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FOOD TOXICOLOGY
Current Advances and Future Challenges
Edited by
Ashish Sachan, DVM, MVSc, PhD
Suzanne Hendrich, PhD
Apple Academic Press Inc. Apple Academic Press Inc.
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Library and Archives Canada Cataloguing in Publication
Food toxicology : current advances and future challenges / edited by Ashish Sachan, DVM, MS, PhD,
Suzanne Hendrich, PhD.
Includes bibliographical references and index.
Issued in print and electronic formats.
ISBN 978-1-77188-617-8 (hardcover).--ISBN 978-1-315-16107-5 (PDF)
1. Food--Toxicology. I. Sachan, Ashish, editor II. Hendrich, Suzanne, editor
RA1258.F6615 2017 615.9'54 C2017-906617-X C2017-906618-8
Library of Congress Cataloging-in-Publication Data
Names: Sachan, Ashish, editor. | Hendrich, Suzanne, editor.
Title: Food toxicology : current advances and future challenges / editors, Ashish Sachan, Suzanne
Hendrich.
Other titles: Food toxicology (Sachan)
Description: Toronto ; New Jersey : Apple Academic Press, 2018. | Includes bibliographical references
and index.
Identifiers: LCCN 2017046191 (print) | LCCN 2017047026 (ebook) | ISBN 9781315161075 (ebook)
| ISBN 9781771886178 (hardcover : alk. paper)
Subjects: | MESH: Food--toxicity | Food Contamination
Classification: LCC RA601 (ebook) | LCC RA601 (print) | NLM WA 701 | DDC 363.19/2--dc23
LC record available at https://lccn.loc.gov/2017046191
Apple Academic Press also publishes its books in a variety of electronic formats. Some content that appears
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ABOUT THE EDITORS
Ashish Sachan, DVM, MVSc, PhD
Ashish Sachan, DVM, MVSc, PhD, is a veterinarian licensed in toxicology
by the College of Veterinarians of Ontario (CVO), Canada. Dr. Sachan has
been involved with toxicological sciences for more than twenty years in both
the university and industrial settings. Dr. Sachan’s publications and books
have widely covered advancements in the field of pharmacology and toxi-
cology, including research topics related to ethnopharmacology, pesticide
toxicology, and nanosensor technologies. He received his PhD in toxicology
from the Department of Biochemistry, Biophysics and Molecular Biology,
Iowa State University, USA. His PhD involved the development of aptas-
ensor technologies to detect toxic chemical species of forensic significance.
Dr. Sachan has been inducted into the Iowa State University chapter of the
Honors Society of Agriculture–Gamma Sigma Delta. Currently he is the
Director of Toxam, Inc. and also serves on the board of directors for the
Society of Toxicology of Canada (STC). His current professional interests
include the regulatory affairs and the scientific and business development of
agricultural and veterinary products.
Suzanne Hendrich, PhD
Suzanne Hendrich, PhD, is a University Professor and the Lura M. Lovell
Fellow at the Department of Food Science and Human Nutrition at Iowa
State University, where she has been on the faculty since 1987. Dr. Hendrich
has authored more than 150 research papers and abstracts, mainly on the
bioavailability of dietary constituents, such as soybean isoflavones, which
may prevent chronic diseases. Her mycotoxin research has focused mainly
on fumonisin and deoxynivalenol metabolism, bioavailability, and detoxifi-
cation. Her current food toxicology interests include safety of dietary ingre-
dients such as digestion-resistant starches, interactions between gut bacteria
and foodborne toxicants, and safety of dietary supplements. Dr. Hendrich
compiles an annual report based on data from the American Association of
Poison Control Center comparing foodborne toxicants, including dietary
vi About the Editors
botanical, vitamin and mineral supplements, seafood toxins, and other food-
borne toxicants for their adverse effects. She writes a “foodtox” blog (https://
foodtoxicologyprof.wordpress.com/) for which she critiques research on
food chemical and dietary supplement safety. Dr. Hendrich earned her BA in
biology from UCLA and her PhD in nutrition, UC Berkeley.
