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The Clinical Nanomedicine Handbook 1st Edition Sara
Brenner Digital Instant Download
Author(s): Sara Brenner
ISBN(s): 9781439834794, 1439834792
Edition: 1
File Details: PDF, 38.30 MB
Year: 2013
Language: english
THE CLINICAL
NANOMEDICINE
HANDBOOK
Sara Brenner, MD, MPH - Editor
The Clinical
NANOMEDICINE
HANDBOOK
The Clinical
NANOMEDICINE
HANDBOOK
Sara Brenner, MD, MPH - Editor
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2014 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20130923
International Standard Book Number-13: 978-1-4398-3479-4 (eBook - PDF)
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Contents
Preface............................................................................................................................................. vii
Cover Art Credits���������������������������������������������������������������������������������������������������������������������������ix
Editor................................................................................................................................................xi
Contributors.................................................................................................................................. xiii
1. Nanotechnology Applications for Infectious Diseases...................................................1
Ellis H. Tobin, MD
2. Nanotechnology Applications in Dermatology.............................................................. 85
David Schairer, MD; Jason Chouake, MD; Adnan Nasir, MD; and Adam Friedman, MD
3. Nanotechnology Applications in Ophthalmology....................................................... 195
Eman Elhawy, MD and John Danias, MD, PhD
4. Nanotechnology Applications in Urology...................................................................... 213
Himanshu Aggarwal, MD and Barry A. Kogan, MD
5. Nanotechnology Applications in Preventive Medicine and Public Health............ 235
Julielynn Wong, MD, MPH and Sara Brenner, MD, MPH
6. Nanotechnology Applications in Vascular Medicine and Surgery.......................... 249
Manish Mehta, MD; Philip S.K. Paty, MD; W. John Byrne, MD; Yaron Sternbach, MD;
John B. Taggert, MD; and Kathleen J. Ozsvath, MD
7. Therapeutic Applications and Targeted Delivery of Nanomedicines and
Nanopharmaceutical Products.......................................................................................... 321
Heidi M. Mansour, PhD and Chun-Woong Park, PhD
© 2008 Taylor & Francis Group, LLC v
Preface
Nanomedicine is the medical application of nanotechnology in the prevention, diagnosis,
and treatment of diseases. The Clinical Nanomedicine Handbook is intended to serve as an
authoritative reference for clinicians, including physicians, nurses, healthcare providers,
dentists, scientists, and researchers involved in clinical applications of n anotechnology.
Although many texts and publications have been released on various topics at the
intersection of nanotechnology, biology, and medicine, none have approached the
convergence of these fields from a distinctly clinical vantage point.
The American Society for Nanomedicine and the National Institutes of Health (NIH)
highlight the emergence of nanomedical innovations as a necessary enabler in the
development and deployment of preventive, diagnostic, and therapeutic medical tools of
the twenty-first century. These will be driven by the application of nanotechnology and
engineering principles to clinical interventions, which manipulate single molecules or
molecular assemblies in cells, drugs, or medical devices.
At the intersection of traditionally siloed disciplines, nanomedicine is blazing a path for
truly innovative, cutting edge, preventive interventions, rapid diagnostics, and effective
treatments. Current research and applications in specialties are covered in this handbook,
which is sure to expand in the coming years. Potential applications, as cited by the NIH,
include nanotechnologies that enable physicians to identify and destroy primary cancer
cells before metastasis, molecular procedures that can remove a dysfunctional cellular
component and replace it with an engineered biological machine, and nanoscale pumps
that deliver targeted drug therapy. The NIH also predicts that nanomedicine will enable
the development of novel tools that will allow scientists to build synthetic biological
devices, such as high-throughput sensors to scan for the presence of infectious agents or
metabolic imbalances, as well as nano-enabled therapeutics aimed at rapidly addressing
the identified problem.
From an economic perspective, nanotechnology and its affiliated applications are pro-
jected to impact every known industry and create entirely new industrial clusters such as
nanomedicine and nanobioscience. Nanotechnology accounted for nearly $300 billion in
2009 and is projected to hit $2.6 trillion by 2014. It is predicted that the economic impact of
nanotechnology will approach the size of the information technology and telecom indus-
tries combined with the potential to be 10 times larger than the biotechnology economy in
the next 5 years. In terms of revenue, 16% of goods in healthcare and life sciences will
incorporate nanotechnology. In other words, nanobioscience products alone are expected
to be a $416 billion industry by 2014.
