Decision Making in Small Animal Oncology 1st Edition

David J. Argyle - PDF Download (2025)

https://ebookultra.com/download/decision-making-in-small-animal-
oncology-1st-edition-david-j-argyle/

Visit ebookultra.com today to download the complete set of

ebooks or textbooks
 We believe these products will be a great fit for you. Click
the link to download now, or visit ebookultra.com
to discover even more!

Small Animal Oncology 1st Edition Joanna Morris

https://ebookultra.com/download/small-animal-oncology-1st-edition-
joanna-morris/

Cancer Management in Small Animal Practice 1st Edition

Carolyn J. Henry Dvm Ms Dacvim (Oncology)

https://ebookultra.com/download/cancer-management-in-small-animal-
practice-1st-edition-carolyn-j-henry-dvm-ms-dacvim-oncology/

Small Animal Oncology An Introduction 1st Edition Susan M.

North

https://ebookultra.com/download/small-animal-oncology-an-
introduction-1st-edition-susan-m-north/

Saunders Solutions in Veterinary Practice Small Animal

Oncology 1st Edition Foale Bsc Bvetmed Dsam Dipecvim
Mrcvs
https://ebookultra.com/download/saunders-solutions-in-veterinary-
practice-small-animal-oncology-1st-edition-foale-bsc-bvetmed-dsam-
dipecvim-mrcvs/
Environmental Decision Making in Context A Toolbox 1st
Edition Chad J. Mcguire

https://ebookultra.com/download/environmental-decision-making-in-
context-a-toolbox-1st-edition-chad-j-mcguire/

Clinical Decision Making in Mental Health Practice 1st

Edition Jeffrey J. Magnavita

https://ebookultra.com/download/clinical-decision-making-in-mental-
health-practice-1st-edition-jeffrey-j-magnavita/

The Psychology of Judicial Decision Making 1st Edition

David E. Klein

https://ebookultra.com/download/the-psychology-of-judicial-decision-
making-1st-edition-david-e-klein/

Decision Making in Medieval Agriculture 1st Edition Stone

https://ebookultra.com/download/decision-making-in-medieval-
agriculture-1st-edition-stone/

Collective Animal Behavior David J. T. Sumpter

https://ebookultra.com/download/collective-animal-behavior-david-j-t-
sumpter/
Decision Making in Small Animal Oncology 1st Edition
David J. Argyle Digital Instant Download
Author(s): David J. Argyle, Malcolm J. Brearley, Michelle M. Turek
ISBN(s): 9780813822754, 0813822750
Edition: 1
File Details: PDF, 5.55 MB
Year: 2008
Language: english
Decision Making in Small
Animal Oncology
Decision Making in Small
Animal Oncology

David J. Argyle
B.V.M.S., Ph.D., D.E.C.V.I.M.-C.A. (Oncology) M.R.C.V.S.

Malcolm J. Brearley
M.A., Vet.M.B., M.Sc. (Clinical Oncology), DipE.C.V.I.M.-C.A. (Oncology), F.R.C.V.S.

Michelle M. Turek
D.V.M., D.A.C.V.R. (Radiation Oncology), D.A.C.V.I.M. (Oncology)

A John Wiley & Sons, Inc., Publication

Edition first published 2008
©2008 Wiley-Blackwell

Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program has been
merged with Wiley’s global Scientific, Technical, and Medical business to form Wiley-Blackwell.

Editorial Office
2121 State Avenue, Ames, Iowa 50014-8300, USA

For details of our global editorial offices, for customer services, and for information about how to apply for permission to
reuse the copyright material in this book, please see our website at www.wiley.com/wiley-blackwell.

Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted
by Blackwell Publishing, provided that the base fee is paid directly to the Copyright Clearance Center, 222 Rosewood
Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license by CCC, a separate
system of payments has been arranged. The fee codes for users of the Transactional Reporting Service are ISBN-13:
978-0-8138-2275-4/2008.

Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and
product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective
owners. The publisher is not associated with any product or vendor mentioned in this book. This publication is designed
to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding
that the publisher is not engaged in rendering professional services. If professional advice or other expert assistance is
required, the services of a competent professional should be sought.

Disclaimer
The contents of this work are intended to further general scientific research, understanding, and discussion only and are
not intended and should not be relied upon as recommending or promoting a specific method, diagnosis, or treatment by
practitioners for any particular patient. The publisher and the author make no representations or warranties with respect
to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without
limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment modifications,
changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment,
and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for
each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for
added warnings and precautions. Readers should consult with a specialist where appropriate. The fact that an organization
or Website is referred to in this work as a citation and/or a potential source of further information does not mean that the
author or the publisher endorses the information the organization or Website may provide or recommendations it may
make. Further, readers should be aware that Internet Websites listed in this work may have changed or disappeared
between when this work was written and when it is read. No warranty may be created or extended by any promotional
statements for this work. Neither the publisher nor the author shall be liable for any damages arising herefrom.

Library of Congress Cataloguing-in-Publication Data

Argyle, David J.
Decision making in small animal oncology / David J. Argyle, Malcolm J. Brearley, Michelle M. Turek.—1st ed.
p.; cm.
Includes bibliographical references and index.
ISBN 978-0-8138-2275-4 (alk. paper)
1. Dogs—Diseases—Diagnosis—Decision making. 2. Cats—Diseases—Diagnosis—Decision making. 3. Tumors in
animals. 4. Veterinary oncology. I. Brearley, Malcolm J. II. Turek, Michelle M. III. Title.
[DNLM: 1. Neoplasms—veterinary. 2. Algorithms. 3. Cat Diseases—diagnosis. 4. Cat Diseases—therapy.
5. Decision Support Techniques. 6. Dog Diseases—diagnosis. 7. Dog Diseases—therapy. SF 910.T8 A695d 2008]

SF992.C35A74 2008
636.089′6994—dc22
2008007429

A catalogue record for this book is available from the U.S. Library of Congress.