CONTENTS
List of Contributors........................................................................................ ix
List of Abbreviations....................................................................................xiii
Preface......................................................................................................... xix
1. Biomarkers in Food Toxicology......................................................................1
Juan Antonio Gimenez Bastida and José Moisés Laparra Llopis
2. Mucosal Exposome and Food Toxicity Biomarkers....................................27
Yuseok Moon
3. Toxicity of Ingested Nanomaterials..............................................................47
Yi Cao
4. Safety Evaluation of Chemistries Used in the Food and
Beverage Processing and Packaging Industries..........................................67
Martin Hoagland, Kathryn Sande, Alison Behling, and Nathan Pechacek
5. Developmental Neurotoxicity Considerations for
Food Additive Safety......................................................................................93
Yen-Ching Wu, Shruti V. Kabadi, and April Neal-Kluever
6. Protective Effect of Food-Grade Lactic Acid Bacteria
Against Oxidative Stress..............................................................................151
J. E. Aguilar-Toalá, B. Vallejo-Cordoba, A. F. González-Córdova,
R. García-Varela, H. S. García, and A. Hernández-Mendoza
7. Mycotoxins....................................................................................................179
Suzanne Hendrich
8. Endocrine-Disrupting Chemicals in Food and their
Toxicological Implications...........................................................................199
S. Raisuddin and Shikha Sharma
9. Radionuclides in Foods................................................................................251
Mohamed Abdelrazek Abdelaleem
10. Metal Toxicity in Foods...............................................................................291
M. Carmen Rubio Armendáriz, Arturo Hardisson de la Torre,
Ángel J. Gutiérrez Fernández, Dailos González Weller, Soraya Paz Montelongo,
Consuelo Revert Gironés, and José M Caballero Mesa
viii Contents
11. Toxicological Risks of Waste Burning Residues in Foods:
A View on Low-Income Countries..............................................................337
Ilaria Proietti and Alberto Mantovani
12. Introduction to Epithelial-to-Mesenchymal Transition and Its
Role as Potential Marker in Food Toxicology...........................................361
Ludovic Peyre and Maeva Giraudo
13. Regulation and Monitoring of Pesticide Residues in
Water and Food in Brazil............................................................................391
Luciano Zanetti Pessôa Candiotto, Luneia Catiane de Souza,
Vanessa Jacob Victorino and Carolina Panis
14. Aptamers as Advanced Nanosensing Tools in Food Safety......................433
Ashish Sachan
Index......................................................................................................................455
LIST OF CONTRIBUTORS
Mohamed Abdelrazek Abdelaleem
Nuclear Research Center, Atomic Energy Authority, Cairo 13759, Egypt. E-mail: Abdelrazek_MD@
yahoo.com
J. E. Aguilar-Toalá
Centro de Investigación en Alimentación y Desarrollo A. C., carretera a la Victoria Km. 0.6, Hermosillo,
Sonora 83304, México
M. Carmen Rubio Armendáriz
Área de Toxicología, Universidad de La Laguna, 38071 La Laguna, Tenerife, Islas Canarias, España.
E-mail:
[email protected]Juan Antonio Gimenez Bastida
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical Center,
Nashville, TN 37212, United States
Alison Behling
Ecolab, St. Paul, MN, United States
Luciano Zanetti Pessôa Candiotto
Group of Advanced Studies in Health Sciences, State University of West Paraná, UNIOESTE, Campus
Francisco Beltrão, Paraná, Brazil
Yi Cao, PhD
Key Laboratory of Environment-Friendly Chemistry and Applications of Ministry of Education, Lab of
Biochemistry, College of Chemistry, Xiangtan University, Hunan 411105, PR China. E-mail: caoyi39@