© 2008 Taylor & Francis Group, LLC vii
Cover Art Credits
Silver np 4 (Blue image wedges): Cluster of green-route
synthesized silver nanoparticles under a TEM. Center for
Converging Technologies, University of Rajasthan, Jaipur,
India. Photographed by Sahil Tahiliani & Abhijeet Mishra.
2011.
Silver np 1 (Green image wedges): Electron micrograph
of chemically synthesized silver nanoparticles of various
shapes i.e. rods, sphere, pyramidical etc. Center for
Converging Technologies, University of Rajasthan,
Jaipur, India. Photographed by Sahil Tahiliani & Ruchir
Priyadarshi. 2012.
Nci-vol-2505-300 (Orange image wedges): Electron
micrograph of macrophages in the brain before and after
in vitro infection by HIV-I. Laboratory of Tumor Cell
Biology. National Cancer Institute. Dr. Suzanne Gartner
(photographer). 1990.
SEM blood cells (Red image wedges): Scanning electron
microscope image of normal circulating human blood
cells. National Cancer Institute. Bruce Wetzel and Harry
Schaefer (photographers). 1982.
© 2008 Taylor & Francis Group, LLC ix
Editor
Dr. Sara Brenner is a preventive medicine and public health
physician at the College of Nanoscale Science and Engineering
(CNSE), State University of New York, s erving as the assistant
vice president for NanoHealth Initiatives and an assistant pro-
fessor of n
anobioscience. Her research and initiatives aim to
develop novel nanotechnology a pplications in the life sciences,
including medicine and public health.
She leads health and safety research related to nanoparticle
and engineered nanomaterial exposures in the workplace,
consumer marketplace, and environment. She is chair of the
steering committee for the NanoHealth and Safety Center at
CNSE, a public–private partnership that is addressing gaps in
our understanding of the safety and risk associated with the
unique characteristics of nanoscale materials. Dr. Brenner’s research team incorporates
theory from many disciplines such as physics, engineering, biology, genetics, toxicology,
medicine, public health, epidemiology, industrial hygiene, and environmental science to
advance risk assessment and reduction strategies for occupational e xposures, monitoring
of materials that may impact population health and public safety, and the development of
industrial practice standards for product safety. She is also the CNSE program director of
the MD/PhD program in medicine and nanoscale science or engineering, a program that
she helped cofound with SUNY Downstate Medical Center. It is the first dual-degree clini-
cal training program in nanomedicine that aims to produce a new, hybrid generation of
physician researchers.
She is also the recipient of the Albany-Colonie Chamber of Commerce Women of
Excellence Award 2012 Emerging Professional.
© 2008 Taylor & Francis Group, LLC xi
Contributors
Himanshu Aggarwal, MD Heidi M. Mansour, PhD
Division of Urology Division of Dermatology
Department of Surgery Department of Medicine
Albany Medical Center Albert Einstein College of Medicine
Albany, New York Bronx, New York
Sara Brenner, MD, MPH Manish Mehta, MD
SUNY College of Nanoscale Science and The Vascular Group, PLLC
Engineering The Institute for Vascular Health and
Albany, New York Disease
W. John Byrne, MD Albany Medical College
The Vascular Group, PLLC and
The Institute for Vascular Health and Vascular Research and Registry
Disease Albany, New York
Albany Medical College
Adnan Nasir, MD
Albany, New York
Department of Dermatology
Jason Chouake, MD The University of North Carolina at
Division of Dermatology Chapel Hill
Department of Medicine Chapel Hill, North Carolina
Albert Einstein College of Medicine
Bronx, New York Kathleen J. Ozsvath, MD
The Vascular Group, PLLC
John Danias, MD, PhD The Institute for Vascular Health and
Department of Ophthalmology Disease
SUNY Downstate Medical Center Albany Medical College
Brooklyn, New York Albany, New York
Eman Elhawy, MD Chun-Woong Park, PhD
Flushing Hospital Medical Center Division of Dermatology
Flushing, New York Department of Medicine
Albert Einstein College of Medicine
Adam Friedman, MD Bronx, New York
Division of Dermatology
Department of Medicine Philip S.K. Paty, MD
Albert Einstein College of Medicine The Vascular Group, PLLC
Bronx, New York The Institute for Vascular Health and
Disease
Barry A. Kogan, MD Albany Medical College
Division of Urology Albany, New York
Department of Surgery
Albany Medical Center David Schairer, MD
and Division of Dermatology
Urological Institute of Northeastern Department of Medicine
New York Albert Einstein College of Medicine
Albany, New York Bronx, New York
© 2008 Taylor & Francis Group, LLC xiii
xiv Contributors
Yaron Sternbach, MD Ellis H. Tobin, MD
The Vascular Group, PLLC Department of Medicine
The Institute for Vascular Health and Albany Medical College
Disease and
Albany Medical College Upstate Infectious Diseases
Albany, New York Associates
Albany, New York
John B. Taggert, MD
The Vascular Group, PLLC Julielynn Wong, MD, MPH
The Institute for Vascular Health and Center for Innovative Technologies and
Disease Public Health
