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1-the prolongation of dosing interval

can be achieve to reduce the potential
of adverse effects with drug have
narrow therapeutic index.

A, correct

B. false

2-toxic plasma level in some patients

who the narrow therapeutic index due

A. inter variation between patients

B,.....

C,...

drug that have very short half live less

than 0.5h they are

A, absorption rate»»» elimination rate

B, can be formulated in sustained

release dosage form

C, can not be formulated in sustained

release dosage form (elimination
rate»»» absorption rate)

C, All the above

4-hydrodynamically balance systems.

A, floating the system porous products

by effervescence
 A, individual molecules in the liquid
state

B..
C, high density system
C...
D, All the above
10-polymer use in the reserve system
Except 5-single unit dosage form my be
emptied out into the duodenum in
A hydroxypropylcellose
A_nothing fashion
B_Ethylcellulose
B, all or nothing fashion
C_Eudragit RS
C, fashion
D_Eudragit RL
D, All the above
11-the polarity and positive charge of
quaternary ammonium group to 6-that swell upon absorption of liquid
from the gastric fluid, leading to
A_control of polymer coating film of increase their size.
water into core of system
A_barium sulphate
B__control of polymer coating film of
water into core of drug B_zinc oxide

C_create non pores with the coating C_hydrogels

film control drug release D_titanium dioxide
C_nagative charge careta pores with 7-this Fick, s law can used to obtain
coating film control drug release steady state of drug dissolution it bot
12-PLGA systm that change over time

A_of lactic hydrophobic moity to A_correct

glycolic acid hydrophilic allow to B_false
control drug release
8-Fick, s first law of diffusion the
B_variation of ratio of lactic acid polymer use should not dissolved in
hydrophilic moity to glycol lic acid
hydrophbic allow to control drug A_dissolution system
release
B_diffusion system

C_bioeroation system
c variation of ratio of glycol lic acid
D_biodegradation system
hydrophilic allow to control drug
release 9-diffusion is the mass transport of
material
D variation of ratio of lactic acid
 C-depends on features of the target hydrophobic moity to glycol lic acid
site hydrophilic allow to control drug
release
D-high accumulation of system carrier
13-Acutrim system is multi layer oral
18-To achieve site-specific delivery of osmotic control DDs in the form of
a drug, an effective targeting system tablet coating phenyl propanolamin
may comprise Except hyrochlorid is feerly water soluble drug
A-drug A_correct
B-targeting agent B_false
C-copolymers 14-oral adiministration water form the
D-carrier
1 GIT will enter the system to swelling
the push layer Except
19-Microparticles
A_Elmentrary osmotic pumps

B-pull push system

These particles are in the micrometer
size range (PS 15-20µm) and have C-multi layer system
important clinical applications in drug D-water swellabll polymer
delivery and do not have target agent
15_control release DDSS although IV
A-correct infusion of drug has many advantage
B-false including a sterile to enhance the
patient compliance
20-Nanoparticles (NPs) Except
A_correct
A-used for passive targeting or active
targeting B-false

B-The loaded drugs are either within 16-in most cases the polymer material
the particle matrix or attached to the is chosen that system are sometimes
particle surface. called diffusion controlled

C-solid particulate entities in the A_release are physical separate

nanometer range (1-1000 nm) B_release rate limited step
D-The target agent are either within the C....
particle matrix or attached to the
particle surface. D....

21-these NPs are prepared from solid Passive targeting Except

lipids (lipids with high melting point)
A-high release of drug at the target site

B-macrophagic cells can be targete

site
 ineffective or toxic drug level. This is and dispersed in an aqueous phase.
very important for potent drugs This type of NPs is used for delivery of
(hormons) poorly water-soluble drugs.

A-correct A-Polymeric NPs

B-false B-Solid-lipid NPs

26-Osmosis is the diffusion of solvent C-Nanoparticles NPs

molecules across a semipermeable
membrane that separate two solutions D-non the above
with different concentrations. 22-Polymeric NPs are widely used to
A-correct deliver low aqueous solubility drugs
where they have a hydrophobic core
B-false and a hydrophilic surface.

