STEM CELL REPAIR & REGENERATION V2 Volume 2
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editors
Nagy A Habib
Natasa Levicar
Myrtle Y Gordon
Long Jiao
Nicholas Fisk
Imperial College London, UK
Stem Cell Repair
and Regeneration
volume2
The Hammersmith Series 2
Imperial College Press
ICP
Published by
Imperial College Press
57 Shelton Street
Covent Garden
London WC2H 9HE
Distributed by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
STEM CELL REPAIR AND REGENERATION
Volume 2
Copyright © 2007 by Imperial College Press
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the Publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to
photocopy is not required from the publisher.
ISBN-13 978-1-86094-711-7
ISBN-10 1-86094-711-5
Typeset by Stallion Press
Email:
[email protected] Printed in Singapore.
JQuek - Stem Cell Repair.pmd 1 4/17/2007, 4:38 PM
January 12, 2007 16:33 WSPC/Book -SPI-B448 Stem Cell Repair and Regeneration, Vol. 2 Trim Size for 9in x 6in FM
Contents
Contributors ix
Preface xvii
Chapter 1. Defining Progenitors Based on Their Expression
of Aldehyde Dehydrogenase 1
Robert W. Storms
Chapter 2. Fetal Mesenchymal Stem Cells are More
Primitive than Adult Mesenchymal Stem Cells 17
Cecilia Götherström, Pascale V. Guillot and
Nicholas M. Fisk
Chapter 3. The Immunoregulatory Role of Mesenchymal
Stem Cells 35
Francesco Dazzi and Jennifer Timoshanko
Chapter 4. Understanding Cell Migration Through the
Paradigm of T-Lymphocyte Homing 49
Vincenzo Mirenda and Federica M. Marelli-Berg
v
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vi Contents
Chapter 5. Blueprint for the Response of Blood and Bone
Marrow-Derived Stem Cells and Their Progeny
to Hypoxia 61
Suzanne M. Watt, Jon Smythe, Andreas Fox,
Youyi Zhang, Nita Fisher, Grigorios Tsaknakis,
Sinead Forde, Sarah Hale, Dacey Ryan,
Emma Frith and Enca Martin-Rendon
Chapter 6. The Potential of Stem Cells in Tissue Engineering 85
Nicholas D. Evans and Julia M. Polak
Chapter 7. Joint Tissue Engineering 107
Cosimo De Bari, Costantino Pitzalis and
Francesco Dell’Accio
Chapter 8. Adult Stem Cells as a Treatment for Liver Diseases 125
Nataša Levičar
Chapter 9. The Generation of Pancreatic Beta Cells from
Stem Cells: Intra- and Extrapancreatic Sources 139
Mairi Brittan, Naomi J. Guppy, Tariq G. Fellous
and Malcolm R. Alison
Chapter 10. Cytokines and Stem Cell Differentiation into
Cardiomyocyte Lineage Cells 165
Ioannis Dimarakis
Chapter 11. Regulatory Networks Controlling Neural Stem
Cell Self-renewal and Differentiation 181
Yanhong Shi
Chapter 12. Demyelination as a Therapeutic Target in Spinal
Cord Injury 201
Jill R. Faulkner and Hans S. Keirstead
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Contents vii
Chapter 13. Microchimeric Foetal Stem Cells and
Non-Invasive Prenatal Genetic Diagnosis 223
Magued Adel Aziz Mikhail
Chapter 14. The Role of Stem Cells in Liver and
Gastrointestinal Cancer 241
Malcolm R. Alison, Nicholas A. Wright
and Simon Leedham
Chapter 15. Embryonic Stem Cells: Innovation in Predictive
Toxicology 269
Gabriela Gebrin Cezar and Jessica Quam
Index 285
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Contributors
Malcolm R. Alison
Centre for Diabetes and Metabolic Medicine
Queen Mary’s School of Medicine and Dentistry
Institute of Cell and Molecular Science
4 Newark Street, Whitechapel
London E1 2AT, UK
Mairi Brittan
Centre for Diabetes and Metabolic Medicine
Queen Mary’s School of Medicine and Dentistry
Institute of Cell and Molecular Science
4 Newark Street, Whitechapel
London E1 2AT, UK
Gabriela Gebrin Cezar
Stem Cell Safety Sciences Laboratory
Department of Animal Sciences
University of Wisconsin-Madison
1675 Observatory Drive
Madison, WI 53706, USA
Francesco Dazzi
Stem Cell Biology Unit
Kennedy Division of Rheumatology
Faculty of Medicine
Imperial College London
Hammersmith Hospital, Du Cane Road
London W12 0NN, UK
ix
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x Contributors
Cosimo De Bari
Department of Rheumatology
King’s College London School of Medicine
5th Floor Thomas Guy House, Guy’s Hospital Campus
London SE1 9RT, UK
Francesco Dell’Accio
Department of Rheumatology
King’s College London School of Medicine
5th Floor Thomas Guy House, Guy’s Hospital Campus
London SE1 9RT, UK
Ioannis Dimarakis
Cancer Surgery Section, Department of Oncology
Division of Surgery, Oncology, Reproductive Biology and Anaesthetics
Imperial College London
Hammersmith Hospital, Du Cane Road
London W12 0NN, UK
Nicholas D. Evans
Tissue Engineering and Regenerative Medicine Centre
Imperial College London
