Biosensors and Cancer, 1st Edition
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Biosensors and Cancer
Editors
Victor R. Preedy PhD DSc
Professor of Nutritional Biochemistry
School of Medicine
King’s College London
and
Professor of Clinical Biochemistry
King’s College Hospital
UK
Vinood B. Patel
Department of Biomedical Science
School of Life Sciences
University of Westminster
London
UK
p,
A SCIENCE PUBLISHERS BOOK
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Version Date: 20120710
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Preface
Biosensors have a simplistic concept but a great deal of sophistication in
design, manufacture and application. They essentially have biological
components within them and are used to detect, monitor or quantify
substances. They use a variety of physical platforms and technologies. The
biological components may include enzymes, membranes and cells or any
other naturally occurring biological product. Some have artificial biological
components such as modified molecules or polymers. Biosensors may be
used to detect single or groups of molecules and have wide applicability
to the life sciences. Each chapter in Biosensors and Cancer has an abstract,
key facts, applications to other areas of health and disease and a “mini-
dictionary” of key terms and phrases within each chapter. Finally, each
chapter has a series of summary points. In this book focussing on cancer
we have chapters on biosensors based on or utilizing optical imaging,
surface plasmon resonance, microcantilevers, electrochemistry, aptamers,
fluorescence, electrochemistry, nanobiosensors and nanowires. There are
also chapters on oxidative damage to DNA, miRNA, leukemia, breast cancer,
BCR-ABL activity, single living cells and thyroid cancer. Drug discovery,
cancer diagnosis, anticancer drugs, and cancer detection identifying marker
molecules for prostate cancer are also covered. Contributors to Biosensors
and Cancer are all either international or national experts, leading
authorities or are carrying out ground breaking and innovative work on
their subject. The book is essential reading for oncologists, cancer workers
and scientists, medical doctors, health care professionals, pathologists,
biologists, biochemists, chemists and physicists, general practitioners as
well as those interested in disease and sciences in general.
The Editors
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Contents
Preface v
List of Contributors xi
Section 1: General
1. Functional Optical Imaging-based Biosensors 3
Pablo Iglesias and Jose A. Costoya
2. Use of a Surface Plasmon Resonance (SPR) Biosensor to 20
Characterize Zwitterionic Coatings on SiO2 for Cancer
Biomarker Detection
Norman D. Brault, Shaoyi Jiang and Qiuming Yu
3. Microcantilever-based Biosensor Array for Tumor 43
Angiogenic Marker Detection
Riccardo Castagna and Carlo Ricciardi
4. Electrochemical DNA Biosensors at the Nanoscale 62
Rosa Letizia Zaffino, Wilmer Alfonso Pardo, Mònica Mir and
Josep Samitier
5. Aptamer-based Biosensors for Cancer Studies 85
Ilaria Palchetti and Marco Mascini
6. Fluorescent Biosensors for Cancer Cell Imaging and 101
Diagnostics
May C. Morris
7. Electrical and Electrochemical Immunosensor for 125
Cancer Study
Seung Yong Lee and Seung Yong Hwang
8. Multifunctional Nanobiosensors for Cancer 146
Dai-Wen Pang and Er-Qun Song
viii Biosensors and Cancer
9. Silicon Nanowire Biosensor for Cancer Markers 164
Yang-Kyu Choi and Chang-Hoon Kim
Section 2: Blood, Molecules and Cells
10. DNA-electrochemical Biosensors and Oxidative Damage 187
to DNA: Application to Cancer
Victor Constantin Diculescu and Ana Maria Oliveira Brett
11. Asparaginase-based Asparagine Biosensors and Their 211
Application to Leukemia
Neelam Verma and Kuldeep Kumar
12. Breast Cancer Detection Using Surface Plasmon 229
Resonance-Based Biosensors
Chii-Wann Lin and Chia-Chen Chang
13. Detection of miRNA with Silicon Nanowire Biosensors 248
Guo-Jun Zhang
14. Biosensors for BCR-ABL Activity and Their Application to 268
Cancer
Yusuke Ohba, Stephanie Darmanin, Tatsuaki Mizutani,
Masumi Tsuda and Takeshi Kondo
15. Optical Fiber Nanobiosensor for Single Living Cell 284
Detections of Cancers
Xin Ting Zheng and Chang Ming Li
16. Microfluidic Biosensors for Thyroglobulin Detection and 300
Application to Thyroid Cancer
Seokheun Choi and Junseok Chae
Section 3: Treatments and Organs Specific Applications
17. Optical Biosensors and Applications to Drug Discovery 321
and Development in Cancer Research
Carlo Bertucci and Angela De Simone
18. Single-Chain Fragment Variable Recombinant Antibodies 337
and Their Applications in Biosensors for Cancer Diagnosis
Xiangqun Zeng and Ray Mernaugh
19. DNA Biosensor for Rapid Detection of Anticancer Drugs 359
Sigen Wang and Ruili Wang
Contents ix
20. Using UV Light to Engineer Biosensors for Cancer 378
Detection: The Case of Prostate Specific Antigen
Maria Teresa Neves-Petersen, Antonietta Parracino and
Steffen B. Petersen
Index 395
About the Editors 401
Color Plate Section 403
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List of Contributors
Carlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via
Belmeloro 6, 40126–Bologna, Italy.
