AC–2539
Faculty of Pharmacy
B.Pharm. Semester—VI (New) Examination
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PHARMACOLOGY—III
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Paper—BP602T
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Time : Three Hours] [Maximum Marks : 75
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INSTRUCTIONS TO CANDIDATES
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(1) All questions carry marks as indicated.
(2) Answer ALL questions.
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(3) Illustrate your answers wherever necessary with the help of neat sketches.
(4) Use pen of Blue/Black ink/refill only for writing the answer book.
1. Multiple Choice Questions :
(1) Which one of the following can be administered orally and by inhalation ?
(a) Epinephrine
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(b) Albuterol
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(c) Isoproterenol
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(d) Terbutaline
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(2) Which of the following drugs act through a cytosolic receptor ?
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(a) Cromolyn sodium
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(c) Zafirlukast A (d) Omalizumab
(3) Codeine is used clinically as :
(a) Analgesic (b) Antitussive
(c) Antidiorrhoeal (d) All of the above
(4) Mechanism of action : Cytoprotection, binds to the ulcer base, antibacterial effect :
(a) Metronidazole (b) Omeprazole
(c) Ranitidine (d) Bismuth compounds
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(5) The mechanism of action of rifampin includes an inhibition of which of the followingil
enzymes ?
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(a) DNA dependent RNA polymerase (b) Topoisomerase-II
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(c) Arabinosyl transferase (d) RNA dependent DNA polymerase
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(6) The drug used for malaria chemoprophylaxis and treatment : A R
(a) Chloroquine (b) Quinidine
(c) Quinine (d) Sulfonamides
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(7) Which point in the replication cycle appears most easily blocked by antivirals ?
(a) Virus absorption (b) Virus penetration
(c) Virus RNA and DNA replication (d) Exit of viruses from the cell
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(8) Antifungal polyene macrolide that preferentially binds to fungal ergosterol which alters
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cellular permeability :
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(a) Ketoconazole (b) Amphotericin B
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(c) Flucytosine (d) Griseofulvin
A (e) Clotrimazole
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(9) An azole most commonly used for topical treatment of candidiasis :
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(a) Amphotericin B (b) Clotrimazole
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(c) Griseofulvin (d) Flucytosine
(10) Drug used for treatment of an asymptomatic form of amoebiasis is :
(a) Chloroquine (b) Diloxanide
(c) Emetine (d) Doxycycline
(11) Antileprotic drug also used in lepra reaction is :
(a) Ciprofloxacin
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(b) Clofazimine
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(c) Rifampicin (d) Dapsone
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(12) Which is not a common cause of UTIs in men ?
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(a) Erectile dysfunction
(c) Urinary stone A R (b) Catheter usage
(d) Enlarged prostate
(13) Which major organ can be affected by untreated syphilis ?
(a) Heart (b) Brain
(c) Liver (d) (a) and (b)
(14) Drug of choice in treatment of hemolytic anemia in newborns :
(a) Cyclosporine (b) Prednisone
(c) OKT3 monoclonal antibody (d) Rho(D) immune globulin
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(15) Inhibits antigen recognition of B-cell :
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(a) Prednisone (b) Azathioprine
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(c) Tacrolimus (d) Rho(D) immune globulin
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(16) Which of the following chelating agents is recommended for acute lead poisoning with
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signs of encephalopathy ?
(a) Succimer (b) Dimercaprol
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(c) Calcium EDTA (d) Both (b) and (c)
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(17) Which of the following are potential effects of a teratogen on a fetus ?
(a) Death (b) Low birth weight
(c) Neural defects (d) All of the above
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(18) Which of the following receptors is not involved in nausea and vomiting ?
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(a) Dopamine (b) Acetylcholine
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(c) Histamine (d) Serotonin
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(e) All are involved
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(19) Which is a contraindication of lubricant laxative use ?
(a) Renal dysfunction (b) Recumbent patients
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(c) Use simultaneously with psyllium (d) Flatulence
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(20) What is the target for clavulanic acid ?
(a) Transpeptidase enzyme (b) l -ala racemase
(c) β-lactamase (d) Penicillin acylase 1×20=20
2. Long answer questions (solve any two) :
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(a) Explain spectrum of action, mechanism of action, uses and adverse effects of
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Tetracyclines.
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(b) Describe malaria cycle. Write the pharmacology of antimalarial drugs.
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(c) What are organophosphorus compounds ? Explain symptoms, mechanism and treatment
for organophosphorus poisoning. 2×10=20
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Short answer questions (solve any seven) :
(a) Write notes on (any two) :
(i) Antiviral drugs
(ii) Immunostimulants
(iii) Teratogenicity.
(b) Explain the treatment for urinary tract infections.
(c) Describe the principles of treatment of poisoning.
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(d) Describe the pharmacology of Mebendazole. a il
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(e) Classify antifungal agents. Write mechanism of action and uses of Fluconazole. m
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(f) Define antitussives. Write p’cological actions and uses of Codeine Sulphate.
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(g) Explain spectrum, mechanism of action, uses and adverse effects of co-trimoxazole.
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(h) Write an account on Digestants and Carminatives. A
(i) Define chronopharmacology. Write the significance of biological clock. 7×5=35
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