Set in 9 on 11.5 pt Sabon by SNP Best-set Typesetter Ltd., Hong Kong

Printed in Singapore by Markono Print Media Pte Ltd

1 2008
To Sally, Blythe and Sam. For all your love and support, this is what I was doing
upstairs for all those weeks.
David J. Argyle

To Gregg, for his loving support of my endeavors. And to Mom, Dad and John
for their lasting wisdom and encouragement.
Michelle M. Turek

I should like to dedicate this book to my early mentors, Dave Bostock and the
late Larry Owen, who inspired me into clinical oncology. Also to my colleagues
over the years with whom I have continued to learn, and finally to the
oncologists of the future – if I have helped inspire them in any way then I
consider that a great honor.
Malcolm J. Brearley
Contents

Contributors ix
Foreword xi

1 Introduction: Cancer Biology and Terminology 3

David J. Argyle

2 Paraneoplastic Syndromes 19
Mala G. Renwick and David J. Argyle

3 Clinical Approach to the Cancer Patient 45

David J. Argyle, Malcolm J. Brearley, and Michelle M. Turek

4 Biopsy, Tissue Handling, and Interpretation 51

David J. Argyle and Elspeth Milne

5 Cancer Treatment Modalities 69

David J. Argyle, Malcolm J. Brearley, Michelle M. Turek, and Linda Roberts

6 Tumors of the Skin and Subcutis 129

Valerie MacDonald, Michelle M. Turek, and David J. Argyle

7 Mast Cell Tumors 147

Suzanne Murphy and Malcolm J. Brearley

8 Canine and Feline Histiocytic Disorders 161

David J. Argyle and Laura Blackwood

9 Canine Lymphoma and Leukemia 171

Michelle M. Turek, Corey Saba, Melissa C. Paoloni, and David J. Argyle

10 Feline Lymphoma and Leukemia 197

David J. Argyle, Corey Saba, and Melissa C. Paoloni

11 Splenic Tumors 211

Malcolm J. Brearley and Suzanne Murphy

12 Gastrointestinal Tumors 217

David J. Argyle and Corey Saba

13 Tumors of the Respiratory System 239

Michelle M. Turek

14 Endocrine Tumors 283

David J. Argyle and Laura Blackwood
vii
viii Contents

15 Tumors of the Urinary System 303

David J. Argyle and Alison Hayes

16 Tumors of the Reproductive Tract 315

David J. Argyle

17 Canine and Feline Mammary Tumors 327

David J. Argyle, Michelle M. Turek, and Valerie MacDonald

18 Tumors of the Musculoskeletal System 337

Malcolm J. Brearley and Alison Hayes

19 Tumors of the Brain, Spinal Cord, Peripheral Nerves, and Special Senses 355
Malcolm J. Brearley and David J. Argyle

20 Miscellaneous Tumors 369

David J. Argyle

Index 373
Contributors

David J. Argyle BVMS PhD DECVIM-CA Valerie MacDonald, BSc, DVM

(Oncology) MRCVS Diplomate ACVIM (Oncology)
RCVS and European Specialist in Veterinary Associate Professor
Oncology Western College of Veterinary Medicine
William Dick Professor of Veterinary University of Saskatchewan
Clinical Studies 52 Campus Drive, Saskatoon, SK S7N 5B4
Royal (Dick) School of Veterinary Studies
The University of Edinburgh Elspeth Milne BVM&S PhD DipECVCP DipRCPath
Hospital for Small Animals FRCVS
Easter Bush Veterinary Centre Head of Division of Veterinary Clinical Sciences
Roslin, Midlothian Royal (Dick) School of Veterinary Studies
EH25 9RG Easter Bush Veterinary Centre
Roslin
Laura Blackwood BVMS PhD MVM CertVR Midlothian
DipECVIM-CA (Oncology) MRCVS EH25 9RG
RCVS & European Specialist in Veterinary Oncology
Senior Lecturer in Medicine (Oncology) Suzanne Murphy BVM&S MSc (Clin Onc) Dip
Small Animal Teaching Hospital ECVIM-CA (Oncology) MRCVS
The Leahurst Campus European and Royal College Recognised Specialist in
Chester High Road Small Animal Oncology
Neston Head, Oncology Unit
Wirral Animal Health Trust
CH64 7TE Lanwades Park
Kentford, Suffolk
Malcolm J. Brearley, MA VetMB MSc(Clin Onc) UK, CB8 7UU
DipECVIM-CA(Oncology) FRCVS
European & RCVS Recognised Specialist in Melissa C. Paoloni, DVM, DACVIM (Oncology)
Veterinary Oncology National Institutes of Health, National Cancer
Principal Clinical Oncologist Institute
The Queen’s Veterinary School Hospital Center for Cancer Research, Comparative Oncology
University of Cambridge Program
Madingley Road NIH/NCI
Cambridge CB3 0ES 37 Convent Dr., RM 2144
UK Bethesda, MD 20892

Alison Hayes BVMS CertVR MSC(Clin Onc) Dip Mala G. Renwick BSc. Bvet.Med MSc. (Clinical
ECVIM-CA(Oncology) MRCVS Oncology) MRCVS
RCVS Recognised Specialist in Veterinary Oncology Lecturer in Clinical Oncology
European Specialist in Veterinary Oncology Royal (Dick) School of Veterinary Studies
Senior Clinical Oncologist The University of Edinburgh
Animal Health Trust Hospital for Small Animals
Lanwades Park Easter Bush Veterinary Centre
Kentford, Suffolk Roslin, Midlothian
UK, CB8 7UU EH25 9RG
ix
x Contributors

Linda Roberts Dip AVN (Medical) RVN Michelle M. Turek, DVM, DACVIM (Oncology),
Royal Canin Cancer & Wellness Nurse DACVR (Radiation Oncology),
Royal (Dick) School of Veterinary Studies Staff oncologist
Hospital for Small Animals Angell Animal Medical Center’s Cancer Care Center,
Easter Bush Veterinary Centre Boston, MA
Roslin, Midlothian
EH25 9RG

