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George S. Stergiou
Gianfranco Parati
Giuseppe Mancia Editors
Home Blood
Pressure
Monitoring
Updates in Hypertension and
Cardiovascular Protection
Series Editors
Giuseppe Mancia
Milano, Italy
Enrico Agabiti Rosei
Brescia, Italy
The aim of this series is to provide informative updates on both the knowledge and
the clinical management of a disease that, if uncontrolled, can very seriously damage
the human body and is still among the leading causes of death worldwide. Although
hypertension is associated mainly with cardiovascular, endocrine, and renal
disorders, it is highly relevant to a wide range of medical specialties and fields –
from family medicine to physiology, genetics, and pharmacology. The topics
addressed by volumes in the series Updates in Hypertension and Cardiovascular
Protection have been selected for their broad significance and will be of interest to
all who are involved with this disease, whether residents, fellows, practitioners, or
researchers.
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland
AG 2020
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether
the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of
illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and trans-
mission or information storage and retrieval, electronic adaptation, computer software, or by similar or
dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publica-
tion does not imply, even in the absence of a specific statement, that such names are exempt from the
relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book
are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the
editors give a warranty, expressed or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional
claims in published maps and institutional affiliations.
This Springer imprint is published by the registered company Springer Nature Switzerland AG
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
v
vi Preface
practice. This book endorsed by the European Society of Hypertension presents the
current knowledge on all the aspects of home blood pressure monitoring, including
the technology of devices, the clinical relevance of the method, the optimal protocol
and clinical application, the clinical indications for general and special populations,
the application in clinical research, and the international consensus on clinical imple-
mentation. A total of 39 international experts in blood pressure measurement research
have contributed in preparing 16 chapters in this book, which aim to guide clinicians
in the optimal application of home blood pressure monitoring and to stimulate
researchers in filling the gaps in knowledge by performing further trials.
References
1. Stergiou GS, Kario K, Kollias A, McManus RJ, Ohkubo T, Parati G, et al. Home
blood pressure monitoring in the 21st century. J Clin Hypertens.
2018;20:1116–21.
2. Stergiou GS, Siontis KC, Ioannidis JP. Home blood pressure as a cardiovascular
outcome predictor: it’s time to take this method seriously. Hypertension.
2010;55:1301–3.
3. Parati G, Stergiou GS, Asmar R, Bilo G, de Leeuw P, Imai Y, et al. European
Society of Hypertension guidelines for blood pressure monitoring at home: a
summary report of the Second International Consensus Conference on Home
Blood Pressure Monitoring. J Hypertens. 2008;26:1505–26.
4. Parati G, Stergiou GS, Asmar R, Bilo G, de Leeuw P, Imai Y, et al. ESH Working
Group on Blood Pressure Monitoring. European Society of Hypertension prac-
tice guidelines for home blood pressure monitoring. J Hum Hypertens.
2010;24:779–85.
5. Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison
Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/
ASPC/NMA/PCNA guideline for the prevention, detection, evaluation and man-
agement of high blood pressure in adults: a report of the American College of
Cardiology/American Heart Association Task Force on clinical practice guide-
lines. Hypertension. 2018;71:e13–e115.
6. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al.
ESC/ESH Guidelines for the management of arterial hypertension: The Task Force
for the management of arterial hypertension of the European Society of Cardiology
and the European Society of Hypertension. J Hypertens. 2018;36:1953–2041.
7. Stergiou GS, Kollias A, Zeniodi M, Karpettas N, Ntineri A. Home blood pres-
sure monitoring: primary role in hypertension management. Curr Hypertens
Rep. 2014;16:462.
8. Stergiou GS, Parati G. Home blood pressure monitoring may make office mea-
surements obsolete. J Hypertens. 2012;30:463–5.
9. Pickering TG, Miller NH, Ogedegbe G, Krakoff LR, Artinian NT, Goff D. Call
to action on use and reimbursement for home blood pressure monitoring: execu-
tive summary: a joint scientific statement from the American Heart Association,
American Society of Hypertension, and Preventive Cardiovascular Nurses
Association. Hypertension. 2008;52:1–9.
