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more information – www.cambridge.org/9781107648654
Evidence for Health
From Patient Choice to Global Policy
Evidence for Health
From Patient Choice to Global Policy
Anne Andermann
Associate Professor, Department of Family Medicine,
Associate Member, Department of Epidemiology, Biostatistics and Occupational Health, and
Research Associate in Public Health and Primary Health Care, St Mary’s Research Centre,
McGill University, Montreal, Canada
cambridge university press
Cambridge, New York, Melbourne, Madrid, Cape Town,
Singapore, São Paulo, Delhi, Mexico City
Cambridge University Press
The Edinburgh Building, Cambridge CB2 8RU, UK
Published in the United States of America by Cambridge University Press, New York
www.cambridge.org
Information on this title: http://www.cambridge.org/9781107648654
© A. Andermann 2013
Printed and bound in the United Kingdom by the MPG Books Group
A catalogue record for this publication is available from the British Library
Every effort has been made in preparing this book to provide accurate and up-to-date information which is in
accord with accepted standards and practice at the time of publication. Although case histories are drawn
from actual cases, every effort has been made to disguise the identities of the individuals involved.
Nevertheless, the authors, editors and publishers can make no warranties that the information contained
herein is totally free from error, not least because clinical standards are constantly changing through
research and regulation. The authors, editors and publishers therefore disclaim all liability for direct or
consequential damages resulting from the use of material contained in this book. Readers are strongly
advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that
they plan to use.
I have written this book for Lara and Ben, with the
hope that promoting evidence-informed decisions
will allow them to live in a healthier and more
equitable world.
Contents
Foreword page ix
Preface xi
Endorsements xv
About the author xvii
Acknowledgments xix
1 Introduction 1
2 Strategies for improving health 5
3 Understanding how decisions influence health 26
4 Producing evidence to inform health decisions 74
5 Facilitators and barriers to using evidence 121
6 Making evidence-informed decisions 146
7 Conclusion 175
Index 199
vii
Foreword
Tikki Pang
Visiting Professor, Lee Kuan Yew School of Public Policy,
National University of Singapore, Singapore and formerly
Director, Research, Policy and Cooperation, World Health Organization,
Geneva, Switzerland
ix
x Foreword
Second, is its implicit message that the need to understand the importance of evidence is
as relevant and important for a doctor, a nurse, or an individual patient and consumer, as it is
for senior policy-makers at national or global levels. All of these people must, ultimately,
make decisions pertaining to the health of human beings, be it at the level of an individual or
whole populations, both in developed and developing countries.
Third, is that it offers many universal lessons and recommendations on the importance
and use of evidence, which are applicable beyond the health sector to other sectors that
nonetheless have a direct or indirect influence on human health. The book thus speaks to
the reality of an increasingly globalised world where health challenges are transnational,
multidimensional and multi-sectoral.
In addition to its obvious value as a practical “A to Z” guide for decision-makers, the book
should be compulsory reading at the postgraduate level in the fields of public policy and
public administration, where future decision-makers need to be sensitized to the thoughts of
Goethe, who famously said “knowing is not enough, we must apply; willing is not enough, we
must act”.
I have no doubt that this landmark publication will go a long way in advancing the
cause of evidence-informed decision-making, which is the foundation for creating and
maintaining strong and sustainable health systems. Robust health systems can then achieve
their ultimate goal of improving the health status and lives of the people they serve in an
ethical, equitable and sustainable manner.
Preface
The idea for this book came to me when I was teaching a course on epidemiology to graduate
students in the Health and Health Policy (HHP) Programme at Princeton University’s
Woodrow Wilson School for Public and International Affairs. Many of my students were
completing a Master’s degree in Public Administration (MPA) or Public Policy (MPP). They
had already worked in government or for well-known international non-governmental
organisations (NGOs) and had been involved in making decisions that could affect the
health of hundreds of thousands of people. Yet for the most part they did not have any
formal education or training in health sciences upon which to base these decisions. With
undergraduate degrees in political science, management and economics, the process of
producing, appraising and using scientific evidence was a “black box” that was unveiled
during the course so that the students could be more critical readers of the research literature
(or even of reports of the literature published in the media, which is where most people read
about scientific evidence). Even health practitioners working on the frontlines – including
doctors, nurses, midwives, lay health workers and others – are not always well versed in
research methods and how research findings can be used to improve health. While evidence
is certainly not the only “ingredient” that goes into decision-making for health, making
decisions without evidence is like sailing the seas without a map and compass. Therefore, to
foster more evidence-informed decision-making, I thought it would be important to write a
book targeted towards practitioners and policy-makers that demystifies the process of
knowledge production and illustrates the complexity of decision-making so that knowledge
users are better able to incorporate the scientific evidence into decisions, to thereby influence
health outcomes in a more strategic and informed way. This is by no means an epidemiology
textbook, but rather a practical guide to evidence-informed decision-making with the goal of
improving health and reducing health inequities.