xtu.edu.cn
Arturo Hardisson de la Torre
Área de Toxicología, Universidad de La Laguna, 38071 La Laguna, Tenerife, Islas Canarias, España
Luneia Catiane de Souza
Group of Advanced Studies in Health Sciences, State University of West Paraná, UNIOESTE, Campus
Francisco Beltrão, Paraná, Brazil
Ángel J. Gutiérrez Fernández
Área de Toxicología, Universidad de La Laguna, 38071 La Laguna, Tenerife, Islas Canarias, España
H.S. García, PhD
Unidad de Investigación y Desarrollo de Alimentos, Instituto Tecnológico de Veracruz, M.A. de Quevedo
2779, Col. Formando Hogar, Veracruz, Veracruz 91897, México
R. García-Varela, PhD
CIATEJ, Autopista Monterrey-Aeropuerto, Km 10. Parque PIIT. Via de Innovacion 404, Apodaca, NL
66629, México
Maeva Giraudo, PhD
Environment and Climate Change Canada, Aquatic Contaminants Research Division, 105 McGill Street,
Montreal, QC, Canada H2Y 2E7. E-mail:
[email protected]. Tel.: +1 514 283 5036. E-mail:
[email protected] x List of Contributors
Consuelo Revert Gironés
Área de Toxicología, Universidad de La Laguna, 38071 La Laguna, Tenerife, Islas Canarias, España
A.F. González-Córdova, PhD
Centro de Investigación en Alimentación y Desarrollo A. C., carretera a la Victoria Km. 0.6, Hermosillo,
Sonora 83304, México
Suzanne Hendrich
University Professor and Lura M. Lovell Faculty Fellow, Food Science & Human Nutrition-H Science,
Iowa State University, Ames, IA, USA. E-mail:
[email protected]A. Hernández-Mendoza, PhD
Centro de Investigación en Alimentación y Desarrollo A. C., carretera a la Victoria Km. 0.6, Hermosillo,
Sonora 83304, México. E-mail: [email protected]
Martin Hoagland
Nalco Water, An Ecolab Company, Naperville, IL, United States
Shruti V. Kabadi, PhD
FDA/CFSAN/OFAS/DFCN, 5100 Paint Branch Pkwy, HFS 275, College Park, MD 20740, United States
José Moisés Laparra Llopis
Immunonutrition and Health Group, Valencian International University, C/Gorgos, 5-7, 46021 Valencia,
Spain. E-mail:
[email protected]Alberto Mantovani
Noodles Onlus, Nutrition & food safety and wholesomeness, Rome, Italy; Istituto Superiore di Sanità,
Viale Regina Elena 299, 00161 Rome, Italy
José M. Caballero Mesa
Área de Toxicología, Universidad de La Laguna, 38071 La Laguna, Tenerife, Islas Canarias, España
Yuseok Moon, PhD ATS
Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sciences, Pusan
National University School of Medicine, Yangsan, South Korea; Immunoregulatory Therapeutics Group
in Brain Busan 21 Project, Busan, South Korea. E-mail:
[email protected]April Neal-Kluever, PhD, DABT
FDA/CFSAN/OFAS/DFCN, 5100 Paint Branch Pkwy, HFS 275, College Park, MD 20740, United
States. E-mail:
[email protected]Carolina Panis
Group of Advanced Studies in Health Sciences, State University of West Paraná, UNIOESTE, Campus
Francisco Beltrão, Paraná, Brazil; Laboratory of Inflammatory Mediators, State University of West
Paraná, UNIOESTE, Campus Francisco Beltrão, Paraná, Brazil. E-mail: [email protected]
Nathan Pechacek
Ecolab, Eagan, MN, United States. E-mail: [email protected]
Ludovic Peyre, PhD
UMR 1331 TOXALIM (Research Center in Food Toxicology), Institut National de la Recherche
Agronomique (INRA), Laboratory of Xenobiotic’s Cellular and Molecular Toxicology, 400 route des
Chappes, BP 167, 06903 Sophia-Antipolis Cedex, France. E-mail:
[email protected]Ilaria Proietti
European Commission, Joint Research Centre (JRC), Economics of Agriculture—Sustainable Resources,
Edificio Expo. C/Inca Garcilaso 3, 41092 Seville, Spain; Noodles Onlus, Nutrition & food safety and
wholesomeness, Rome, Italy
List of Contributors xi
S. Raisuddin
Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi
110062, India. E-mail: [email protected]
Ashish Sachan
Toxam Inc., Guelph, ON, Canada. E-mail: [email protected]
Kathryn Sande
Ecolab, Eagan, MN, United States
Shikha Sharma
Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi
110062, India
B. Vallejo-cordoba, PhD
Centro de Investigación en Alimentación y Desarrollo A. C., carretera a la Victoria Km. 0.6, Hermosillo,
Sonora 83304, México
Vanessa Jacob Victorino