Albany Medical College Toronto, Ontario, Canada
Albany, New York
© 2008 Taylor & Francis Group, LLC
1
Nanotechnology Applications for Infectious Diseases
Ellis H. Tobin, MD
CONTENTS
1.1 Introduction............................................................................................................................. 2
1.1.1 Basic Nanoscience Concepts.....................................................................................3
1.2 Specialty of Infectious Diseases........................................................................................... 4
1.3 Scope of Infectious Diseases................................................................................................. 7
1.4 Magnitude of Infectious Diseases........................................................................................ 8
1.5 Nanoscience Principles, Methods, and Terminology Relevant to Infectious
Diseases.................................................................................................................................. 10
1.6 Current Approach to Diagnosis of Infections.................................................................. 11
1.7 Infectious Diseases: Nanobiosensing Interface................................................................ 12
1.7.1 Photonic Biosensing: Semiconductors................................................................... 14
1.7.2 Quantum Dot Semiconductors and Infectious Diseases Biosensing................ 15
1.7.2.1 Quantum Dots and Virus Detection....................................................... 17
1.7.2.2 Quantum Dot Biosensing and Human Immunodeficiency Virus..... 17
1.7.2.3 Quantum Dot Biosensing and Respiratory Syncytial Virus............... 18
1.7.2.4 Quantum Dot Biosensing and Influenza Virus..................................... 19
1.7.2.5 Quantum Dot Biosensing and Hepatitis Viruses.................................. 20
1.7.2.6 Quantum Dot Biosensing and Other Viruses........................................ 20
1.7.3 Quantum Dots, Bacteria, and Bacterial Toxin Detection.................................... 21
1.7.3.1 Quantum Dot Biosensing and Bacteria: General Principles................ 21
1.7.3.2 Quantum Dot Biosensing and Biofilms.................................................. 23
1.7.3.3 Quantum Dot Biosensing and Food-Borne Bacteria............................ 24
1.7.3.4 Quantum Dot Biosensing and Syphilis.................................................. 25
1.7.3.5 Quantum Dot Biosensing and Mycobacteria......................................... 25
1.7.3.6 Quantum Dot Biosensing and Bacterial Toxins.................................... 26
1.7.4 Quantum Dot Biosensing and Fungi..................................................................... 27
1.7.5 Quantum Dot Biosensing and Parasites................................................................ 28
1.7.6 Quantum Dot Biosensing: Conclusions................................................................ 29
1.8 Plasmonic Nanobiosensing: Emphasis on Infectious Diseases.....................................30
1.8.1 Plasmonics: Basic Principles....................................................................................30
1.8.2 Surface Plasmon Resonance Biosensing Scheme 1: Detection of Light
Scattering................................................................................................................... 31
1.8.3 Surface Plasmon Resonance Biosensing Scheme 2: Colorimetric Detection.... 32
1.8.4 Surface Plasmon Resonance Biosensing Scheme 3: Surface Plasmon
Wave-Based Detection.............................................................................................34
1.8.5 Surface Plasmon Resonance Biosensing Scheme 4: Surface-Enhanced
Raman Scattering-Based Detection........................................................................ 36
1.8.6 Plasmonic Nanobiosensing: Conclusions.............................................................. 37
© 2008 Taylor & Francis Group, LLC 1
2 The Clinical Nanomedicine Handbook
1.9 Bio-Barcodes and Infectious Diseases–Nanobiosensing................................................ 38
1.9.1 Bio-Barcode Infectious Diseases–Nanobiosensing: Conclusions...................... 40
1.10 Magnetic Nanoparticles and Infectious Diseases Biosensing: Introduction............... 40
1.10.1 Magnetic Capture and Separation of Microorganisms....................................... 41
1.10.2 Magnetic Remanence and Infectious Diseases Nanobiosensing...................... 41
1.10.3 Magnetic Relaxation Nanoswitches and Infectious Diseases
Nanobiosensing........................................................................................................42
1.10.4 Magnetic Nanoparticles and Infectious Diseases Biosensing:
Miscellanea and Conclusions..................................................................................44
1.11 Microcantilever-Based Infectious Diseases Biosensing.................................................. 45
1.11.1 Microcantilever-Based Infectious Diseases Biosensing: Conclusions.............. 47
