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Monoclonal Antibody and Peptide Targeted
Radiotherapy of Cancer 1st Edition Raymond M. Reilly
Digital Instant Download
Author(s): Raymond M. Reilly
ISBN(s): 9780470613207, 0470613203
Edition: 1
File Details: PDF, 6.55 MB
Year: 2010
Language: english
MONOCLONAL ANTIBODY
AND PEPTIDE-TARGETED
RADIOTHERAPY OF
CANCER

Edited by

Raymond M. Reilly
MONOCLONAL ANTIBODY
AND PEPTIDE-TARGETED
RADIOTHERAPY OF
CANCER
MONOCLONAL ANTIBODY
AND PEPTIDE-TARGETED
RADIOTHERAPY OF
CANCER

Edited by

Raymond M. Reilly
Copyright  2010 by John Wiley & Sons, Inc. All rights reserved.

Published by John Wiley & Sons, Inc., Hoboken, New Jersey

Published simultaneously in Canada

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Library of Congress Cataloging-in-Publication Data:

Monoclonal antibody and peptide-targeted radiotherapy of cancer / edited by

Raymond M. Reilly.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-0-470-24372-5 (cloth)
1. Cancer–Radioimmunotherapy. 2. Monoclonal antibodies–Therapeutic use.
3. Tumor proteins. I. Reilly, Raymond.
[DNLM: 1. Neoplasms–radiotherapy. 2. Antibodies, Monoclonal–therapeutic
use. 3. Peptides–therapeutic use. 4. Radioimmunotherapy–methods. 5. Receptors,
Peptide–therapeutic use. QZ 269 M751 2010]
RC271.R26M66 2010
616.990 40642–dc22 2009045879

Printed in Singapore

10 9 8 7 6 5 4 3 2 1
To my mother, who always used to ask me, “What is a monoclonal antibody?”
and, in another life would have been a wonderful scientist with
her inborn fascination with medical discovery and knowledge.
 CONTENTS

Preface xvii
Contributors xxi

1. Antibody Engineering: Optimizing the Delivery Vehicle 1

Diane E. Milenic
1.1 Introduction 1
1.2 Intact Murine Monoclonal Antibodies 2
1.3 Recombinant Immunoglobulin Molecules 4
1.3.1 Chimeric Monoclonal Antibodies 5
1.3.2 Humanized Monoclonal Antibodies 6
1.3.3 Human Monoclonal Antibodies 9
1.4 Nanobodies 10
1.5 Domain-Deleted Monoclonal Antibodies 12
1.6 Hypervariable Domain Region Peptides 13
1.7 Fv Fragments 14
1.7.1 Multimeric Fv Forms 16
1.8 Minibodies 19
1.9 Selective High Affinity Ligands 21
1.10 Affibodies 21
1.11 Other Strategies 23
1.11.1 Fc Domain and the Neonatal Fc Receptor 23
1.11.2 PEGylation 25
1.11.3 Albumin Binding 26
1.12 Concluding Remarks 28
References 28

2. The Radiochemistry of Monoclonal Antibodies and Peptides 39

Raymond M. Reilly
2.1 Introduction 39
2.2 Tumor and Normal Tissue Uptake of Monoclonal
Antibodies and Peptides 40
2.3 Selection of a Radionuclide for Tumor Imaging 41
2.4 Selection of a Radionuclide for Targeted Radiotherapy 44

vii
viii CONTENTS

2.5 Labeling Antibodies and Peptides with Radiohalogens 47

2.5.1 Iodine Radionuclides 47
2.5.2 Bromine Radionuclides 51
2.5.3 Fluorine Radionuclides 53
2.5.4 Astatine Radionuclides 56
2.6 Labeling Antibodies and Peptides with Radiometals 57
2.6.1 Technetium Radionuclides 57
2.6.2 Rhenium Radionuclides 62
2.6.3 Indium Radionuclides 63
2.6.4 Yttrium Radionuclides 69
2.6.5 Gallium Radionuclides 71
2.6.6 Copper Radionuclides 72
2.6.7 Lutetium Radionuclides 74
2.6.8 Lead, Bismuth, and Actinium Radionuclides 74
2.7 Characterization of Radiolabeled mAbs and Peptides 75
2.7.1 Evaluation of the Homogeneity of Radiolabeled
mAbs and Peptides 75
2.7.2 Measurement of Radiochemical Purity 77
2.7.3 Measurement of Immunoreactivity/Receptor
Binding Properties 78
2.7.4 Evaluation of In Vitro and In Vivo Stability 80
2.7.5 Preclinical Biodistribution, Tumor Imaging,
and Dosimetry Studies 81
2.7.6 Preclinical Studies to Evaluate Antitumor Effects
and Normal Tissue Toxicity 81
2.7.7 Kit Formulation and Pharmaceutical Testing 82
2.8 Summary 82
Acknowledgments 83
References 83

3. The Design of Radiolabeled Peptides for Targeting

Malignancies 101
Leonard G. Luyt
3.1 Introduction 101
3.2 Peptide Targets 101
3.3 Peptides as Cancer Targeting Agents 102
3.3.1 Discovery of Novel Cancer Binding Peptides 104
3.3.2 The Addition of a Radionuclide to a Peptide 108
3.3.3 Improving the In Vivo Behavior of Peptides 113
3.4 Multimodality Agents 114
3.5 Future Outlook 115
References 115
 CONTENTS ix

4. Peptide Receptor Radionuclide Therapy in Patients with

Somatostatin Receptor-Positive Neuroendocrine Tumors 121
Martijn van Essen, Dik J. Kwekkeboom, Wouter W. de Herder, Lisa Bodei,
Boen L. R. Kam, Marion de Jong, Roelf Valkema, and Eric P. Krenning
4.1 Introduction 121
4.2 Radiotherapy with 111In-Octreotide 122
4.3 Radiotherapy with 90 Y-DOTATOC 123
4.4 Targeted Radiotherapy Studies with 177Lu-Octreotate 124
4.5 PRRT with Other Somatostatin Analogues 128
4.6 Comparison of Different PRRT Studies 129
4.7 Comparison with Chemotherapy 129
4.8 Options for Improving PRRT and Future Directions 130
4.9 Conclusions 133
References 133

5. Targeted Radiotherapy of Central Nervous System Malignancies 139

Michael R. Zalutsky, David A. Reardon, and Darell D. Bigner
5.1 Malignant Brain Tumors 139
5.2 Rationale for Locoregional Therapy 140
5.3 Targeted Radiotherapy of Brain Tumors 141
5.4 Rationale for Tenascin-C as a Target for Radionuclide Therapy 142
5.4.1 Tenascin-C Targeting Vehicles 143
5.4.2 BC-2 and BC-4 mAbs: The Italian Experience 144
5.4.3 Antitenascin-C mAb 81C6: The Duke Experience 146
5.4.4 Strategies for Improving the Efficacy
of 81C6-Based Targeted Radiotherapy 150
5.4.5 Evaluation of More Stable Constructs: Human/Mouse
Chimeric 81C6 152
5.4.6 Evaluation of More Potent Radionuclides:
Astatine-211-Labeled CH81C6 154
5.4.7 Pretargeted Radioimmunotherapy 155
5.4.8 Receptor-Targeted Peptides 156
5.4.9 Chlorotoxin 157
5.5 Perspective for the Future 158
Acknowledgments 159
References 159

