HEALTH

 Defined as a state of complete physical, mental and

social well- being of a person.
 Healthy people are efficient at work. This increases
productivity and economic prosperity.
 Improper functioning of one or more organs or
systems of the body is adversely affected, gives rise
to various signs and symptoms i.e we have disease.
FACTORS THAT AFFECT HEALTH
 Balanced diet
 Personal hygiene
 Regular exercise
 Good habits
HOW TO ACHIEVE GOOD HEALTH ?
 Knowledge about diseases, their cause and effect
Vaccination/ immunisation
Control of vectors
Proper disposal of waste
Consumption of clean food and water
Maintenance of hygiene
Diseases
 Improper functioning of one or more organs or systems of
the body is adversely affected, gives rise to various signs and
symptoms i.e we have disease.
 Diseases which can easily transmit from one person to other
by any means are called infectious or communicable
diseases.
 Diseases which can not be transmitted from one person to
another are called non-infectious or non-
communicable diseases.
 Disease causing organisms are said to be pathogen.
INFECTIOUS DISEASES

 Virus -Common cold, polio, measles
 Bacteria - Typhoid, pneumonia, plague, diphtheria,
tetanus
 Protozoa -Malaria, amoebiasis
 Fungi -ringworm
 Helminthes -Ascariasis, filariasis, taeniasis
TYPHOID

 Pathogen: Salmonella typhi (bacterium)

 Organs affected: small intestine, migrate to other organs
through blood.
 Method of transmission: contamination of food and
water.
 Symptoms:
 Sustained high fever (39o to 40o C)
 Weakness, stomach pain, constipation, headache and loss of
appetite.
 Intestinal perforation and death may occur.
 Test: Typhoid fever could be confirmed by Widal test.
PNEUMONIA:

 Pathogen: Streptococcus pneumoniae and Haemophilus

influenzae.
 Organs affected: Alveoli of lungs, alveoli get filled with
fluid.
 Method of transmission: inhaling the droplets/aerosols
released by infected person. Sharing glasses and other
utensils.
 Symptoms:
 Fever, chills, cough and headache.
 In severe cases the lips and finger nails turn gray to bluish
colour.
COMMON COLD:

 Pathogen: Rhino viruses.

 Organs affected: nose and respiratory passage
 Method of transmission:
 Direct inhalation of droplets from infected person.
 Through contaminated objects like pen, books, cups,
computer key board.
 Symptoms:
 Nasal congestion and discharge, sore throat, hoarseness,
cough.
MALARIA:

 Pathogen: Plasmodium. (P. vivax, P. malariae, P. ovale, P.

falciparum)
 Malignant malaria caused by P. falciparum is fatal.
 Organs affected: liver, RBC.
 Method of transmission: by biting of female anopheles
mosquito (vector)
 Symptoms: high fever and chill, fever occurs on every
alternate day, vomiting.
AMOEBIASIS (Amoebic dysentery)

 Pathogen: Entamoeba histolytica a protozoan parasite.

 Organs affected: large intestine of man
 Method of transmission:
 House fly acts as mechanical carrier.
 Contamination water and food with faecal matter.
 Symptoms:
 Constipation, abdominal pain and cramps.
 Stools with excess mucous and blood clots.
ASCARIASIS:

 Pathogen: Ascaris lumbricoids (nematode)

 Organs affected: intestine of man
 Method of transmission: Contaminated water,
vegetables, fruits.
 Symptoms:
 Internal bleeding, muscular pain, fever, anemia.
 Blockage of the intestinal passage.
FILARIASIS OR ELEPHANTIASIS:

 Pathogen: Wuchereria (W.bancrofti and W. Malayi)