27-The lowest potent drugs are the A-correct

suitable for sustained release,
because they used in low therapeutic B-false
doses, due to the following reasons 23-Properties of dendrimer systems
The dose in sustained-release dosage except
forms for covering about 24 hr is A-can be modified with targeting
usually 2 to 3. times the dose of the groups for active targeting
immediate-release dosage forms.
B-have higher drug-loading capacities
A-correct
C-carry drugs within the construct
B_false
D-have lowest drug-loading capacities
28-Generally, the water influx into
these systems depends except 24-The aim of developing the
controlled-release DDSs is to achieve
A_level of osmotic pressure similar profiles of drug plasma
B-copolymers concentration as those achieved by IV
infusion, so that these controlled-
C-thickness release DDSs provide predictable and
reproducible profiles of drug
D-surface area
A_correct
29-The used reservoir systems release
drugs at zero-order kinetics, where the B-false
drug amount is greater than its
solubility. Except 25-the controlled-release DDSs provide
the disadvantages The drug plasma
A_the released drug molecules are concentration is at the desired level for
replaced by dissolution of undissolved a prolonged time, avoiding the
drug, leading to constant drug-release fluctuation and the potential
 permeability. rates.

a) Correct B_the released drug molecules are

replaced by dissolution of dissolved
b) False drug, leading to constant drug-release
34-Polymers used in sustained rates.
reservoir systems include: C_dissolved and undissolved drugs
a) Ethylcellulose coexist within the reservoir.

b) Eudragit RS D _non the above

c) Sodium Carboxymethyl Cellulose 30-Deponit system is

(SCMC A-hybrid system
35-Effervescence produces gas, B_non-linear of drug concentration
resulting in a floating system. provides a zero-order release profile
a) Correct C_additionally coated with a polymeric
b) False film.

36-Sustained release offers D_control the drug release according

advantages in multiple-unit dosage to the zero-order release kinetics.
forms, such as pellets or layered 31-addition, vegetable oils may be
granules. added to the hydrodynamically
a) Correct balanced systems in

b) False order to reduce the density of systems

and control the drug release
37-For sustained-release tablets, how
much more drug is typically contained A_correct
compared to immediate-release B_false
tablets?
32-Phosphatidylglycerol These
A) 1 times phospholipids have a hydrophilic head
B) 2 to 3 times and two hydrophobic chains, are
product to
C) 4 to 5 times
A, Soluble carrier systems
D) Equal amounts
B, water-soluble polymers
38-What might occur due to poor
control in the release of drugs from C, Particulate carrier systems
sustained-release systems? D, non the above
A) Better patient adherence 33-The polarity of quaternary
B) Toxic plasma levels in some ammonium groups controls
43-What should the absorption rate be patients
for effective sustained-release
systems? C) Enhanced absorption in the GIT

A) Less than 0.1/hr D) Increased drug stability

B) Approximately equal to the 39-Which of the following factors can

elimination rate influence the gastric emptying time?

C) Greater than 0.5/hr A) Temperature of the drug

D) Unpredictable B) Caloric content of the meal

44-Why are sustained-release systems C) Size of the dosage form

beneficial for drugs with short half- D) Formulation of the drug
lives?
40-What is one advantage of sustained
A) They increase the peak plasma -release dosage forms for patients?
concentration
A) Increased frequency of dosing
B) They allow for less frequent dosing
B) Decreased patient compliance
C) They enhance drug solubility
C) Reduced potential for adverse
D) They prevent drug degradation effects
45-Which of the following is a type of D) Unpredictable plasma
gastroretentive drug delivery system? concentration
A) High-density systems 41-When should gastroretentive
B) Low-density systems systems generally not be
administered?
C) Expandable systems
A) After meals
D) All of the above
B) In the fed state
46-What is the primary mechanism of
drug release in osmotic pressure C) In the fasted state
systems? D) During sleep
A) Diffusion through a solid membrane 42-Which type of drug is least suitable
B) Osmotic pressure pushing the drug for sustained-release formulations?
through a release opening A) Drugs absorbed in the duodenum
C) Chemical reaction within the tablet B) Drugs with a narrow absorption
D) Temperature-induced release window

47-Osmotic pressure-activated C) Highly potent drugs

systems are designed primarily for D) Drugs with a wide therapeutic index
 therapeutic index which type of drug delivery?

B) They should have a wide A) Intravenous

therapeutic index
B) Transdermal
C) They should be unstable in the GIT
C) Oral
D) They should be highly solubl
D) Subcutaneous
52-Which type of drug is most suitable
for sustained-release formulations? 48-What is the rate-limiting step in
bioerodible sustained-release
A) Drugs with a very short half-life systems?

B) Highly potent drugs A) Drug solubility

C) Drugs with a narrow therapeutic B) Matrix biodegradation rate

index
C) Drug absorption rate
D) Drugs that are absorbed only in the
lower intestine D) Patient metabolism

53-Which type of drug is most suitable 49-Which of the following absorption

for sustained-release formulations? characteristics is favorable for
sustained-release drug formulations?
A) Drugs with a very short half-life
A) Low absorption rate
B) Highly potent drugs
B) High absorption rate
C) Drugs with a narrow therapeutic
index C) Absorption only in the lower GIT

D) Drugs that are absorbed only in the D) Absorption by passive diffusion onl
lower intestine 50-What is the maximum weight for a
ansr B tablet or capsule intended for oral

administration?