Corey Saba, DVM, DACVIM (Oncology)

Assistant Professor of Oncology
University of Georgia
College of Veterinary Medicine
501 DW Brooks Drive
Athens, GA 30606
Foreword

Cancer is a major cause of morbidity and mortality in domestic animals. Recent reports suggest that there is
an increase in the prevalence of diagnosed cases of cancer in dogs and cats, partly because of the increased life
span through improved nutrition, vaccination, and control of infectious disease. As a consequence there is
increased demand on the practitioner to diagnose and manage cancer patients in general practice.
This book is not a comprehensive oncology text. It was specifically written to
• Provide veterinary students with the cancer knowledge they need in general practice.
• Provide general practitioners with a readable practice manual for rapid reference.
• Answer the common questions that specialist oncologists are asked by practitioners every day.
We have tried to arrange the material in the form of easy-to-follow algorithms that allow the clinician to
make appropriate decisions when faced with a cancer patient. We have also stressed the need for practitioners
to work with their pathologists and local specialist oncologists to provide the best care for their patients.
The reader must acknowledge that this is a rapidly changing field and best practice and knowledge may
change over time. Consequently, the authors recommend that readers should check the most up-to-date infor-
mation on procedures and drugs (including formulation, dose, and method of administration) prior to embark-
ing on therapy.

David J. Argyle
Malcolm J. Brearley
Michelle M. Turek

xi
Decision Making in Small
Animal Oncology
1
INTRODUCTION: CANCER BIOLOGY
AND TERMINOLOGY
David J. Argyle

A Definition of Tumor
• A tumor is any tissue mass or swelling and may or may not be neoplastic.
• Neoplasia is the abnormal growth of a tissue into a mass. It is usually phenotypically recognized by the
fact that its cells show abnormal growth patterns and are no longer under the control of normal
homeostatic growth-controlling mechanisms.
• Neoplasms can be considered as either benign or malignant tumors. Although the range of mechanisms
involved in the development of tumors and the spectrum of tissues from which tumors are derived is
diverse, they can be classified into three broad types:
1. Benign Tumors: Broadly speaking, these tumors arise in any of the tissues of the body and grow locally.
They can grow to a large size but are not invasive. Their clinical significance is their ability to cause local
pressure, cause obstruction, or form a space-occupying lesion such as a benign brain tumor. Benign tumors
do not metastasize.
2. In situ Tumors: These are often small tumors that arise in the epithelium. Histologically, the lesion appears
to contain cancer cells, but the tumor remains in the epithelial layer and does not invade the basement
membrane or the supporting mesenchyme. A typical example of this is preinvasive squamous cell carci-
noma affecting the nasal planum of cats.
3. Cancer: This refers to a malignant tumor, which has the capacity for both local invasion and distant spread
by the process of metastasis.

A Definition of Cancer
• Cancer is a disease of all vertebrate species and is well documented throughout history, with fossil records
indicating dinosaurs of the Jurassic period suffered from the disease.
• The Greek physician Galen is accredited with describing human tumors of having the shape of a crab,
with leglike tendrils invading deep into surrounding tissues—hence, the term cancer.

Key Point
We define cancer as any malignant growth or tumor caused by abnormal and uncontrolled cell divi-
sion, able to invade tissues locally and able to spread to other parts of the body through the lymphatic
system or the bloodstream. This is obviously a simplistic attempt at describing a complex disease that
can utilize a myriad of biological pathways to sustain growth and proliferation.

3
4 Decision Making in Small Animal Oncology

Nomenclature
The nomenclature of tumors is based upon two concepts:
• First, tumors can be considered as either benign or malignant. For simplicity, the pathobiological
differences between benign and malignant are outlined in Table 1.1.
• The second concept is concerned with the tissue or cell of origin (Tables 1.2, 1.3).

Cancer Biology
• Fundamental to our basic understanding of mammalian physiology is the concept of homeostasis.
• If we consider the body as a multicellular unit, cells within this unit form part of a specialized society that
cooperates to promote survival of the organism. In terms of homeostasis, cell division, proliferation, and
differentiation are strictly controlled and a balance exists between normal cell birth and the natural cell
death (Argyle and Khanna, 2006).
• Cancer can be considered as a breakdown in cellular homeostasis leading to uncontrolled cell division and
proliferation, which ultimately leads to a disease state.

The Pathways to Cancer

• For many years, cancer researchers have considered a stochastic model of cancer development (McCance
and Roberts, 1997).

Table 1.1. The biological differences between benign and malignant tumors

Feature Benign Malignant

Degree of Cells of benign tumors demonstrate a Malignant tumors demonstrate a range of

differentiation stage of development at which they differentiation from very good to very poor. A
have their mature morphological and severe lack of differentiation is referred to as
functional characteristics: and are thus anaplasia.
considered to be well
differentiated.
Growth rate Benign tumors often grow slowly and have Malignant tumors have a wide range of growth
periods of dormancy when no growth is rates.
recognized.
Mode of growth The mode of growth is considered to be The mode of growth is initially by expansion, but
by expansion, and tumors are eventually by invasion. There is no capsule
usually encapsulated. containing the tumor and the borders are ill
defined. Once malignant cells have infiltrated
outside their normal confines, they travel along
the natural cleavage plains and interstices of
tissue.
Metastatic The ability for tumor cells to spread and Malignant tumors have varying capability to
potential grow in distant organs (metastasis) is metastasize. This can be via the
NOT a feature of benign tumors. hematogenous, lymphatic, or trans-serosal
routes.
Host The effect on the host is usually through Often life threatening based on the
consequences the presence of a space-occupying tumor’s destructive effects on tissues and
lesion. Consequently, this can be a vital organs, and its ability to metastasize.
minimal effect (benign lipoma in the
subcutaneous tissue); or can be life
threatening (benign brain tumor).
Chapter 1 Introduction 5

Table 1.2. The nomenclature of benign tumors

Tissue or Cell of Origin Naming

Mesenchymal Named by the addition of the suffix oma to the cell type of origin:
• Fibrous tissue = fibroma
• Fat tissue = lipoma
• Cartilage = chondroma
Glandular epithelium Referred to as adenoma:
• A benign tumor of the sweat gland epithelium would be a sweat gland
adenoma.
Protective epithelium (squamous or Referred to as papilloma:
transitional) • Squamous papilloma of the skin (wart)
• Transitional papilloma of the urinary bladder
Nervous tissue Named by the addition of the suffix oma to the cell type of origin:
• A benign tumor of the astrocytes would be an astrocytoma.