My main argument throughout this book is that the health of individuals and populations
is a product of the many decisions that we make on a daily basis. If our world has enormous
(and some might say highly unethical) health inequities whereby some people can expect to
die at age 40 whereas in other parts of the world people live on average to age 80, it is because
we make it so and we allow these disparities to continue. These are not laws of nature. There
are just people, like you and me, making a series of decisions that have consequences for
health – even when these decisions are being made outside of the health sector. The flip side
of this is that we also have the power to change the health landscape, or even our own health,
but this depends upon using the best available scientific evidence to inform decision-making,
and ensuring that decisions are not thwarted by vested interests or lack of political will.
Indeed, making evidence-informed decisions is not a straightforward process. I recall my
experiences as a researcher in a health technology assessment (HTA) agency. The role of this
organisation, at arm’s length from the Ministry of Health, was to provide government with
evidence-informed recommendations for improving health services, and ultimately for
improving health. My role was to develop a process for evidence-informed decision-making
xi
xii Preface
with regard to genetic screening that also made explicit the underlying value judgements and
ethical considerations. However, there was a clash with the economist on the Board
of Directors who strongly believed that all considerations can be incorporated into a
cost-effectiveness analysis and who disagreed that cost issues are just one aspect – rather
than the central aspect – of decision-making. On another occasion, there was a clash with a
fellow researcher – a devout Catholic and anti-abortionist – who was developing recom-
mendations for prenatal screening that would affect the entire population. To what extent
should her own personal values be permitted to influence recommendations made in a multi-
cultural society where citizens do not share the same values? How can we ensure that value
judgements are made explicit rather than pretending that they do not exist? Even risk
tolerance varies from person to person. How to choose a threshold for an entire population
when some people would be comfortable with a risk of 1 in 100 of carrying an affected fetus,
and others would be unable to sleep at night if they had a risk of 1 in 1,000? This book
illustrates that decision-making for health is a highly complex and contentious area where
even experts can disagree on the best process for making these decisions – and quite often,
there isn’t a systematic or explicit process being used at all.
While there is no single, universally accepted approach to decision-making, this book
provides an algorithm that uses a series of questions for arriving at evidence-informed
decisions that take into consideration the multiple complexities and value judgements
involved. In many ways, the process (i.e. being participatory and involving stakeholders, as
well as being explicit in justifying why a certain decision is made) is just as important as the
product (i.e. the final decision made).
From my later experiences working as a public health consultant for another government
agency that provides technical assistance to local health regions, I witnessed first-hand how
decisions made by government can be very poorly received when certain stakeholders do not
understand how these decisions were made and feel that the decisions are unfair. Quite
literally there were fists thumping on tables and cries of injustice, followed by vehement
accusations that the government was simply trying to save money and ration services. This
was true decision-making in action. Not for the faint of heart. My role was to chaperone the
process of revisiting the decision, which was done in a systematic, evidence-informed and
participatory way. Everyone walked through the process together and various experts were
called in as needed to clarify certain issues. The key was that everyone was on the same page
and could appreciate the multiple complexities and considerations involved. While the local
stakeholders still wanted to lobby for their cause, they were much more understanding the
second time around when the government made the exact same decision – because this time
there was also a clear explanation and understanding of why this decision was made. Of
course, this does not mean that it was a straightforward case. Indeed, when the policy-maker
from the Ministry asked for my opinion prior to making their decision public, I had to admit
that it was a bit of a grey zone. On the one hand, offering this new preventive service to the
region could be justified on the basis that this region has a somewhat higher prevalence of the
health problem in question. On the other hand, this would be one of the first jurisdictions
worldwide to offer such a service outside of a research context, there are many known
technical and ethical ramifications involved in introducing this service, and the health
problem is also fairly common in other neighbouring jurisdictions (although not quite as
prevalent), which would lead to inequities in terms of access to services (also known as the
“postcode lottery”). Thus, there were reasons given that clearly explained why the govern-
ment chose not to go ahead with the introduction of this service – it was not simply a case of
Preface xiii
rationing health care and saving money. Moreover, as the knowledge base and the context
evolve, this decision could certainly be revisited over time to see whether these reasons still
apply in future. The more I am involved in decision-making at a political level, the more
I empathise with the challenges involved in integrating so many diverse considerations and
viewpoints, and the more I believe in the value of a systematic approach that makes these
multiple factors explicit.