6. Radioimmunotherapy for B-Cell Non-Hodgkin Lymphoma 169

Thomas E. Witzig
6.1 Introduction 169
6.2 Radioimmunotherapy 170
6.2.1 Historical Background of RIT 170
x CONTENTS

6.2.2 Radionuclides Used in RIT 171

6.2.3 Administration of RIT: General Principles and Practice 173
6.2.4 Characteristics of Radiolabeled Monoclonal
Antibodies to CD20 175
6.2.5 Clinical Results of Anti-CD20 RIT for Relapsed NHL 179
6.2.6 Safety of Bexxar RIT 185
6.2.7 Radiolabeled Rituximab 187
6.3 Antibodies Against CD22 187
6.3.1 Radiolabeled Epratuzumab 187
6.4 RIT Versus Immunotherapy 188
6.5 RIT in Rituximab Refractory Patients 189
6.6 RIT for Previously Untreated Patients 190
6.7 RIT for Relapsed Large-Cell Lymphoma 191
6.8 RIT for Transformed Lymphoma 192
6.9 RIT for Mantle Cell Lymphoma 192
6.10 Long-Term Results of RIT 193
6.11 Risk of Myelodysplasia with RIT 193
6.12 Feasibility of Treatment After RIT Failure 194
6.13 Combinations of RIT and Chemotherapy 195
6.14 High-Dose RIT with Stem Cell Support 197
6.14.1 Use of RIT After Stem Cell Transplantation 199
6.15 RIT for Central Nervous System Lymphoma 200
6.16 Retreatment with RIT 200
6.17 RIT in Children with Relapsed NHL 201
6.18 RIT in Patients with Lung Involvement 201
6.19 RIT in Patients with Skin Lymphoma 202
6.20 RIT in Patients with >25% Marrow Involvement 202
6.21 RIT in Older Patients 202
6.22 RIT in Hodgkin’s Disease 203
6.23 Viral Infections After RIT 203
6.24 Radiation Therapy After RIT 203
6.25 Summary 203
6.26 Future Directions 204
References 205

7. Radioimmunotherapy of Acute Myeloid Leukemia 219

Todd L. Rosenblat and Joseph G. Jurcic
7.1 Introduction 219
7.2 Antigenic Targets 220
7.3 Radionuclide Selection 220
7.4 Radiolabeling 222
7.5 Pharmacokinetics and Dosimetry 225
7.5.1 Pretargeted Approaches 226
 CONTENTS xi

7.6 RIT with b-Particle Emitters 227

7.6.1 131I-M195 and 131I-Lintuzumab 227
7.6.2 90Y-Lintuzumab 230
7.6.3 131I-Labeled p67 230
7.6.4 131I-Labeled BC8 230
7.6.5 188Re-Anti-CD66 231
7.7 RIT with a-Particle Emitters 232
7.7.1 Preclinical Studies 232
7.7.2 213Bi-Lintuzumab 232
7.7.3 225Ac-Lintuzumab 233
7.8 Summary 234
References 234

8. Pretargeted Radioimmunotherapy of Cancer 241

Robert M. Sharkey and David G. Goldenberg
8.1 Introduction 241
8.2 The Challenge of Improving Tumor/Nontumor Ratios 243
8.3 Pretargeting: Uncoupling the Antibody–Radionuclide
Conjugate 246
8.3.1 Bispecific Antibodies and Radiolabeled Haptens 246
8.3.2 Pretargeting: Development
of Avidin/Streptavidin and Radiolabeled Biotin 250
8.3.3 Pretargeting with Oligonucleotide/Complementary
Oligonucleotide Immunoconjugates 251
8.3.4 Core Principles Associated with Pretargeting Procedures 252
8.4 Clinical Studies of Pretargeting 260
8.4.1 “Two-Step” Pretargeting with Streptavidin
Immunoconjugates and 90Y-Biotin 260
8.4.2 “Three-Step” Pretargeting with Streptavidin
Immunoconjugates and 90Y-Biotin 263
8.4.3 Bispecific Antibody-131I-Hapten-Peptide 266
8.5 Prospects for Combination Therapies 268
8.6 Future Innovations 270
8.7 Conclusions 274
References 274

9. Targeted Auger Electron Radiotherapy of Malignancies 289

Raymond M. Reilly and Amin Kassis
9.1 Introduction 289
9.2 Radiobiological Effects of Auger Electrons 290
9.2.1 Relative Biological Effectiveness 291
xii CONTENTS

9.2.2 DNA Damage 292

9.2.3 Bystander Effects 293
9.3 Selection of an Auger Electron-Emitting Radionuclide 294
9.4 Microdosimetry 296
9.4.1 The “Cross-Dose” Contribution 298
9.5 Molecular Targets for Auger Electron Radiotherapy of Cancer 299
9.5.1 DNA Synthesis Pathways as a Target 299
9.5.2 Somatostatin Receptors 300
9.5.3 Epidermal Growth Factor Receptors 310
9.5.4 Targeting HER2 Receptors 318
9.5.5 Other Antigens/Receptors in Solid Tumors 321
9.5.6 Cell-Surface Epitopes in Lymphomas 324
9.5.7 Targeting CD33 Epitopes in Acute Myeloid Leukemia 327
9.6 Small-Molecule Auger Electron Radiotherapy 329
9.6.1 Radiolabeled Estradiol Analogues 329
9.6.2 Radiolabeled mIBG Analogues 330
9.6.3 DNA Intercalating Agents 331
9.7 Summary and Conclusions 332
Acknowledgments 333
References 333

10. Viral Introduction of Receptors for Targeted Radiotherapy 349

Kathryn Ottolino-Perry and Judith Andrea McCart
10.1 Introduction 349
10.2 Viral Vectors 352
10.2.1 Nonreplicating Viruses 352
10.2.2 Replicating Viruses: Mechanism of Tumor Cell Specificity 352
10.3 Virally Delivered Receptors 354
10.3.1 Somatostatin Receptor 354
10.3.2 Sodium Iodide Symporter 363
10.3.3 Other Receptors 375
10.4 Combined Oncolytic and Targeted Radiotherapy 381
10.5 Summary 382
References 382

11. Preclinical Cell and Tumor Models for Evaluating

Radiopharmaceuticals in Oncology 397
Ann F. Chambers, Eva A. Turley, John Lewis, and Leonard G. Luyt
11.1 Introduction 397
11.2 Traditional Approaches to Preclinical
Evaluation of Radiotherapeutics 399
 CONTENTS xiii

11.3 Models of Cancer 402

11.3.1 Cancer as a Complex Collection of Neoplastic Diseases 403
11.3.2 Human Breast Cancer Cell Culture Models 404
11.3.3 Animal Models 405
11.4 Animal Models for Evaluating Radiopharmaceuticals:
Unresolved Issues and Challenges for Translation 407
References 410

