Name:

HUCOM
Medical Laboratory Sciences
Department
Final Exam of Immunology &
Serology
3rd Year- 1st semester-2019/2020 A
Number of pages (6) Time Allowed: Two Hours Date: 30/12/2019

Immunology:

Choose the correct answer:

1- Naturally acquired active immunity would be most likely acquired though which of the following
processes:
a- Vaccination
b- Drinking colostrum
c- Natural birth
d- Infection with disease causing organism followed by recovery ✅
2- Which of the following substances will not stimulate an immune response unless they are bound
to a larger molecule?
a- Antigen
b- Virus
c- Hapten ✅
d- Antibody
3- B and T cells are produced by stem cells that are found in:
a- Bone marrow☑️
b- Thymus gland
c- Spleen
d- Lymph nodes
4- Which of the following immune cells/molecules are most effective at destroying intracellular
pathogens?
a- T helper cells
b- B cells
c- Antibodies
d- T cytotolytic cells✅
5- B cells that produce and release large amount of antibody are called:
a- Basophils
b- Plasma cells ✅
c- Memory cells
d- N killer cells
6- The specificity of antibody is due to:
a- Its valence
b- The heavy chains
c- The Fc portion of the molecules
d- The variable portion of the heavy and light chain✅

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7- Cell mediated immunity is carried out by ………….. while humoral immunity is mainly carried out
by:
a- B cells/T cells
b- Epitopes/Antigens
c- Antibodies/Antigens
d- T cells/B cells ✅
8- The ability of the immune system to recognize self antigens versus nonself antigens is an example
of:
a- Specific immunity
b- Cell mediated immunity
c- Humoral immunity
d- Tolerance ✅
9- The ability of the host to resist infections by the pathogens is called…
a- Infection
b- Immunity✅
c- Hypersensitivity
d- Allergy
10- Present since birth and it has no memory:
a- Innate immunity✅
b- Humoral immunity
c- Cell mediated immunity
d- Active natural aquired immunity
11- Which of the following antibody gives a primary immune response?
a- IgG
b- IgM✅
c- IgA
d- IgE
12- Which of the following antibidies involved in allergy
a- IgG
b- IgM
c- IgA
d- IgE✅
13- The system that recognizes foreign molecules and acts to immubilize, neutralize or destroy them
is the:
a- Integumentary system
b- Circulatory system
c- Immune system✅
d- Lymphatic system
14- Collective and coordinated response to the introduction of foreign substances is called:

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 a- Immunity
b- Immune response ✅
c- Immunology
d- Immune system

15- Play major roles in destruction of intracellular bacteria due to the presence of granules
containing myeloperoxidase and lysozyme in its cytoplasm:
a- Neutrophils ✅
b- Monocyte
c- Natural killer cell
d- Eosinophils
16- Activates B cells in the production of antibodies:
a- T helper 1
b- Plasma cell
c- T helper 2✅
d- T cytotoxic
17- Acts quickly and acts against any type of invading agent non specifically :
a- Adaptive immunity
b- Natural immunity✅
c- Hypersensitivity
d- Autoimmunity
18- CD4 T cells are generally restricted by:
a- CD-1
b- MHC class-1
c- MHC clast-2✅
d- B2 microglobulin
19- MHC class -1 molecules are primarly involved in:
a- Recogition in glycolipid antigens
b- Resistant to fungi
c- Resistant to viruses✅
d- Activation of neutrophils
20- Macrophages activation to kill intracellular pathogens is primarily mediated by:
a- IL-2
b- IFN-gamma✅
c- IL-12
d- IL-5
21- Which of the following statement is true about Th-1 cells ?
a- They do not produce TNF-alpha
b- They do not express CD4
c- They do not binds to soluble proteins
d- They do not activate macrophages☑️

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22- Injuction of anti-venom to a patient for snake bite is an example of :
a- Naturally aquired active immunity
b- Artificially aquired active immunity
c- Naturally aquired passive immunity
d- Artificially aquired passive immunity✅
23- Newborns get their antibodies from mothers milk. This is an example of :
a- Naturally aquired active immunity
b- Artificially aquired active immunity
c- Naturally aquired passive immunity✅
d- `Artificially aquired passive immunity