(nematode parasite)
 Organs affected: lymphatic vessels of the lower limbs,
genital organs.
 Methods of transmission: biting of infected female culex
mosquito.
 Symptoms:
 Chronic inflammation of the organs where they live for many
years.
 Abnormal swelling of lower limb, scrotum, penis.
 Hence the disease named as elephantiasis or Filariasis.
RING WORMS
 Pathogen: Microsporum,Trichophyton and Epidermophyton (fungi)
 Organs affected: Skin, nails, folds of skin, groin.
 Method of transmission:
 Acquired from the soil.
 Using towel, clothes or even comb of infected individuals.
 Symptoms:
 Appearance of dry, scaly lesions in skin nails and scalp.
 Lesion accompanied with intense itching.
 Heat and moisture help these fungi to grow.
PREVENTION AND CONTROL OF INFECTIOUS
DISEASES:
 Maintenance of personal and public hygiene is very important for
prevention and control of many infectious diseases.
 Personal hygiene includes:
 Consumption of clean drinking water, food vegetable fruits.
 Keeping the body cleans.

 Public hygiene includes:
 Proper disposal of waste and excreta
 Periodic cleaning and disinfection of water reservoirs, pools, cesspools.
 Standard practices of hygiene in public catering.

 In case of air-borne diseases, close contact with the infected persons
or their belongings should be avoided.
For vector borne diseases

 To control or eliminating the vectors and the breeding places.

 Avoiding stagnation of water in and around residential areas.
 Regular cleaning of household coolers.
 Use of mosquito nets.
 Introducing fishes like Gambusia in pond that feeds on
mosquito larvae.
 Spraying of insecticides in ditches, drainage area and swamps.
 Window and doors must be fitted with wire mesh.
 All these precautions are use full for vector borne disease like
dengue and Chickungunya, malaria and filarial etc.
IMMUNITY:

 The overall ability of the host to fight the disease causing

organism by immune system is called immunity.
 There are two types of immunity:
 Innate Immunity.
 Acquired Immunity. Active and Passive
Innate (non-specific) immunity:

 Called inborn immunity.

 Always available to protect out body.
 This is called the first line of defense.
 Consists of various barriers that prevent entry of foreign
agents into the body.
 If enters they are quickly killed by some other components of
this system.
Different types of barriers
are as follows:
 Physical barriers
 Skin is the main barrier which prevents entry of micro-
organism.
 Mucous coating of the epithelium lining of respiratory,
gastrointestinal and urinogenital tracts helps in trapping
microbes.
 Physiological barriers:
 Acidity of the stomach kills most ingested microbes.
 Lysozyme in tears, saliva, and snot kills bacteria by
digesting bacterial wall.
 Pyrogen released by WBC raise body temperature to
prevents growth of microbes in out body.
 Interferon induces antiviral state in non-infected cells.
 Phagocytic barrier:
 Polymorpho-nuclear leukocytes (PMNL-
neutrophils), macrophages, and natural killer cells in
the blood and tissues kill pathogen by phagocytosis.
Inflammatory barrier
 When there is injury to the tissue there is release of
histamine and prostaglandins by the mast cells.
 Due to vasodilation there is leakage of vascular fluid
containing serum proteins with antibacterial activity.
 Further there is influx of Phagocytic cells into the affected
area.
Acquired (specific) immunity:

 It is also known as adaptive immunity.

 This immunity developed after birth when encountered
with pathogen.
 It supplements the immunity provided by the innate
immunity.
 Acquired immunity has following unique features:
 Specificity: distinguish specific foreign molecules.
 Diversity: recognize vast variety of foreign molecules.
 Discrimination between self and non-self: it is able to
recognize and respond to molecules that are foreign or non-self.
It will not respond to our own cell or molecules.
 Memory: after responding to the foreign microbes and
elimination, this immune system retains the memory of that
encounter (primary immune response).The second
encounter with the same microbe evokes a heightened immune
response. (Secondary immune response)
 Acquired immunity is carried out by two special types of
lymphocytes:
 B-lymphocytes.
 T-lymphocytes.