12. Radiation Biology of Targeted Radiotherapy 419

David Murray and Michael Weinfeld
12.1 Introduction 419
12.2 Targeted Radionuclide Therapy: Concepts 420
12.3 Radiation-Induced DNA Damage 421
12.4 Cellular DNA Damage Surveillance–Response Networks 422
12.5 Mammalian DNA-Repair Pathways 425
12.5.1 The BER Pathway 426
12.5.2 DSB-Repair Pathways 427
12.6 Modes of Cell Death Following Radiation Exposure 428
12.6.1 Apoptosis 428
12.6.2 Necrosis 429
12.6.3 Accelerated Senescence 430
12.6.4 Autophagy 430
12.6.5 Mitotic Catastrophe 430
12.7 Conventional Models for Cell Survival Curves,
Fractionation, and Dose-Rate Effects 431
12.8 Low-Dose Hyperradiosensitivity-Increased
Radioresistance 433
12.8.1 Phenomenology of HRS-IRR 433
12.8.2 Mechanistic Basis of HRS-IRR 435
12.8.3 Ultrafractionation 445
12.9 Inverse Dose-Rate Effects 447
12.10 Cross fire 451
12.11 The Radiobiological Bystander Effect 452
12.12 The Adaptive Response 453
12.13 A Possible Contribution from Low-Dose
Radiobiological Mechanisms to TRT Tumor
Responses? 455
12.14 Use of Radionuclides Other Than b-Particle Emitters 456
12.15 Role of Tumor Hypoxia and Fractionation Effects 457
12.16 Summary and Future Directions 458
Acknowledgments 458
References 458
xiv CONTENTS

13. Dosimetry for Targeted Radiotherapy 473

Sui Shen and John B. Fiveash
13.1 Introduction 473
13.2 Basic Concepts of MIRD Dosimetry 475
13.2.1 MIRD Equations 475
13.2.2 Cumulated Radioactivity and Residence Time 476
13.2.3 Radionuclide Data 476
13.2.4 Penetrating and Nonpenetrating Radiation
and the Absorbed Fraction 477
13.3 Preclinical Dosimetry 477
13.3.1 Data Collection 477
13.3.2 Preclinical Macrodosimetry 479
13.3.3 Nonuniform Distribution and Multicellular Dosimetry 480
13.4 Clinical Dosimetry Methods 481
13.4.1 Planar Conjugate View Imaging 481
13.4.2 Accounting for Scatter Effects in SPECT
and Planar Quantification 483
13.4.3 3D CT/Spect/Planar Hybrid Methods 485
13.4.4 3D PET 487
13.5 Dosimetry for Dose-Limiting Organs and Tumors 487
13.5.1 Marrow Dosimetry 488
13.5.2 Other Normal Organ Toxicity 491
13.5.3 Tumor Dosimetry 492
13.6 Conclusions 495
References 496

14. The Bystander Effect in Targeted Radiotherapy 507

Carmel Mothersill and Colin Seymour
14.1 Introduction 507
14.2 Historical Review of Bystander Effects in the Context
of Radiation Damage to Cells 508
14.3 New Knowledge and the Pillars of the Developing
New Paradigm 509
14.3.1 Key Points and Historical Time Line 510
14.4 Concept of Hierarchical Levels of Assessment of Targeted
Radiation Effects 513
14.5 The New Meaning of the LNT Model 513
14.5.1 Relating Dose to Effect, Harm, and Risk 514
14.6 Techniques for Studying Bystander Effects 514
14.6.1 Emerging Biomarkers of Nontargeted Radiation Effects 514
14.7 Bystander Phenomena in Targeted and Conventional
Radiotherapy 515
 CONTENTS xv

14.8. Mechanisms Underlying Bystander Effects and

Detection Techniques 518
14.9. The Future 520
References 521

15. The Role of Molecular Imaging in Evaluating Tumor Response

to Targeted Radiotherapy 527
Norbert Avril
15.1 Introduction 527
15.2 Positron Emission Tomography 528
15.2.1 Background and Basic Principles 528
15.2.2 PET Radiotracers 529
15.2.3 PET and PET/CT Imaging of Biologic
Features of Cancer 530
15.3 Response to Cancer Treatment Including
Targeted Radiotherapy 533
15.3.1 Conventional Methods Used to Evaluate
Treatment Response 533
15.3.2 Molecular Imaging for Monitoring
Treatment Response 534
References 539

16. The Economic Attractiveness of Targeted Radiotherapy:

Value for Money? 543
Jeffrey S. Hoch
16.1 Introduction 543
16.2 Applying Economics in Theory 544
16.2.1 A Simple Constrained Optimization Problem 545
16.3 Applying Economics in Practice 552
16.3.1 How are Economic Evaluations Used to Make
Decisions in Practice? 552
16.3.2 Challenges and Concerns 554
16.3.3 How Does the Model Affect the Results? 557
16.4 The Economic Attractiveness of Targeted Radiotherapy:
the Case of 90Y-Ibritumomab Tiuxetan (Zevalin) 559
16.4.1 What has been Published about the
Cost-Effectiveness of Zevalin? 559
16.4.2 Why the Scottish Medicines Consortium Said “No”
(Again) 563
16.5 Conclusions 564
References 565
xvi CONTENTS

17. Selected Regulatory Elements in the Development of

Protein and Peptide Targeted Radiotherapeutic Agents 571
Thomas R. Sykes and Connie J. Sykes
17.1 Introduction 571
17.2 Administrative and Organizational Elements 573
17.3 Pharmaceutical Quality Elements 575
17.3.1 Tumor Targeting Component 577
17.3.2 Radionuclide Binding Component 583
17.3.3 Radionuclide Component 585
17.3.4 Drug Product 587
17.4 Nonclinical Study Elements 593
17.4.1 (Radio)pharmacology Studies 595
17.4.2 Safety Pharmacology Studies 597
17.4.3 Toxicology Studies 598
17.5 Clinical Study Elements 601
17.5.1 Pre-Phase 1 and Exploratory Phase 1
Clinical Investigations 602
17.5.2 Traditional Phase 1 to Phase 3 Clinical Trials 605
17.6 Summary 607
Dedication 608
References 608

Index 613
 PREFACE

In June 2009 at the 56th annual meeting of the Society of Nuclear Medicine in Toronto,
the “Image of the Year” was selected by Dr. Henry N. Wagner Jr. from Johns Hopkins
University [Figure 1(1)]. This image illustrated the high sensitivity of positron
emission tomography (PET) with 18 F-2-fluorodeoxyglucose (18 F-FDG) to reveal
complete responses as early as 3 months post-treatment with 90 Y-ibritumomab
tiuxetan (Zevalin) or 131 I-tositumomab (Bexxar) in patients with non-Hodgkin’s
lymphoma (NHL) (2). These two radioimmunotherapeutics are the first to be approved
by regulatory authorities for treating cancer. By highlighting this image, Dr. Wagner
not only recognized the great advances that have been made over the past three decades
in radioimmunotherapy (RIT) of NHL (3) but also pointed the way toward how this
approach could be combined with achievements in imaging (4) to help further advance
the field of molecularly targeted radiotherapy.
There remain many challenges to be overcome, however, particularly to extend the
impressive results seen in NHL to RIT of the more prevalent solid tumors (3). RIT and
peptide-directed radiotherapy (PDRT) of solid tumors have been restricted by low
tumor uptake, dose-limiting toxicity to normal tissues including the bone marrow, and
an intrinsically greater radioresistance (3). Nonetheless, the success of RITof NHL has
proven that this approach is scientifically sound, translatable to clinical practice, and
feasible. Moreover, there has recently been progress in the treatment of solid tumors
with targeted radiotherapeutics, particularly using innovative pretargeting techniques
and in the setting of minimal residual disease (3).
My goal in assembling this book was to provide a single resource that would
constitute an expert discussion of the diverse aspects of the field of monoclonal
antibody and peptide-targeted radiotherapy of cancer. The chapters cover a wide range
of topics including the optimization of design of biomolecules and their radiochem-
istry, cell and animal models for preclinical evaluation, important discoveries from key
clinical trials of their effectiveness for the treatment of malignancies, an understanding
of their radiation biology and dosimetry, considerations in their regulatory approval,
and health economics issues that need to be appreciated to ultimately see their
widespread use in clinical oncology. New emerging areas such as the role of molecular
imaging in evaluating the response and resistance to targeted radiotherapy, a discus-
sion of the bystander effect that may enhance its effectiveness, and the potential of
combining cytolytic virus therapy with targeted radiotherapy have also been included.
Many of the chapters were authored by internationally renowned experts who have
made seminal discoveries in the field and by others who are leaders in areas that will be
important to its future. I am grateful to all authors for their excellent contributions and
xvii
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 CHAPTER XVI.
WHICH REVEALS THE WAY OF THE SORCERER.

