Department of Pharmacology

Pre University Practical Examination

Date -08.01.2024 BATCH -A
Total marks = 100 Time : 2.15 Hrs
1. Spotters ……………………………………….10 marks
2. ADR ………………………………………........05 marks
3. Prescription Writing ……………………..05 marks
4. Prescription Auditing……………… …… 05 marks
5.Quiz……………………………………………….04 marks
6. Drug Interactions ………………………….02 marks
7. Drug Promotional Literature …………02 marks
8. Dose Calculations…………….……… …..02 marks
9. Table Viva -1………………………………….15 marks
10. Table Viva- 2…………………………………15 marks
11. Table Viva -3…………………………………15 marks
12. Grand Viva …………………………………..20 marks
SPOTTER (10 X 1 Marks =10)

Time -2 minutes for each spot

1. (a)Name the teratogenic effect
(b)one drug responsible for it ?
2. (a) Identify the plant shown in the image

(b) Name the drug obtained from it and

which part of plant?
3.(a) Identify the adverse drug reaction

(b)Name one drug responsible for it?

Q4. [A]Name the ADR shown.

[B]Name the drug responsible?

Q5 .[A]Name the ADR shown in the given
image?
[B]Name the drug responsible?
6.(A) Name the drug delivery system
(B) give one advantage ?
 Q7.Name the 2 drug delivery system shown.
(a)
(b)
• (a)

• (b)
Q8.[A]Name the ADR shown in the given image?
[B]Name the drug responsible?
9. (A) drug given in the strip belongs
to which class ?
(b) what is the mechanism of action ?
 Q10.[A] What is the osmolarity of the given
drug?
[B] Write Composition of the given drug with
osmolarity of each component?
 Q1.Identify the given image. Name
one advantage of using the given drug
delivery system
Q2.Therapeutic index is calculated
with which of following equations?

[A]ED50/LD50
[B] LD50/ED50
[C] ED50*LD50
[D] ED50+LD50
 Q3.Identify the drug delivery system.
Name one drug delivered by this system.
Name one advantage of using the given drug
delivery system
 Q4.Which among following is not a
second messenger?
[A]cyclic AMP

[B]Guanyl cyclase

[C]Diacyl-glycerol

[D]Inositol triphosphate
 Q5. Antidote used in
acetaminophen poisoning
.
Q6.Name one use of the given drug.
Q7.Name one drug following order of
kinetics as shown by graph A, graph B.
Q8.Gray baby syndrome is caused by
which drug?
Q9.[A]Name the ADR shown in the
given image?
[B]Name the drug responsible?
 Q10.[A] What is the osmolarity of the given
drug?
[B] Write Composition of the given drug with
osmolarity of each component?
 Spot - 1
DOG BLOOD PRESSURE

A B A

Q. What is drug A?

Q. Name the phenomenon ?

 SPOT-2
Q) Identify the instrument and its uses
 Spot - 3

Q. Identify the Instrument

Q. Write its uses.
 SPOT- 4

Q1.Identify the condition ?

Q2.Name one Drug causing this condition?
SPOT 5 Q) Write uses of different
doses of Aspirin ?
 SPOT-6

• Q. Criticize and comment on the rationality of

the following combination of drugs.

Trimethoprim + Sulphamethoxazole
 SPOT-7

Q) Identify the instrument

Q) Write its uses
 SPOT -8

Q) Write two drugs causing raised intracranial

pressure.
 SPOT -9

Q)This drug belongs to which group ?

Q) Write its effect on eye ?
9. (A) drug given in the strip belongs
to which class ?
(b) what is the mechanism of action ?
SPOT 10. Identify the instrument and its 2 uses
 ADR(Adverse Drug Reactions)
(1 x5 Marks =5 )

Time - 20 minutes

Fill ADR FORM & perform

causality assessment using
Naranjo scale and WHO UMC
method for following case ?
Case 1
Mr Sushant A Gupta, 30-years old male with 68 kg weight was diagnosed as
a case of bacterial meningitis. He was started empirically with Inj
Ceftriaxone 2 g IV OD and Inj Vancomycin 500 mg IV slowly in 30 minutes
6 hrly on 12.10.2015 at 9 AM. After 30 minutes of drug administration, he
started developing fever with chills, urticaria, popular rash over face,
abdomen and limbs and intense flushing. His blood pressure was 90/60 mm
of Hg. Both the antibiotics were stopped and he was treated with Inj.
Pheniramine 25 mg IM at 10 AM following which the reaction completely
subsided at 2 PM on same day. At 5 PM on same day, the Inj Vancomycin
was re-introduced to the patient. Same symptoms developed again within 1
hour and resolved 4 hrs after administration of Inj. Pheniramine 25 mg IM.