 The B-lymphocytes produce a group of proteins in response
to pathogen into the blood to fight with them
calledantibody.
 T-lymphocytes do not produce antibody but help B-cells to
produce them
 Structure of antibody:

 Each antibody has four

polypeptide chains.
 Two small chains called light
chains.
 Two longer chains called heavy
chains.
 Antibody represented as H2L2.
 Different classes of antibody
produced in out body are IgA,
IgM, IgD, IgE and IgG.
AMI vs. CMI:

 Immune response by the B-cells by production of antibody is

called Antibody mediated immune responseor humoral
immune response.
 Immune response by T-cells is by activation of cytotoxic
killer cells which detects and destroys the foreign cells and also
cancerous cells called cell mediated immune response.
 Rejection of organs transplants are due to T-lymphocytes.
 Tissue matching, blood group matching are essential for organ
transplantation.
 Even after tissue typing immune-suppressants is required before
and after transplantation.
Active immunity:

 When the host is exposed to antigens, which may be in the

form of living or dead microbes or other proteins, antibodies
are produced in the host body.
 Active immunity is slow and takes time to give its full
effective response.
 Injecting microbes deliberately during immunization or
infection of microbes naturally induce active immunity.
Passive immunity:

 Ready made antibodies are directly given to protect the body

against foreign agents.
 Colostrums of mother contain abundant antibody
(IgA) to protect the child.
 Foetus receives some antibody (IgG) from mother during
pregnancy
Vaccination and Immunization:

 The principle of immunization or vaccination is based on the

property of ‘memory, of the immune system.
 In vaccination, a preparation of antigenic protein of pathogen
or inactivated/weakened pathogen (vaccine) is introduced
into the body.
 The antibodies produced in the body against vaccine,
(antigen) would neutralize the pathogenic agents during
actual infection.
 The vaccines also generate memory B and T-cells that
recognize the pathogen quickly on subsequent exposure.
Passive immunization:

 Preformed antibody or antitoxin injection for specific

antigen.
 Injection of antivenin for snake bite to counter the snake
venom
Vaccine production:

 Recombinant DNA technology has allowed the production of

antigenic polypeptide of pathogen in bacteria and yeast.
 Vaccine produced by this approach allows large scale
production of antigen for immunization. E.g. hepatitis-
B produced from yeast.
Allergies:

 The exaggerated response of the immune system to certain

antigens present in the environment is calledallergy.
 The substance to which such immune response is produced
is allergen.
 IgE is produced during allergic reactions.
 Common allergens are dust, pollen, animal dander etc.
 Common symptoms are sneezing, watery eyes, running nose etc.
 Allergy is due to release of histamine and serotonin from
the mast cells.
 Drugs like anti-histamine, adrenalin and steroid quickly reduce
symptoms of allergy.
 Auto immunity:

 Memory based acquired immunity able to distinguish foreign molecules or cells (pathogen)
from self-cells.
 Sometimes due to genetic and other unknown reasons the body attacks self cells. This results
in damage to the body cells and is called auto-immune disease. E.g. Rheumatoid
arthritis, Multiple sclerosis
 Immune system in our body:
 The immune system consists of
 Lymphoid organs
 Lymphoid tissues
 T and B-cells.
 Antibodies.

 Immune system recognizes the foreign antigens, responds to them and remembers
them.
 The immune system also plays important role in:
 Allergic reaction
 Auto immuno diseases and
 Organ transplantation.
 Primary lymphoid organs: bone marrow and thymus, production
and maturation of lymphocytes take place.
 Secondary lymphoid organs: spleen, tonsil, lymph node, Payer’s
patches of small intestine and appendix,
where proliferation and differentiation of lymphocyte take place.
 Bone marrow is the main lymphoid organ where all blood cell
including lymphocytes are produced.
 Thymus is a bilobed organ located near the heart, beneath the
breastbone.
 B-lymphocytes are produced and matured in bone marrow.
 T-lymphocytes are produced in bone marrow but matured in thymus
 The spleen
 Large bean shaped organ mainly contain lymphocytes and phagocytes.
 Acts as a filter of the blood by trapping blood-borne micro-organisms.
 Spleen is also serves as the large reservoir of erythrocytes.

 Lymph node:
 Small solid structure located at different points along the lymphatic system.
 Traps the micro-organisms or other foreign antigens.
 Antigen trapped into the lymph node responsible for activation and
differentiation of lymphocytes and cause immune response.

