THE CHEMICAL STRUCTURE OF DNA
THE SUGAR PHOSPHATE ‘BACKBONE’ WHAT HOLDS DNA STRANDS TOGETHER?
BASE BASE BASE DNA strands are held together by hydrogen bonds between bases on adjacent
strands. Adenine (A) always pairs with thymine (T), while guanine (G) always
pairs with cytosine (C). Adenine pairs with uracil (U) in RNA.
O O O
O O O H
H
P O O P O O P O O N O H N
N N H O
O- O- O-
N G N H N C
N A N H N T
DNA is a polymer made up of units called nucleotides. The nucleotides are
N N
made of three different components: a sugar group, a phosphate group, and a N N
base. There are four different bases: adenine, thymine, guanine and cytosine. N H O
O
H
A ADENINE T THYMINE FROM DNA TO PROTEINS
NH2 The bases on a single strand of DNA act as a code. The letters form three letter
codons, which code for amino acids - the building blocks of proteins.
H HN
N
N DNA RNA PROTEIN
TRANSCRIPTION TRANSLATION
O N O
N N H An enzyme, RNA polymerase, transcribes DNA into mRNA (messenger
ribonucleic acid). It splits apart the two strands that form the double helix, then
reads a strand and copies the sequence of nucleotides. The only difference
between the RNA and the original DNA is that in the place of thymine (T),
G C
another base with a similar structure is used: uracil (U).
GUANINE CYTOSINE
DNA SEQUENCE T T C C T G A A C C C G T T A
O
mRNA SEQUENCE U U C C U G A A C C C G U U A
H O N NH2
N AMINO ACID Leucine
HN
Phenylalanine Leucine Asparagine Proline
In multicellular organisms, the mRNA carries genetic code out of the cell
HN nucleus, to the cytoplasm. Here, protein synthesis takes place. ‘Translation’ is the
H2N N N process of turning the mRNA’s ‘code’ into proteins. Molecules called ribosomes
carry out this process, building up proteins from the amino acids coded for.
© Andy Brunning/Compound Interest 2018 - www.compoundchem.com | Twitter: @compoundchem | FB: www.facebook.com/compoundchem
Ci This graphic is shared under a Creative Commons Attribution-NonCommercial-NoDerivatives licence. BY NC ND