Contents
vii
viii Contents
Index�������������������������������������������������������������������������������������������������������������������� 171
Devices for Home Blood
Pressure Monitoring 1
Roland Asmar, Anastasios Kollias, Paolo Palatini,
Gianfranco Parati, Andrew Shennan, George S. Stergiou,
Jirar Topouchian, Ji-Guang Wang, William White,
and Eoin O’Brien
R. Asmar (*)
Foundation-Medical Research Institutes (F-MRI®), Geneva, Switzerland
e-mail: [email protected]
A. Kollias
Hypertension Center STRIDE-7, National and Kapodistrian University of Athens,
School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece
G. S. Stergiou
Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of
Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece
e-mail: [email protected]
P. Palatini
Department of Medicine, University of Padova, Padova, Italy
e-mail: [email protected]
G. Parati
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic
Sciences, Milan, Italy
e-mail: [email protected]
A. Shennan
Department of Women and Children’s Health, School of Life Course Sciences, FoLSM,
King’s College London, London, UK
e-mail: [email protected]
J. Topouchian
Diagnosis and Therapeutic Center, Hôtel Dieu Hospital, Paris, France
e-mail: [email protected]
J.-G. Wang
The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University
School of Medicine, Shanghai, China
W. White
Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT, USA
e-mail: [email protected]
E. O’Brien
The Conway Institute, University College Dublin, Dublin, Ireland
1.1 Introduction
The use of home blood pressure (BP) monitoring (HBPM) for hypertension manage-
ment is recommended by most of the international guidelines [1–4]. While these
recommendations provide information on HBPM indications, procedures, and
thresholds of BP values, they provide very few, or no, indications on device choice.
In fact, the hypertension guidelines of the European Society of Hypertension (ESH)
and the European society of cardiology (ESC) simply indicate: “HBPM …performed
with semiautomatic validated BP monitors…; use of Apps as a cuff-independent
means of measuring BP is not recommended; Telemonitoring and smartphone appli-
cations may offer additional advantages [4].” No other information on the device
choice is indicated. The other guidelines [1–3] do not provide more indications
(Table 1.1). Given the worldwide increasing dissemination of HBPM, more detailed
indications on choice and use of HBPM devices are therefore necessary to guide
physicians, patients, and users towards an adequate choice of suitable equipment.
In the absence of guidance on how to choose a reliable HBPM device and con-
sidering the great popularity of HBPM which is now widely available in most coun-
tries, the device market has evolved into an uncontrolled one with about 80% of
marketed devices either not validated or with questionable accuracy [5]. This global
BP monitoring market reached US$ 16.9 billion in 2015 and is expected to reach
US$ 23.8 billion in 2020, thus being one of the most lucrative markets in the field
of cardiovascular health [5, 6].
The widespread use of HBPM, the scientific recommendations of its use, and the
large financial potential of the device market emphasize the need of device accuracy
and certification and the necessity of providing clear guidance to this market by giv-
ing strict indications for the choice of HBPM devices. Publication of lists of validated
home BP devices has been successfully conducted. Updated lists of the validated
devices are available at several non-profit (www.bihsoc.org, https://hypertension.ca)
or for-profit organizations: www.medaval.ie, www.dableducational.org [3, 7–9].
Despite the establishment of such lists, they are currently accessed only by small
groups of scientists and experts and thus do not reach most of the concerned public,
including physicians, pharmacists, and patients [5]. The purpose of this chapter is to
describe the main characteristics of the most widely used HBPM devices and to help
prescribers, consumers, and users in choosing the most reliable and suitable device.
Several techniques for measuring BP are used by HBPM devices. These devices are
either manual, semiautomated, or automated. Semiautomated are characterized by
automatic inflation and manual cuff deflation; automated devices are characterized
by automatic cuff inflation and deflation. The most widely used techniques are
described below.
The manual auscultatory method to detect the Korotkoff sounds using either aneroid
or mercury devices—where mercury manometers remain available —are not rec-
ommended for HBPM as they require substantial patient training and regular cali-
bration [1–4].
and pulse rate from the collected oscillometric signal. Most of these devices acquire
data for measurements during cuff deflation whereas others do this during cuff infla-
tion. Since each device has its own specific proprietary algorithm and technical
characteristics, the measurement accuracy of one device cannot be extrapolated to
another even if produced by the same manufacturer. Moreover, since the cuff in the
oscillometric method is used not only to obtain arterial occlusion but also as a sen-
sor to collect the oscillometric signal, experts agree that each oscillometric device
must be used only with its own specific cuff(s) as provided by the manufacturer.
