Subject: Novel Drug Delivery System (69324)
Year and Sem: Final Year B. Pharmacy Sem VII, Choice Based R-2019
Duration: 3 Hours Total marks: 75
N.B.: 1. All questions are compulsory
2. Figures to right indicate full marks.
Question Question Max.
No. Marks
Q.I Multiple Choice Questions (Answer all) 20
1 Which of the following is a pharmacokinetic factor aiding in the selection 1
of drug candidates to be formulated as a sustained release drug delivery
system?
a) Dose
b) Partition coefficient
c) Stability
d) Half life
2 Drug release from a diffusion-controlled reservoir system is governed by 1
which of the following equations?
a) Fick’s law
b) Noyes Whitney equation
c) Hixson & Crowell equation
d) Higuchi equation
3 A critical property for a polymer for drug delivery is 1
a) cost effectiveness
b) non-biodegradable
c) antigenicity
d) lack of drug binding sites
4 An example of a naturally occurring polymer is 1
a) carbopol
b) ethyl cellulose
c) polyethylene glycol
d) gelatin
5 Correct sequence of steps involved in coacervation phase separation is 1
a) Formation of three immiscible phases, deposition, rigidisation
b) Rigidisation, deposition, formation of three immiscible phases
c) Rigidisation, formation of three immiscible phases, deposition
d) Formation of three immiscible phases, rigidisation, deposition
6 Optical Microscopy can be used to determine size of 1
a) Liposomes
b) Nanoparticles
c) Niosomes
d) Microspheres
7 Drug candidate for buccal mucoadhesive system shall have 1
a) High dose
b) Low dose
c) Bitter taste
d) High molecular weight
8 Lipid soluble drug passes through the buccal mucosa 1
through______pathway.
a) Transcellular
b) Intercellular
c) Paracellular
d) Post cellular
9 Osmotic pressure is given by 1
a) π = VRT
b) V = π RT
c) π =n RT
d) π = h V RT
10 How do hormone releasing IUDs act? 1
a) causing lysis of sperms
b) making the uterus unsuitable for the fertilized egg to implant
c) reducing the motility of sperms
d) prevent release of egg
11 A component of the transdermal patch that prevents leakage and accepts 1
printing is
a) polymer matrix
b) release liner
c) adhesive
d) backing membrne
12 Which of the following is a tackifier used in a Pressure Sensitive 1
adhesive?
a) titanium oxide
b) zinc oxide
c) mineral oil
d) rosin esters
13 Which of the following volatile liquid can be used to formulate a floating 1
drug delivery system?
a) Methanol
b) Cyclopentane
c) Liquid paraffin
d) Acetone
14 Which of the following polymer can be used to formulate a 1
hydrodynamically balanced systems?
a) Ethyl cellulose
b) Cellulose acetate phthalate
c) Hydroxy propyl methyl cellulose
d) Polyvinyl pyrrolidone phthalate
15 A physiological factor affecting particle deposition in the airways is 1
a) inspiratory flow rate
b) particle size
c) particle density
d) aerosol velocity
16 1
A disadvantage of Dry Powder Inhaler is
a) powders are at lower energy state
b) problems in dose uniformity
c) patient inspiratory flow rate insignificant
d) requires propellant
17 Advantages of Nanoparticles are 1
a) Increased dose
b) Simple preparation methods
c) Improved dissolution
d) Increase in side effects
18 Basic components of liposomes include 1
a) Polymer
b) Surfactants
c) Phospholipids
d) Viscosity builder
19 Which of the following statements is correct? 1
a) HPMC forms an in situ gel by a change in pH
b) Carbopol forms an in situ gel by changing the temperature
c) Poloxamer forms an in situ gel by changing temperature
d) Sodium alginate forms an in situ gel by a change in temperature
20 The material used in the construction of a Lacrisert is: 1
a) Hydroxypropyl methylcellulose
b) Hydroxypropylcellulose
c) Hydroxyethylcellulose
d) Methylcellulose
QII Answer any Two 20
1 Discuss the parameters to be considered while selecting a drug candidate 10
to be formulated as a controlled drug delivery system.
Any five parameters 2M each
2 Explain the steps of coacervation phase separation. Write in detail any 10
one method used for formation of three immiscible phases.
Formation of three immiscible phases 2M
Deposition 1M
Rigidisation 1M
Any one Method of formation of 3 phases in detail with diagram 6M
3 Enlist the advantages and limitations of ocular inserts. Classify them and 10
explain in detail Ocusert.
Advantages and limitations of ocular inserts 2M
Classification 1M
Explain in detail Ocusert with diagram 7M
QIII Answer any Seven 35
1 Differentiate between matrix and reservoir systems. 5
Any 5 points 1M each
2 Define ‘polymers’. Classify them based on their origin and biostability. 5
Definition 1M
Classification based on origin 2M
Classification based on biostsbility 2M
3 Discuss formulation consideration for buccal drug delivery systems. 5
Significance of each component 3M
Examples 2M
4 Briefly describe the various types of Nasal drug delivery systems. 5
Nasal spray 2.5M
Nebulizer 2.5M
5 Explain the design of any one type of Intra-uterine device. 5
Any one type of IUD- Advantages & Disadvantages 1M
Description 3M
Uses 1M
6 Explain the factors affecting transdermal permeation. 5
Physicochemical properties of permeate molecule 2M
Physicochemical properties of drug delivery system 1.5M
Physiological and pathological condition of the skin 1.5M
7 Explain the concept of gastroretention and enlist the advantages and 5
limitations associated with the system.
Explain the concept of gastroretention 3M
Enlist advantages and limitations 2M
8 What are targeted drug delivery systems? Write their advantages and 5
disadvantages.
Explain Targeted DDS 2M
Enlist advantages and disadvantages 3M
9 Write a note on temperature-sensitive in-situ gels as an ocular drug 5
delivery system.
State concept of temperature-sensitive in-situ gel 1M
Explain in brief this approach 4M
