[Total No. of Pages : 3 011134 First M.B.B.S. (2019) Supplementary Examination Summer - 2020 ‘Total Duration : Section A + B = 3 Hours BIOCHEMISTRY -! Section B Marks : 80 SECTION-B Instructions: 1) Use blue/black ball point pen only. 2) Donotwrite anything on the blank portion of the question paper. Ifwritten anything, such type of act will be considered as an attempt to resort to unfair means. 3) All'questions are compulsory. 4) The number to the right indicates full marks. 5) Draw diagrams wherever necessary. 6) Distribution of syllabus in Question Paper is only meant to cover entire syllabus within the stipulated frame. The Question paper pattern is a mere guideline. Questions can be asked from any paper's syllabus into any question paper. Students cannot claim that the Question is out of syllabus. As it is only for the placement sake, the distribution has been done. 7) Use a common answer book for all Sections. 2. Brief answer questions (Any Ten out of Eleven): [10 x 2 = 20 a) b) c) da) °) N- 6654 What is suicide inhibition? Give one example. Structural difference between starch and glycogen. What is renal threshold of blood glucose .Give two examples of glycosuria. Name two phospholipids present in cell membrane. Why excessive ingestion of alcohol leads to hypoglycemia? Give four therapeutic uses of enzymes.011134 g) Give two examples of Antigen presenting cells (APC). h) Give two examples of antioxidant enzymes. i) Give P:0 ratio of NADH and FADH2. - ) Give two examples of nitrogen containing glycerophosphatides. k) Give four inhibitors of Complex IV in electron transport chain. 3. Short Answer Questions (Any Eight out of Nine) : [8 x 5 =40] a) Rapoport Leubering Cycle and its significance. b) Fatty Liver- Definition, causes & lipotropic factors. [14242] c) Explain enzyme specificity with suitable examples. d) Write a note on beneficial and adverse effects of dietary fibers. ) Name four chemical carcinogens. Add a note on Ames assay. [243] f) Enumerate five immunoglobulins with their functions. 2) Anobese person came to the hospital with complaints of )) Polyuria i) Thirst iii) Weakness iv) Increased appetite On investigation random blood sugar was found to be 160 mg%. 1) What is the probable diagnosis? ll 2) What is the importance of OGTT in such patients. 1 3) What is the significance of HbAIC testing? 2] ae N - 6654011134, h) A four year old child was brought to the hospital with oedema on face and lower limbs. On examination, the child had sparse, soft & thin hair. The parents complained that the child is lethargic and does not have any craving for food. The symptoms typically appeared after a younger brother was born, i) Whatis the likely disorder? (1 ii) Whats the biochemical defect? (1) ii) Why symptoms appeared after birth of sibling brother? 0) iv) Why such patients are likely to have fatty liver? [2] i) Importance of Communication with patients in local language. 4. Long Answer Questions (Any Two out of Three): + [2 x 10 = 20] a) Describe glycogenolysis. Explain its regulation and enumerate three glycogen storage diseases alongwith deficient enzymes. [4+3+3] b) Discuss cholesterol- biosynthesis under following headings. [1+5+2+2] it) Site & organs ii) Synthetic pathway iti) Regulation iv) Functions ¢) Discuss Election Transport Chain, Adda note on Inhibitors and Uncouplers of oxidative phosphorylation, [6+4] >> > N - 6654 -3-