Medicinal Mushrooms III

© 1998 Christopher Hobbs

Mushrooms have been valued throughout the world as both food and
medicine for thousands of years. In virtually every culture people enjoy
hunting for wild mushrooms. Europeans have always appreciated their
gastronomic value. In Japan, pushcart vendors on the streets still sell
medicinal mushrooms to the average citizen who uses them to maintain
health and promote longevity. Some Japanese people have even been said
to travel hundreds of miles in order to collect wild mushrooms that grow
only on very old plum trees­­such as the Reishi­­renowned as a cure for
cancer and degenerative diseases. Likewise, for over 3,000 years the
Chinese have used and revered many fungi for their health­giving
properties, especially tonics for the immune system.

Today, these health­promoting mushrooms are becoming an integral part

of a healing diet. Further, they may also be an excellent food for staying
trim and healthy. Because fats occur in mushrooms in minor amounts,
especially compared with protein and carbohydrates, and the fatty fraction
consists predominantly of unsaturated fatty acids, such as linoleic acid,
they may be the perfect food for losing weight and maintaining a healthy
heart and cardiovascular system.

Some Major Medicinal Mushrooms

Shiitake

Shiitake (Lentinula edodes) is a prized mushroom with a delicious taste

and texture. It is used medicinally for diseases involving depressed
immune function­including cancer, AIDS, environmental allergies,
Candida infections, and frequent flu and colds. Shiitake is also beneficial
for soothing bronchial inflammation and regulating urine incontinence (Bo
and Yun­sun, 1980), as well as for reducing chronic high cholesterol.
Japanese products containing LEM, a polysaccharide­rich extract from the
shiitake mushroom, and similar extracts from maitake are currently
undergoing trials in Japan and the U.S. to test their effectiveness in
treating various forms of cancer.

According to one prominent Japanese researcher, lentinan (a cell­wall

constituent extracted from the fruiting bodies of shiitake) is an
immunomodulating agent which may be useful both as a general
rejuvenative for older persons, as well as prophylactically to protect
healthy, physically active young people from overwork and exhaustion
(Aoki, 1984).

Dose: The traditional dose of the whole dried shiitake in tea, soup,
or other dishes is given as 6­16 grams; fresh­about 90 grams (Bo
and Yun­sun, 1980).

According to manufacturers' recommendations and the few clinical trials

performed with humans, in the early stages of AIDS or chronic hepatitis
the best dose of LEM may be between 2­6 grams/day in 2 or 3 divided
doses. Once the disease is more stable, the dosage may be decreased,
perhaps to 1/2 ­1 gram per day (Sharon, 1988).

Commercial preparations of shiitake are available in natural food markets.

Standardized extracts are preferred because the amount of lentinan present
is clearly stated on the bottle. Note that although fresh shiitake can be a
valuable dietary supplement, the amount one would need to eat for
medicinal doses is so high that it might cause digestive upset. That is why
LEM, which is concentrated and easily absorbed, is preferred as medicine.

Reishi

Reishi (Ganoderma lucidum) is, without doubt, one of the most famous
medicinal mushrooms. It is known as ling­zhi in China and reishi in Japan.
In the last 20 years, reishi has been tested in human clinical studies and is
thought to be beneficial for a wide variety of disorders, including
neurasthenia, insomnia, rhinitis, and duodenal ulcers (Ying et al, 1987). It
has also been used for liver pain, symptoms associated with anorexia,
retinal pigmentary degeneration, and progressive muscular dystrophy;
(Chang & But, 1986; Chang et al, 1984; Huidi & Zhiyuan, 1982). Reishi
has also shown favorable results in treating hepatitis (Chang & But, 1986),
chronic bronchitis; coronary heart disease, allergies, and altitude sickness.
Traditionally, reishi was very expensive, because it only grew in the wild,
but it is currently both accessible and affordable due to cultivation
techniques developed in the last 20 years (Willard, 1990). Today it is used
primarily for aging­related conditions and cancer and as an immune
stimulant.

Dose: The dose in tincture form is 10 ml 3x/day; in tablet form (for

insomnia) the dose is 1 g tablets, 3x/day.

Maitake

Maitake (Grifola frondosa) is a delectable mushroom that is extremely

popular in Japan. In the U.S. it is currently being studied in medical clinics
in the U.S. for patients with breast and colorectal cancers (Miller, 1994).
In China a maitake extract was shown to have an anticancer effect in
patients with lung, stomach, hepatocellular cancers, and leukemia.
Reduced side effects from chemotherapy have also been reported (Nanba,
1994a,b). Dr. Joan Priestley, MD reports that her patients with Kaposi's
sarcoma and other symptoms of AIDS show improvement when
administered maitake extract, and Dr. David Hughes, MD has had
positive results with Kaposi's sarcoma lesions (Nanba, 1994a). It
potentially benefits diabetics (lowering blood glucose) and people with
hypertension.