Reflecting these experiences, the scope of this book is very broad, from the personal
decisions that individual patients make about their own health to global policy decisions that
can impact the health of millions of people worldwide. As a graduate student at Oxford
University, the focus of my doctoral research was to better understand the expectations and
information needs of women presenting to primary care, and what factors could promote
evidence-informed patient choice. Later, as a family doctor, I experienced the daily chal-
lenges of helping my own patients make difficult decisions about their health: for instance,
whether to undergo surgery that can improve quality of life but entails a certain risk of dying
during the procedure or to forego surgery and live as long as possible with increasingly
impaired function. As a public health physician working to promote the health of an
Aboriginal population in the North of Canada (for public health physicians, the “patient”
is the population), I was involved in examining the Health Impact Assessments of economic
development projects and making recommendations on how to balance the needs of various
disadvantaged populations in the North in a way that is fair and maximises benefits while
minimising harm. As well, while working at the World Health Organization (WHO) in
Geneva, I advocated for universal access to primary health care worldwide as an important
method of social protection and lever for tackling health inequities. Currently, I combine
public health practice at the local and national level, clinical work in a university-affiliated
teaching hospital serving a diverse multi-cultural community, supervision and training of
medical students and residents, and global health research aimed at empowering frontline
health workers to tackle the social causes of poor health. I therefore write this book wearing
several “hats”: as a policy-maker, a researcher, an educator, a health practitioner and even as a
patient.
As one moves from patient choice to global policy, the level of complexity increases
significantly. Yet, all decisions fundamentally entail various trade-offs when considering the
different options and balancing the overall benefits and harms of choosing one option over
another. Through this book, I hope that I can help policy-makers and practitioners to make
more evidence-informed decisions for improving health. In particular, with the growing
emphasis on the upstream social determinants of health, I hope that this book will also reach
decision-makers outside of the health sector, as decisions made in areas such as education,
employment, housing, gender equality and so forth are fundamental to tackling the major
health inequities of our time. To make progress in reducing these inequities, we need
evidence-informed decisions that consider the health impact of all policies, not just those
involving the health care system. Better-informed decisions can lead to healthier and more
equitable societies. It is up to us to choose.
Endorsements
“To enable individuals to be in control of their lives, action is needed on the social circumstances in which
people are born, grow, live, work, and age. Evidence for Health: From Patient Choice to Global Policy is
an innovative and timely book that provides important insight on how to make more transparent and
informed decisions that will result in healthier individuals and more equitable societies.”
Professor Sir Michael Marmot, Director, UCL Institute of Health Equity, London, UK, and formerly
Chair, WHO Commission on the Social Determinants of Health
“Evidence for health seems self-evident, however, Andermann in her thought-provoking book, points not
only to the value of evidence, but also to the imperative to learn how to integrate it more systematically in
all decisions related to health from local to global. Progress on this front would certainly contribute to
better decisions and better health.”
Dr. Timothy Evans, Dean, BRAC School of Public Health, Dhaka, Bangladesh, and formerly Assistant
Director General of the World Health Organization, Geneva, Switzerland
“Public health has too often focused on making recommendations about what people ought to do rather
than considering what changes behaviours and policies. Drawing from multiple disciplines, Andermann
thoughtfully addresses this challenge, reviewing how we make decisions that affect health – from the
individual to the global level – and detailing how we can generate and best make use of evidence to reduce
health inequities and improve people’s health.”
Dr. Kumanan Rasanathan, Health Section, United Nations Children’s Fund (UNICEF), New York,
USA
“This book addresses key questions confronted by policymakers, health practitioners and the population at
large. Written in a very simple and user-friendly manner, Evidence for Health will be a highly valuable
tool for understanding and addressing health inequities in both developed and developing countries.”
Mr. Saeed Awan, Director, Centre for the Improvement of Working Conditions & Environment,
Department of Labour and Human Relations, Government of Punjab, Lahore, Pakistan
“A fresh, thoughtful, and panoramic look at the role of evidence in health. This book should be of interest to
any student of public health or public policy.”
Dr. Peter Singer, Professor of Medicine and Director, Sandra Rotman Centre, University Health
Network and University of Toronto
“Decision-making is a complex process, particularly in medicine and public health. It frequently implies
the simultaneous display of technical abilities, political appraisals, and moral judgements. Anne
Andermann’s book, Evidence for Health: From Patient Choice to Global Policy, makes this process
accessible to all. I have no doubt that it will become an invaluable tool for health professionals working in
clinical, management, and public health settings.”
