Oxygen Transport to Tissue XXXII
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Editors
Joseph C. LaManna
Department of Physiology and Biophysics
Case Western Reserve University School of Medicine
10900 Euclid Avenue
Cleveland Ohio 44106
USA
[email protected]
Michelle A. Puchowicz
Department of Nutrition
Case Western Reserve University School of Medicine
Cleveland Ohio 44106
USA
[email protected]
Kui Xu
Department of Neurology
Case Western Reserve University School of Medicine
Cleveland Ohio 44106
USA
[email protected]
David K. Harrison
Institute of Cellular Medicine
Newcastle University
Newcastle upon Tyne
United Kingdom
[email protected]
v
Duane F. Bruley
Synthesizer, Inc.
2773 Westminster Rd
Ellicott City Maryland 21043
USA
[email protected]
Acknowledgments
Sponsors
As President of the 2009 Meeting of the International Society on Oxygen Trans-
port to Tissue, held from July 5–9, 2009 in Cleveland, Ohio, USA, I would like to
acknowledge the tremendous support of the following sponsors:
Special thanks also to Suzanne Foss, ISOTT Meeting Secretariat, and her volun-
teers: Girriso Benderro, D’Arbra Blankenship, Tim Darlington, Sylvia Hart, Eliza-
vii
viii Acknowledgments
beth Hilow, Molly Karl, Elias Kikano, David Litvin, Obinna Ndubuizu, Jon Niemi,
Ali Serhal, Xiaoyan Sun, Solomon Raju Bhupanapadu Sunkesula, Kevin Train, and
Constantinos Tsipis.
Reviewers
The ISOTT 2009 editors would like to thank the following reviewers:
Scientific Review Panel
Donald G. Buerk (University of Pennsylvania, Philadelphia, USA)
Giuseppe Cicco (University of Bari, Italy)
Chris Cooper (University of Essex, Colchester, UK)
Paula Dore-Duffy (Wayne State University School of Medicine, Detroit, USA)
Andras Eke (Semmelweis University of Medicine, Budapest, Hungary)
Elaine Fisher (University of Akron, USA)
Albert Gjedde (University of Copenhagen, Denmark)
Jerry D. Glickson (University of Pennsylvania, Philadelphia, USA)
David K. Harrison (Newcastle University, Newcastle upon Tyne, UK)
Fahmeed Hyder (Yale University, New Haven, USA)
Kyung A. Kang (University of Louisville, USA)
Periannan Kuppusamy (Ohio State University, Columbus, USA)
Nicola Lai (Case Western Reserve University, Cleveland, USA)
Joseph C. LaManna (Case Western Reserve University, Cleveland, USA)
Arnulf G. Mayer (University of Mainz, Germany)
William Pearce (Loma Linda University School of Medicine, USA)
Michelle A. Puchowicz (Case Western Reserve University, Cleveland, USA)
Sophy Sundarajan (Case Western Reserve University, Cleveland, USA)
Ilias Tachtsidis (University College London, UK)
Eiji Takahashi (Saga University, Japan)
Oliver Thews (University of Mainz, Germany)
Sabine Van Huffel (Katholieke Universiteit Leuven, Belgium)
Peter W. Vaupel (University of Mainz, Germany)
William Welch (Georgetown University, Washington DC, USA)
David F. Wilson (University of Pennsylvania, Philadelphia, USA)
Martin Wolf (University of Zurich, Switzerland)
Christopher B. Wolff (St. Bartholomew’s and the Royal London Hospital, Lon-
don, UK)
Technical Reviewers
Laraine Visser-Isles (Rotterdam, The Netherlands)
Eileen Harrison (Durham, UK)
Acknowledgments ix
Organization of ISOTT 2009
The 37th Annual Meeting of
the International Society on Oxygen Transport to Tissue
July 5–9, 2009, Cleveland, Ohio, USA
The International Society on Oxygen Transport to Tissue is an interdisciplinary so-
ciety comprising about 250 members worldwide. Its purpose is to further the under-
standing of all aspects of the processes involved in the transport of oxygen from the
air to its ultimate consumption in the cells of the various organs of the body.
The annual meeting brings together scientists, engineers, clinicians and mathe-
maticians in a very unique international forum for the exchange of information and
knowledge, the updating of participants on latest developments and techniques, and
the discussion of controversial issues within the field of oxygen transport to tissue.
Founded in 1973, the society has been the leading platform for the presentation
and discussion of many of the technological and conceptual developments within the
field, both at the meetings themselves and in the proceedings of the society. These
have been published in the “Advances in Experimental Medicine and Biology” series.
Examples of some of the areas in which members have made highly signifi-
cant contributions to the field include spectrophotometric and magnetic resonance
methods, electrode techniques, mathematical modeling of oxygen transport, and the
understanding of local regulation of oxygen supply to tissue and fluorocarbons-blood
substitutes.