After a restless night, gladdened somewhat by the thought that I

had saved Crystal from a terrible fate, but for the most part troubled
by fears of further danger, I rose early, and, passing through the gap
in the plantation where I had encountered the wizard negro, walked
over the field and down the valley towards the beach, thinking that
perhaps I might learn something of Tiki’s fate.
Finding nothing to guide me, I climbed a high hill seaward, which
overlooked the lower part of the Sound. From that vantage ground I
could see nearly the whole of the slender arm of the sea which
reached inland, the failing breath of the land breeze ruffling its
waters. A glance at the sheltered cove where the yacht had been
anchored told me that Cazotl had either shifted his position or put out
to sea. I scanned the whole length of the Sound, and at last
discerned the yacht passing into the shadows of the high cliffs which
opened on to the Pacific. Her sails were swelling out to the breeze,
and it was with a feeling of great relief that I watched her disappear
between the high rocks. But my relief did not outlive reflection, for I
soon saw that it was not at all probable that Cazotl would relinquish
his object after one failure.
The sun had risen high in the sky by the time I had returned to the
house, and while waiting for the breakfast-bell I strolled round the
verandah. When I came to the corner dedicated to Tiki, I was
surprised to find that faithful Maori coiled up on his bed of straw,
wrapped in his mat, and fast asleep. He must have returned in my
absence.
With an inconsiderate impatience to know what had befallen him I
stooped down and touched him on the shoulder, knowing from
experience that the slightest thing would wake him But he did not
stir. I then shook him soundly, but he made no sign. With a sudden
apprehension I bent over him and listened for his breathing. It was
regular and deep; he was evidently sleeping off the effects of that
strange poison, and, as far as I could judge, he was best left alone.
On going inside I encountered Grey coming downstairs.
“Good morning, Warnock,” he said, as he grasped my hand. “That
was an extraordinary affair last night—can’t think what possessed
the girl: she’s never done anything of that kind before. Good job you
saw her, or there’s no telling what might have happened.”
“Yes, it was lucky I happened to be abroad,” I replied; “I went out
to enjoy the thunderstorm.” Then I explained briefly how it had
occurred, but omitted all mention of the negro and his infernal arts,
as I thought it was better to keep that mysterious and alarming part
of the matter to myself.
“Is she up yet?” I asked in conclusion.
“No; I’ve just been in to see her. She’s fast asleep and seems
perfectly all right.”
“Ah! yes,” I said with assumed carelessness; “that’s the way out of
those peculiar fits: to let them sleep as long as ever they will.”
With that we went to breakfast, and discussed at length the details
of our proposed journey north, which was now finally fixed for the
following day. Grey’s manager was to arrive on the morrow, and, the
day after, we were to proceed overland to a seaport some thirty
miles to the north, and there take our passage in a sailing ship which
Grey had ascertained was bound for Golden Bay, the coast line of
which was situated not fifty miles from the Table Land.
From time to time during the day I learned by repeated inquiries
that Crystal was still sleeping peacefully, but my mental state was
one of extreme tension; for, being ignorant of the after effects of the
strange poison, I was tormented with a thousand apprehensions.
Every half-hour I paid visits to Tiki, for in his condition I felt I had
something to go by. It calmed my fears a little to find that his pulse
was uniformly regular, that his breathing was normal, and that there
were no signs of anything more alarming than a very deep sleep
which, as far as I could judge, was perfectly natural. In this way,
taking Tiki’s state to represent hers, I watched over Crystal in my
imagination the whole day long, now tortured with fears for the issue,
and now relieved by the healthy symptoms.
 In my wanderings in and out and about the house I remembered
the wizard’s reed tube, and found it again in the place where I had
hidden it. It was a strange-looking reed, seven knotted, and marked
with peculiar characters and signs. The darts were arranged in little
receptacles round the mouthpiece. Three were left. I extracted one
and inspected it. There was a blood-red tip to it, and this crimson dye
I knew was the poison. The safest course would be to burn the
accursed things, lest they should do damage by accident.
Accordingly, I took them to the kitchen grate and burnt them. What
the poison was I have no idea, but, as I threw them in one by one,
each emitted a jet of some gas, which burned many colours in
succession, giving a peculiar wail, like the cry of a tortured dumb
animal. So horrible, and yet so plaintive and pathetic was this faint
sound, that I was inclined to confess there was more than poison in
those accursed messengers of evil. Then I burned the tube and
returned to my restlessness.
At length, late in the afternoon, I was standing beneath the nut-
trees, whither I had wandered in my anxiety, when, hearing a rustle
of a dress outside, I looked up and encountered Crystal as she
parted the screen of leaves and came towards me. My fears
bounded off in an instant, for her face was the picture of buoyant
health, and the flush of confusion on her cheeks made her look
radiant.
She extended her hand to me and said, “It’s very absurd for
people to walk in their sleep, but I am very grateful to you all the
same.”
“What are you grateful for?” I asked, wondering how much of the
affair she remembered.
“Why, father told me you found me walking in the garden and
brought me in,” she replied, looking hard at me with unwavering
eyes, though her cheeks were crimson.
“Oh! he told you that, did he?”
“Yes, but not until I made him. He wouldn’t tell me anything about it
at first.”
“You remembered something of what happened, then, and
questioned him for the rest?”
 “Yes, I remembered a little and insisted on being told the whole
story.”
“Will you tell me what you remember?” I urged.
She passed beneath the head of the hammock, and walking up to
the hedge, plucked a piece of the pink geranium-bloom. Turning to
me with a shy smile she held it out towards me.
“I will give you this pretty flower,” she said lightly, “if you will never
speak about it again—it was all so absurd.”
“I’m not joking, Miss Grey,” I said half angrily; “I must know—I will
know.” I had a horrible fear that could only be dispelled by the
knowledge that she could account for all the acts of that infernal
wizard.
The smile faded from her lips. She drew herself up and anger
darted from her black eyes.
“You dare to ask me what I do not choose to tell?” she said, and
never was a man so withered in spirit by a look from a woman’s eyes
as I was then. What was the mystery in them? They seemed to
belong not to this age, but to be looking at me from the beginning of
the world. For a moment I could hardly understand that they should
be set in the lovely face before me.
But the flash of anger passed, and, before I could falter a
crestfallen apology, she said, “Forgive me; I was forgetting all I owe
to you. My temper was too hasty.”
“I think I was too hasty in demanding to know what did not concern
me,” I ventured. “Perhaps I have been too hasty all along in
meddling with affairs that——”
“Ah! don’t say that,” she broke in, with a sharp pain in her voice;