Chelsea and Westminster Hospital
3rd Floor, Lift Bank D
369 Fulham Road
London SW10 9NH, UK
Jill R. Faulkner
Reeve-Irvine Research Center
Department of Anatomy and Neurobiology
2111 Gillespie Neuroscience Research Facility, College of Medicine
University of California at Irvine
Irvine, CA 92697-4292, USA
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Contributors xi
Tariq G. Fellous
Centre for Diabetes and Metabolic Medicine
Queen Mary’s School of Medicine and Dentistry
Institute of Cell and Molecular Science
4 Newark Street, Whitechapel
London E1 2AT, UK
Nita Fisher
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford
Nuffield Department of Clinical Laboratory Services
University of Oxford, Oxford, UK
Nicholas M. Fisk
Experimental Fetal Medicine Group
Institute for Reproductive and Developmental Biology
Division of Surgery, Oncology, Reproductive Biology and Anaesthesia
Imperial College London
Centre for Fetal Care
Queen Charlotte’s and Chelsea Hospital
Hammersmith Campus, Du Cane Road
London W12 0NN, UK
Sinead Forde
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford
Nuffield Department of Clinical Laboratory Services
University of Oxford, Oxford, UK
Andreas Fox
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford
Department of Plastic and Reconstructive Surgery
Stoke Mandeville Hospital
Stoke Mandeville, UK
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xii Contributors
Emma Frith
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford, UK
Cecilia Götherström
Experimental Fetal Medicine Group
Institute for Reproductive and Developmental Biology
Division of Surgery, Oncology, Reproductive Biology and Anaesthesia
Imperial College London
Hammersmith Campus, Du Cane Road
London W12 0NN, UK
Pascale V. Guillot
Experimental Fetal Medicine Group
Institute for Reproductive and Developmental Biology
Division of Surgery, Oncology, Reproductive Biology and Anaesthesia
Imperial College London
Hammersmith Campus, Du Cane Road
London W12 0NN, UK
Naomi J. Guppy
Centre for Diabetes and Metabolic Medicine
Queen Mary’s School of Medicine and Dentistry
Institute of Cell and Molecular Science
4 Newark Street, Whitechapel
London E1 2AT, UK
Sarah Hale
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford, UK
Hans S. Keirstead
Reeve-Irvine Research Center
Department of Anatomy and Neurobiology
2111 Gillespie Neuroscience Research Facility, College of Medicine
University of California at Irvine
Irvine, CA 92697-4292, USA
January 12, 2007 16:33 WSPC/Book -SPI-B448 Stem Cell Repair and Regeneration, Vol. 2 Trim Size for 9in x 6in FM
Contributors xiii
Simon Leedham
Cancer Research UK
London Research Institute
London, UK
Nataša Levičar
Cancer Surgery Section, Department of Oncology
Division of Surgery, Oncology, Reproductive Biology and Anaesthetics
Imperial College London
Hammersmith Hospital, Du Cane Road
London W12 0NN, UK
Federica M. Marelli-Berg
Department of Immunology
Division of Medicine, Faculty of Medicine
Imperial College London
Hammersmith Hospital, Du Cane Road
London W12 0NN, UK
Enca Martin-Rendon
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford, UK
Magued Adel Aziz Mikhail
Cancer Surgery Section, Department of Oncology
Division of Surgery, Oncology, Reproductive Biology and Anaesthetics
Imperial College London
Hammersmith Hospital, Du Cane Road
London W12 0NN, UK
Vincenzo Mirenda
Department of Diabetes, Endocrinology and Internal Medicine
King’s College London School of Medicine
at Guy’s, King’s College and St. Thomas’ Hospitals
5th Floor Thomas Guy House, Guy’s Hospital Campus
London SE1 9RT, UK
January 12, 2007 16:33 WSPC/Book -SPI-B448 Stem Cell Repair and Regeneration, Vol. 2 Trim Size for 9in x 6in FM
xiv Contributors
Costantino Pitzalis
Department of Rheumatology
King’s College London School of Medicine
5th Floor Thomas Guy House, Guy’s Hospital Campus
London SE1 9RT, UK
Julia M. Polak
Tissue Engineering and Regenerative Medicine Centre
Imperial College London
Chelsea and Westminster Hospital
3rd Floor, Lift Bank D
369 Fulham Road
London SW10 9NH, UK
Jessica Quam
Stem Cell Safety Sciences Laboratory
Department of Animal Sciences
University of Wisconsin-Madison
1675 Observatory Drive
Madison, WI 53706, USA
Dacey Ryan
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford, UK
Yanhong Shi
Neuroscience Division
Beckman Research Institute at City of Hope National Medical Center
1500 E. Duarte Rd
Duarte, CA 91010, USA
Jon Smythe
Stem Cell Laboratory
National Blood Service — Oxford
NHS Blood and Transplant Authority, Oxford, UK