54-What is an important characteristic A) 0.5 g

of drugs formulated for sustained B) 1 g
release regarding their therapeutic
index? C) 2 g

A) They should have a narrow D) 3 g

therapeutic index
51-What is an important characteristic
B) They should have a wide of drugs formulated for sustained
therapeutic index release regarding their therapeutic
index?
C) They should be unstable in the GIT
A) They should have a narrow
 ansrB

D) They should be highly soluble

58-Osmotic pressure-activated ansrB

systems are designed primarily for
which type of drug delivery?

A) Intravenous 55--What is the maximum weight for a

tablet or capsule intended for oral
B) Transdermal
administration?
C) Oral
A) 0.5 g
D) Subcutaneous
B) 1 g
ansrC
C) 2 g

D) 3 g
59.What is the primary mechanism of
drug release in osmotic pressure ansr B
systems?

A) Diffusion through a solid membrane 56.Which of the following absorption

B) Osmotic pressure pushing the drug characteristics is favorable for
through a release opening sustained-release drug formulations?

C) Chemical reaction within the tablet A) Low absorption rate

D) Temperature-induced release B) High absorption rate

ansrB. C) Absorption only in the lower GIT

D) Absorption by passive diffusion

only
60 .Which of the following is a type of
gastroretentive drug delivery system? ansrB

A) High-density systems

B) Low-density systems 57 .What is the rate-limiting step in

bioerodible sustained-release
C) Expandable systems systems?

D) All of the above A) Drug solubility

ansr D B) Matrix biodegradation rate

C) Drug absorption rate

D) Patient metabolism
 A) After meals 61 .Why are sustained-release
systems beneficial for drugs with
B) In the fed state short half-lives?
C) In the fasted state A) They increase the peak plasma
D) During sleep concentration

ansr C B) They allow for less frequent dosing

C) They enhance drug solubility

D) They prevent drug degradation

ansrB

65-.What is one advantage of

sustained-release dosage forms for 62.What should the absorption rate be
patients? for effective sustained-release
A) Increased frequency of dosing systems?

B) Decreased patient compliance A) Less than 0.1/hr

C) Reduced potential for adverse B) Approximately equal to the

effects elimination rate

D) Unpredictable plasma C) Greater than 0.5/hr

concentration D) Unpredictable

ansrB
66-Which of the following factors can 63-Which type of drug is least suitable
influence the gastric emptying time? for sustained-release formulations?
A) Temperature of the drug A) Drugs absorbed in the duodenum
B) Caloric content of the meal B) Drugs with a narrow absorption
C) Size of the dosage form window

D) Formulation of the drug C) Highly potent drugs

D) Drugs with a wide therapeutic index

67-.What might occur due to poor ansr B

control in the release of drugs from
sustained-release systems?
64.When should gastroretentive
A) Better patient adherence systems generally not be
B) Toxic plasma levels in some administered?
patients
 b) Eudragit RS C) Enhanced absorption in the GIT

c) Sodium Carboxymethyl Cellulose D) Increased drug stability

(SCMC)

d) Eudragit RL

ansr C
86 .For sustained-release tablets, how
much more drug is typically contained
compared to immediate-release
72. The polarity of quaternary tablets?
ammonium groups controls
permeability. A) 1 times

a) Correct B) 2 to 3 times

b) False C) 4 to 5 times

ansrB D) Equal amounts

. 72-Eudragit RL contains a double

amount of quaternary ammonium,
resulting in higher permeability than 69. Sustained release offers
RS advantages in multiple-unit dosage
forms, such as pellets or layered
A_correct . granules.

B-false a) Correct

73-Matrix systems can be either: b) False

a) Homogeneous: non-porous ansr B

b) Heterogeneous: porous

C...... 70- Effervescence produces gas,

resulting in a floating system.
D......
a) Correct
73-Osmosis except
b) False
a) Dissolvable semipermeable
membranes ansr A

b) Diffusion between solutions of

different concentrations
71- Polymers used in sustained
c) Separation of solutions by reservoir systems include:
semipermeable membran
a) Ethylcellulose
 D, non the above D-non the above

74-Progestaset provides controlled

release in ocular inserts.

‫ﺗﻌﺒﻨﺎ ﻣﻦ اﺟﻠﻜﻠﻢ ﻓﻼ‬

a) Correct

B-false
‫ﻻﺗﻨﺴﻮﻧﺎ ﺑﺪﻋﺎﺋﻜﻢ‬ 75-The Trans-Nitro system describes
nitroglycerin dispersion in a silicone oil
matrix.

a) Correct

b) False

76-The matrix consists of layers with

different concentrations of
nitroglycerin.

a) Deponit

b) Catapres

77-Ionic liposomes are positively

charged and used to deliver DNA/RNA.

a) Correct

b false

is to refer to

A-Eudragit RL

B-dendrimer

C, Micelles