“you have found me a father, you will give me back my mother, and I
—I have spoken angrily to you.” A tear glistened on her lashes; her
bosom heaved beneath the white folds of her dress, and in her eyes
was a tender light of love.
A wild thrill passed through me. In another moment I should have
done a rash thing—indeed, in after years I often wished I had done
that rash thing, that I had clasped that lovely one in my arms for a
brief second and then been struck dead. But the lapse of half that
time showed that the love-light was not for me. She raised her eyes,
but not to mine, and said with sweet repetition, “My mother! My
mother!”
With a slight start she recalled herself and turned to me.
“Do you know, I feel there is hardly anything I could not tell to you,”
she said. “That was why I told you my dream, which I have never
told to another living soul, not even to my father. And now, if, after
what I said a minute ago, you would care to hear what I remember of
last night I will tell you—but it is all very stupid.”
“If I think it is stupid I will say so,” I said.
Crystal seated herself upon the hammock, and, taking off her hat,
placed it in her lap, where she proceeded to fasten the geranium-
bloom among the other fresh flowers therein, as an excuse for
keeping her eyes cast down in shyness at what she considered the
stupidity of her story. I remained standing, for my suspense was
keen, and I felt that I should understand it better than she did.
“Well,” she said, “I dreamed that I was sitting on a bank, when a
black snake suddenly hissed and darted at my shoulder. The pain of
the bite and the horror of the thing woke me, or I suppose I dreamed
that it woke me, for what followed was exactly as if I had been
awake, though of course it was nothing more than a vivid dream. Is it
possible to dream that you are sitting up in bed, wide awake? It was
very strange, but I thought that I was awake, and that I had lost all
power to move. For a moment I listened to the thunder. Then I heard
a voice—a peculiar, harsh, hollow voice, telling me that I must follow
its directions, and be oblivious of all other things—for this, the voice,
was the only thing. It may seem strange, but I did as it directed
without the slightest hesitation. It seemed the most natural thing in
the world to get up and walk downstairs in obedience to this ugly
voice. Out of the house and across the lawn I followed it, until I came
to the way that leads through the plantation. There for a moment I
seemed to be at a loss. Then something—I cannot tell what, except
that it was not the voice—must have stood in my way and held me,
for, when I could again hear the only thing there was in the world, I
was unable to follow, although I struggled to do so. At last the
obstacle let me pass, and soon afterwards I caught up with the
voice, which guided me back again into the house, where it told me
that it had no further authority over me, and that other voices should
command me for awhile. After that I heard it no more, and I have
confused memories of taking a hot bath, with Jane and Mary fussing
about me. Then I must have gone to bed, but I can remember
nothing more till I awoke an hour ago. Was it not absurd? But some
of it must have been real, for I did walk out into the garden.”
I reflected a moment before I spoke. Her memory evidently
covered every inch of the ground. The pain in the shoulder, which
must have been the prick of the negro’s dart discharged during the
first flash of lightning after he gained her room; the falling under the
influence of the poison a moment later; the hearing of the voice in
the darkness, and the ready obedience to its suggestions; the
struggling with an obstacle which was not the voice, but myself, and
subsequently the finding of what she mistook for the voice and
followed back to the house—these were the points of a story, the
details of which must have taken place in the few minutes which
elapsed between my missing the grotesque fragment in the burnt
patch of scrub, and walking round the plantation to re-enter the
grounds again through the opening where I had encountered the
embodied “voice” and its would-be victim.
I glanced up from my rapid reflection, and, encountering Crystal’s
smile at what she supposed was the absurdity of her story, said:
“Your dreams affect me just as if you were recounting an adventure
that had really taken place. Why do you make them so vivid?”
Then we both laughed the matter away.
Later in the evening I visited Tiki again, and found him sitting up
with a puzzled expression on his face.
“Is the little maiden safe?” he asked on seeing me.
“Quite safe,” I replied, and narrated briefly what had happened.
“Where were you all last night?” I inquired when I had finished.
“He Wanaki,” he replied, shaking his head slowly, “I have it
somewhere in my mind where I was, but it slips away from my grasp
like an eel from the hand. I have the head of the lizard, but the tail is
cut off, and, though I can hear it rustling among the leaves, I cannot
find it. This is the head of the lizard, O Wanaki. I watched the great
canoe from sunset on into the night, and, when it was very dark, I
heard a small canoe leave it and take its way towards the end of the
water. I followed it along the shore, and when it came to the beach
down there I stood near by in the darkness and heard some voices.
Then someone made his way up the beach, and I followed the sound
of his footsteps. He must have heard me, for he stopped and made a
noise like the word of the weka22 when it is hiding. E Tama! I was
mad to take his head, for I knew he was going to steal the little
maiden. I rushed towards the ‘word’ and laid about me with my stick.
Again and again I did this, rushing at the ‘word’ in the dark to take
the head of it and lay it at the feet of the little maiden. But every time
I beat the air and nothing more, and every time I heard someone
laugh far away in Reinga. Eta! my only fear was for the little maiden,
so I followed the footsteps again up the valley until we came to the
field out there. The footsteps stopped. Tawhaki was beginning to
move overhead. The light of his eyes would soon show me where to
strike. The light came. I saw the taepo near at hand and rushed at
him. He raised a long stick to his mouth, and some stinging thing
struck me in the shoulder. Then, O Wanaki, I rushed on and on over
all the earth, and the darkness of Porawa closed on me as I went.
“That is the head of the lizard, O Wanaki, but the tail of it is cut off
and wriggles away when I stretch out my hand to grasp it. What has
happened to me between that and this is gone—gone like last year’s
kohu leaves.”
For a space neither of us spoke, but my thoughts were busy. At
length, jumping to a conclusion I said:
“Tiki! did you know that we are to leave here the day after to-
morrow?”
“Yes; the little maiden told me so.”
“Did you know that we are going to land in Golden Bay?”
“Yes, and go overland to the Great Tapu.”
“Ah! all right—very well—now you’d better go and get something
to eat.”
I rose and walked round the verandah, sick at heart. It was as I
had feared. That infernal wizard had, without a doubt, gleaned all our
plans from Tiki while in the obedient condition, and then sent him
home to sleep, with the assurance that on waking he would
remember nothing of what had taken place from the moment he fell
under his influence up to the time he came out of it. There was but
one conclusion to all this. Cazotl had sailed for Golden Bay to await
our arrival.
 CHAPTER XVII.
LOVE AT SECOND SIGHT.