E-mail: [email protected]
Norman D. Brault
Department of Chemical Engineering, at the University of Washington,
USA.
E-mail: [email protected]
Ana Maria Oliveira Brett
Departamento de Química, Faculdade de Ciências e Tecnologia,
Universidade de Coimbra, 3004-535 Coimbra, Portugal.
E-mail: [email protected]
Riccardo Castagna
Politecnico di Torino, Applied Science and Technology, Department, Corso
Duca degli Abruzzi 24, 10129 Torino, Italy.
Junseok Chae
School of Electrical, Computer, and Energy Engineering, Arizona State
University, Tempe, Arizona, USA.
E-mail: [email protected]
Chia-Chen Chang
Institute of Biomedical Engineering, National Taiwan University, Taipei,
Taiwan.
E-mail: [email protected]
Seokheun Choi
School of Electrical, Computer, and Energy Engineering, Arizona State
University, Tempe, Arizona, USA.
E-mail: [email protected]
Yang-Kyu Choi
Department of Electrical Engineering, KAIST, 335 Gwahangno, Yuseong-gu,
Daejeon 305-701, Republic of Korea.
E-mail: [email protected]
xii Biosensors and Cancer
Jose A. Costoya
Molecular Oncology Laboratory MOL, Departmento of Fisioloxia, Facultade
de Medicina, Rua San Francisco s/n, 15782 Santiago de Compostela, Galicia,
Spain.
E-mail: [email protected]
Stephanie Darmanin
Laboratory of Pathophysiology and Signal Transduction, Hokkaido University
Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638, Japan.
Current Affiliation: Centre for Infectious Medicine F59, Department of
Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge,
Stockholm 14186, Sweden.
E-mail: [email protected]
Victor Constantin Diculescu
Instituto Pedro Nunes, Laboratório de Electroanálise e Corrosão, Rua Pedro
Nunes, 3030-199 Coimbra, Portugal.
E-mail: [email protected]
Seung Yong Hwang
Division of Molecular and Life Science, College of Science & Technology
Hanyang University & GenoCheck Co. Ltd., Ansan, Gyeonggi-do, Korea.
E-mail: [email protected]
Pablo Iglesias
Molecular Oncology Laboratory MOL, Departmento of Fisioloxia, Facultade
de Medicina, Rua San Francisco s/n, 15782 Santiago de Compostela, Galicia,
Spain.
E-mail: [email protected]
Shaoyi Jiang
Department of Chemical Engineering, at the University of Washington,
USA.
E-mail: [email protected]
Chang-Hoon Kim
Department of Electrical Engineering, KAIST, 335 Gwahangno, Yuseong-gu,
Daejeon 305-701, Republic of Korea.
E-mail: [email protected]
Takeshi Kondo
Department of Hematology & Oncology, Hokkaido University Graduate
School of Medicine, N15W7, Kita-ku, Sapporo 060-8638, Japan.
E-mail: [email protected]
List of Contributors xiii
Kuldeep Kumar
Biosensor Technology Lab, Department of Biotechnology, Punjabi University,
Patiala-147 002, India.
E-mail: [email protected]
Seung Yong Lee
Department of Bio-Nano Technology, Hanyang University, Ansan,
Gyeonggi-do, Korea.
E-mail: [email protected]
Chii-Wann Lin
Institute of Biomedical Engineering, National Taiwan University, Taipei,
Taiwan.
E-mail: [email protected]
Marco Mascini
Dipartimento di Chimica Ugo Schiff, Università degli studi di Firenze,
Via della Lastruccia 3, Sesto Fiorentino (Fi), Italia.
E-mail: [email protected]
Ray Mernaugh
Department of Biochemistry, School of Medicine, Vanderbilt University,
Nashville, TN 37232, USA.