 Mucosal associated lymphoid tissues (MALT):
 Located within the lining of major tract (respiratory, digestive and urinogenital
tracts)
 It constitutes 50% of lymphoid tissues.
AIDS:

 Stands for Acquired Immuno Deficiency Syndrome.

 Deficiency of immune system that acquired during life time and
not congenital disease.
 Syndrome means a group of symptoms.
 AIDS was first reported in 1981.
 AIDS is caused by HIV (Human Immuno deficiency Virus)
 HIV is retrovirus, having RNA as the genetic material.
 Method of transmission:
 Sexual contact with infected persons.
 Transfusion of contaminated blood and blood products.
 Sharing infected needles as intravenous drug user.
 From infected mother to the foetus through placenta
 Life cycle of HIV:
 After getting into the body the HIV enters into macrophages orT-
helper cells.
 The viral RNA genome replicated to form viral DNA with the enzyme
called reverse transcriptase.
 The viral DNA gets incorporated into the host cell’s DNA by an
enzyme called integrase, and directs the infected cell s to produce
virus particle.
 The macrophage continues to produce virus and acts as HIV factory.
 Virus released from macrophage attack T-helper cells.
 There is progressive reduction in the number of T-helper cells.
 Due to reduction of T-helper cells the person starts suffering from
infections of other virus, fungi and even parasites like Toxoplasma.
 The patient becomes immuno deficient and more prone to other
disease.
Diagnosis:
 ELISA (enzyme linked Immuno-sorbent assay)
Prevention of AIDS:
 AIDS has no cure, prevention is the best option.
 Safe blood for transfusion
 Use of disposable needles
 Free distribution of condoms.
 Prevention of drug abuse
 Advocating safe sex and promoting regular checkup.
 CANCER

 Uncontrolled cell division leads to production of mass of cell called cancer.

 Cancerous cell lost the property of contact inhibition.
 Cancerous cell just continue to divide giving rise to masses of cell called tumors.

 Benign tumors:
 Normally remain confined to their original location
 Do not spread to other location.
 Cause little damage.

 Malignant tumors:
 Mass of proliferating cells called neoplastic or tumor cells.
 These cells grow very rapidly.
 Invade and damage surrounding tissues.
 These cells actively divide and grow; they also starve the normal cells.
 Cancerous cells escape from the site of origin and moves to distant place by blood, wherever
they get lodged make the normal cell cancerous. This property is called metastasis.
Causes of cancer:
 Normal cells transformed into cancerous neoplastic cells by
physical, chemical and biological agents. These agents are
called carcinogen.
 Physical agents: ionizing radiation like X-rays, gamma rays
non-ionizing radiations like UV-rays.
 Chemical agents: Tobacco smoke, sodium azaide, Methyl
ethane sulphonate.
 Biological agents:
 Cancer causing viruses called oncogenic viruses have a gene
called viral oncogenes, induce transformation of neoplastic cells.
 Cellular oncogenes (c-onc) or proto oncogenes in normal
cells, when activated lead to oncogenic transformation of the normal
cells.
Cancer detection and diagnosis
 Biopsy and histopathological study of the tissues
 Radiography like X-rays, CT (computerized tomography)
 MRI (magnetic resonance Imaging).
 Presence of antibodies against cancer-specific antigen.
Tretment of cancer
 Surgery
 Radiation therapy
 Immunotherapy
 Chemotherapy
 Cryosurgery
 Laser therapy.
 α-interferone a response modifier used to detect the cancer.
 DRUGS AND ALCOHOL ABUSE:
Opioid
 The drugs which bind to specific opioid receptor present
incentral nervous system and gastrointestinal tract.
 Heroin commonly called smack,
chemicallydiacetylmorphine.
 It is white, odourless, bitter crystalline compound.
 Obtained by acetylation of morphine.
 Extracted from latex of poppy plant Papaver somniferum.
 Generally taken by snorting and injection.
 Heroin is depressant and slows down body function
Canabinoids
 Group of chemicals that interact with the canabinoid receptors
of brain.
 Obtained from inflorescence of Cannabis sativa.
 Flower top, leaves and resin of cannabis plant are used in
various combinations to produce marijuana, hashish,
charas and ganja.
 Generally taken by inhalation and oral ingestion
 Effects on cardiovascular system of the body.
Cocaine
 Coca alkaloid or cocaine is obtained from coca plant Erythroxylum coca.
 It interferes with transport of neuro-transmitter dopamine.
 Cocaine is commonly called as coke or crack is usually snorted.
 Potent stimulating effect on central nervous system.
 Produces sense of euphoria and increased energy.
 Excessive dosage causes hallucination.