Table 1.3. The nomenclature of malignant tumors

Tissue or Cell of Origin Naming

Mesenchymal Named by the addition of the suffix sarcoma to the cell type of origin:
• Fibrous tissue = fibrosarcoma
• Fat tissue = liposarcoma
• Cartilage = chondrosarcoma
Glandular epithelium Referred to as adenocarcinoma:
• A malignant tumor of the sweat gland epithelium would be a sweat
gland or apocrine adenocarcinoma.
Protective epithelium (squamous or A malignant tumor of squamous epithelium would be a squamous cell
transitional) carcinoma.
A malignant tumor of transitional epithelium would be a transitional cell
carcinoma.
Round cell tumors Lymphoma and other lymphoid neoplasia
Plasmacytoma and multiple myeloma
Histiocytoma and other histiocytic diseases
Mast cell tumor
Transmissible venereal tumor
With the exception of the transmissible venereal tumor, round cell
tumors affect cell lines of hemolymphatic origin

• In this, cancer formation is the phenotypic end result of a whole series of changes that may have taken a
long period of time to develop.
• Following an initiation step produced by a cancer-forming agent on a cell, there follows a period of tumor
promotion (Figure 1.1). The initiating step is a rapid step and affects the genetic material of the cell. If the
cell does not repair this damage, promoting factors may progress the cell toward a malignant phenotype.
In contrast to initiation, progression may be a very slow process, and may not even manifest in the lifetime
of the animal.
• Over the past 4 decades, cancer research has generated a rich and complex body of information revealing
that cancer is a disease involving dynamic changes in the genome. Each stage of multistep carcinogenesis
reflects genetic changes in the cell with a selection advantage that drives the progression toward a highly
malignant cell. The age-dependent incidence of cancer suggests a requirement for between four and seven
rate-limiting, stochastic events to produce the malignant phenotype.
6 Decision Making in Small Animal Oncology

Initiation

Promotion
Promotion Promotion

Cancer Cell
Metastasis

Any Normal Cell

Figure 1.1. The stochastic model of carcinogenesis: Cancer formation is the phenotypic end result of a whole
series of changes that may have taken a long period of time to develop. They can occur in any cell type in the body.
After an initiation step produced by a cancer-forming agent on a cell is a period of tumor promotion. Each stage of
multistep carcinogenesis reflects genetic changes in the cell with a selection advantage that drives the progression toward
a highly malignant cell. The age-dependent incidence of cancer suggests a requirement for between four and seven
rate-limiting, stochastic events to produce the malignant phenotype. Reprinted from “From Viruses to cancer stem cells:
Dissecting the pathways to malignancy” by Argyle D.J. and Blacking T.M. (The Veterinary Journal, 2007) with kind per-
mission from Elsevier.

Oncogenes

• Seminal to our understanding of cancer biology has been the discovery of the so-called “cancer genes,” or
oncogenes, and tumor suppressor genes.
• The term proto-oncogene is used to describe a gene that, in its native state, does not have transforming
potential to form tumors but that can be altered to promote malignancy. Once altered, the gene is referred
to as an oncogene.
• Most proto-oncogenes are key genes involved in the control of cell growth and proliferation and their
roles are complex.
• For simplicity, the mode of action of proto-oncogenes in the normal cell can be divided as follows (Table
1.4, Figure 1.2):
• Growth factors
• Growth factor receptors
• Protein kinases
• Signal Transducers
• Nuclear proteins
• Transcription factors
• The conversion of a proto-oncogene to an oncogene is a result of somatic events (mutations) in the genetic
material of the affected cell. The activated (mutated) allele of the oncogene dominates the wild-type
(nonmutated) allele and results in a dominant gain of function.
• The mechanisms of oncogene activation include the following (Figure 1.3):
• Chromosomal translocation: Where proto-oncogenes are translocated within the genome (i.e., from one
chromosome to another), their function can be altered. In human chronic myeloid leukemia (CML) a
chromosomal breakpoint produces a translocation of the c-abl oncogene on chromosome nine to a gene
on chromosome twenty-two (bcr). The bcr/abl hybrid gene produces a novel transcript whose protein
product has tyrosine kinase activity and can contribute to uncontrolled cellular proliferation. This tyrosine
 Table 1.4. Oncogenes can be growth factors, growth factor receptors, protein
kinases, signal transducers, nuclear proteins, and transcription factors

Oncogene Class Examples

Growth factors Platelet-derived growth factor (PDGF)
Epidermal Growth Factor (EGF)
Insulin Like Growth Factor-1 (ILGF-1)
Vascular Endothelial Growth Factor (VEGF)
Transforming Growth Factor-β (TGF-β)
Interleukin-2 (IL-2)
Growth factor PDGF-Receptor (PDGF-R)
receptors EGFR-Receptor (erbB-1)
ILGF-1 Receptor (ILGF-R)
VEGF-Receptor (VEGFR)
IL-2 receptor (IL-2R)
Hepatocyte Growth Factor Receptor (met)
Heregulin Receptor (neu/erbB-2)
Stem Cell Factor Receptor (kit)
Protein kinases Tyrosine Kinase, e.g.: bcr-abl, src
Serine-Threonine Kinase, e.g.: raf/mil, mos
G-protein signal GTPase, e.g.: H-ras, K-ras, N-ras
transducers
Nuclear proteins Transcription factors, e.g.: ets, jun, fos, myb, myc, rel