Therefore, HBPM devices must be considered as the combination of a device and
its accompanying cuff(s), whereas the cuff size and type used in the auscultatory
method may not be applicable.
Electronic oscillometric devices require little to no training and are user-friendly,
relatively inexpensive, and generally not affected by observer bias if used correctly.
These devices, as well as all the other BP measurements devices, must meet the
requirements of national and international regulatory bodies for medical devices such
as the Food and Drug Administration (FDA) in the United States (US), and the CE
(Conformité Européene) labeling according to the medical device Directives and
Regulations in Europe. Since these regulations are mainly focused on safety rather
than accuracy, it is recommended to use only devices that have undergone independent
validation and passed the criteria of established validation protocols (CF. Accuracy).
Automatic oscillometric devices have been designed to measure BP at different
arterial sites. The most popular (and recommended) ones are those measuring BP at
the upper-arm (brachial artery) level and to a lesser extent those measuring BP at the
wrist (radial artery) level. Even though several automated wrist devices have suc-
cessfully passed recommended validation protocols, they are considered less accu-
rate than the upper-arm devices. Oscillometric wrist device accuracy can be affected
by wrist anatomy and position (with reference to the heart level), as well as by the
wrist cuff characteristics (soft or pre-shaped). The pre-shaped cuffs are easier for
patients to use but they conform less well than the soft one to the wrist.
Many of the electronic oscillometric devices include additional features such as
memory, connectivity (PC, smartphone, or telemonitoring), and position sensor (CF
Features), which may facilitate the HBPM procedures and improve its impact for
hypertension management.
Taking into consideration all these aspects, current guidelines recommend the
use of automated electronic oscillometric upper-arm cuff devices which meet regu-
latory authority requirements and have been validated according to established pro-
tocols. Moreover, some of these guidelines also do support wrist devices if used
correctly in certain clinical circumstances. Indeed, wrist measurements can be help-
ful when the upper-arm cuff cannot be correctly fitted or is structurally impossible,
such as in obese subjects with a very large upper-arm circumference.
for office BP measurement, are accurate and require less maintenance than the aner-
oid device, their use for HBPM is not recommended. Additionally, the use of the
auscultatory method remains affected by observer bias and other disadvantages of
this method; moreover, they are more expensive than most of the other digital oscil-
lometric HBPM devices. If a hybrid device is used for HBPM, then the automatic
oscillometric method would be preferable.
For many years, many device manufacturers have been attempting to develop cuff-
less BP measurement devices as these would avoid many of the inconveniences
associated with cuff measurements. Among these techniques such as tonometry,
pulse wave velocity, pulse transit time, and plethysmography, the plethysmographic
approach appears to be the most likely method to succeed [11]. Briefly, plethysmog-
raphy measures volume changes. When applied to an arterial segment, the measured
changes of volume are transformed into changes of pressure with calculation of
systolic and diastolic BP and pulse rate values according to specific algorithms. To
date, most of the cuffless devices used at the finger or at the wrist level (watches,
bracelets), or even those applied at the earlobe level, are based on the plethysmo-
graphic method. These use an infrared (or other) photoelectric sensor to record
changes in pulsatile blood flow by calculating the light absorption changes, which
are then translated into BP values. Cuffless BP values are derived through various
methods including calculation of pulse transit time, analysis of the signal using the
Fast Fourier Transform (FFT) and Generalized Transfer Function (GTF), or rela-
tionships between BP and the arterial radial volume changes.
Accuracy of most plethysmography-based cuffless devices for BP measurements
which may be used for HBPM remains controversial. In fact, to our knowledge,
none of these very popular devices (watches, bracelets, smartphone Apps) satisfy
regulatory requirements or has been validated according to currently established
protocols. Therefore, despite their large distribution, mainly as multiple parameters
monitoring bracelets or watches, the use of these devices is not presently recom-
mended for HBPM as their accuracy and reliability remains highly questionable. It
should be mentioned, however, that established validation standards have not been
developed to assess cuffless devices and a new ISO standard for such devices is cur-
rently under development.