1.12 Miscellaneous Infectious Diseases–Nanobiosensing Strategies................................... 48
1.12.1 Fluorescent Europium Nanoparticle Biosensors.................................................. 48
1.12.2 Silica Nanoparticle Biosensors................................................................................ 48
1.12.3 Liposome Nanobiosensors...................................................................................... 48
1.12.4 Carbon Nanotube and Nanowire Biosensors....................................................... 49
1.12.5 Microbial-Based Biosensing.................................................................................... 49
1.13 Infectious Diseases Nanobiosensing: Summary and Conclusions............................... 50
1.14 Application of Nanotechnology to Antimicrobial Therapy and Prevention of
Infectious Diseases: Introduction....................................................................................... 51
1.14.1 Perspectives on Antimicrobial Therapy and Prevention of Infectious
Diseases...................................................................................................................... 51
1.14.2 Overview of Antimicrobial Pharmacology Principles........................................ 51
1.14.3 Nanoparticles Having Inherent Antimicrobial Activity.................................... 52
1.14.4 Silver Nanoparticles: Antimicrobial Activities and Anxieties...........................54
1.14.5 Nanostructures Having Inherent Antibiofilm Activity...................................... 56
1.14.6 Nanostructures as Antimicrobial Carriers........................................................... 57
1.14.7 Liposomes: Approved Antimicrobial Nanocarriers............................................ 57
1.14.8 Nanoparticles, Vaccines, and Vaccine Delivery................................................... 60
1.15 Infectious Diseases—Nano Therapeutic and Prevention Strategies: Summary......... 61
1.16 Nanotechnology–Infectious Diseases Interface: Conclusions....................................... 62
Acknowledgments......................................................................................................................... 62
References........................................................................................................................................63
1.1 Introduction
It has long been an axiom of mine that the little things are infinitely the most important.
Sir Arthur Conan Doyle (1900)
Infectious diseases (IDs) are the clinical manifestations that result from infections due
to a myriad of pathogenic viruses, bacteria, fungi, and parasites, whereas the discipline
of ID is the research and clinical practices having to do with host–pathogen interactions,
diagnosis, treatment, and prevention of infection. The application of nanotechnology to
ID heralds a much anticipated interface, one with potentially far-reaching implications.
Indeed, some of the earliest applications of nanotechnology to medicine were in the field
of ID: the use of gold nanoparticles (GNPs) for immunolabeling of salmonella surface
© 2008 Taylor & Francis Group, LLC
Nanotechnology Applications for Infectious Diseases 3
antigens (Faulk and Taylor 1971), the encapsulation of amphotericin and doxorubicin
within liposomal nanoparticles to treat fungal infections and AIDS-associated Kaposi’s
sarcoma, respectively (Lopez-Berestein et al. 1989; Bogner et al. 1994), and the use of
pegylated interferon to treat hepatitis C (Zeuzem et al. 2000). It can even be argued that
one of the earliest examples of the application of nanotechnology to ID, although neither
were called that back then, dates to the early Renaissance, when Paracelsus used colloidal
gold to treat tuberculosis (TB) and syphilis (DeWitt 1918; Dykman and Khlebtsov 2010).
This chapter explores the nanotechnology–ID interface, two disciplines accustomed to
dealing with matter on a small scale. It endeavors to make the argument that the union
of these disciplines will have a large impact on healthcare in technologically advanced as
well as resource-limited parts of the world. The contextual framework of the chapter is one
that introduces the nanoscientist and non-ID practitioner to the profession of ID and the
ID clinician to fundamental concepts of nanoscience that have direct applications to their
medical specialties. An emphasis is placed on nanotechnology applied to the detection and
analysis of microbial pathogens and biomarkers of infection. Many of these applications,
in this study, are in the proof-of-concept stage of development, while others are in various
phases of clinical research. Several nanotechnology applications, liposomal amphotericin
for example, are in current clinical practice.
Nanotechnology is a scientifically diverse discipline that initially encompassed engi-
neering, materials science, physics, and chemistry. It has expanded to involve the biological
sciences, where the fields of nanobiotechnology and nanomedicine are rapidly emerging.
