TotalChrom
Chromatography Data Systems
Streamlining your
laboratory workflow
maximize productivity with
TotalChrom CDS
Acquiring, processing, reporting, reviewing and TotalChrom data systems can be deployed in stand-
approving data is a streamlined series of operations alone, thin client, or enterprise client/server computing
in PerkinElmer®’s TotalChrom® Chromatography Data environments. When configured with a PerkinElmer
System (CDS) software, designed to fit your laboratory Gas Chromatograph (GC) or Liquid Chromatograph (LC),
workflow and maximize productivity. With its scalable the data system serves as both an instrument controller
architecture, 21 CFR Part 11 compliance features and and data manager for the overall system. Compatible
proven algorithms, TotalChrom offers a computing with most commercial LCs and GCs, TotalChrom data
strategy to manage your chromatography data quickly systems are the best choice for chromatography data
and securely in both regulated and non-regulated handling in demanding multi-user, instrument, and
environments. site environments.
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stable, scalable architecture
Seamless, networked data acquisition routines that ensure 100 percent data integrity. The
Chromatography data can be collected throughout your interfaces continue data collection and instrument
network through PerkinElmer Intelligent Interfaces and control even if the network, clients, or servers become
LINK modules. These modules allow chromatographs inoperative. Data collection on a TotalChrom data
from any location to be easily and inexpensively con- system can run virtually non-stop.
nected to your LAN and accessed by users from any
network location. The TotalChrom system’s unique Designed for growth and change
data protection features assure that data acquisition PerkinElmer’s “start here” strategy allows you to
in progress is never disrupted or compromised. implement TotalChrom systems in stages that fit your
needs. New users are accommodated by simply adding
Non-stop data acquisition more PC clients. You can easily add additional servers
with 100% integrity to increase system capacity, add file services, and
accommodate new workgroups. There is no limit to
Communications from each interface module to the
the number of instruments you can access from any
host computer include special TotalChrom security
location on the network.
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streamlining your
The entire process from setting up an analytical method to the fin
The entire process from setting up an analytical method
to the final approval of reports is a streamlined series of
operations in TotalChrom.
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laboratory workflow
nal approval of reports is a streamlined series of operations in TotalChrom.
Optional
TotalChrom
applications
PerkinElmer offers a complete
suite of applications integrated
with TC to meet customer’s
demands:
IRIS™ Spectral Processing
software developed by
PerkinElmer is a sophisticated
application that allows users
to navigate, process and report
PhotoDiode Array spectra,
offering a full suite of functionality
and an intuitive user interface all
protected under a fully 21 CFR
Part 11 compliant architecture.
Turbo Method Development
software automates HPLC
method development and
validation processes such
as solvent optimization, and
robustness testing on samples
of known/unknown composition.
Gel Permeation Chromatog-
raphy (GPC) software uses
specific algorithms for gel
permeation analysis.
w w w. p e r k i n e l m e r. c o m 5
quickly and easily build
methods and sequences
Instrument control parameters, such as oven temperature Visually optimize methods
and pressure ramps for GC, or solvent gradients for LC, Optimize data handling methods in seconds using
are displayed as both graphic profiles and numeric the Graphic Method Editor (GME) to set integration
grids for rapid visualization of your experiment. The parameters, add component names to known peaks
Sequence Editor uses a template to quickly and conve- and groups, and define amounts of standards and
niently build a complex list of injections in the editor’s typologies of compounds.
spreadsheet. Editing tools facilitate the entry of para-
meters common to selected rows or fields in the spread-
TotalChrom provides two specific tools for
sheet, saving time and eliminating errors from
reporting, to meet the different needs of the
repetitive entry of common values.
users: the standard report and TC Publisher
Standard report
TotalChrom data systems handle peak detection, integration, The standard TotalChrom reporting tool provides
various basic report formats for quantitative analysis and
and analysis with the most sophisticated algorithms, refined allows users to tailor results with customized headers
and labels, expressions (mathematical formulas), and
through years of experience in chromatographic data pro- footers. Numerous report options provide formatting
choices and automated ASCII output file creation.
cessing. Even when pushing the limits of detection, TotalChrom’s
Special Summary Report and Suitability Report options
sophisticated routines minimize the impact of noise on results. enable users to obtain additional information on the
operation of the analytical system, and support the
analyst in the method validation process.