Growth Growth Factor

Factors Receptors

Nuclear and
Transcription factors

Signal Transduction

Cell Growth and Proliferation

Figure 1.2. Oncogenes are normal cellular genes involved in cell growth and proliferation: Most
proto-oncogenes are key genes involved in the control of cell growth and proliferation and include growth factors, growth
factor receptors, protein kinases, signal transducers, nuclear proteins, and transcription factors. The conversion of a
proto-oncogene to an oncogene is a result of somatic events in the genetic material of the target tissue. The activated
allele of the oncogene dominates the wild-type allele and results in a dominant gain of function. The mechanisms of
oncogene activation include chromosomal translocation, gene amplification, point mutations, and viral insertions. Reprinted
from “From Viruses to cancer stem cells: Dissecting the pathways to malignancy” by Argyle D.J. and Blacking T.M. (The
Veterinary Journal, 2007) with kind permission from Elsevier.

7
Other documents randomly have
different content
The Project Gutenberg eBook of The History
of Patient Grisel, 1619
 This ebook is for the use of anyone anywhere in the United
States and most other parts of the world at no cost and with
almost no restrictions whatsoever. You may copy it, give it away
or re-use it under the terms of the Project Gutenberg License
included with this ebook or online at www.gutenberg.org. If you
are not located in the United States, you will have to check the
laws of the country where you are located before using this
eBook.

Title: The History of Patient Grisel, 1619

Editor: George Laurence Gomme

Henry B. Wheatley

Release date: September 28, 2019 [eBook #60373]

Most recently updated: October 17, 2024

Language: English

Credits: Produced by Richard Tonsing, hekula03, and the Online

Distributed Proofreading Team at http://www.pgdp.net
(This
file was produced from images generously made
available
by The Internet Archive

*** START OF THE PROJECT GUTENBERG EBOOK THE HISTORY OF

PATIENT GRISEL, 1619 ***
 Chap-Books
and
Folk-Lore Tracts.
Edited by

G. L. Gomme, F.S.A.

and

H. B. Wheatley, F.S.A.

First Series.

IV.
 THE HISTORY
OF

PATIENT GRISEL.
1619.

EDITED, WITH AN INTRODUCTION,

BY

HENRY B. WHEATLEY, F.S.A.

LONDON:
PRINTED FOR THE VILLON SOCIETY.

1885.
 Introduction.

The narrative of the Patient Griselda is one of the most wide-

spread of the stories which have come down to us from the Middle
Ages. It has been annexed to the highest literature by such poets as
Boccaccio, Petrarch and Chaucer, and has been brought within reach
of the meanest capacities by the ballad-mongers and the writers of
penny histories.
We cannot trace the story back farther than the middle of the
fourteenth century, when Boccaccio incorporated it into his
Decameron (day 10, novel 10); but it must have had a previous
existence in Italy, for Petrarch says in his letter to Boccaccio that
when he read it in the Decameron he remembered how pleased he
had been with it when he heard it many years before. When his
memory was thus revived in the story that charmed him so much he
set to work to learn it by heart, so that he might repeat it to his
friends. He then translated it into Latin for the benefit of those who
did not know Italian.[1] That he did repeat the story to his friend we
learn from the Clerk of Oxenford’s Prologue to his tale in the
Canterbury Tales, where he says:—
“I wil yow telle a tale, which that I
Lerned at Padowe of a worthy clerk,
As provyd by his wordes and his werk.
He is now deed, and nayled in his chest,
Now God yive his soule wel good rest!
Fraunces Petrark, the laureat poete,
Highte this clerk, whos rethorique swete
Enlumynd al Ytail of poetrie.”

1. See Originals and Analogues of Chaucer’s Canterbury Tales, part ii. pp.
150–176 (Chaucer Society).
 There has been much controversy over these words. We must all
wish to believe that Chaucer met Petrarch at Padua and was friendly
with him; but although it is highly probable that he did so we have no
actual evidence other than this passage. Some say that Chaucer is not
speaking here in his own name but in that of a fictitious character,
and therefore the statement goes for nothing. Another objection is
that here Chaucer’s indebtedness to Boccaccio is overlooked and all
the credit is given to Petrarch. It is highly probable however that
Chaucer was interested in the story from Petrarch’s talk, and that
when he decided to make it one of his Canterbury Tales he adapted it
from Petrarch’s translation of Boccaccio, which is referred to farther
on in the Prologue:—
“I say that he first with heigh stole enditeth
(Er he the body of his tale writith)
A proheme, in the which descrivith he
Piemounde, and of Saluces the contre,
And spekith of Appenyne the hulles hye,
That ben the boundes of al west Lombardye.”