Group of Advanced Studies in Health Sciences, State University of West Paraná, UNIOESTE, Campus
Francisco Beltrão, Paraná, Brazil
Dailos González Weller
Área de Toxicología, Universidad de La Laguna, 38071 La Laguna, Tenerife, Islas Canarias, España;
Servicio de Inspección Sanitaria y Laboratorio, Área de Salud de Tenerife, Servicio Canario de Salud,
Rambla de Santa Cruz, 38006 Santa Cruz de Tenerife, España
Yen-Ching Wu, PhD
FDA/CFSAN/OFAS/DFCN, 5100 Paint Branch Pkwy, HFS 275, College Park, MD 20740, United States
LIST OF ABBREVIATIONS
AD antimicrobial division
ADHD attention deficit hyperactivity disorder
ADI acceptable dietary intake
AECOSAN Spanish Consumer Agency for Food Safety and Nutrition
AhRs aryl hydrocarbon receptors
AJs adherent junctions
AMU atomic mass units
AOP adverse outcome pathway
APEs alkylphenol ethoxylates
APs alkylphenols
ASD autism spectrum disorder
ASR auditory startle reflex
ATSDR Agency for Toxic Substances and Disease Registry United
States
AuNPs gold nanoparticles
BBB blood–brain barrier
BCB blood–cerebral spinal fluid barrier
BHA butylated hydroxyanisole
BHT butylated hydroxytoluene
BMD benchmark dose
BMP bone-morphogenetic protein
BMR benchmark response
BPA bisphenol A
CCK cholecystokinin
cEDI cumulative estimated daily intake
CFR Code of Federal Regulations
CFs consumption factors
CFSAN Center for Food Safety and Applied Nutrition
CI confidence interval
CLA conjugated linoleic acid
CNS central nervous system
CS-UCNPs core/shell upconversion nanoparticles
CTC circulating tumor cells
DBP di-n-butyl phthalate
xiv List of Abbreviations
DC dietary concentration
DDD daily dietary dose
DEHP di-(2-ethylhexyl) phthalate
DiDP di-isobutylpthalate
DILs Derived Intervention Levels
DiNP di-isononylpthalate
DL-PCB dioxin-like polychlorinated biphenyls
DLPFC dorsolateral prefrontal cortex
DnBP di-n-butylpthalate
DNT developmental neurotoxicity testing
DON deoxynivalenol
DRCs dioxin-related compounds
ECM extracellular matrix
EDCs endocrine-disrupting chemicals
EDI estimated daily intake
EDs endocrine disruptors
EECs enteroendocrine cells
EFSA European Food Safety Authority
EGF epidermal growth factor
ELONA enzyme-linked oligonucleotide assay
EMT epithelial-to-mesenchymal transition
EPA US Environmental Protection Agency
EPS exopolysaccharides
ERs estrogen receptors
EU European Union
FAO/WHO United Nations for Food and Agriculture/World Health
Organization
FAP Food Additive Petition
FCN Food Contact Notification
FCSs food contact substances
FCSS food contact surface sanitizers
FDA US Food and Drug Administration
FFQ food frequency
FGF fibroblast growth factor
FIFRA Fungicide and Rodenticide Act
FOB functional observation battery
FQPA Food Quality Protection Act
FSIS Food Safety and Inspection Service
GBS Guillain–Barre syndrome
GIT gastrointestinal tract
List of Abbreviations xv
GJs gap junctions
GL Guideline Levels
GnRH gonadotropin-releasing hormone
GPCRs G-protein-coupled receptors
GR glutathione reductase
GRAS generally recognized as safe
HDAC histone deacetylase
HEDP 1-hydroxyethane 1,1-diphosphonic acid
HGF hepatocyte-growth factor
HPA hypothalamic–pituitary–adrenal
HPG hypothalamic–pituitary–gonadal
HRP horseradish peroxidase
HTS high-throughput screening
IARC International Agency for Research on Cancer
IBD inflammatory bowel disease
IGF insulin-like growth factor
IQ intelligence quotient
JAK janus kinase
JECFA Joint FAO/WHO Expert Committee on Food Additives
LCR lifetime cancer risk
LOD limit of detection
LRET luminescence resonance energy transfer
LSPR localized surface plasmon resonance
MAPKs mitogen-activated protein kinases
MEHP mono(2-ethyl-hexyl) phthalate
MEP monoethyl phthalate
MET mesenchymal-to-epithelial transition
MiBP mono-isobutyl phthalate
MnBP mono-n-butyl phthalate
MNPs magnetic nanoparticles
MOG Modified One Generation
MPCs maximum permissible concentrations
MWM Morris Water Maze
NCGC NIH Chemical Genomics Center
NM nanomaterial
NOAEL no observed adverse effect level
NP nonylphenol
NPEs nonylphenol ethoxylates
NTP National Toxicology Program
OBs osteoblasts