Note:
• Inj Vancomycin
o Brand Name: Vanzid
o Manufacturer: SWACH Healthcare
o Batch number: KKIL098
o Expiry date: Mar 2016

• Inj Ceftriaxone
o Brand Name: Taximax
o Manufacturer: Wedley Labs
o Batch number: OPO659
o Expiry date: Dec 2016
Case 1
Mr Sushant A Gupta, 30-years old male with 68 kg weight was diagnosed as
a case of bacterial meningitis. He was started empirically with Inj
Ceftriaxone 2 g IV OD and Inj Vancomycin 500 mg IV slowly in 30 minutes
6 hrly on 12.10.2015 at 9 AM. After 30 minutes of drug administration, he
started developing fever with chills, urticaria, popular rash over face,
abdomen and limbs and intense flushing. His blood pressure was 90/60 mm
of Hg. Both the antibiotics were stopped and he was treated with Inj.
Pheniramine 25 mg IM at 10 AM following which the reaction completely
subsided at 2 PM on same day. At 5 PM on same day, the Inj Vancomycin
was re-introduced to the patient. Same symptoms developed again within 1
hour and resolved 4 hrs after administration of Inj. Pheniramine 25 mg IM.


Note:
• Inj Vancomycin
o Brand Name: Vanzid
o Manufacturer: SWACH Healthcare
o Batch number: KKIL098
o Expiry date: Mar 2016

• Inj Ceftriaxone
o Brand Name: Taximax
o Manufacturer: Wedley Labs
o Batch number: OPO659
o Expiry date: Dec 2016
Case 1
Mr Sushant A Gupta, 30-years old male with 68 kg weight was diagnosed as
a case of bacterial meningitis. He was started empirically with Inj
Ceftriaxone 2 g IV OD and Inj Vancomycin 500 mg IV slowly in 30 minutes
6 hrly on 12.10.2015 at 9 AM. After 30 minutes of drug administration, he
started developing fever with chills, urticaria, popular rash over face,
abdomen and limbs and intense flushing. His blood pressure was 90/60 mm
of Hg. Both the antibiotics were stopped and he was treated with Inj.
Pheniramine 25 mg IM at 10 AM following which the reaction completely
subsided at 2 PM on same day. At 5 PM on same day, the Inj Vancomycin
was re-introduced to the patient. Same symptoms developed again within 1
hour and resolved 4 hrs after administration of Inj. Pheniramine 25 mg IM.


Note:
• Inj Vancomycin
o Brand Name: Vanzid
o Manufacturer: SWACH Healthcare
o Batch number: KKIL098
o Expiry date: Mar 2016

• Inj Ceftriaxone
o Brand Name: Taximax
o Manufacturer: Wedley Labs
o Batch number: OPO659
o Expiry date: Dec 2016
 PRESCRIPTION WRITING
(1X 5 Marks = 5 )

Time - 20 minutes

1.Write a suitable PRESCRIPTION for patient

suffering from STATUS ASTHMATICUS ?
2.What are different parts of prescription ?
3.What is the full form of Rx in medical term?
4.What is the impotance of AGE ?
 PRESCRIPTION WRITING
(1X 5 Marks = 5 )

Time - 20 minutes

1.Write a suitable PRESCRIPTION for patient

suffering from TYPE II DIABETES MELLITUS?
2.What are different parts of prescription ?
3.What is the full form of Rx in medical term?
4.What is the impotance of WEIGHT ?
 PRESCRIPTION WRITING
(1X 5 Marks = 5 )

Time - 20 minutes

1.Write a suitable PRESCRIPTION for patient

suffering from STATUS EPILEPTICUS ?
2.What are different parts of prescription ?
3.What is the full form of Rx in medical term?
4.What is the impotance of ADDRESS of patient ?
AUDIT THE PRESCRIPTION under
following headings ?
(1 x 5 Marks )