That this is the true origin of the Clerk’s tale is confirmed by the
fact that Petrarch varied somewhat from Boccaccio’s original, and in
these variations Chaucer follows Petrarch. An impossible tale such as
this requires all the art of the true poet to make it delightful to us,
and this of course we have in Chaucer. It is far different when we
come to read the common-place prose of the chap-book or the
equally common-place verse of the ballad-monger.
The picture of patience carried to the extreme in the wife and of
brutal violence in the husband is so out of harmony with our present
views that it is somewhat difficult to read the story with patience. We
are wrong, however, in taking it in this spirit, and Professor Hales
has so beautifully expressed the true motive of this mediæval picture
that I feel I cannot do better than transfer to these pages his remarks
in the publication of the Chaucer Society containing Originals and
Analogues of some of Chaucer’s Canterbury Tales:[2]—“Now, it is the
characteristic of the unsophisticated mediæval litterateur that he
deals with one idea at a time. It would often lead to a highly injurious
conclusion to attach at all equal a moral importance or rather any
moral importance to the subordinate parts of what he sets forth. The
central lesson is kept well in view; the others must look to
themselves. The principal figure is brought into relief with
enthusiasm; on the mere surroundings and background little or no
care is spent.... And so in the story of Griselda: if we would read it in
the spirit of the day when it became current we should not vex
ourselves into any righteous indignation against the immediate
author of her most touching distresses. The old story does not make
the marquis a monster in human shape; indeed, it represents him as
a man of a noble and lovable nature; if he is not so, then even in the
end Griselda reaps no earthly reward in permanently securing his
admiration and love. And yet this marquis perpetrates inexpressible
cruelties; he is a very wolf, ruthlessly teasing and tearing the gentlest
of lambs. The explanation is in accordance with what has just been
said: the patience of Griselda is the one theme of the tale, and
nothing else is to be regarded. In relation to her the marquis has no
moral being; he is a mere means of showing forth her supreme
excellence; a mere mechanical expedient. He is no more morally than
a thorn in the saint’s footpath, or a wheel, or a cross. Surely it is vain
to be wroth with him. Who rages against the mere fire that enfolds
the martyr, or the nails that pierce the hands of a crucified Believer?
Indeed, nothing in the tale is of any ethical moment but the carriage
of the heroine herself. The eyes and the heart of the old century when
she first appeared were fastened devoutly on that single form, and let
all else go by. She is wifely obedience itself, nothing else. Before that
virtue all other virtues bow. It enjoys a complete monopoly, an
absolute sway. Other moral life is suspended in this representation of
it. She has but one function; for her there is but one sin possible, and
that is to murmur. She is all meekness, all yielding, all resignation.
2. Part ii. 1875, p. 174.
“Such a figure has comparatively few charms for us of these latter
days. But it pleased the world once—even down to Shakespeare’s
time, who himself portrayed it in one of his earliest plays: Catherine
in the Taming of the Shrew is a phase of Griselda. Perhaps in ages
when much most ignorant abuse of women prevailed in literature—
abuse springing mainly out of the vile prejudices and superstitions of
the mediæval Church—some such figure might have been expected to
arise. It is the figure of a reaction. The hearts of men refused to
accept the dishonouring pictures so often drawn of their fellow
mortals. They rose in a loyal insurrection against lying fables of
essential wantonness and of shameful obstinacy. To such chivalrous
rebels the pale, sad, constant face of Griselda showed itself as the
image of far other experiences and histories; and they gazed on it as
on the face of their saint. With an infinite reverence they saw her still
calm and quiet in the midst of anguishes, with heart breaking but lips
uttering no ill word, with eyes that through the tears with which
kindly nature of herself would relieve the terrible drought of sorrow
still looked nothing but inalienable tenderness and love.”
The French have claimed for their country the origination of the
story of Griselda; but their claim cannot be allowed. The Abbé de
Sade in his Life of Petrarch asserts that the story is to be found in a
manuscript called Le Parement des Dames; but it appears that this
manuscript was the work of Olivier de la Marche, who was not born
until long after the death of Boccaccio. Boccaccio’s novel was
translated into French and published at Paris about the year 1510 as
La Patience de Grisilidis; it was published also at Troyes about 1562.
Apparently, however, the French were the first to bring Griselda
upon the stage; for, according to Warton, the Comedians of Paris
represented a mystery in French verse entitled Le Mystere de
Griseildis, Marquis de Saluces, mis en rime françoise et par
personnaiges in 1393. This was not printed until about 1550, when
Jehan Bonfons published it at Paris. His edition was reprinted in
1832.
Ralph Radcliffe, a somewhat voluminous play-writer, who
flourished towards the close of the reign of Henry VIII., is said by
John Bale to have written an English comedy entitled “Patient
Griselde,” and Hans Sachs in Germany converted the story into a
drama as early as 1550; but in Italy, the land of its birth, it was not
dramatised until 1620.
It was not possible for a story which had early taken such a strong
hold upon the popular imagination to remain long without becoming
the property of the ballad-writer, but we cannot tell if he forestalled
the writer of popular histories. In the Stationers’ Registers we find
three entries of Griselda as early as the year 1565–6; the following
two relate to the ballad:—

Rd. of Owyn Rogers, for his lycense for pryntinge of a ballett intituled the
sounge of pacyente Gressell unto hyr make [mate]
 iiij d.

Rd. of Wylliam greffeth, for his lycense for pryntinge of ij ballettes to the
tune of pacyente gressell
iiij d.

Now the second of these entries seems to point to an earlier ballad,

as it must have taken some time for the tune of Patient Grissell to
become so popular; and therefore there is great probability in Mr.
Chappell’s conjecture that the original ballad was published before
1557, in which year the Registers commence.
All the ballads of Griselda now in existence are essentially the
same as that printed in The Garland of Goodwill by Thomas
Deloney; and, as the same ballad, divided into chapters with prose
chapters at the beginning and end, is printed in The Pleasant and
Sweet History of Patient Grissell (reprinted by Mr. Collier for the
Percy Society), it has been suggested that this tract was also written
by Deloney. This famous ballad-monger is supposed to have
commenced writing about the year 1586, so that it is probable that
the ballad of 1565–6, and the even earlier one suggested above, have
ceased to exist. The following is a list of the different titles of
Deloney’s ballad:—
A most pleasant Ballad of patient Grissell, to the tune of “The
Bride’s Good-morrow.”

The earliest known edition, printed in Collection of Seventy-nine Black-

Letter Ballads and Broadsides, 1870. P. 17. (Roxburghe Ballads, ed. W.
Chappell, vol. ii. p. 268.)

Of Patient Grissel and a Noble Marquess. To the tune of “The

Bride’s Good-morrow.”

T. Deloney’s Garland of Good-Will. 1678. Part 2. (Percy Society. No. 112.

1851.)
The earliest edition of the Garland must have been published before 1600,
as Deloney died in that year.
 A most excellent and vertuous Ballad of the Patient Grissell. To the
tune of “The Bride’s Good-morrow.” London. Printed by John
Wright. [1640?] (Roxburghe Ballads, vol. i. pp. 302–3.)
The first part ends—
“My gracious Lord
Must have his will obeyd.”

And the second begins—

“She tooke the Babies
Even from the nursing ladies.”