24- Vaccination is an example of :

a- Naturally aquired active immunity
b- Artificially aquired active immunity✅
c- Naturally aquired passive immunity
d- Artificially aquired passive immunity
25- All the following comes under non-specific defence machanism except:
a- Fever
b- Phagocytes
c- Cell mediated immunity✅
d- Complement system
26- Which of the following is the site of T cell maturation?
a- Bone marrow
b- Thymus ✅
c- Spleen
d- Appendix
27- Primary lymphoid organs include:
a- Thymus and spleen
b- Thymus and bone marrow✅
c- Thymus, bone marrow and spleen
d- Thymus, bone marrow, spleen and lymph nodes
28- Antibodies are
a- Proteins
b- Glycoproteins☑️
c- Carbohydrates
d- Nucleic acid
29- The antigen binding site on an antibody is called:
a- Antitope
b- Epitope
c- Paratope✅
d- Endotope
30- Antigen presentation by endogenous involves:

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 a- Antigen presentation to to cytotoxic T cells✅
b- Antiden presentation to Th1 cells
c- Antigen presentation to B cells
d- Antigen prasentaion on MHC class II
31- The cytotoxic T cells recognize antigen in assiciation with:
a- Class I MHC determinants✅
b- Class II MHC determinants
c- Class III MHC determinants
d- Class I MHC and class II determinants
32- Presence of ………….. can be used to separate helper T cells from cytotoxic T cells
a- Class II MHC
b- CD-2
c- CD-3
d- CD-4✅

33- Immune disorders include:

a- Hypersensitivity
b- Auto-immune diseases
c- Immunodeficiency
d- All of these✅
34- The inappropriate response of immune system towards a relatively harmless antigen causing
harm to the host is referred as:
a- Auto-immune diseases
b- Hypersensitivity✅
c- Immunodeficiency
d- Tolerance
35- Which one of the following is a cell mediated hypersensitive reaction:
a- Type I
b- Type II
c- Type III
d- Type IV✅
36- Which of the following types of hypersesitive reactions is antibody mediated:
a- Type I
b- Type II
c- Type III
d- All of these☑️
37- Type III hypersensitivity is triggered by:
a- Mast cells and IgE
b- K cells and IgG
c- Deposition of antigen antibody coplexes ✅
d- T h cells
38- C3 convertase in altenative pathway is:

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 a- C2aC4b
b- C3bBbP✅
c- C3bBbPC3b
d- C2aC4bC3b
39- Membrane attack complex (MAC) in complement system formed of:
a- C6C7C8C9
b- C5bC6C7C8C9✅
c- C3bC6C7C8C9
d- C5bC5C6C7C8
40- …………… Increase the inflammatory response by binding to mast cells in complement system:
a- C5a and C3a✅
b- C5b and C3a
c- C5b and C3b
d- All of these

Serology
1) Typing of RBCs with antiserum reagent represents which type of reaction?
a. Direct hemagglutination
b. Passive hemagglutination
c. Reverse passive hemagglutination
d. Inhibition hemagglutination
2) Precipitation differs from agglutination in which way?
a. Precipitation can be used only as a qualitative method
b. Precipitation occurs with univalent antigen, whereas agglutination requires multivalent antigen
c. Precipitation involves a soluble antigen, whereas agglutination involves a particulate antigen
d. Precipitation can be performed only in agar gel
3) When soluble antigens diffuse in a gel that contains antibody, in which zone does optimum
precipitation occur?
a. Prozone
b. Zone of equivalence
c. Postzone
d. a & c
4) In which zone might an antibody-screening test be false negative?
a. Prozone
b. Zone of equivalence
c. Postzone
d. None of the above
5) Which of the following refers to the intensity of attraction between an antibody and a single
antigenic determinant?
a. Affinity
b. Avidity
c. Cross-reactivity
d. Zone phenomenon
6) The harmful effects of a bacterial toxin or virus are eliminated by a specific antibody, in:
a. Agglutination reactions
b. Precipitation reactions
c. Neutralization reactions
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 d. Complement fixation reactions
7) Haemolysisis an indicator of a negative serum in:
a. Agglutination reactions
b. Precipitation reactions
c. Neutralization reactions
d. Complement fixation reactions
8) Which of the following is characteristic of direct immunofluorescence?
a. The anti-human immunoglobulin has the fluorescent dye
b. Requires two wash steps
c. Antibody is fixed on a solid phase
d. Microbial antigens can be rapidly identified by this method
9) Which of the following is characteristic of an indirect ELISA?
a. The anti-human immunoglobulin has the enzyme label
b. The surface of the well is coated with known antigen
c. The intensity of coloris directly proportional to the amount of patient antibody present in the
sample
d. All of the above
10) Is a sensitive assay based on a competition between labeled antigen and non-labeled antigen
present in the sample, for a fixed amount of specific antibody in a limited time:
a. Immunofluorescence
b. Enzyme-linked immunosorbent assay
c. Radioimmunoassay
d. Western Blot