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Assignment Epi

The document outlines the sample size calculation for a case-control study with 80% power and a 0.05 significance level, aiming to detect an odds ratio of 2.5 or greater. It concludes that a total of approximately 172 individuals, consisting of 86 cases and 86 controls, is needed based on the given parameters. The proportion of exposed individuals in the control group is 25%.

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20 views

Assignment Epi

The document outlines the sample size calculation for a case-control study with 80% power and a 0.05 significance level, aiming to detect an odds ratio of 2.5 or greater. It concludes that a total of approximately 172 individuals, consisting of 86 cases and 86 controls, is needed based on the given parameters. The proportion of exposed individuals in the control group is 25%.

Uploaded by

madhuritu.medha
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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08.03.

2024

Assignment 1- Epidemiology II (PBH 742.2)

Madhu ritu Bhadra Medha


ID: 2325385680
Question: How many cases and controls do I need for this scenario?
 80% power
 0.05 significance level
 Equal number of cases and controls
 Want to detect an OR of 2.5 or greater
 The proportion of exposed among control group is 25%

Here, r = 1 (equal number of case and control)


Z β = 0.84 (for 80% power)

Z α = 1.96 (for 0.05 significance level)


2

p2 = 25% = 0.25 (proportion of exposed among control group)

OR = 2.5 or greater

¿ × p2
At first, p1=
p2 ( ¿−1 ) +1

2.5× 0.25
¿
0.25 ( 2.5−1 ) +1

0.625
¿
1.375
¿ 0.4545

0.4545+ 0.25
Average proportion, p=
2
¿ 0.3523

( )
2
( p ) (1− p ) Z β + Z α
As we know, 1 2
n=(r + )× 2
r ( p 1− p2)

0.3523 ( 1−0.3523 ) ( 0.84 +1.96 )2


¿2× 2
( 0.4545−0.25 )
1.7890
¿2×
0.0418
¿ 2 ×42.7
≈ 2 ×43

Case ≈ 86

Control ≈ 86

Total ≈ 172

So, the calculated answer indicates that, based on the specific scenario, I need a total sample size
of approximately 172 individuals (86 cases + 86 controls) for the case-control study.

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