Scribd
Upload
52 views4 pages

Glycogen+Worksheet 5

The document provides an overview of glycogen metabolism, including the processes of glycogen synthesis and degradation, the role of hormones, and the enzymes involved. It also discusses the advantages of glycogen as an energy source, the differences between glycosidic linkages, and glycogen storage diseases. Key concepts such as the rate-limiting enzymes and the mechanisms of action for various enzymes are outlined.

Uploaded by

Sm George
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
52 views4 pages

Glycogen+Worksheet 5

The document provides an overview of glycogen metabolism, including the processes of glycogen synthesis and degradation, the role of hormones, and the enzymes involved. It also discusses the advantages of glycogen as an energy source, the differences between glycosidic linkages, and glycogen storage diseases. Key concepts such as the rate-limiting enzymes and the mechanisms of action for various enzymes are outlined.

Uploaded by

Sm George
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 4

Supplemental Learning for Biochemistry

Glycogen Metabolism
BIG PICTURE (thus far):
Pathway Process (what is happening Hormone State of the
AND WHY) active body
(fed/fasting)
Glycolysis

Gluconeoge
nesis
Glycogenoly
sis
Glycogenesi
s

GLYCOGEN METABOLISM
1. When does the body use glucose from stored Glycogen vs
Gluconeogenesis?

2. Name the TWO glycosidic linkages.


a. linear linkage
b. branched linkage

3. What is the difference between the reducing and non-reducing ends of


glycogen?

4. What is glycogenin, and where is it found in glycogen?

5. List the advantages of glycogen being branched.

6. List the advantages of Glycogen over Fat as an energy source.

7. Name the two tissues that contain the major glycogen stores and state
how each uses their stored glycogen.
a.
b.

8. When would the body be storing glycogen vs breaking it down?


a. Storing:
b. Degrading:

9. Name the rate-limiting enzyme of (a) glycogen synthesis and (b)


glycogen degradation.
1
a. Synthesis:
b. Degradation:
i. Coenzyme:
10.
Glycogen Synthesis
Enzyme Mechanism of Action
1. Phosphoglucomutase

2. UDP-glucose
pyrophosphorylase
3. Glycogen Synthase

4. Glycosyl α4:6
transferase
(Branching enzyme)

5. Nucleoside diphosphate
kinase
Name the lysosomal enzyme that also degrades glycogen.

Glycogen Degradation
Enzyme Mechanism of Action
1. Glycogen
phosphorylase
2. Glycosyl α4:4
transferase
(domain of debranching
enzyme)
3. Amylo α1:6 glucosidase
(domain of debranching
enzyme)
4. Phosphoglucomutase
2
Glycogen Synthesis Glycogen Degradation
Allosteric Regulation
Glycogen Synthase Glycogen Phosphorylase
Activators Liver Muscle Liver Muscle

Inhibitors

Hormonal Regulation (Outline the mechanism)


Glycogen Synthase Glycogen Phosphorylase
(via phosphorylase kinase)
Activators

3
Inhibitors

Summary of Glycogen Storage Diseases:


Primary Organ
Glycogen Storage Manifestations (extra
Enzyme Deficient Affected (extra
Disease info.)
info.)
Von Gierke’s
Disease (Type 1a)
Pompe’s Disease
(Type II)
McArdle’s
Syndrome (Type V)

Her’s Disease
(Type VI)

You might also like