Local Organizing Committee
Cynthia M. Beall (Cleveland, OH, USA)
Walter Boron (Cleveland, OH, USA)
Marco E. Cabrera1 (Cleveland, OH, USA)
Jeffrey L. Duerk (Cleveland, OH, USA)
Serpil Erzurum (Cleveland, OH, USA
Elaine Fisher (Akron, OH, USA)
Charles L. Hoppel (Cleveland, OH, USA)
Periannan Kuppusamy (Columbus, OH, USA)
Richard Martin (Cleveland, OH, USA)
Gheorghe Mateescu (Cleveland, OH, USA)
Michelle A. Puchowicz (Cleveland, OH, USA)
Kingman P. Strohl (Cleveland, OH, USA)
Kui Xu (Cleveland, OH, USA)
1 Deceased
x Acknowledgments
International Advisory Board
Giuseppe Cicco (Bari, Italy)
Kyung Kang (Louisville, KY, USA)
Per Liss (Uppsala, Sweden)
Eiji Takahashi (Saga, Japan)
ISOTT Officers and Executive Committee
Joseph C. LaManna (President, Cleveland, OH, USA)
Oliver Thews (Secretary, Mainz, Germany)
Peter E. Keipert (Treasurer, San Diego, CA, USA)
Duane F. Bruley (Knisely Award Committee, Baltimore, MD, USA)
Eiji Takahashi (Past President, Saga, Japan)
Martin Wolf (President-Elect, Zurich, Switzerland)
Arthur Fournell (Dusseldorf, Germany)
Fahmeed Hyder (New Haven, CT, USA)
Paul Okunieff (Gainesville, FL, USA)
Hiromi Sakai (Tokyo, Japan)
Ludwig Schleinkofer (Munich, Germany)
Ilias Tachtsidis (London, United Kingdom)
Sabine van Huffel (Leuven, Belgium)
William Welch (Washington, DC, USA)
Newly Elected Members of the Executive Committee
Donald Buerk (Philadelphia, PA, USA)
Michelle A. Puchowicz (Cleveland, OH, USA)
Lin Li (Philadelphia, PA, USA)
Conference Secretariat
Suzanne Foss (Cleveland, OH, USA)
Dedication
The 37th ISOTT Conference President, Joseph C. LaManna,
would like to dedicate this volume in memory of Marco E.
Cabrera, who had attended previous ISOTT meetings and was
an integral part of the Local Organizing Committee for the
Cleveland meeting before his sudden and untimely death in
February, 2009.
Acknowledgments xi
Joseph C. LaManna and Marco E. Cabrera at ISOTT 2007, Uppsala, Sweden.
Marco E. Cabrera received his undergraduate degree in physics from the Univer-
sidad del Valle de Guatemala in 1978 and his Ph.D. degree in biomedical engineering
from Case Western Reserve University in 1995. He achieved the rank of Associate
Professor in the Departments of Pediatrics Biomedical Engineering, and Physiology
and Biophysics. His research focused on regulation of energy metabolism in cardiac
and skeletal muscles in response to exercise and adaptations to physical inactivity
and training. It combined dynamic experimental measurements and computational
models that encompassed mechanisms at the cellular, tissue, and whole body levels.
Marco believed passionately in a quantitative systems physiology approach for
the in vivo study of organisms. His vision was endorsed by NIH funding of the Center
for Modeling Integrated Metabolic Systems (MIMS). He was active professionally
on the editorial board of the Journal of Biological Chemistry and assistant editor of
Exercise and Sports Sciences Reviews as well as a Fellow of the American College of
Sports Medicine and a member of the American Physiological Society, Biomedical
Engineering Society, and American Society of Biochemistry and Molecular Biology.
Marco was a dear friend, valued research collaborator, and esteemed mentor. His
ready smile, enthusiasm, and breadth of vision engaged many friends and collabora-
tors. Marco’s research scope encompassed a wide variety of fields including exercise
physiology, human and animal performance evaluation, metabolic systems biology,
mathematical modeling, and computer simulation. He had an exceptional ability to
develop collaborations with theoretical and experimental researchers from different
fields that could contribute to quantitative understanding of exercise and metabolism.
Marco had a variety of wonderful collaborations locally at Case Western Reserve
University, University Hospitals of Cleveland, and the Cleveland Clinic as well as
nationally and internationally. To achieve the research goals that Marco set forth, his
collaborators and students will continue along the path that he started.
xii Acknowledgments
Awards
The Melvin H. Knisely Award
The Melvin H. Knisely Award was established in 1983 to honor Dr. Knisely’s accom-
plishments in the field of the transport of oxygen and other metabolites and anabolites
in the human body. Over the years, he has inspired many young investigators and
this award is to honor his enthusiasm in assisting and encouraging young scientists
and engineers in various disciplines. The award acknowledges outstanding young
investigators. This award was first presented during the banquet of the 1983 annual
conference of ISOTT in Ruston, Louisiana. The award includes a Melvin H. Knisely
plaque and a cash prize.