There is a copy of the ballad (in one, not two parts) in the Percy Folio
Manuscript. See Hales and Furnivall’s edition, 1868, vol. iii. p. 421.

An excellent Ballad of a Noble Marquiss and Patient Grissel.

(Collection of Old Ballads, 1723, vol. i. p. 252.)
The following entries in the Stationers’ Registers would appear to
refer to the Ancient, True, and Admirable History printed in this
volume. It is stated to be translated from the French, but this
statement is of no value, and it is evidently of pure English
manufacture. The edition of 1619 is the earliest known to exist:—

1565–6. Rd. of Thomas Colwell, for his lycense for prynting of an history of
meke and pacyent Gresell
iiij d.

1568–9. Rd. of Thomas Colwell, for his lycense for pryntinge of the hystory
of pacyent gresell, &c.
viij d.

The History of the Noble Marquis of Salus, or Patient Grissel.

Printed and sold in London. [1780?] 12mo. Pp. 24. Another edition.
Aldermary Churchyard, n. d.

A reduced chap-book edition of the History printed in this volume. It seems

to have been published in this form as early as 1703.
 When Mr. J. Payne Collier edited for the Percy Society “The
History of Patient Grisel, two early Tracts in Black-Letter, with an
Introduction and Notes,” 1842, he printed after the Ancient, True,
and Admirable History “The Pleasant and Sweet History of Patient
Grissell, shewing how she from a poore man’s daughter came to be a
great lady of France, being a Patterne to all vertuous women.
Translated out of Italian. London. Printed by E. P. for John Wright,
dwelling in Giltspur Street at the Signe of the Bible.”
This is divided into eleven chapters, of which 1, 2, 10, and 11, are in
prose; chapters 3 to 9 contain the ballad referred to previously, and it
is most probable that the whole tract was the production of Deloney.
The date is cut off, but the pamphlet was probably printed about
1630, and it is doubtless a late edition of a popular chap-book. The
copy in the British Museum is apparently the same as that used by
Mr. Collier. It is handsomely bound in morocco, and in the inside is
written in pencil, “Cost me eight pounds unbound.” There are two
titles: the first is “The History of the Noble Marques,” with a woodcut
of Griselda at the spinning-wheel. On the back of this is the woodcut
of Elizabeth, reproduced on the title of the Percy Society reprint.
The play of Ralph Radcliffe is now lost, so that the comedy
published in 1603 and reprinted in 1841 is the only one known to
exist. We have here a curious instance of the danger of asserting of
any particular book that it is unique. When Mr. Collier reprinted the
play for the Shakespeare Society he said that there was no copy in the
British Museum, and that the only copies he knew of were one in the
Bodleian and another in the possession of the Duke of Devonshire,
who also had an imperfect copy which he presented to Collier. There
is now a copy in the British Museum, and in it is this note in ink:
“The only copy extant.—J. B. 1788.” Under this is a pencil note: “I
have seen another copy, but it was imperfect—G. N.” On the title-
page is written “William Shakespeare,” apparently one of the Ireland
forgeries.
The following entry occurs in Henslowe’s Diary:—

“Received in earnest of Patient Grissell by us Tho. Dekker, Hen. Chettle and

Willm. Hawton the sume of 3 li. of good and lawfull money by a note sent from
Mr. Robt. Shaa’s the 19th of December, 1599. By me,
 Henry Chettle.
W. Haughton.
Thomas Dekker.”

The Robert Shaa or Shaw here mentioned was, Mr. Collier tells us,
one of the temporary managers of the company of the Earl of
Nottingham’s players. The comedy was entered at Stationers’ Hall for
publication on the 28th March, 1600, as “the Plaie of Patient
Grissell,” but it did not appear until three years afterwards.
The Pleasant Comodie of Patient Grissill. As it hath beene sundrie
times lately plaid by the right honorable the Earle of Nottingham
(Lord high Admirall) his servants. London. Imprinted for Henry
Rocket, and are to be solde at the long shop under S. Mildred’s
Church in the Poultry. 1603. 4to. 42 leaves.
The play is anonymous, but the entry in Henslowe’s Diary informs
us who the authors were.
Patient Grissil: a Comedy by Thomas Dekker, Henry Chettle, and
William Haughton. Reprinted from the Black-Letter edition of 1603,
with an Introduction and Notes [by J. Payne Collier]. London.
Printed for the Shakespeare Society. 1841. The introduction contains
an interesting account of the history of Griselda.
On August 30th, 1667, Pepys saw at Bartholomew Fair the puppet
play of “Patient Grizill,” and Warton in a note to his History of
English Poetry writes: “I need not mention that it is to this day
represented in England on a stage of the lowest species and of the
highest antiquity: I mean a puppet show.”
“The Patient Countess,” in Percy’s Reliques from Warner’s Albions
England, is a totally different story from that of the patient wife of
the Marquis Walter.
Warton mentions a MS. poem by William Forrest, and, as it has
lately been printed, I give the title here, although it contains no
notice of the original Grisild.
The History of Grisild the Second: a Narrative in Verse of the
Divorce of Queen Katharine of Arragon. Written by William Forrest,
sometime Chaplain to Queen Mary I., and now edited for the first
time from the Author’s MS. in the Bodleian Library by the Rev. W. D.
Macray, M.A., F.S.A. London. Printed by Whittingham and Wilkins
at the Chiswick Press, 1875. 4to. Roxburghe Club.
The Griselda literature is a tolerably large one, and it is therefore
scarcely necessary in this place to give more than the above general
indication of an interesting subject. It may be noted that the titles of
the works on the subject in the library of the British Museum occupy
nine pages of the manuscript catalogue.
The patience of Griselda is almost as much a common-place of
literature as that of Job, and writers are full of references to her cruel
fate. In a Balade translated by Lydgate from the Latin “Grisilde’s
humble patience” is recorded.
In Thomas Feylde’s “Contraversye bytwene a Lover and a Jaye,”
printed without date by Wynkyn de Worde, we read:—
“Ryght fewe of Grysyldes kynde
Is now left on lyve.”

