Materials in the new sunscreens with the encapsulation of ZnO and octocrylene in poly
(styrene-co-methyl methacrylate) nanoparticles via miniemulsion polymerization. [1]
Zinc oxide (ZnO) nanoparticles and 3-(trimethoxysilyl)propyl methacrylate (MPS) were
purchased from Sigma-Aldrich. Acetic acid (CH3COOH, P.A) and ethanol (C2H5OH, P.A.)
were purchased from Vetec and Dinâmica. For the miniemulsion polymerization reactions the
following reagents were used: Crodamol GTCC (Alfa Aesar), Lutensol AT50 (BASF),
potassium persulfate (KPS, K2S8O2) (Vetec, P.A), Univul N539 T octocrylene (OC) (BASF),
sodium bicarbonate (NaHCO3) (Vetec, P.A), methyl methacrylate (MMA, C 5H8O…)
Sunscreen nanoparticle suspensions are prepared via the novel Flash NanoPrecipitation
process (FNP), which involves rapid micromixing followed by block copolymer directed
assembly of nanoparticles. (inorganic and organic filters)[2]
- The block copolymer stabilizer is polystyrene-block-polyethylene glycol (PS-b-PEG)
with a homopolymer polystyrene (PS)
- Three organic filters, ethylhexyl triazone (Uvinul T 150), benzophenone-3 (Uvinul M
40), and diethylamino hydroxybenzoyl hexyl benzoate (Uvinul A Plus) and two nano-
sized inorganic filters, zinc oxide and titanium dioxide
- Flash NanoPrecipitation (FNP) is a new technology for the preparation of
multifunctional nanoparticles (NPs) via rapid solvent displacement using amphiphilic
diblock copolymers to direct precipitation of hydrophobic species.
+ Two steps: (1) the hydrophobic actives along with amphiphilic diblock copolymers
are dissolved in a water miscible organic solvent such as tetrahydrofuran or acetone;
and (2) the organic phase is rapidly mixed with an antisolvent (water) in a multi-inlet
vortex mixer (MIVM) to create homogeneous mixing on the order of milliseconds.
- Materials: Diethylzinc (Zn(Et)2), titanium(IV) isopropoxide (TTIP), octadecene, oleic
acid, hexadecyl amine, and ethanol were purchased from Sigma–Aldrich (St. Louis,
MO, USA). HPLC grade tetrahydrofuran (THF), deionized water with a resistivity of
18 MΩ cm.
Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and
photoprotection[3]
the influence of polysorbate 85 (P-85) and poloxamer 188 (P-188) as stabilizing agents
- 2 techniques:
+ The emulsification-diffusion technique (kỹ thuật nhũ hoá- khuếch tán): the
formation of an oil-in-water emulsion between a partially water-miscible solvent
saturated with water
+ The solvent displacement procedure (quy trình dịch chuyển dung môi):
Nanoparticles are formed by a dissolution of polymer in water-miscible organic
solvent (e.g. acetone) followed by a transfer of the organic phase into an aqueous
phase containing a surfactant
- Materials: Poly(ε-Caprolactone) P(CL), with molecular mass of 10,000, was supplied
by Fluka. Octyl methoxycinnamate (Parsol® MCX), OMC, was obtained from
Givaudan-Roure (Vernier, Switzerland). Two non-ionic stabilizing agents were tested:
Poloxamer 188, P-188, (Pluronic® F 68, BASF, Ludwigshafen, Germany) and
Polysorbate 85, P-85, (Tween® 85, Atlas Chemie, Germany). Satiaxane CX 91 (SCX
91), acetone and ethanol (EtOH) were purchased from Fluka. Polysorbate 80, P-80
INFLUENCE OF NATURAL POLYMER DERIVED FROM STARCH AS A SENSORY
MODIFIER IN SUNSCREEN FORMULATIONS
- The polymer was able to promote a very soft and velvety feel on the skin when used
in a sunscreen formulation, and it was able to mitigate and noticeably reduce the
oiliness of the skin
- Materials: glyceryl monostearate, cetostearyl alcohol; octyl metoxicinamate, octyl
salicylate, avobenzone, homosalate; phenonip® (INCI name: Phenoxyethanol,
Methylparaben, Ethylparaben, Butylparaben , Propylparaben, Isobutylparaben,
Clarient, United Kingdom), disodium EDTA and deionized water, with the addition
of: (A) 2.0% Aluminum Starch Octenylsuccinate (Dry-Flo® Pure, Akzo Nobel) or (B)
without the addition of polymer
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