Nanotechnology exploits the complex and remarkably unique properties of matter at the
nanoscale (Planinsic, Lindell, and Remskar 2009; Kim, Rutka, and Chan 2010). Although
detailed descriptions of these fundamental physicochemical properties are beyond the
scope of this chapter, simplified illustrations are provided so that a working knowledge of
the nanobiotechnology–ID interface can be gained. There is little doubt that the practice of
medicine will be profoundly influenced by nanotechnology, and the confluence of biology
and nanotechnology will have a dramatic impact on ID.
1.1.1 Basic Nanoscience Concepts
To begin a discussion of nanotechnology with relevance to ID, it is useful to introduce a
few basic concepts pertaining to the properties of matter at the nanoscale. Nanostructures
possess a very large ratio of surface area to volume. This concept can be intuited at the
macroscopic (bulk) scale by considering the ratio of surface area to volume of a single
pad of sticky notes. Now consider the ratio when all the individual notes from the pad
are stuck to the sides of a refrigerator. Amplify that relationship a million times as you
contemplate the ratio of surface area to volume of nanosticky notes. A nanoparticle may
consist of just a few atoms, or in the case of nano-thin films and filaments, it may be just a
few atoms thick. Given the surface area-to-volume relationship discussed earlier, it is easy
to appreciate that a large fraction of the atoms that make up the nanostructure reside on
its surface (Eustis and EL-Sayed 2006). The behavior of these surface atoms confers many
of the unique properties associated with matter at the nanoscale. To give nanoscale dimen-
sions an ID perspective, it will be helpful to consider that human immunodeficiency virus
(HIV) particles have a diameter of approximately 120 nm, and the diameter of nanocrystal
quantum dots (QDs) and magnetic nanoparticles (MNPs) range between 1 and 40 nm.
Surface atoms are relatively reactive, having fewer neighbors to share chemical bonds
(Roduner 2006). This facilitates the attachment of a variety of molecules (e.g., antibiotics,
nucleotides, proteins, antibodies, and aptamers) to nanostructured surfaces by chemical
© 2008 Taylor & Francis Group, LLC
4 The Clinical Nanomedicine Handbook
and electrostatic means. The optical and electronic properties of the surface atoms behave
differently than at the bulk scale. This is, in part, due to quantum confinement, a term used
to describe the effects on electron energy levels as they are squeezed into the boundary
limits of nanostructures (Roduner 2006). Quantum confinement influences how nanopar-
ticles interact with electromagnetic energy, and imparts unique luminescent and electric
conducting properties that can be exploited in biomedical science.
In addition to their unique optoelectronic properties, nanoparticles can be engineered
to develop distinctive magnetic and superparamagnetic behaviors (Gossuin et al. 2009).
They can be made small enough to contain single magnetic domains that impart large
magnetic moments, a property that lends itself to many biomedical applications. Examples
of nanoparticle properties and behaviors and how they interface with ID will be provided
throughout this chapter. Before arriving at the interface, however, a brief description of ID
and the scope of ID are in order.
1.2 Specialty of Infectious Diseases
For a period of time from approximately 1965 to 1985, there was considerable optimism
that medical science had succeeded in controlling the emergence and spread of major IDs,
and as a result, the need for ID specialists would rapidly decline (Ervin 1986; Fauci 2001;
Petersdorf 1986; Spellberg et al. 2008). Great progress had been made in childhood immuni-
zations and in the eradication or significant reduction of IDs such as smallpox, poliomyeli-
tis, TB, and guinea worm (Aylward et al. 2000). Unfortunately, the optimistic expectations
made at the time were somewhat naïve and definitely short lived. IDs continue to be the
most prevalent health-care problem throughout the world (Fauci 2001). The ID optimists
of the mid-twentieth century did not anticipate the following: the ongoing global wave of