It was the last day at the home of Crystal, and it was the last day,
too, of my fool’s paradise, from which I was driven by a fact as
startling as a flaming sword. Love at first sight was a thing I well
understood, but love at ‘second sight’ was a matter which before that
day I should have rejected as a wild impossibility—a thing to be
sworn to only by a class of visionaries who will swear to anything,
even on hearsay, provided it be sufficiently marvellous. The tale of
my love at first sight, its beginning, its hopes, its fears, and its fate—
not its ending—may be inferred from the brief attention I have called
to it here and there in this history of adventure; but Crystal Grey’s
love at ‘second sight’ for another, whom she had never seen in the
flesh, but who stood none the less surely between her and me, must
be told in detail.
It was scarcely surprising that a deep love which sprang up in full
tide in the brief space that it requires for the senses to transmit an
image to the brain and impress its meaning on the heart, should not
flow silently for very long. Up to the day of which I write it had not
entered Crystal’s mind that she was as a goddess in my eyes; it had
not occurred to her that when, filled with thoughts of the great
happiness which I, as a mere instrument in the hands of a loving
Providence, had brought her, she let her dark eyes meet mine with
the warm regard of a pure soul in them, I should be blinded by love
into the fatal conclusion that she could return my love. But something
occurred to Grey. That very morning, as we stood alone on the
verandah after breakfast, he had said to me: “Warnock, my friend, I
like you—I seem to have known you a long, long time. Listen to me. I
have found my daughter; Heaven may will it that I shall find my wife;
and then, when times are more settled, it may chance that, in the
man who will have been instrumental in restoring these two greatest
blessings, I may find a son.” He placed his hand on my arm, as he
added with a smile, “My dear boy, I know what I am talking about. I
may have forgotten nearly half of my life, but I can see what I can
see. Speak to her, Warnock. Speak to her, my dear boy. Nothing
would please me more than to call you my son.” With a final hearty
clap on my shoulder he left me wondering how on earth he could
have found out what I had revealed only to the stars and the setting
sun. It is strange how people in love fancy that no one can know the
fact until they are told.
So I spoke to Crystal, and in accordance with the matter-of-fact
bed-rock of my nature, I did not waste many words in doing it. After
spending most of the day in reviewing mazes of words which might
possibly hold my feelings and convey them, I scattered everything to
the winds, emptied my brain, and, with a full heart, strode down to
the nut-trees, where I stood before her with my hat in my hand and
said, “Crystal! I want to tell you something.”
She looked a little surprised at my first use of her Christian name,
but, looking up, said sweetly, “What is it, Wanaki?”
“It is this,” I said. “I love you more than anything else in the world:
so much that—that——”
I paused, for a look of pain flitted across her brow and the colour
left her cheeks. She rose from her seat and stood facing me, with a
soft, despairing sorrow in her eyes, while to her lovely face was
added a sadness that made it more lovely still; for even in that
moment, while I seemed plunged for ever into outer darkness, the
sweet soul of tender pity and pain suffusing the face of the woman I
loved was like balm to my crushed spirit.
“Wanaki, oh, Wanaki!” she said, “I am more sorry than I can say. I
owe you everything, but I cannot return your love. Oh! I could take
my heart out and crush it for what it tells me—that I cannot turn it to
you: that I cannot love you, Wanaki.”
Her words sounded in my ears like a plaintive lament sung over
my dead hopes, over the ashes of my heart. I knew not what to say;
for awhile I stood dumb, trying to conceal my pain. But she, watching
me with anxious eyes, searched it out, and turned away with a low
moan. Her bosom heaved beneath her white dress—I knew it was
with sorrow for me—but she said no more.
“Why?—tell me why!” I said at length, with a vague feeling that this
terrible state of things required some explanation; “do you love
someone else?”
She looked at me for a moment without answering. Then she said:
“Yes, but—but he—I have never seen him.”
She averted her eyes and hung her head in a manner which
showed me that she considered I had a kind of right to question her
as to the cause of my misery.
“You love a man you have never seen?” I said quickly, feeling
there was a ray of hope.
“You hated a man you had never seen,” she replied just as quickly;
“the man in the picture whom you called a fiend—you hated him
because his face revolted you. Then why should I not love a man I
have never seen?”
“But I saw the face depicted, and I hated the meaning of it.”
“Well, I too have seen a face, and I love the meaning of it.” She
spoke still sadly, but like a woman who means to hold her own.
“In the same way as you saw the other?” I asked with a gleam of
intelligence.
“Yes; in dreams—in many dreams. For years my heart has been
given to the heart of the man whose face I see in dreams.”
“But do you believe that man exists in the flesh?”
“Yes; I believe I shall meet him some day.” A light chased the
sadness from her eyes—a light like that of a star when night is
darkest.
“But you rejected the idea that the vile one, whose face you have
pictured, had any original on earth—why deny to the one what you
grant to the other?”
“I do not fear the vile one enough to believe in him, but my love for
the other compels belief.”
“It is a phantom of the brain,” I urged on hearing this. “What proof
have you that it is the presentment of a living man?”
“None, except a strange feeling I have in regard to it.”
I was silent for a little. I felt an uncompromising belief in her
strange feelings.
“Listen, Wanaki,” she said after a pause. “You told me of a man
who saw his heart’s desire depicted in a sculptured stone, and when
you spoke of his love I said I quite understood it. I meant that his
love was similar to mine: he loved the ideal woman—I love the ideal
man.”
I bent my brows and tacitly admitted the similarity.
“Tell me what he is like,” I said presently, “so that I may try to
understand.”
She placed her hand within the bosom of her dress and drew forth
a cameo attached to a golden chain.
“Honestly,” I said as I drew near to examine it, “I do not see why a
mere face should carry such conviction with it. And why,” I added to
myself, as she unfastened the chain and placed the cameo in my
hand, “why should a mere dream face, an unsubstantial vision of the
brain stand between me and——”
There I paused, for my glance had fallen upon the face which I
had just assured Crystal was a phantom of the brain.
Heavens! It was the face of my friend Kahikatea! The lofty,
massive forehead, surrounded by his orderly-disorderly mane, his
brows slightly bent with thought, his nostrils dilated in the way I knew
so well, his lips set firm with purpose, and his eyes, full of his
inexplicable love, gazing into space and slightly raised, as if to some
distant mountain top—this was the picture of my friend, even down
to his short brown beard and moustache—this was the man whom
Crystal loved, yet had never seen in the flesh. His look recalled the
moment, when, by the false grave beneath the great rimu, I asked
him to come with me to search for Crystal, and he replied that he
had hitched his waggon to a star, that he had made up his mind to
search for Hinauri, the Daughter of the Dawn, and would not turn
aside to look for the daughter of a mortal woman.
As I gazed in silence at the face of my friend, a wicked lie rose up
out of the ashes of my heart, and threatened to gain the mastery.
Then I looked up and met Crystal’s eyes burning into mine, and felt
my love leap up again and light the way through the dark. Thoughts
crowded tumultuously through my brain, and clearest of all was the
thought that Kahikatea, worshipping his ideal as depicted in the
image of Hinauri, had renounced all other women, Crystal among
them. Therefore it would be cruel to tell her that she was in exactly
the same position as I was.
 I said, “I have the same feeling about it as you have, I will regard it
as the face of a living man. It is my love tells you this from the centre
of my heart, for my love for you is the grandest thing I have ever
known. But what should you do if, when you meet him in the flesh,
you find that his love is given to another?”
“I do not know,” she replied slowly, “but my heart tells me I should
be plunged into the dark.”
“But what if you found, as I have found with you, that he loves an
abstraction—something less real than yourself——”
She looked up quickly. “You mean if he was like your friend, who
loves the ideal woman in marble?”
Before I could reply, and while she regarded me attentively, I felt
my eyelids flutter together as if the light were too strong. Then I said,
“Yes, supposing he were like that friend of mine—would you
despair?”
“I should not attempt to stand between him and his ideal,” she
replied decisively.
I handed her back the cameo, saying, “Neither will I attempt to
stand between you and yours, while you love it as you do.”
There was a pause, in which Crystal remained looking straight
before her as if she had not heard my last words. Presently she
turned to me with a perplexed expression and asked quickly:
“Why did you compare him to your friend? Why did you start when
you saw his face? Why did you—Wanaki! there is something you are
hiding from me.”
She stood before me, her bosom heaving with emotions that
showed upon her face as pain and joy struggling together. I saw that
it was useless for me to attempt to conceal what her quick intuition
had already grasped.
“Yes,” I admitted. “I would have concealed it from you, because
you would be happier not to know it. But my tongue carried me too
far. The face you have shown me is the face of my friend Kahikatea,
who has renounced the love of woman for love of a symbol of pure
womanhood—an ideal beauty wrought upon a piece of cold marble
which he has seen, and you have seen, in the mountain cave where
you were born.”
 The struggle between joy and pain upon her face came to an end,
and joy sat there triumphant in her eyes.
“Oh! you have explained the meaning of his face. His love is far
above the world. I see in his eyes the prayers of all great men for
something more divine in woman—the demand for some higher
strength and beauty of being than has hitherto been required of us.
Ah! Wanaki, if one woman can do anything in this great world, I will
see that the prayer of the man I love shall be answered to some
extent in the hearts of women.”
On the plane of this high love she was safe, but I knew that there
would be times when her more direct and personal love for
Kahikatea would rebel against the fact that she herself was to him
merely as one in a great multitude. She did not know, neither did I
tell her, that although Kahikatea never lost sight of the symbolic
meaning he had attached to Hinauri, yet he, in his turn, had a direct
and personal love for Hinauri herself. Once, when we had been
discussing that part of the legend which told of her return in the
future he had said, “You call my fascination a piece of extravagant
poetry, a love for a mere abstraction, but I tell you, Warnock, that if
the marble Hinauri were suddenly transformed into a living woman,
she would still be my ideal, but at the same time as real to me as any
woman can be to the man who loves her.” Had I told Crystal flatly
that the man whom she loved loved another, I could not have put
more accurately what I knew; but not wishing to lessen the power of
her resolve to work her love out in the world, I merely said: “Your
nature is good and strong: you will carry out your resolve in the way
that your star directs, but for myself, you must forgive me if during
our journey north I am a sadder, if a better, man for this great love of
mine.”
She looked at me sorrowfully, while a tear came from the black
depths of those eyes of night and glistened in her lashes. It trembled
and fell. She turned in silence and passed out through the screen of
leaves. That tear was more to me than any words could have
conveyed.
 CHAPTER XVIII.
TE MAKAWAWA IS STARTLED.