Dr. Julio Frenk, Dean of the Faculty, Harvard School of Public Health, and former Minister of Health of
Mexico
xv
About the author
Chapter
NaN
Dr. Anne Andermann is a family physician, a public health specialist and a former Rhodes
Scholar. Her doctoral studies at Oxford University focused on the impact of new genetic and
genomic technologies in primary care, and she later worked for the Quebec Health
Technology Assessment Agency (formerly AETMIS) on developing guidance for population-
based genetic screening policy-making. Dr. Andermann has also worked at the World Health
Organization (WHO) in Geneva on research capacity strengthening in low- and middle-
income countries. During that time, she was a member of the WHO Research Ethics Review
Committee and a main contributing author to the World Health Report 2008 on increasing
universal access to primary health care. Dr. Andermann is currently an Associate Professor in
the Department of Family Medicine at McGill University, Regional Medical Officer for Health
Canada’s First Nations and Inuit Health Branch (FNIHB), Public health physician for the Cree
Board of Health and Social Services of James Bay Northern Quebec (CBHSSJB), Chair of the
public health theme for the new undergraduate medical curriculum at McGill’s Faculty of
Medicine, practising physician and Chair of the Community-Oriented Primary Care (COPC)
Committee at St Mary’s Hospital, and founder of an international research collaboration that
aims to provide guidance and support for frontline health workers so that they can play a
greater role in addressing the social causes of poor health and reducing health inequities. Her
main area of interest is promoting the health of vulnerable and marginalised populations,
including women and child health, Aboriginal health, global health and the health of families
with rare and orphan genetic diseases. In 2011, she received the Canadian Rising Stars in
Global Health Award from Grand Challenges Canada. This is her first book.
xvii
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Plate XLIII.
Larger image
Larger image
The pattern shop, where all work originates, is fitted with the
usual pattern-making machinery, including a core-making machine.
The iron foundry, which was begun in 1790,[70] and around
which the large engineering establishment has since been raised
step by step, continues to do sound work. There are four cupolas, of
a combined capacity of about 20 tons, and cylinders up to 120 in. in
diameter are cast. These facts suggest the satisfactory character of
the equipment.
The brass foundry is an equally important department, where
first-class work is done. There are fifty-two crucible pots in use,
varying in size up to 150 lb., and of a collective capacity of about 2
tons; also an air furnace capable of producing at one heat 12 tons of
metal, for such heavy castings as are required for preparing shaft
liners, large sea chests for naval ships, etc. The strength of
Admiralty gun metal made in this foundry is up to 18 tons per
square inch, with 30 per cent. of elongation in a 2-in. length. The
foundry is served by an electrically-operated jib crane.
In the forge and smiths' shops a large amount of detail work is
done, in units ranging up to 3 tons in weight. The hammers vary up
to 15 cwt. power. A considerable amount of die-stamping is done in
connection with auxiliary engine forgings, etc. All paddle-wheels are
made in this department. The blast for the fires is got from an
electrically-driven fan.
The machine shop, which was one of the first constructed with a
completely glazed roof, occupies a site on a steep slope, one side
being formed by a heavy retaining wall, as shown in the engraving
on Plate XLIX., facing page 106. At the level of the top of the wall,
which is 25 ft. high, there is the light machine shop, while at the end
of the bay and over the annexe situated to the left of the engraving,
is the brass-finishing shop. There is a 2-ton hoist between the
erecting-shop floor and the galleries, so that no inconvenience, so
far as transport is concerned, is involved by this arrangement.
Originally a stream ran down the hill and over the site on which
the Works are located, and its waters have for many years been
utilised as a source of power. A special 24-in. inward-flow turbine
works in the conduit which conveys the water across the site, and
this turbine develops continuously 80 horse-power. This serves to
drive some of the machines in the boiler works. The turbine runs in
parallel with a compound vertical engine, which drives the shafts
actuating the groups of small machines in the engine shop. Many of
the larger tools, however, are electrically-driven by separate motors,
the current being transmitted from the central station already
described.
The engravings on Plates XXXIX. and XLIX., facing pages 92 and
106 respectively, illustrate the main machine shop, which has a
width of 60 ft., and, with the adjoining bay, accommodates some of
the finest marine engineering tools made. Perhaps the best
indication of their efficiency is the fact that three weeks suffice for
the machining of the parts of a complete set of engines to develop
2000 horse-power. The shops are traversed by five overhead electric
cranes, ranging up to 40 tons lifting capacity.