Melvin H. Knisely Award Recipients:
1983 Antal G. Hudetz, Hungary 1984 Andras Eke, Hungary
1985 Nathan A. Bush, USA 1986 Karlfried Groebe, Germany
1987 Isumi Shibuya, Japan 1988 Kyung A. Kang, Korea/USA
1989 Sanja Batra, Canada 1990 Stephen J. Cringle, Australia
1991 Paul Okunieff, USA 1992 Hans Degens, Netherlands
1993 David A. Benaron, USA 1994 Koen van Rossem, Belgium
1995 Clare E. Elwell, UK 1996 Sergei A. Vinogradov, USA
1997 Chris Cooper, UK 1998 Martin Wolf, Switzerland
1999 Huiping Wu, USA 2000 Valentina Quaresima, Italy
2001 Fahmeed Hyder, Bangladesh 2002 Geofrey De Visscher, Belgium
2003 Mohammad N. Khan, USA 2004 Fredrick Palm, Sweden
2005 Nicholas Lintell, Australia 2006 No award was made
2007 Ilias Tachtsidis UK 2008 Kazuto Masamoto, Japan
2009 Rossana Occhipinti, USA
The Dietrich W. Lübbers Award
The Dietrich W. Lübbers Award was established in honor of Professor Lübbers’s
long-standing commitment, interest, and contributions to the problems of oxygen
transport to tissue and to the society. This award was first presented in 1994 during
the annual conference of ISOTT in Istanbul, Turkey.
Dietrich W. Lübbers Award Recipients:
1983 Antal G. Hudetz, Hungary 1984 Andras Eke, Hungary
1985 Nathan A. Bush, USA 1986 Karlfried Groebe, Germany
1987 Isumi Shibuya, Japan 1988 Kyung A. Kang, Korea/USA
1989 Sanja Batra, Canada 1990 Stephen J. Cringle, Australia
Acknowledgments xiii
1991 Paul Okunieff, USA 1992 Hans Degens, Netherlands
1993 David A. Benaron, USA 1994 Koen van Rossem, Belgium
1995 Clare E. Elwell, UK 1996 Sergei A. Vinogradov, USA
1997 Chris Cooper, UK 1998 Martin Wolf, Switzerland
1999 Huiping Wu, USA 2000 Valentina Quaresima, Italy
2001 Fahmeed Hyder, Bangladesh 2002 Geofrey De Visscher, Belgium
2003 Mohammad N. Khan, USA 2004 Fredrick Palm, Sweden
2005 Nicholas Lintell, Australia 2006 No award was made
2007 Ilias Tachtsidis UK 2008 Kazuto Masamoto, Japan
2009 Rossana Occhipinti, USA
The Britton Chance Award
The Britton Chance Award was established in honor of Professor Chance’s long-
standing commitment, interest, and contributions to the science and engineering
aspects of oxygen transport to tissue and to the society. This award was first presented
in 2004 during the annual conference of ISOTT in Bari, Italy.
Britton Chance Award Recipients:
2004 Derek Brown, Switzerland 2005 James Lee, USA
2006 Hanzhu Jin, China/USA 2007 Eric Mellon, USA
2008 Jianting Wang, USA 2009 Jessica Spires, USA
The Duane F. Bruley Award
The Duane F. Bruley Award was established in 2003 and first presented by ISOTT at
the 2004 annual conference in Bari, Italy. This award was created to provide travel
funds for student researchers in all aspects of areas of oxygen transport to tissue.
The awards signify Dr. Bruley’s interest in encouraging and supporting young re-
searchers to maintain the image and quality of research associated with the society. As
a co-founder of ISOTT in 1973, Dr. Bruley emphasizes cross-disciplinary research
among basic scientists, engineers, medical scientists, and clinicians. His pioneering
work constructing mathematical models for oxygen and other anabolite/metabolite
transport in the microcirculation, employing computer solutions, were the first to
consider system nonlinearities, time dependence, including multidimensional diffu-
sion, convection, and reaction kinetics. It is hoped that receiving the Duane F. Bruley
Award will inspire students to excel in their research and will assist in securing future
leadership for ISOTT.