It was a fortnight later, when after various stoppages on the way

north, we sailed down across Golden Bay towards Wakatu. Mindful
of my conclusion that Tiki had unknowingly divulged our plans to
Cazotl, I kept it to myself, but argued with Grey that it would be
better to land on the western side of Tasman Bay, proceed to Te
Makawawa’s pa, and thence to the Table Land. Grey fell in with this
proposal, and accordingly we passed down the coast, round
Separation Point, and were landed at the mouth of the river above
which the pa stood.
It was a clear, quiet morning when the boat took us in from the
ship. Dreamer Grey, the brim of his buff bush hat drawn over his
eyes to keep off the glare of the early sun, sat in the stern dreaming,
not of a forgotten past, but of the possibilities of the near future. He
flicked the ash quietly from his cigar; it fell with a hiss into the smooth
water and drifted astern.
“There is the pa, look,” said Crystal, touching his arm with one
hand, while with the other she pointed to the ridge of the cliff a mile
away on the coast.
I followed the direction of her finger and saw, standing against a
thin fleecy white cloud with a strip of summer blue beneath it, the
palisading of Te Makawawa’s pa.
“It is a good omen,” I said merrily, turning towards them; “there is
the pa; there is the fleecy cloud beyond it, and there in the further
distance is the clear blue sky.”
Grey turned up the brim of his hat and let the sun shine on his
happy face as he gazed up at the pa.
“And what is it you see in the clear blue sky, Miss Grey?” I asked,
catching the now well-known look of longing in Crystal’s eyes
beneath the shadow of her sun bonnet.
She looked across to me and smiled, while her hand slid down her
father’s coat sleeve and pressed his own on the gunwale of the boat.
Then her lips moved, and, though she said nothing, the movement
could have been only the two words, “My mother!”
“A good omen let it be,” said Grey, and threw his cigar away.
“With all my heart!” I replied, knocking the dottle from my pipe and
standing up, for the nose of the boat was running on to the sandy
shore in a convenient place to land.
With what buoyant steps we followed Tiki along the way he knew
beneath the fern palms and overhanging trees that skirted the
beach! It was one of those clear, bright mornings which, on a
shelving shore between the glistening bush and the sparkling sea,
are only to be interpreted by the liquid song of the korimako, sipping
dew and honey as he sings in the flowering trees, or by the merry
fantail’s laugh, as with tail outspread she chases the gnat, which
twists and turns in the sunlight.
“Tiki,” I said presently, “you go on ahead and tell Te Makawawa we
are coming. We can find the way all right.”
On board the ship the sailors had fitted the Maori out with a
civilised costume, and he looked supremely ridiculous, for neither
had he been made for the clothes nor the clothes for him. As he
vanished ahead of us I smiled, wondering what sort of a reception he
would get from the old chief, whose ideas were of a most
conservative nature.
“I should like to be present when Tiki stands before Te Makawawa
in those clothes,” I said. “The old chief’s a gentleman of the old
school: he will be scandalised.”
Hardly were the words out of my mouth when sounds of someone
talking fell upon our ears, and presently we turned a bend of the path
and came full upon Tiki face to face with the old chief. The latter had
so warmed up to his subject that he did not see us, and partly
shielded by the trees we stood and watched them in the open space
before us. Te Makawawa’s attitude and picturesque garb, from the
feathers in his white hair to the flowing fringe of his kaitaka, were in
themselves a rebuke to Tiki; but his words added a sting to the
rebuke, which made my poor faithful Maori look even more ridiculous
than I had thought possible.
“Eta! you have not the dignity that belongs to our race. What have
you done with it? Exchanged it for that pair of trousers, and they are
put on wrong way now. What have you done with the mana of your
ancestors? Given it away for that old coat, and it’s splitting under the
arm. What have you done with the bravery and prowess of your
tribe? Traded it for that shirt without any buttons, that collar fastened
with a piece of flax, that hat which makes you look so beautiful. What
have you done with the blood of the Rangitane which runs in your
veins—of Toi our ancestor, and of Kupakupa, who made us Maori? I
expect you have bartered it all for a bottle of waipiro. Eta! did our
ancestors make scarecrows of themselves like this? Did they go to
such foolishness to frighten the birds? Tiki, you’re a big fool. You’re
like the stupid ones, trying to bring about the time when the Maori
cannot hold up his head at all. You’re weak in the knees, and you put
those trousers on to hide it. I think your whole backbone would
scarcely make one good fishhook.”
“What a contrast,” whispered Crystal, who had understood the
chief’s words perfectly. “I like the old fellow, even if he did steal my
father and mother and myself. But don’t you think Tiki has had
enough?” The poor Maori was trembling beneath the scorn of the
aged one.
“I think so, yes,” I replied. “You stay here till I call you.” And I
stepped out into the open space.
“Te Makawawa!”
He turned on the instant and came towards me. “He Pakeha!” he
said, “the Friend of the Forest Tree. I saw the canoe coming in and
came down to meet it. You have found the little maiden, Keritahi
Kerei—good! Where is she?”
“O Chief! I have found the little maiden, and I have also brought
the man who has forgotten the faces that he knew.”
I called to them, and they came from behind the trees.
Crystal stood before him looking like a mountain lily in her white
dress. As soon as Te Makawawa’s bright eyes rested upon her he
started, and, drawing back the step he was taking, remained in an
attitude of astonishment. His eyes wandered from her face and form
to me, and there was a question, a perplexity, almost a doubt written
on the lines of his rugged visage.
“Friend of the Forest Tree! is this wild white swan, such as a man
sees once in a lifetime, the little maiden?—or have you deceived
me?”
“The Friend of the Forest Tree does not deceive,” said Crystal,
before I could speak. “If you are Te Makawawa I am the little maiden