E-mail: [email protected]
Chang Ming Li
School of Chemical and Biomedical Engineering, Center for Advanced
Bionanosystems Nanyang Technological University, 70 Nanyang Drive,
Singapore 637457.
E-mail: [email protected]
Mònica Mir
Nanobioengineering Laboratory, Institute for Bioengineering of Catalonia
(IBEC), Barcelona Science Park, Baldiri i Reixac, 10, 08028, Barcelona,
Spain.
E-mail: [email protected]
Tatsuaki Mizutani
Laboratory of Pathophysiology and Signal Transduction, Hokkaido
University, Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-
8638, Japan.
Current Affiliation: Ludwig Boltzmann Institute for Cancer Research,
Waehringerstrasse 13A, A-1090, Vienna, Austria.
E-mail: [email protected]
xiv Biosensors and Cancer
May C. Morris
CRBM-CNRS-UMR 5237, University of Montpellier-IFR122, 1919 Route de
Mende, 34293 Montpellier, France.
E-mail: [email protected]
Maria Teresa Neves-Petersen
Nanobiotechnology Group, Department of Biotechnology, Chemistry and
Environmental Sciences, University of Aalborg, Sohngaardsholmsvej 57,
DK-9000 Aalborg, Denmark.
E-mail: [email protected]
Yusuke Ohba
Laboratory of Pathophysiology and Signal Transduction, Hokkaido
University, Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-
8638, Japan.
E-mail: [email protected]
Ilaria Palchetti
Dipartimento di Chimica Ugo Schiff, Università degli studi di Firenze,
Via della Lastruccia 3, Sesto Fiorentino (Fi), Italia.
E-mail: [email protected]
Dai-Wen Pang
Key Laboratory of Analytical Chemistry for Biology and Medicine
(Ministry of Education), College of Chemistry and Molecular Sciences,
Research Center for Nanobiology and Nanomedicine, (MOE 985 Innovative
Platform), State Key Laboratory of Virology, Wuhan University, Wuhan
430072, People’s Republic of China.
E-mail: [email protected]
Wilmer Alfonso Pardo
Nanobioengineering Laboratory, Institute for Bioengineering of Catalonia
(IBEC), Barcelona Science Park, Baldiri i Reixac, 10, 08028, Barcelona,
Spain.
E-mail:
Antonietta Parracino
Nanobiotechnology Group, Department of Physics and Nanotechnology,
University of Aalborg, Sohngaardsholmsvej 57, DK-9000 Aalborg,
Denmark.
E-mail: [email protected]
Steffen B. Petersen
Nanobiotechnology Group, Department of Health Science and Technology,
Aalborg University, Frederik Bajers Vej 7 D2, Aalborg, Denmark.
E-mail: [email protected]
List of Contributors xv
Carlo Ricciardi
Politecnico di Torino, Applied Science and Technology, Department, Corso
Duca degli Abruzzi 24, 10129 Torino, Italy.
E-mail: [email protected]
Josep Samitier
Nanobioengineering Laboratory, Institute for Bioengineering of Catalonia
(IBEC), Barcelona Science Park, Baldiri i Reixac, 10, 08028, Barcelona,
Spain.
E-mail:
Angela De Simone
Department of Pharmaceutical Sciences, University of Bologna, Via
Belmeloro 6, 40126–Bologna, Italy.
E-mail: [email protected]
Er-Qun Song
Key Laboratory of Luminescence and Real-Time Analysis of the Ministry
of Education, College of Pharmaceutical Sciences, Southwest University,
Chongqing, 400715, People’s Republic of China.
E-mail:[email protected]
Masumi Tsuda
Laboratory of Pathophysiology and Signal Transduction; Hokkaido
University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-
8638, Japan.
E-mail: [email protected]
Neelam Verma
Biosensor Technology Lab, Department of Biotechnology, Punjabi University,
Patiala-147 002, India.
E-mail: [email protected]
Ruili Wang
Division of Pharmacotherapy and Experimental Therapeutics, School of
Pharmacy, University of North Carolina, 311 Pharmacy Lane, CB# 7569,
Chapel Hill, NC 27599-7569, USA.
E-mail: [email protected] and [email protected]
Sigen Wang
Department of Radiation Oncology& Department of Physics and Astronomy,
University of North Carolina, 101 Manning Drive, CB# 7512, Chapel Hill,
NC 27599-7512, USA.
E-mail: [email protected] and [email protected]