Duane F. Bruley Award Recipients:
2004 Helga Blocks (Belgium); Jennifer Caddick (UK); Charlotte Ives (UK);
Nicholas Lintell (Australia); Leonardo Mottola (Italy); Samin Rezania
xiv Acknowledgments
(Iran/USA); Ilias Tachtsidis (UK); Liang Tang (China/USA); Iyichi Sonoro
(Japan); Antonio Franco (Italy)
2005 Robert Bradley (UK); Harald Oey (Australia); Kathy Hsieh (Australia); Jan
Shah (Australia)
2006 Benn S. Gooch (UK); Ulf R. Jensen (Germany); Smruta S. Koppaka (USA);
Daya Singh (UK); Martin Tisdall (UK); Bin Wong (China); Kui Xu
(China/USA)
2007 Dominique De Smet (Belgium); Thomas Ingram (UK); Nicola Lai (USA);
Andrew Pinder (UK); Joke Vanderhaegen (Belgium)
2008 Sebastiano Cicco (Italy)
2009 Lei Gao (UK); Obinna Ndubuizu (USA); Joke Vanderhaegen (Belgium);
Jianting Wang (USA)
Preface
The International Society on Oxygen Transport to Tissue (ISOTT) is an interdisci-
plinary society comprising about 250 members worldwide. Its purpose is to further
the understanding of all aspects of the processes involved in the transport of oxygen
from the air to its ultimate consumption in the cells of the various organs of the body.
Oxygen has played a substantial role in the evolution process of biological systems,
including human, as the key molecule for energy production and genetic adaptation
to the environment. Considering that the physiological function of oxygen is an ex-
tremely diverse and multidisciplinary research area, increased involvement of basic
medical scientists, clinicians, and biomedical engineers in ISOTT was encouraged.
The annual meeting brings together scientists, engineers, clinicians and math-
ematicians in a unique international forum for the exchange of information and
knowledge, the updating of participants on latest developments and techniques, and
the discussion of controversial issues within the field of oxygen transport to tissue.
Founded in 1973, the society has been the leading platform for the presentation
and discussion of many of the technological and conceptual developments within the
field, both at the meetings themselves and in the proceedings of the society.
Examples of some of the areas in which members have made highly significant
contributions to the field include Near Infrared Spectroscopy (NIRS) and other spec-
trophotometric and magnetic resonance methods, electrode techniques, mathematical
modeling of oxygen transport, and the understanding of local regulation of oxygen
supply to tissue and fluorocarbons-blood substitutes.
The 37th Annual ISOTT conference was held in Cleveland, Ohio, USA from
July 5–9, 2009. The meeting consisted of one featured presentation by Jay Dean,
Ph.D., from the Department of Molecular Pharmacology and Physiology, Hyperbaric
Biomedical Research Laboratory at the University of South Florida. His topic was
“Oxygen and the World War II Aviator.” In addition, there were 21 featured lectures,
12 organized sessions, 56 general oral presentations, and 19 poster presentations.
We welcomed 134 total participants comprised of 71 full, 13 social, 34 student, 10
daily, and 6 outside exhibitor registrations.
Our venue was the campus of Case Western Reserve University (CWRU), in-
cluding the recently built Village at 115 dormitory-style housing facility where most
xv
xvi Preface
participants stayed. Participants were provided with many opportunities to interact,
both scientifically and socially, during the conference and after hours in an informal
atmosphere. Evening activities were structured to take advantage of Cleveland as
well as CWRU’s proximity to the University Circle cultural institutions. The high-
light of the 2009 ISOTT meeting was the Closing Banquet held at the Rock and
Roll Hall of Fame and Museum where several of our participants entertained us
with their musical talents! Visit the website of http://www.case.edu/isott09/ to view
information on the Annual Meeting in Cleveland, Ohio.
Joseph C. LaManna, Ph.D.
President, ISOTT 2009
Contents
Editors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv
Part I Near Infrared Spectroscopy
1 The Western Reserve, Edward Morley, and Oxygen . . . . . . . . . . . . . . . 3
Joseph C. LaManna, Ph.D.
1.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
1.2 The Western Reserve of Connecticut . . . . . . . . . . . . . . . . . . . . . . . . . 4
1.3 Edward Williams Morley (1838–1923) . . . . . . . . . . . . . . . . . . . . . . . 4
1.4 The Composition of the Atmosphere (1879–1882) . . . . . . . . . . . . . . 6
1.5 The Michelson–Morley Collaboration (1884–1887) . . . . . . . . . . . . . 6
1.6 The Atomic Weight of Oxygen (1884–1895) . . . . . . . . . . . . . . . . . . 7
1.7 The Rest of the Story . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
2 Analysis of the Changes in the Oxidation of Brain Tissue
Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during
Hypercapnoea . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Ilias Tachtsidis, Martin M. Tisdall, Caroline Pritchard, Terence S. Leung,
Arnab Ghosh, Clare E. Elwell, and Martin Smith
2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
2.2 Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
2.3 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
2.4 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
xvii