of many moons ago whom you carried on your shoulder. Do you not
remember the heitiki round my neck, and the little kaitaka of kiwi
feathers I wore? See! my black eyes and hair! do you not remember
them?”
She threw off her sun bonnet as she spoke, and stood facing him,
as if half conscious of her sculpturesque loveliness.
The question, the perplexity, the almost-doubt deepened upon his
face.
“Eta!” he said, turning to Grey; “is this your daughter with the eyes
and hair of ancient night? Speak, O Man-who-has-forgotten; does Te
Makawawa dream in the daytime?”
Grey, knowing nothing of the language, turned to me and we
spoke together, while the chief gazed long at Crystal.
“O Chief,” I said at length, “the Man-who-has-forgotten says this is
the little maiden left by Tiki in his hut while he slept. But why do you
doubt my word, O Tohunga? Do you think the little white Children of
the Mist have changed the child? Kahikatea and his friend have ever
spoken the truth to you.”
“I do not doubt,” he replied quietly, showing me his palm. “These
last days are full of dreams to me. My eyes are growing dim, and I
see strange things against the setting sun. O people of the Great
Tribe, take no heed of an old man’s dreams. Tiki!”—he turned to the
be-trousered one with a return of his indignation—“hasten to the pa
and bid them prepare a feast, and tell my maidens that a mountain
lily will take root among them. Go, O Tiki, and tell them not to waste
their time in laughing at a man who was once a warrior, with the
blood of the Tane-nui-a-Rangi in his veins, but is now a thing that
has been hatched from an egg like a bird.”
Tiki did not wait for the point of this piece of satire. He and his
trousers vanished in all haste, and Te Makawawa, bidding us follow,
strode before in silence.
“What a lordly savage,” said Grey, as we followed on; “but why did
he seem so startled at the sight of my daughter?”
“He seemed to doubt my identity,” said Crystal.
 “Perhaps it was his way of demanding proof,” I suggested, but I
could not conceal from myself that there was something to be
cleared up in his strange behaviour.
When we reached the pa on the high cliff Grey and I were allotted
a house to ourselves, while Crystal was handed over by Te
Makawawa to the charge of the maidens of highest rank, who were
forcible in their expressions of joy when they found she could speak
their own tongue. I caught sight of her standing among a little group,
like a fair white queen among her dusky maidens. I saw by the
gestures of the Maori girls that they were asking her to let down her
hair. She hesitated a moment, then, withdrawing the pins, let it fall
and shook the long, heavy masses out over her shoulders, till they
rippled down almost to her knees. Loud cries of admiration came
from the girls as they took up the loosened tresses in their hands
and stroked and patted them tenderly, likening them to the
undulating seaweed called rimu rehia, long, shining, glistening; and
again to the darkness of the furthest caves, where the winds were
bound by Maui. Thus they lifted it up and stroked and talked to it,
while it awoke their simple hearts to poetry. Then, as Crystal
gathered it all together again and fastened it up, they stood wide-
eyed, with many expressions of wonder that pakeha women should
do this strange thing.
As a result of a private talk with the old chief, I learnt that Ngaraki
had paid him a visit some days before, and had told him strange
things. The Great Tohungas of the Earth had spoken to him, saying
that the return of Hinauri was near, and that he must lay the
foundations of a new priesthood in the temple, and gather the tribes
upon the Table Land. Messages had been sent to many tribes, and
some had already settled upon the high plain under the rule of
Ngaraki. Te Makawawa assured me they were gathered for peace,
and not for war. Within the space of a few days his own tribe would
journey on to the Great Tapu.
“And what is your plan for restoring Keritahi Kerei to her mother?” I
asked.
“Listen, Pakeha!” he replied, lowering his voice. “The Great
Tohungas do not speak to Ngaraki only. I too have heard their words
—when all the world was dark and still. I will guide you and the
maiden, and the Man-who-has-forgotten to the white cave where the
woman still lives. But I would not meet the eye of Ngaraki, for he is
fierce and terrible, and I could not explain this thing to him. Because
of these things, friend, we must wait until Ngaraki goes into the
islands of the south to gather together the men to whom he will teach
the ancient wisdom. That will be on the morning after the full moon,
for you must know, O son, that an ancient rite of the temple requires
the presence of the priest on the night when the moon is full. We
shall set out then on the third day from this, so that we shall reach
the Table Land as Ngaraki leaves it.”
I agreed to this plan, and it was settled. In the meantime it
occurred to me that, unknown to Crystal, I might take a journey to
the hut of Kahikatea. Accordingly, early on the following day, I set out
and arrived at the hut just as my friend was preparing for a journey.
“Have you found her?” were his first words as he came down the
slope in front of his hut to meet me.
“Yes,” I replied; “she is at the pa, and I want you to come and see
her. Then we could all journey together to the mountain—with Te
Makawawa as a guide.”
“When are you going to start?” he asked.
“The day after to-morrow.”
“That’s too late,” he said; “I’m going to start now, as soon as I can.
I’ve almost worked my way through the rock, but ran out of powder,
and had to go across the bay for more.” The look in his eyes was far
away and abstracted as he added: “It’s a strange undertaking,
Warnock, and it is a strange madness that has laid hold of me; but
there’s method in it, and I mean to see that perfect face and form
again.”
I saw that the desire of the poet for the symbol of his dreams was
still strong within him, but nevertheless, I fulfilled the object of my
visit.
“If you wish to see a perfect face and form,” I said, “come back to
the pa with me. I cannot imagine anyone more perfect than Crystal
Grey. Come back and let us all go together. The ‘way of the fish’ is
easier than the ‘way of the spider.’ My dear Kahikatea, long solitude
has made dreams and visions too real to you.”
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