emerging and reemerging IDs as illustrated in Table 1.1 (Jones et al. 2008; Morens, Folkers,
and Fauci 2008; Olano and Walker 2011); the increasing prevalence of an elderly population
with waning immunity (U.S. Department of Health and Human Services 2011); the prolif-
eration of immunosuppressed patients receiving cytoreductive chemotherapies, immune-
modulating drugs, hematopoietic stem cell, and solid organ transplantations (Barshes,
Goodpastor, and Goss 2004; Wahrenberger 1995); the expansive use of indwelling cath-
eters, prostheses, and implantable medical devices that interferes with host defense barri-
ers and invites the formation of biofilms (Donlan and Costerton 2002; Zimmerli, Trampuz,
and Ochsner 2004; Baddour et al. 2010; Hooton et al. 2010; Hodgkiss-Harlow and Bandyk
2011; WHO 2011b); the initial expansion, and later contraction, of newly discovered anti-
microbials and their attendant overuse (Boucher et al. 2009; Gyssens 2011; Jabes 2011); the
mathematical complexities of antimicrobial pharmacokinetics (PKs) and pharmacody-
namics (PDs) (Drusano 2007); the increase in type and variety of drug-resistant micro-
organisms, and the ease and speed with which they are transmitted within health-care
settings and between distant geographic communities (Kunin 1993; Small 2009; Rice 2009;
Parija and Praharaj 2011); the realization that ID agents are capable of causing certain
types of cancer, gastric ulcers, and other similar chronic medical conditions (Suzuki, Saito,
and Hibi 2009; Hannu 2011; de Martel et al. 2012; Zaghloul and Gouda 2012); the chang-
ing climate, geologic, and demographic patterns that have altered the interplay between
humans, reservoirs, and vectors of IDs (WHO 2009; Shuman 2010; Ermert et al. 2012); the
persistence of crushing poverty, wars, floods, and drought that promotes starvation, poor
© 2008 Taylor & Francis Group, LLC
Nanotechnology Applications for Infectious Diseases 5
TABLE 1.1
Emerging Infectious Agents Described Since 1967
Year Infectious Agent
1967 Marburg virus
1969 Lassa virus
1971 JC virus
1972 Norovirus
1973 Rotavirus
1975 Parvovirus B19
1976 Vibro vulnificus, Cryptosporidium parvum
1977 Ebola virus, Clostridium difficile, Legionella pneumophila, Hantaan virus,
Campylobacter spp
1979 Cyclospora cayetanensis
1980 HTLV-1
1981 Staphylococcus aureus toxic shock syndrome toxin
1982 Borrelia burgdoferi, HTLV-II, prion diseases
1983 HIV-1, Helicobacter pylori, hepatitis E virus
1984 Haemophilus influenzae aegyptus
1985 Enterocytozoon bieneusi, Borna disease virus
1986 Chlamydia pneumoniae, HIV-2
1987 Dhori virus
1988 Human herpes virus 6, Barmah Forest virus
1989 Rickettsia japonica, hepatitis C virus
1990 Hepatitis E virus, Balamuthia mandrillaris
1991 Guanarito virus, Encephalitozoon hellem, Ehrlichia chaffeensis
1992 Vibrio cholerae 0139, Bartonella henselae, Rickettsia honei, Tropheryma
whippelii
1993 Sin Nombre hantavirus
1994 Anaplasma phagocytophilum, Hendra virus, Sabia virus, human
herpesvirus 7, human herpesvirus 8
1996 Andes virus, Creutzfeldt-Jakob disease (new variant)
1997 Rickettsia slovaca, Influenza A H5N1a
1998 Menangle virus, Brachiola vesicularum
1999 Ehrlichia ewingii, Nipah virus
2000 Whitewater Arroya virus
2001 Human metapneumovirus
2002 Cryptosporidium hominis
2003 SARS-coronavirus
2004 Monkeypox virus, human corona virus NL63
2005 Human bocavirus, human coronavirus HKU1b, HTLV-3, and
HTLV-4
2009 Influenza A H1N1 (“swine flu”)
Source: Olano, J.P. and D.H. Walker, Arch. Pathol. Lab. Med., 135, 83–91, 2011.
Abbreviations: HIV, human immunodeficiency virus; HTLV, human T-cell lym-
photropic virus; SARS, severe acute respiratory syndrome.
a Bird flu.
b Identified in Hong Kong.
© 2008 Taylor & Francis Group, LLC
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Wonderful. W. Britain, 4v, 1928-29, see Hammebton (Sir J. A.), ed.
Wonderful London, 3v, 1926-27, see Adcock (A. St. J.), ed. Wong
Quincey (J.) [Wen-hsien Wang]. Chinese hunter. Forew. by Lin
Yvitang. 8°. 1939 Wonlar-Larsky (Nadine), wife of Dimitri Wonlar-
Larslcy, form. Nabokoff. The Russia that I loved. s8°. [1937] ♦Wood
& iron. A storv of Africa wr. in memory of H. U. C. " 8°. [1934]
Wood, The family of. see Falkneb (F.) The W. fam. of Burslem, 1912.