Dose: The recommended dose is 3­7 grams a day in supplement

form, in tea, or in cooking (soups, etc.).

O ster

Oyster mushroom (Pleurotus ostreatus) is extremely delicious as well as

conferring various health­giving properties. Traditionally, it has been used
to strengthen veins and relax tendons. In China oyster mushroom is
indicated for joint and muscle relaxation (Yang & Jong, 1989). A product
containing oyster mushroom, called "Tendon­easing powder," is effective
in the treatment of lumbago, numbed limbs, and tendon and blood vessel
discomfort.

In the Czech Republic, extracts have been made from the fruiting bodies
as the main ingredient in dietary preparations recommended for prevention
of high cholesterol (Opletal, 1993). The dried oyster mushrooms are said
to be high in iron, so they are potentially good blood builders.

Dose: The recommended dose is 3­9 grams daily.

Enokitake

F. velutipes is a popular edible mushroom in Japan where a tender

cultivated form of the wild version is called "enokitake." It is commonly
used in Japanese cooking and increasingly can be found in salads in
gourmet restaurants. If taken on a regular basis, Flammulina velutipes may
prevent, as well as cure, liver disease and gastroenteric ulcers (Ying et al,
1987; Yoshioka et al, 1973).

Enokitake contains several types of amino acids including valine, which

inhibits the growth of Ehrlich ascities tumour and sarcoma 180 in mice;
and lysine, reported to increase body height and weight (Ying et al, 1987).
Enokitake contains a cardiotoxic protein (flammutoxin) that is rendered
harmless when subjected to heat (100 degrees C) for 20 minutes. I would
caution against the chronic use of enokitake raw in salads or other dishes.
 Dose: The dose is 8­9 g/day.

Sources of Medicinal Fungi

Bulk mushrooms
Natural food stores (reishi, shiitake)
Markets (shiitake, oyster)
Chinese herb dealers (reishi, cordyceps, zhu ling, hoelen, auricularia, etc.)
Herb shops (reishi)
Home grown­­logs, supplies (shiitake, oyster, reishi, others)
From the wild (oyster, reishi, turkey tails, auricularia, tremella, honey
mushroom, chanterelles, and many others)

Po dered concentrates (capsules, tablets, granules)

Natural food stores (reishi, shiitake, maitake, cordyceps)
Chinese herb dealers (formulas, freeze­dried granules to make instant tea,
reishi tea cubes)
Herb shops (same as natural food stores)
Selected drug stores (reishi)

Liquid e tract products (tinctures, ampules­­extract in honey base)

Natural food stores (reishi, shiitake, cordyceps, rarely others)
Herb shops (same as above)
Chinese herb dealers (reishi, shiitake, cordyceps)

Making Preparations

Since the scientific literature seems to point to whole mushroom fruiting

bodies as being especially active as antitumor agents and immune
enhancers, I recommend taking dried and powdered mushrooms by the
teaspoon, either in a cup of ginger tea, or even sprinkled into soup or on
stir­frys and rice, etc. When placed in "00" capsules, the average amount
of powdered mushroom/capsule is about 400 mg. For mild to moderate
immune support I recommend 2 capsules morning and evening. For
specific immune­suppressed conditions, take 2­3 capsules 3 times a day.

To make a mushroom extract that is stronger and more readily assimilated,

try simmering the mushrooms (as many fruiting bodies or pieces as can be
covered by the water in a pot) for about an hour. Strain off the dark tea
and replace the liquid with fresh water to cover the mushrooms and
simmer for another 30 minutes. Strain the new tea and add it to the first
decoction; simmer several hours until it is reduced to a thick paste. Take
this paste off the heat, scrape it out with a cake spatula, and knead it with
an organic rice or wheat flour to a dough­like consistency. Pack small
pieces of this dough into "00" capsules and take 1 of them morning and
evening. The dough can also be dried in a food drier or oven with low
heat. The dried extract pieces can then be powdered in a blender or coffee
grinder. The powder can be packed into capsules or sprinkled on food.

Teas and Soups

Teas are a good way to use medicinal mushrooms, and they should be
simmered until the tea is somewhat dark and strong­tasting­­about 40
minutes to an hour.

For soups, add a variety of vegetables to the mushroom tea stock. Fish,
chicken, or a little red meat can be added for certain deficiency conditions.
Drink the broth (1­3 cups a day) and eat the vegetables.