 Other plants with hallucinogenic properties are :
 Atropa belladonna
 Datura.

 Canabinoids are also being abused by some sportspersons.
Medicinal use of drugs
 Barbiturates, amphetamines, benzodiazepines, lysergic acid
diethyl amide (LSD) used as medicines to help patients cope
with mental illnesses, depression and insomnia.
 Morphine is a very effective sedative and painkiller used for
surgery patient
 Plant product with hallucinogenic property have used as folk-
medicine, religious ceremonies and rituals.
 Tobacco
 It is smoked, chewed or used as a snuff.
 Tobacco contains nicotine an alkaloid.
 Nicotine stimulates Adrenal glands to raise blood pressure and
increased heart rates.
 Smoking tobacco is associated with cancer of lung, urinary
bladder, and throat, bronchitis, emphysema, coronary heart
disease, gastric ulcer etc.
 Smoking increased CO content of blood reduce oxygen carrying
capacity of hemoglobin.
 Tobacco chewing is associated with cancer of oral cavity.
Adolescence and Drug/Alcohol Abuse:
 The period between 12-18 years of age may thought of an
adolescent period.
 Adolescent is a bridge linking childhood and adulthood.
 Curiosity, need for adventure and excitement, and
experimentation, are the common cause of drug/alcohol
abuse.
 Addiction and dependence:
 Addiction is a psychological attachment to certain effects such as
euphoria and a temporary feeling of well-being associated with
drugs and alcohol.
 With repeated use of drugs the tolerance level of the receptors
present in our body increases. Consequently the receptors respond
only to higher doses of drugs or alcohol leading to greater intake
and addiction.
 Use of drugs even once, can be a fore-runner to addiction.
 Dependence is the tendency of the body to manifest a characteristic
and unpleasant withdrawal syndrome if regular dose of
drugs/alcohol is abruptly discontinued.
 Withdrawal syndrome characterized by anxiety, shakiness, nausea
and sweating.
 Effects of Drug / Alcohol Abuse:
 Immediate effects are reckless behavior, vandalism and violence.
 Excessive doses of drugs may lead to coma and death due to respiratory failure, heart
failure or cerebral hemorrhage.
 Warning sign of drug and alcohol abuse among youth include:
 Drop in academic performance,
 Unexplained absence from school/college.
 Lack of interest in personal hygiene
 Withdrawal, isolation, depression fatigue, aggressive and rebellious behavior.
 Deterioting relationship with family and friends.
 Loss of interest in hobbies.
 Change in eating and sleeping habits.
 Fluctuation in weight and appetite.

 Intravenous drug user more prone to acquire infections like AIDS and hepatitis.
 The chronic use of drugs and alcohol damages nervous system and cause of liver
cirrhosis.
 Use of drug and alcohol during pregnancy affect the foetus.
 Prevention and control:
 Avoid undue peer pressure.
 Education and counseling.
 Seeking help from parents and peers.
 Looking for danger signs.
 Seeking professional and medical help.
 Abbreviations:
 PMNL : Polymorpho-Nuclear Leukocytes
 CMI : Cell Mediated Immunity
 ELISA : Enzyme Linked Immuno sorbent Assay
 HLA : Human Leukocyte Antigen
 MALT : Mucosal Associated Lymphoid Tissue
 SCID : Severe Combined Immuno Deficiency
 NACO : National AIDS Control Organization.
 MRI : Magnetic Resonance Imaging.
 CT: computerized tomography.
Thanking you