„ Montagu (F. M.) Mem. of the fam. of W., of Largo, 1863. Wood
(Mrs. —). ♦Letters fr. the Irish Highlands of Cunnemarra. By a family
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C. 1946 The physics of music. [5th ed.] 8°. [1950] Wood (Alfred
Cecil). A hist, of the Levant Company. 8°. O. 1935 A hist, of
Nottinghamshire. [Thoroton Soc] 8°. Nott'm. 1947 Nottinghamshire
in the Civil War. 8°. O. 1937 Wood (Allen H.) Grow them indoors:
window ledge & house gardening. 8°. 1939 Wood (Anthony 4). John
Milton, f. Fasti Oxon. (1691), see Daebishire (H.), ed. Early lives of
M., 1932. Life & times of W., abr. f. A. Clark's ed. & w. intr. by L.
Powys. 8°. 1932 see Gibson (S.) &c. Index to Rawlinson's coll", (c.
1700-50) for a new ed. of W.'s Athena; Oxon., 1927. & R. Rawlinson.
Parochial collections. Made by A. i W. & R. R. Transcr. &o. by F. N.
Davis. [Oxf. Rec. Soc. vll]. p3 [pagin. cont.] 8°. O. 1929 Wood
(Bryce), Ph.D. Peaceful change & the colonial problem. [Columbia
Univ. Sts. in hist. &o.. No. 464]. 8°. N.Y. 1940' Wood (Charles
Erskine Scott). Heavenly discourse. [Satire]. s8°. N.Y. 1928 Wood
(Christopher), artist, see Newton (E.) C. W., 1901-30, 1938. Wood
(Edith Elmer). An Ober land chalet. 8°. [1911] Wood (Hon. Edward
Frederick Lindley), aft. Ld. Irwin, aft. 3rd Visct. Halifax, see Halifax.
Wood (EUzabeth). Afterglow. s8°. [1947] Wood (Eric). Famous
voyages of gt. discoverers, [repr.] sS". [1927] Wood (Eric Fisher).
The note book of an attache, 7 months in the War zone. 8°. N.Y.
1915 Wood (Eric S.) The anc. buildings of the Harrogate district w.
bibliogr. 8°. [Bradford]. 1946 Wood (Ernest Egerton). An Englishman
defends Mother India. 8°. Madras. 1929 Wood (Ethel Mary), wife of
Maj. Herbert Fred. Wood, form. Hogg. The pilgrimage of
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Argyll. 8°. 1904 ,, ,, rev. & enl. ed., w. t. The Polytechnic & its
founder, Q. Hogg. 8°. 1932 Wood (Frederick A.) Collection for a
paroch. hist, of Chew Magna. [Somerset Arch. &c. Soc: N. Branch].
8°. p.f.a. Bristol. 1903 Wood (Frederick Lloyd Whitfield). The
constitutional development of Australia. s8°. 1933 Wood (Frederick
Thomas). Shakespeare & the plebs.sceENG. Assoc. Essays, vl8.
1933. Wood (George A.) The Anglo-Saxon riddles, see Abebystwyth
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8°. [1950] Wood (Gordon Leslie). Australia: its resources &
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The peopling of Australia, 1928. Wood (Helen). Young workers & th.
jobs in 1936, see United States: Laboe. Children's Bur. Bull. 249,
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Movements of herring in the N. North Sea. [Fishery Board for Scot.,
Sci. investig. No. 3]. Ia8°. E. 1937 Wood (Mrs. Henry), /orm. Ellen
Price [jWooD (Mrs. Ellen)]. East Lynne. [repr.] s8°. 1935 Johnny
Ludlow. auth. & compl. ed. si. s8°. 1912 Roland Yorke. [repr.] s8°.
1923 Wood (Henry Harvey). A 17th c. MS. of poems by Donne &
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About conducting. Pref. note by H. Foss. s8°. 1945 The gentle art of
singing. 4v. fol. O. [1927] Homage to Sir H. W. : world symposium.
[Ed. T. Russell &c.] s8°. [1944] My life of music. Intr. by Sir H. Allen.