1.2.6 Tonometry
Principles of tonometry for measuring radial BP and performing pulse wave analysis
using the transfer function has been reported and described in detail previously else-
where [12]. Briefly, tonometry means “measuring of pressure” whereas applanation
means “to flatten” the arterial wall. Applanation tonometry is performed by placing
one or several tonometers (strain gauge pressure sensor) over the radial artery and
applying soft pressure to obtain an assumed flattened arterial wall. This method was
6 R. Asmar et al.
designed particularly for clinical use by researchers to measure the radial BP and
calculate aortic (central) BP by performing the pulse wave analysis and using algo-
rithms such as the Transfer Function. Considering the importance of aortic BP, man-
ufacturers have tried to extrapolate the use of this technique for HBPM, but this
approach is still under development and at this time remains reserved for research.
Several other techniques to measure BP have been proposed for HBPM. The most
current methods include:
–– Pulse transit time: this technique is based on the assessment of pulse wave veloc-
ity and on use of its reciprocal variable, the pulse transit time, to calculate beat-
by-beat BP values through a dedicated algorithm [13].
–– Smartphone Apps turning the smartphone into a cuffless device. Most of these
Apps use the light absorption changes from a finger to estimate changes in blood
volume and to calculate finger BP values by considering the relationships
between changes of blood volume and the corresponding changes in BP.
HBPM devices measuring or calculating BP at different arterial sites are now avail-
able: upper-arm, wrist, finger, or even aortic. The choice of the arterial site is impor-
tant, not only because most, if not all, of the hypertension studies have been
performed using brachial BP measurements but also because BP values are not
identical at the different arterial sites due to an “amplification” phenomenon.
Most HBPM devices measure BP at the upper-arm level (brachial artery). This mea-
surement is currently recommended by all guidelines.
are now only the ruins of the vaulted basement on which it stood. At the east
end of this range there is a doorway from the cloister giving access to a
staircase, which led down to the lower level of the fratery, &c. The
remainder of the south side was probably all occupied by the refectory,
Fig. 419.—Dryburgh Abbey. Western Doorway.
which would thus be about 77 feet in length by 27 feet in width. The west
wall is almost all that survives. It is ivy clad, and contains a picturesque
circular window, with radiating tracery (Fig. 416). Adjoining
nave and chancel, having a south wing or aisle, containing the Airth vault,
and forming a transept, with a tower at the re-entering angle of the Airth
aisle, and with indications of an aisle on the north side of the choir. There are
also two burial vaults attached to the building, one on the north side and the
other at the south-west angle, called respectively the Bruce and Elphinstone
aisles. The internal length of the church is 79 feet 3 inches by about 19 feet 9
inches in breadth. The most ancient part of the church (Fig. 424) is on the
north side of the nave, and consists of a bay of what has been a nave arcade,
opening into a north aisle. One pillar and respond (tinted black on the Plan),
with the connecting round arch, still
Fig. 424.—Airth Church. North Arcade.
stand. The original arcade probably consisted of three bays extending to near
the west gable, where there are indications, at the ground level, of what
appears to have been the western respond. Whether there was originally a
south arcade or not cannot now be determined, as this part has been entirely
rebuilt, and all traces of the north and south aisles of the nave, if there was a
south aisle, have perished. The existing north bay is 11 feet 3 inches wide,
and the pillar, which is circular, is about 17 inches in diameter. It has a
capital, carved with simple foliage (Fig. 425), and has a square abacus. The
arch has a double set of plain arch stones, with plain soffit.
The few details which survive are extremely interesting, and show this to
have been a building of some importance. Behind the above bay now stands
the burial aisle of the Bruces of Powfoulis. It bears over the doorway the
initials of Sir James Bruce and his wife, Dame Margaret Rollox, of Duncrub,
and on another part the date 1614. It seems probable that this, as well as the
other aisles shown on Plan, contained, on the upper floor, the family seats or
galleries of the respective houses whose arms they bear, and a burial vault
beneath.
appear beneath each of the first crow steps of the gable. This aisle was
probably erected by Alexander Bruce of Stenhous and first of Airth (1452 to
1483), who was a son of Sir Robert Bruce of Clackmannan,[198] and is stated
to have married (first) Janet, daughter of the first Lord Livingstone, by
whom he had no issue. It was probably “our Ladie Aisle, founded and
situated on the south side of the Kirk of Airth,” the chaplainrie of which was
presented by Sir Alexander Bruce of
Airth, the patron, to Robert
Bruce, younger, his son, on 30th
October 1572.