TC Publisher
TC Publisher extends report capabilities beyond
the standard templates by providing a sophisticated
laboratory report generator using standardized tools.
Unique features let you graphically format the exact
report you want without extensive training or special
commands.
Report templates have the ability to perform calcula-
tions between different peaks in the same sample or
even between samples, as well as automate statistical
determination for replicate injections, with full control
over the output format.
Report templates can include control of the graphic
data representation, separate tables for standard and
sample data, and “if/then” conditional logic for
Pass/Fail tests or Limits Checking.
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quickly and easily navigate,
review and approve your data
In the “paper world”, reports need to be reviewed signatures recorded during data acquisition, instrument
and signed. The TotalChrom Review & Approve (R&A) control and data analysis processes ensure that data
feature is a graphical reviewing environment that integrity is always maintained. System features fully
allows intuitive navigation into data and reports, and document all methods, sequences, and reports, including
provides for the implementation of a data approval instrument run logs, and provide a complete and
cycle using electronic signatures. High throughput unambiguous link from the initial experiment to the
applications have dramatically increased the amount final results. Multiple TotalChrom “JobTypes” can be
of information produced every day in a laboratory. created to control who can perform what functions in
This feature streamlines tedious data review by using the system.
a single environment to navigate into data, just like
we navigate into e-mail. With TC R&A, chromatograms, Validation assistance
raw data, results and reports can be easily viewed and
PerkinElmer uses a world-class software development
compared at a glance. Reviewing and approving reports
process to ensure reliability. The TotalChrom system
can be done electronically, with multiple levels of
is developed and structurally validated following a
authority and secure electronic signatures.
certified quality system, which conforms to Good Lab-
oratory Practice (GLP), Good Manufacturing Practice
Unsurpassed 21 CFR Part 11 compliance (GMP) and ISO 9000/2000/TickIT requirements. Our
for regulated labs software development life cycle and documentation
The TotalChrom system features Enhanced Security™, a structure conform to GAMP IV and IEEE guidelines.
proprietary protocol for supporting United States FDA As part of your validation program, an audit of our
21 CFR Part 11 compliance. Audit trails and electronic development site is available.
The Review & Approve interface shows the approval status
at a glance.
w w w. p e r k i n e l m e r. c o m 7
PerkinElmer, Inc.
PerkinElmer continues to drive innovation and perfor- You get the speed, accuracy and reliability you seek –
mance in Gas Chromatography and Liquid Chromatography for the productivity you need. Our service and support
instrumentation and software, with a focus on making people are located in 125 countries throughout the world
your lab more productive and efficient. When bundled and are factory-trained. Compliance does not get any
with TotalChrom and other PerkinElmer software, you get easier than with our Enhanced Security line of software
a complete PerkinElmer solution that is integrated, fully products, including 21 CFR Part 11 technical compliance on
tested and supported. many products. And online consumables and accessories
ordering lets you get your hands on what you need fast.
PerkinElmer Life and
Analytical Sciences
710 Bridgeport Avenue
Shelton, CT 06484-4794 USA
Phone: (800) 762-4000 or
(+1) 203-925-4602
www.perkinelmer.com
For a complete listing of our global offices, visit www.perkinelmer.com/lasoffices
©2005 PerkinElmer, Inc. All rights reserved. The PerkinElmer logo and design are registered trademarks of PerkinElmer, Inc. Clarus, PerkinElmer and TotalChrom are
trademarks and Enhanced Security and TC Publisher are registered trademarks of PerkinElmer, Inc. or its subsidiaries, in the United States and other countries. Microsoft
is a registered trademark of Microsoft Corporation. All other trademarks not owned by PerkinElmer, Inc. or its subsidiaries that are depicted herein are the property of their
respective owners. PerkinElmer reserves the right to change this document at any time without notice and disclaims liability for editorial, pictorial or typographical errors.
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