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1944. ,, Beook (D.) Conductors' gallery &c. & eh. biog. of Sir H. W.,
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Soc. of Arts, abr. f. W.'s official hist., &c., 1935. Wood (Herbert). The
muniments of Edmund de Mortimer, 3rd earl of March cone h. liberty
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George). Christianity & civilisation. s8°. C. 1942 Christianity & the
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WOOD Wood (Herbert Geoige) [continued]. Quakerism &
the future of the Church. Swarthmore Lect., 1920. 8". 1920 Religious
liberty to-day. [Current problems, 31]. s8°. C. 1949 The truth & error
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of God & history. [Church, community & state, v3]. 8°. 1938 & J.
Macmuiray. Christianity & communism. [M632]'. s8°. [1934] Wood
(Herbert John), B.Sc. The search for a Western passage, see Newtox
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of parochial & non-par. registers rel. to Co». of Durham &
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1912 Wood (Rev. James), of Edinburgh. Stories f. Greek mythology.
s8°. 1867 Wood (James), M.A., see Ogden (C. K.), I. A. Richards & J.
W. Poundat. of aesthetics, 1925. Wood (James), prof, of theol. at St.
Andrews. *A vindication of the freedom &o. of the late Gen.
Assembly at St. Andrews & Dundee, see Guthrie (J.) & Sir A.
Johnston. Nulhty &c., 1662. Wood (James G.) The island chapel of
St. Twrog in Severn & The manors of Tintem Parva & Trellech. 8°.
Newport, Mon. 1922 Wood (Lt. Jerry E. R.), ed. Detour: story of
Oflag IV C. Ia8°. 1946 Wood (John), of Bath. An essay towards a
descr. of Bath. 2nd ed., corr. & enl. 2v. 8°. 1749 Wood (John), of the
Pennine Way Assoc. Mountain trail: the Pennine Way f. the Peak to
the Cheviots. 8°. [1947] Quietest under the sun: footT^ays on
Severnside hills. [repr.] 8°. [1945] Wood (John George), M.A. [ps.
George Forrest]. Bees: th. habits &o. s8°. [1853] Common objects of
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*Hist. & antiq. of St. Leonard's, Edinburgh, its chapel & hospital. By
G. Forrest. 8°. E. 1865 Wood (John Henderson) [ps. John O'Rockie].
Through the window (A window cleaner views the world). 8°.
Melbourne. 1937 Wood (Joseph). Liturg. studies. Addr., Manch. Coll.,
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Raymond Whateley, see Whateley. Wood (Margaret E.) Thirteenth-
cent, domestic architecture in England, see Royax Archaeological
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Alice Victoria), see Lloyd (Mabie). Wood (Robert), 1717-71. The
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191.; The tourist's Spain & Portugal. s8°. 1914 Wood (Samuel). The
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[1936] Wood (Thomas Barlow). The story of a loaf of bread. s8°. C.
1913 Wood (Walter). North Sea fishers & fighters. 8°. 1911 The
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Wood (Walter Birkbeck) & J. E. Edmonds. The Civil War in the U.S.;
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WOODHALL WoodhaU (Edwin T.) Crime & the supernatural.
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Woodhouse (James), journeyman shoemaker. Poems on sundry
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King Agis of Sparta & h. campaign in Arkadia in 418 B.C. 8°. O. 1933
Solon the liberator: st. of agrarian problem in Attika in 7th cent. 8°.
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1929 The problem of man's ancestry. s8°. 1918 & S. D. Forteus. The
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England under Edward III. 8°. C. 1934 Woodley (H. G.), ps. [i.e.
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Sussex martyrs, narr. of K. W. (1556-7), 1851. Woodman (T. C.) The
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[1936] Woodruff (Clinton Rogers), ed. City government by
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WOODWARD Woodward (George RatcliJie) [contimied].
Greek epigrams on Timon, Diogenes Sec. Eng. verse by W. [6. w. h.
Domestica, 1925J. s8°. p.p. Highgate. 1931 Greek epigrams, relig. &
dedio. Eng. verse by W. [b. w. h. Domestica, 1925]. 2p. s8°. p.p.
Highgate. 1931 Greek witticisms in Eng. verse. [P3074]. sS".
Highgate. 1929 Low-Sunday at Gangra of Paphlagonia. [P3074]. s8°.
Highgate. 1924 Misc. verse, sacred & secular. [P3103]. s8°. p.p.
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Highgate. 1923 Poemata. [Eng. tr'.f. dr., Lai., Germ.
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1711 vl— 7 contain 92 chiian. v8 has 15 chiian w. diff. title: Ming-
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K.) The life & times of T. Turner of East Hoathly: drawn f. diary,
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[1939] Soldiers of misfortune. The story of Otho Belleme. s8°.
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