Use Summar of Major Medicinal Mushrooms:

(Arranged by Species)

Chanterelle
Main Uses: tumor inhibition
Preparations: fresh or dried
Dose: ad lib.
Contraindications: no toxicity

Enokitake
Main Uses: liver disease, gastroenteric ulcers
Preparations: fresh or dried
Dose: cooked, ad lib.; dried, 8­9 g/day
Contraindications: some toxicity raw; no toxicity cooked

Maitake
Main Uses: high blood pressure, tumor inhibition, liver protectant
Preparations: fresh or dried
Dose: 3­7 g/day
Contraindications: low toxicity

O ster
Main Uses: tumor inhibition, high cholesterol
Preparations: fresh cooked; dried, powdered
Dose: ad lib.
Contraindications: low toxicity

Reishi
Main Uses: immune activation, tumor inhibition, expectorant, hepatitis, hypertension,
nervousness, general weakness
Preparations: dried, liquid extract, tablets
Dose: tincture, 10 ml 3x/day; tablets, 3 1g tab 3x/day
Contraindications: very low toxicity reported

Shiitake
Main Uses: immune regulator, tumor inhibition, antiviral, antibacterial, liver
protectant
Preparations: fresh, dried, liquid extract, tablets
Dose: dried, 6­16 g; fresh, 90 g
Contraindications: no toxicity; some contact dermatitis

Recommended Reading List

Medicinal Mushrooms by Christopher Hobbs.

Kombucha by Christopher Hobbs.
Manual on Mushroom Cultivation by Peter Oei.
Mushrooms Dem stified by David Arora.
Mushrooms in the Garden by Helmut Steineck.
The Shiitake Growers Handbook by P. Przlbylowicz and J.
Donoghue.
The Mushroom Cultivator by P. Stamets and J. Chilton.
Growing Shiitake Mushrooms in a Continental Climate by Mary
Ellen Kozak and J. Krawczyk.
Cultivating Edible Fungi by P.J. Wuest.

Resources

DelfTree Farm
234 Union St., North Adams, MA 01247, 800 243­3742
fresh shiitakes, etc. delivered to your home

Fungi Perfecti
P.O. Box 7634, Olympia, WA 98507, 206 426­9292
Mushroom growing supplies; shiitake logs, etc.

Mayway U.S.A.
1338 Cyperus St., Oakland, CA 94607, 510 208­3113
Chinese herbs in bulk, extracts and other herbal products

Bibliograph

Aoki, T. 1984. "Lentinan". In Immune Modulation Agents and Their

Mechanisms. R.L. Fenichel and M. A. Chirgis, eds. Immunology Studies.
25:62­77.
Bo, L. and Bau Yun­sun. 1980. Fungi Pharmacopoeia (Sinica). Oakland:
Kinoko Co.
Chang, H.M. and P. Pui­Hay But. 1987. Pharmacology and Applications of
Chinese Materia Medica. Vol. 2. Singapore: World Scientific.
Chang, H.M., ed. et al. 1984. Advances in Chinese Medicinal Materials
Research. Singapore: World Scientific.
Huidi, F. and W. Zhiyuan. 1982. The clinical effects of Ganoderma lucidum
spore preparations in 10 cases of atrophic myotonia. J. Trad. Chin. Med. 2:63­
65.
Miller, D. 1994. Current clinical protocol submitted to the N.I.H. Scientific
Director Cancer Treatment Research Foundation, Arlington Heights, IL.
Nanba, H. 1994a. Power of maitake mushroom. Explore Professional (in press).
Nanba, H. 1994b. Activity of maitake D­fraction to prevent cancer growth and
metastasis. J. Naturopathic Med. (In press).
Opletal, L. 1993. Phytotherapeutic aspects of diseases of the circulatory system.
2. The oyster mushroom and its potential use. Cesk. Farm. 42:160­166.
Sharon, T.M. 1988. Personal Observations: Lentinus edodes (shiitake) mycelial
extract. Typescript.
Willard, T. 1990. Reishi Mushroom. Herb of Spiritual Potency and Medical
Wonder. Issaquah: Sylvan Press.
Yang, Q.Y. & S.C. Jong. 1989. Medicinal mushroom in China. Mushroom
Science. XII. (Part I): 631­643. Proceeding of the Twelft International Congress
on the Science and Cultivation of Edible Fungi. From K. Grabbe and O. Hilber
(eds.). Braunschweig ­ Germany: Institue f r Bodenbiologie,
Bundesforschungsanstolt f r Londwirtschoft.
Ying, J. et al. 1987. Icones of Medicinal Fungi From China. Translated by X.
Yuehan. Beijing: Science Press.
Yoshioka, Y. et al. 1973. Studies on antiumor polysaccharides of Flammulina
velutipes (Curt. ex Fr.) Sing. I. Chem. Pharm. Bull. 21:1772­1776.

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