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A Review On Natural Biopolymers in External Drug Delivery Systems For Wound Healing and Atopic Dermatitis

This review discusses the use of natural biopolymers in external drug delivery systems for treating skin wounds and atopic dermatitis. It highlights the advantages of these biopolymers, such as biocompatibility and controlled drug release, which improve therapeutic effectiveness while minimizing side effects. The document also outlines recent advancements in drug delivery systems utilizing various natural polymers to enhance treatment outcomes for skin conditions.

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Kamila Marques
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19 views16 pages

A Review On Natural Biopolymers in External Drug Delivery Systems For Wound Healing and Atopic Dermatitis

This review discusses the use of natural biopolymers in external drug delivery systems for treating skin wounds and atopic dermatitis. It highlights the advantages of these biopolymers, such as biocompatibility and controlled drug release, which improve therapeutic effectiveness while minimizing side effects. The document also outlines recent advancements in drug delivery systems utilizing various natural polymers to enhance treatment outcomes for skin conditions.

Uploaded by

Kamila Marques
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Internationa Journal of Bolg! Macromolecles 253 (2024) 190296 Contents lists available at SsienceDicect International Journal of Biological Macromolecules ELSEVIER Journal homepage: www.elsevier.comilocatellibiomac Review ® A review on natural biopolymers in external drug delivery systems for eat wound healing and atopic dermatitis Patricia C. Pires®'*‘, Fouad Damiri®", Ehsan Nazarzadeh Zare“', Anwarul Hasan", Rasoul Esmaeely Neisiany , Francisco Veiga”, Pooyan Makvandi *", Ana Cléudia Paiva-Santos °"""* Departmen of Paracel Tec, cy of Pharmacy of th Unies of Cina, Univesity of Coimbra, Cin, Porn ‘ meqUmTe: 14g, rp of Pharmac Tene, acy of Pharma fh Um ef Cara, Unverstyof Camb, Cra, Parag “Heth Sac Rae Cnre (CICS UBD, Une of ara arr fee Hon, 200 308 Cah Papa "etree of Bont cd Org Sy (IOSHNTHC), Depart f Cem, Fao Scene Ben W'S, Unvsty Hanon of Ceca, ‘Sth of chesty, Danghn Univer, Danghan 2671645567, an “Ca of Rach np and Ona, Chiara ners, pre 140401, Punch, nie Dipurman of Mehl on nr ageing. Qu Ue, Dot 2713, Qaar * moneda! Reseach Gone, dar Unie, Doh 2713, aur orn Can, sun Unveayof echo Arse 8 44100 vice, Pant Depart fle gcrigHaki Sb Uo, Soe 961707687, on "afr Bog Schon of Bog The Urey of ante. gh OK tars Care fr Roach and Devan, Cire Unser, Himachal Pra 14103, Ia © Dgwtmen of Brats Soe Dew Calg nd Paps STMATS, Sete Unies, Cha 0007, ie * Chae an ierig Reset Tam (RSC), Deparment of Chery, Paar acy of Ben Mal PBN, Uber Slr Moy ‘Simare (USS), Bo Moll 2300, ar, ARTICLE INFO AesTRACT Kegwote Despte the advantages of opel admielstvation nthe weatment of hin dlseases, current marketed preparations polymer foe the challenge ofthe skin's barr effec, leacing to low therapeutic effectiveness and undesirable side ef ® feos. Hence, in recent years the management of skin wounds, the main morbidty-cavsing complication in hospital environments, and atopic dermatitis, the mest common inflammatory skin disease, has beeome 2 great concer. Fortunately, new, more efetive, and safer treatments are alreay underdevelopment, with chitosan, starch, sik ibroin, agarose, hyaluronic ac, alisate, collagen, and gelatin having been sed forthe develop. ment ofanoparices,ipesore, noses and/or hydrogels improve he deliver of several molecules forthe treatment ofthese diseases, Biocompatity,bioderadabily, increased viscosity, controlled érug dlvery, Increased drug retention inthe epidermis, ad overall mitigation of adverse ees, conrbute to an efective trentment,aditonally proving intrinsic antimirobial and wound healing properties In this review, some of the most reent success eases of bopolymerbased dru delivery systems as part of panocarriers semisolid hydenge! matrices, oF both (hyd system, forthe management af sin wounds nd atopic demas are ‘rtcallydisetaed, including compotion and vite er vive and in vve chararteiation, showing the prose ofthese external drug delivery stems 1. Introduction 1.1, Overview: Background and significance ‘The treatment of skin diseases through topical drug administration 7 Gorapondence tA. Hasan, Department of Mechanical and indus Engineering, Qata Univerty, Doha 2713, Qatar. ** Cowespondence te: AC. PavaSantes, Department of Pharmaceutical Techoolgy, Faculty of Pharmacy f the University of Coimbra, Unversity of Coimbra, Coimbra, Portal ‘Bal eres: basin anarul mie @ymallcom (A, Hasan), acsantost wc pt (AC. Pave Santos) np//doLorg/10.1036/}Jbiomac.2024.130296 Received 17 Novernber 2028 Received in revised form 14 February 2024; Accepted 17 February 2024 “Available online 19 Ferry 2024 (0141-8130/6 2024 Publised by Eseier RV. offers significant advantages compared to systemic routes. These ad- vantages include targeted drug delivery, minimized systemic drug ‘expose (and, consequently, fewer systemic side-effects), and avoid ance of hepatic rst-pas effect [1-3]. Topical formulations are also easy [Abbreviations AD Atopic dermatitis AgNPs Silver nanoparticles BMV betamethasone 17-valerate CHX —Chlorhexicine CMA carboxymethyl agarose DDS Drug delivery system DEV lifucortolone valerate HA Hyaluronic Acid HC Hydrocortisone HINTS Halloysite clay nanotubes HT Hydroxytyrosol NP Nanoparticle ‘TEWL Transepidermal water loss 20 NPs tine oxide nanoparticles and painless to administer (non invasiveness), ensuring good patient compliance. They can be tailored to have controlled drug release, leading to therapeutic effects tat las for a longer peri of time [>] "Nevertheless, marketed preparations face considerable challenges, ince ‘the skin's barrier effect makes ic difficult for drugs to permeate it, with ‘existing therapies having lack of effectiveness, need of repeated dosing, and local as well a systemic side effects [5-8]. Hence, the developmen ‘of new, more effective, and safer treatments is greatly needed ‘Among the various diseases and injuries that can affect the skin, atopic dermatitis (AD) and wounds have become a growing concern, not ‘only fo patients bt also for healtheare profesional [9,10]. AD is the ‘mst common inflammatory cutaneous disease, being characterized by a

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