1. Where is most hematopoietic tissue found in adults? 9.

Which of the following is associated with the long-term

a. Lungs storage of iron?
b. Spleen a. Heme
c. Flat Bones b. Hemosiderin
d. Long Bones c. Transferrin
d. Ferritin
2. Which of the following is the cause of thalassemia?
a. structurally abnormal hemoglobin 10. What is the developmental stage of erythrocyte where
b. absent or defective synthesis of polypeptide chain the hemoglobin appears?
in hemoglobin a. Pronormoblast (Rubriblast)
c. excessive absorption of iron b. Basophilic normoblast (Prorubricyte)
d. abnormal or defective porphyrin synthesis c. Polychromic normoblast (Rubricyte)
d. Orthochromic normoblast (Metarubricyte)
3. Which of the following conditions causes decreased
erythrocyte deformability that reduces their lifespan? 11. What is the composition of the normal adult
a. Pyruvate kinase deficiency hemoglobin?
b. Paroxysmal nocturnal hemoglobinuria a. two alpha and two delta chains
c. G6PD deficiency b. three alpha and one beta chain
d. Hereditary acanthocytosis c. two alpha and two beta chains
d. two beta and two epsilon chains
4. Which of the following disease is caused when valine
replaces glutamic acid at position 6 on both beta chains 12. What is/are the RBC metabolic pathway responsible for
of the hemoglobin? the production of 2,3- biphosphoglycerate?
a. Embden-Meyerhof Pathway
a. Hgb SS
b. Hexose Monophosphate Shunt
b. Hgb AS
c. Methemoglobin Reductase Pathway
c. Hgb CC
d. Rapaport-Luebering Shunt
d. Hgb SC
13. Which determination is considered as a reliable
5. When manual procedure is performed, what is/are the assessment of the effective erythropoiesis in the bone
test/s that may affected by excessive ETDA in blood marrow?
collection? a. RBC count
i. packed cell volume b. Reticulocyte count
ii. RBC count c. Hemoglobin
iii. Hemoglobin d. M:E ratio
iv. WBC count
a. i only (produces shrinkage of the RBC) 14. Which of the following substance regulates the affinity
b. ii and iv only of oxygen to the hemoglobin molecule?
c. ii and iii only a. Carbon dioxide
b. 2,3, Diphosphoglycerate
d. i, ii, iii and iv
c. Folic acid
d. Iron Mechanism
6. All of the following anemia is associated with the
problem with heme, except? 15. Which component gives the RBC its negative charge?
a. Iron deficiency anemia a. Spectrin
b. Sideroblastic anemia b. Actin
c. Thalassemia c. glycophorin A
d. Chronic disease/inflammation d. glycophorin B

7. What is the major site of hematopoiesis during the 16. What is the condition associated where RBCs appear
second month of gestation? as crescent shape?
a. yolk sac a. hereditary spherocytosis
b. bone marrow b. pyruvate kinase deficiency
c. liver c. Rh null syndrome
d. spleen d. sickle cell anemia

17. Artifactual drying of the blood smear will cause what

8. All of the following shows microcytic/ hypochromic
type of cells?
anemia, except which?
a. Stomatocytes
a. Iron deficiency anemia b. codocytes
b. Anemia of chronic disease c. dacryocytes
c. Sideroblastic anemia d. echinocytes
d. Aplastic anemia

HEMATOLOGY PART 1 PRE-TEST ANSWERS AND RATIONALIZATION

18. What are the erythrocyte inclusions that make the RBC 27. How does the bone marrow respond to anemic stress?
look like a "blueberry bagel"? a. Production is expanded, and red cells are released
a. Howell-Jolly bodies to the circulation prematurely.
b. basophilic stippling b. Production is expanded, and platelets are rushed
c. Pappenheimer bodies into circulation.
d. Heinz bodies c. Production is diminished, and the M:E ratio is
increased.
19. Heme synthesis occurs in what part of the normoblast? d. Production is diminished, and the M:E ratio is
a. Nucleus unaffected
b. Cytoplasm
c. Mitochondria 28. Increased central pallor of the erythrocytes is described
d. Ribosomes as?
a. Anisocytosis
20. Which of the following is consists of a ring of carbon, b. Poikilocytosis
hydrogen and protoporphyrin IX? c. Pleocytosis
a. Heme d. Hypochromia
b. Globin
c. Both 29. The morphological classification of anemia isased on
d. Neither which of the following?
a. red cell count
21. Which of the following organs is/are resp[onsible for the b. cause of the anemia
“pitting process” of RBCs? c. red cell indices
a. Liver d. reticulocyte count
b. Lymph nodes
c. Spleen 30. Which of the following is true about
d. All of the above cyanmethemoglobin method?
a. measures all hemoglobin pigments
22. Which of the following describes the blood film of a b. measures only oxyhemoglobin
patient with iron deficiency anemia? c. measures all hemoglobin pigments except
a. Occasional burr cells with decreased central pallor sulfhemoglobin
of macrocytes d. measures only methemoglobin
b. Hypochromic microcytes with poikilocytes
c. Normochromic normocytic cells with basophilic
stippling
d. Numerous oval macrocytes with decreased
platelets

23. Increased iron in the mitochondria of normoblasts is

characteristic of which of the following?
a. Aplastic Anemia
b. Sideroblastic Anemia
c. Anemia of chronic disease
d. Iron Deficiency Anemia

24. Which of the following is considered as normal

hemoglobin?
a. Carboxyhemoglobin
b. Sulfhemoglobin
c. Deoxyhemoglobin
d. Methemoglobin

25. All of the following are associated with macrocytic

anemia, except?
a. Vitamin B 12 deficiency
b. Folate deficiency
c. Iron deficiency
d. Fish tapeworm infection in some individual

26. RNA remnants in the RBC are visualized when stained

with?
a. Prussian blue
b. New methylene blue
c. Peroxidase
d. Wright stain

HEMATOLOGY PART 1 PRE-TEST ANSWERS AND RATIONALIZATION