidizing Properties No information available

9.2. Other information

Molecular Formula C4 H9 N O
Molecular Weight 87.12

SECTION 10: STABILITY AND REACTIVITY


10.1. Reactivity
None known, based on information available
10.2. Chemical stability
Stable under normal conditions, Hygroscopic.

10.3. Possibility of hazardous reactions

Hazardous Polymerization Hazardous polymerization does not occur.


Hazardous Reactions None under normal processing.
10.4. Conditions to avoid
Incompatible products. Heat, flames and sparks. Exposure to moisture. Keep away from
open flames, hot surfaces and sources of ignition.

10.5. Incompatible materials


Strong oxidizing agents. Aldehydes. Peroxides. Strong acids.

10.6. Hazardous decomposition products


Carbon monoxide (CO). Carbon dioxide (CO2). Nitrogen oxides (NOx).

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects

Product Information

(a) acute toxicity;


Oral Based on available data, the classification criteria are not met
Dermal Category 4
Inhalation Category 4

Component LD50 Oral LD50 Dermal LC50 Inhalation


Dimethyl acetamide LD50 = 4263 mg/kg ( Rat ) LD50 = 2240 mg/kg ( Rabbit ) LC50 = 8.81 mg/L ( Rat ) 1 h
LD50 > 2 g/kg ( Rat ) LC50 = 2475 ppm ( Rat ) 1 h

(b) skin corrosion/irritation; Based on available data, the classification criteria are not met

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(c) serious eye damage/irritation; Category 2

(d) respiratory or skin sensitization;


Respiratory Based on available data, the classification criteria are not met
Skin Based on available data, the classification criteria are not met

(e) germ cell mutagenicity; Based on available data, the classification criteria are not met
Not mutagenic in AMES Test

(f) carcinogenicity; Based on available data, the classification criteria are not met
There are no known carcinogenic chemicals in this product

(g) reproductive toxicity; Category 1B


Reproductive Effects May cause harm to the unborn child.

(h) STOT-single exposure; Based on available data, the classification criteria are not met

(i) STOT-repeated exposure; Based on available data, the classification criteria are not met

Target Organs None known.

(j) aspiration hazard; Based on available data, the classification criteria are not met
Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting
delayed

SECTION 12: ECOLOGICAL INFORMATION

12.1. Toxicity
Ecotoxicity effects Do not empty into drains. .

Component Freshwater Fish Water Flea Freshwater Algae Microtox


Dimethyl acetamide LC50: > 500 mg/L, 96h EC50 >500 mg/L/48h EC50 >500 mg/L/72h EC50 = 2393 mg/L 30
static (Leuciscus idus) min
EC50 = 4815 mg/L 5
min

12.2. Persistence and degradability Readily biodegradable


Persistence Persistence is unlikely.

12.3. Bioaccumulative potential Bioaccumulation is unlikely

Component log Pow Bioconcentration factor (BCF)


Dimethyl acetamide 0.8 No data available

12.4. Mobility in soil The product is water soluble, and may spread in water systems . Will likely be mobile in the
environment due to its water solubility. Highly mobile in soils

12.5. Results of PBT and vPvB No data available for assessment.

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assessment

12.6. Other adverse effects


Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant This product does not contain any known or suspected substance
Ozone Depletion Potential This product does not contain any known or suspected substance

SECTION 13: DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods

Waste from Residues / Unused Waste is classified as hazardous. Dispose of in accordance with the European Directives
Products on waste and hazardous waste. Dispose of in accordance with local regulations.

Contaminated Packaging Dispose of this container to hazardous or special waste collection point.

European Waste Catalogue (EWC) According to the European Waste Catalogue, Waste Codes are not product specific, but
application specific.
Other Information Waste codes should be assigned by the user based on the application for which the product
was used. Do not empty into drains.

SECTION 14: TRANSPORT INFORMATION

IMDG/IMO Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

ADR Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

IATA Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

14.5. Environmental hazards No hazards identified

14.6. Special precautions for user No special precautions required

14.7. Transport in bulk according to Not applicable, packaged goods


Annex II of MARPOL73/78 and the
SECTION 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories X = listed

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Component EINECS ELINCS NLP TSCA DSL NDSL PICCS ENCS IECSC AICS KECL
Dimethyl acetamide 204-826-4 - X X - X X X X X

Component REACH (1907/2006) - Annex XIV - REACH (1907/2006) - Annex XVII - REACH Regulation (EC
Substances Subject to Restrictions on Certain Dangerous 1907/2006) article 59 - Candidate
Authorization Substances List of Substances of Very High
Concern (SVHC)
Dimethyl acetamide Use restricted. See item 30. SVHC Candidate list - Toxic for
(see reproduction (Article 57 c)
http://eur-lex.europa.eu/LexUriServ/L
exUriServ.do?uri=CELEX:32006R190
7:EN:NOT for restriction details)

National Regulations

Component Germany - Water Classification (VwVwS) Germany - TA-Luft Class


Dimethyl acetamide WGK 1
WGK 2

Component France - INRS (Tables of occupational diseases)


Dimethyl acetamide Tableaux des maladies professionnelles (TMP) - RG 84
Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment.
Take note of Dir 94/33/EC on the protection of young people at work
Take note of Dir 92/85/EC on the protection of pregnant and breastfeeding women at work

15.2. Chemical safety assessment

A Chemical Safety Assessment/Report (CSA/CSR) has not been conducted

SECTION 16: OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3


H312 - Harmful in contact with skin
H319 - Causes serious eye irritation
H332 - Harmful if inhaled
H360D - May damage the unborn child

Legend

CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic
Substances/EU List of Notified Chemical Substances Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances
IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals

WEL - Workplace Exposure Limit TWA - Time Weighted Average


ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer
DNEL - Derived No Effect Level PNEC - Predicted No Effect Concentration
RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50%
LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50% NOEC -
No Observed Effect Concentration POW - Partition coefficient Octanol:Water PBT -
Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative

ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air
Dangerous Goods by Road Transport Association
IMO/IMDG - International Maritime Organization/International Maritime

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Dangerous Goods Code MARPOL - International Convention for the Prevention of Pollution from
Ships
OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate
BCF - Bioconcentration factor VOC - Volatile Organic Compounds
Key literature references and sources for data
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS

Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and
hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit
and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Chemical incident response training.
Fire prevention and fighting, identifying hazards and risks, static electricity, explosive atmospheres posed by vapours and dusts.

Creation Date Oct-2013


Next Revision Date Oct-2023
Revision Summary SDS section 1 updated and update of Format.
.
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of Safety Data Sheet

FSUD3411
Page 12 / 12

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