Time – 20 minutes
 DEPARTMENT OF PHARMACOLOGY

GOVERNMENT MEDICAL COLLEGE KANKER (CG)

PRESCRIPTION AUDIT
AUDIT PARAMETER YES NO NOT APPLICABLE

Name of patient

Age

OPD number

Dose of drug

Dosage of drug

Route of drug

Frequency / Time of administration

Date

Legible

Known allergy documented

Uniform location of treatment order

Non-standard abbreviationused

Presence of therapeutic duplication,

If Any
Drug interaction, If Any

Food drug interaction, If Any

Signature of the doctor

 Quiz (1 x 4 Marks = 4)
Time -15 minutes
Q. A 60 year old male pulmonary TB patient (48kg) was
treated with inj. Streptomycin 1gm IM daily, tab Isoniazid
100 mg TDS and Cap Rifampicin 600 mg daily. Within 14
days his fever subsided, appetite improved and he felt
better. However after 3 weeks he developed weakness
and paraesthesia. He was found to be mentally confused
and tendon reflexes were sluggish.

A) Comment on the dose regimen adopted. HRZE

B) What is the cause of the development of weakness &
paraesthesia after 3 weeks? isoniazid-induced peripheral neuropathy,
C) What will be your future course of action? 1.Symptoms management
2. Monitor TB regimen
3.provide vit.B6
 Quiz (1 x 4 Marks = 4)
Time -15 minutes

Q. A person is brought to the hospital with

complaints of nausea, headache , vomitting ,
dizziness , tachypnea , blurring of vision &
gradually reducing visual acuity .There is a
history of intake of drink from local wine
shop .

a) What is the diagnosis ? Methanol poisonings

b) How will you manage this case ? 1.A,B,C
2. Antidote ethanol
3.sodium bicarbonate to correct metabolic acidosis
 Quiz (1 x 4 Marks = 4)
Time -15 minutes

Q. A patient presents to the emergency

department with warm ,dry skin , dry mouth ,
constipation, dilated pupil and unable to pass
urine since 6to 8h hours. His pulse rate is 120
beats/minute.

(A) What is the diagnosis ? Anticholinergic toxicity

(B)Name the drug used to treat this
condition ? Physostigmine
 DRUG INTERACTIONS
( 1 X 2 Marks =2)
Time – 5 minutes
Write the drug interaction between –

a) Aminoglycosides + Ethacrynic acid

b) Levodopa + Carbidopa
 Criticize the Promotional Brochure
under the following heading-
(1 X 2 Marks = 2 ) Time -20 minutes
1) The name(s) of the ingredient(s).
2) The brand name.
3) Content of active ingredient(s) per dosage form or regimen.
4) Name of other ingredients known to cause problems.
5) Approved therapeutic uses.
6) Dosage form or regimen.
7) Side-effects and major adverse drug reactions.
8) Precautions, contra-indications and warnings.
9) Major interactions.
10) Name and address of manufacturer or distributor.
11) Reference to scientific literature as appropriate.
 DOSE CALCULATIONS
(1X 2 Marks= 2)
Time- 15 minutes

Calculate the dose of tablet cefixime

to be prescribed for 8 year old boy
weighing 25 kg suffering from
urinary tract infection using Young’s
formula
 DOSE CALCULATIONS
(1X 2 Marks= 2)
Time- 15 minutes

Calculate the dose of tablet cefixime

to be prescribed for 8 year old boy
weighing 25 kg suffering from
urinary tract infection using Young’s
formula
 DOSE CALCULATIONS
(1X 2 Marks= 2)
Time- 15 minutes

Calculate the dose of tablet cefixime

to be prescribed for 8 year old boy
weighing 25 kg(=55.1 pound)
suffering from urinary tract infection
using Clark’s Rule.
 DRUG INTERACTIONS
( 1 X 2 Marks =2)
Time – 5 minutes
Write the drug interaction between –

a) Rifampicin + OCP

b) Probenecid + Penicillin
 DRUG INTERACTIONS
( 1 X 2 Marks =2)
Time – 5 minutes
Q Write the drug interactions between-

A) Clonidine + Tricyclic antidepressant

B) Ciprofloxacin + Theophylline