Plate L.
The leading dimensions and the principal work done by the more
important tools afford an idea of the extent of the equipment. There
are several planing and slotting machines, one of which is shown in
the engraving on Plate L., facing this page. There are two combined
machines, to plane 21 ft. and to slot 18 ft., used in connection with
the condensers, cylinders, large bearing frames and sole-plates of
engines, while two other smaller tools are devoted to finishing the
castings for bed-plates and columns. For machining eccentric-rod
ends, etc., there is a 24-in. slotter with a circular table. There are
two high-speed planers with two tool-boxes on the cross-slide, which
take in pieces 10 ft. by 5 ft. by 5 ft., and one to take work 12 ft. by 3
ft. by 3 ft.
In the driving of some of the heavier tools very good results have
been attained by the application of a reversible motor, which in one
case has dispensed with four belts, a pair of bevel wheels, and two
countershafts, reducing enormously the frictional waste, and
enabling higher speeds and quicker return strokes to be attained.[71]
For drilling work there are several large tools. Recently there has
just been fitted a multiple machine which, while primarily intended
for drilling the tube-holes in drums and water-pockets of Yarrow
water-tube boilers, is also utilised in connection with ordinary
machine work. This tool, of which an engraving is given on Plate L.,
facing page 108, was manufactured by Messrs. Campbells and
Hunter, Limited, Leeds. It has a massive cross-slide carrying four
saddles, movable by a powerful screw, driven by spur-gearing and
friction-clutch, controlled from one of the saddles. The steel spindles
are balanced, and have a special self-acting, variable, rack-feed
motion, as well as a quick vertical motion by hand for rapidly
adjusting the drill through the jig. Each spindle can be operated
independently. The table has a sliding motion, directed by two
straight screws coupled to the cross shaft and vertical shaft, and is
carried by a straight bed with three bearing surfaces. This machine,
which weighs 20 tons, is driven by a 30 brake-horse-power electric
motor.
There are two vertical boring mills used for cylinder work, one
being capable of boring up to 120 in. in diameter, and the other to
94 in. in diameter. A combined boring and facing machine, with a
table 4 ft. square, is usefully employed on propeller bosses, valve-
chests, small cylinders, and built-up bed-plates, machine bearings,
etc.
The installation of high-speed lathes is specially noteworthy. In
one, the face-plate can take in 12 ft. in diameter, and, as the length
of bed is 30 ft., it is useful for large surfacing work, as well as for
turning crankshafts of the larger sizes. There are two 12-in. double-
geared lathes for surfacing and screw cutting. These are self-acting,
and the lengths of bed are 19 ft. and 12 ft. respectively. For turning
piston and connecting rods, two screw-cutting lathes of 16-1/4-in.
centres are in use, the length of the bed being 22-1/2 ft. These have
each a triple-gear headstock, and a chuck 48 in. in diameter; with
rack motion and slide-rest feeds. A 20-in. centre lathe, with a bed 28
ft. 6 in. long, is fitted with two saddles and four slide-rests for shaft
liners, etc. Amongst others, there is a 27-in. centre lathe for
shafting, the bed being 36 ft. long.
One of the lathes is illustrated on Plate LI., adjoining page 109.
This is a 48-in. surfacing and boring lathe, by Messrs. John Lang and
Sons, Limited, Johnstone. The two new features introduced are the
variable speed drive and automatic speed-changing mechanism. The
headstocks can be used for single or triple gear, and are so arranged
that, even when running at the greatest speed, there is a reduction
by gearing. With this arrangement the lathes have greater power
when turning small diameters than when the belt is used driving
direct to the main spindle. The spindles, which are hollow, with
hexagonal turrets, are of crucible cast steel, and run in gun-metal
bearings. By means of the speed-changing mechanism, the cutting
speed of the tool is kept practically constant when surfacing. This
means that any surface can be finished off in about one-half of the
time taken by a lathe having the ordinary step-cone drive, where the
workman will not change the position of the belt while surfacing.
The self-acting feed-motions are positive.
Plate LII.
As to the boiler works, the fact that in 1905 the production was
practically one boiler per week is, of itself, testimony to the nature of
the plant adopted. The main boiler shop, together with its yard, has
an area of 7000 square yards, and a height of 45 ft. to the crane
rail, and is served by five overhead electric cranes, ranging in lifting
power up to 100 tons, with numerous jib and other cranes
associated with the various machine tools.
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