Fig. 427.—Airth Church. Terminations.
The effigy (see Fig. 428.), which, as already stated, probably occupied the
tomb in the Airth aisle, lies at present in a mutilated state in the
Fig. 429.—Niche for Fig. 430.— Fig. 431.—Stone in
Statue. Bracket. Airth Castle.
The old structure having become unsuitable, a new church was erected in
1793, and the old building was allowed to fall into ruins. Some portions,
however, were preserved, and converted into mausoleums. In one of these
aisles lie the remains of Henry Dundas, first Lord Melville; in another is
buried the poet Drummond of Hawthornden.
The old church (Fig. 433) consisted of a single oblong chamber 20 feet in
width, with a tower 16 feet square at the west end. The aisles, or
Fig. 434.—Lasswade Church. East, West, and North Elevations.
mausoleums, above referred to, are projected from the north side. The
westmost is roofed with stone slabs, and has a picturesque appearance.
The tower and a portion of the church were of considerable age, and may
be classed as Transition work. In 1866 the tower had become much crushed
and dangerous. While steps were being taken by the heritors
Fig. 435.—Lasswade Church. South Elevation.
to have it strengthened the tower fell. The accompanying drawings were
made before that event.
The tower (Fig. 434) was three stories in height, besides the gables of the
saddle roof which crowned it. The entrance to the tower was from the inside
of the church by a round-headed doorway (see East Elevation), with simple
impost and plain arch with hood moulding. Above this was a large round-
arched opening into the roof of the church. The two lower stories had narrow
pointed windows. The top story had double-pointed lights, with central
mullion in each face. This story had an enriched cornice, above which rose
the east and west gables, each with a small round-headed window. A door
had been knocked into the tower on the south side (Fig. 435), which,
doubtless, helped to weaken it.
In a portion of the south wall of the church, near the tower, there was
preserved an original doorway (see Fig. 435.) about 5 feet 6 inches wide. It
resembled that to the tower in design, having plain jambs, with a string
course forming the imposts, and a plain round arch above, enclosed with a
hood moulding. All the above features seem to point to the structure being
one of the first half of the thirteenth century.
Annexed is a sketch of the effigy of a knight in armour (Fig. 436), which
is lying in the churchyard. There is no record of the knight’s name.
The grave slab (Fig. 439) has lately been fixed into the south wall. Some
time ago it was lying on the floor. It measures 6 feet 2 inches long by 2 feet
3 inches wide, and bears a beautifully lettered inscription to the memory of
Andreas Crichton. In the centre of the slab there is a cross, with the Calvary
steps, and beneath the cross limb a shield with the Crichton arms (a lion
rampant), and on the dexter side a long sword.
In the Exchequer Rolls for the year 1497, Andrew Crichton of Drumcorse
(the name of the estate adjoining the church on the north) first comes into
view. On the 1st May 1502, Crichton entered office as the Chamberlain of
the Lordship of Linlithgowshire. He presents his accounts yearly, his last
being rendered from July 1513 to July 1514, when he presumably died. His
monumental slab was, doubtless, carved shortly after that date.
There is a very beautiful recumbent statue (Fig. 440) lying in the church.
It appears to be an early work, but no record exists to tell whose memory it
commemorates.
Fig. 439.—Bathgate Church. Slab in Church to Andreas Crichton.
Malcolm IV. (1153 to 1165) granted the church of “Bathket,” with certain
lands, to Holyrood.[200] Robert, Bishop of St. Andrews, who died about
1159, confirmed those grants. There was, further, a Papal confirmation in
1164. In 1251, by a taxation of churches in the diocese of St. Andrews, the
vicar of the Church of Bathgate was to receive 12 merks of the altar dues, to
be assigned him at the sight of William, Archdeacon of Lothian, and Master
Alexander, of Edinburgh. This was confirmed by Bishop Gamelin.
Bangor Monastery, 5.
Bathgate Church, description, 474.
Bede, 12.
Beehive Cells, 7, 24, 68.
Benedict Biscop, 12.
Beverley Minster, 54.
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