We are told in Harry White his Humour, printed in 1660, that,

“having lately read the rare history of Patient Grizell, out of it he hath
drawne this phylosophicall position, that if all women were of that
woman’s condition we should have no imployment for cuckin-
stooles.”
The editor of the Collection of Old Ballads, 1723, slily remarks:
—“It may naturally be supposed that he [the poet] had unfortunately
married a shrew, and was willing to preach up the doctrine of
patience to wives, by shewing them the blessings that attend this
great uncommon virtue; and I have inserted it, thinking that
amongst my readers I might have some husbands who would be glad
of carrying such an excellent song to their wives” (vol. i. p. 252).
Much of the popularity of the story must be due to Chaucer, who
first introduced it to English readers and endued it with so much
poetic beauty and grace.
 THE
ANCIENT TRUE AND ADMIRABLE
HISTORY OF
PATIENT GRISEL,
A POORE MANS DAUGHTER IN FRANCE:
SHEWING

How Maides, By Her Example, In Their Good

Behaviour May Marrie Rich Husbands;
And Likewise Wives By Their Patience And
Obedience May Gaine Much Glorie.

WRITTEN FIRST IN FRENCH, AND

Therefore to French I speake and give direction,
For English Dames will live in no subjection.

BUT NOW TRANSLATED INTO ENGLISH, AND

Therefore say not so, for English maids and wives
Surpass the French in goodnesse of their lives.

At London:

Printed by H. L. for William Lugger; and are to be sold at his shop

in Bedlem, neere Moore-Fields.

1619.
The Historie of Patient Grisel, made Marchionesse
of Saluss, in which is Exemplified the true
Obedience and Noble Behaviour of Vertuous
Women towards their Husbands.
 Chap. I.
How the Marquesse of Saluss passed the time of his youth
without any desire of mariage, till he was requested by the
faire entreatie of a favorite, and other gentlemen, to affect
a wife, both for the good of the country and the honour of
himselfe; with his answer to the same.

Betweene the mountaines of Italy and France, towards the south,

lyes the territory of Salus, a country flourishing with excellent townes
and castles, and peopled with the best sort of gentles and peasants:
amongst whom there lived not long since a nobleman of great hope
and expectation, lord of the country, by name Gualter, Marquesse of
Saluss; to whom, as the government appertained by right of
inheritance, so their obedience attended by desert of his worthinesse.
He was young in yeeres, noble of lineage, and such attractive
demeanour, that the best thought it a pleasure to bee commanded by
him, and the worst grew more tractable by his good example: his
delight was in hunting and hawking, and the pleasure of the time
present extinguished the care of the time to come; for he thought not
of mariage, nor to entangle himselfe with the inconveniences of a
wife; till at last the people and noblemen of his country projected the
contrary, as discontented to see him indisposed that way, and
presaging a kind of prosperity to themselves, if by his mariage
posteritie might arise to assure them the better how they might
bestow their obedience hereafter. Whereupon they assembled
together, and made one day amongst the rest a determiner of their
resolutions, choosing out for their speaker a noble knight of great
authority, faire demeanor, eloquent speech, and more inward with
the Marquesse then any of the rest; who, thus acquainted with all
their mindes, and prepared to utter his owne minde, took an
opportunity to acquaint the renowned Marquesse with the matter.
 Most honourable Sir, the great humanity extended towards us, of
which I most especially have participated, hath thus emboldened me
above others, to make a further triall of your patience, and forbearing
my rudeness: not that there is any sufficiency or singularity in me
above others, but in that heretofore I have found you so generous
toward all, I make no question to finde you as gratious toward my
selfe; and in that it hath pleased you to accept of our love, wee are
proud againe to be under your obedience; wherein we shall rejoice
the more, if you now accord to our request the sooner, which is, to
marry without delay. The time passeth, and will not be recalled, your
youth intreats it, and must not be denied; your country importunes
it, and would not bee opposed; your neighbours desire it, and hope to
bee satisfied; and all sorts request it, and wish it for your honour; for
when age approacheth, death attends it at the heeles, and no man
can tell when, or how it will fall upon him. Therefore wee humbly
request you to accept our supplications, and accord to this
importunity, that we may provide by your appointment a lady worthy
of your honour and our subjection. In this wee are the more
suppliant, because it will rebound so much to the good of your
countrey, and the enlarging your renowne; for if it should so fall out
(which God forbid) that you die without issue, we may lament the
losse of our lord, but not redresse the complaints of the people: we
shall want you that was al our comfort, but are sure of distresse to
our everlasting trouble. If then you either love your selfe, or pity us,
frame a heart to this impression, and leave not us to further feare
and disquiet.
When the noble lord had thus apprehended the petition of his
loving subjects, he resolved to answer them as gratiously as they had
propounded the businesse with regard of duty, and so replied: My
dearest friends, you have urged mee to a matter, in which as yet I
have beene a mere stranger; for by nature I delight in liberty, and by
custome continued my pleasures, both which must needs bee curbed
by mariage, and restrained by taking a wife: notwithstanding, I cast
awaie all doubts to pleasure you, and will thinke of no incombrances
so you be satisfied. For though mariage hath many difficulties
attending; especially, the feare of legitimation in our children, and
suspicion of that honour which lies on our wives honesty, yet all shall
be overcome with this resolution, that I shall please you in the same;
for I am resolved, if anie good come for man’s contentment by
mariage, it is from God, to whom I submit this cause, and pray for
the good successe of your wishes, that I may live to maintaine your
peace, as well as my owne pleasure: and look, wherein my
contentment shall enlarge mine honour, your welfare shall be
respected above my life; so that (beleeve it) I will satisfie your
demands, and apply my selfe to the purpose. Only one thing I
request at your hands; to take in worth my choice, and neither insult
if she be a princesse of greatnes, nor repine if she be of meane estate;
but love her because I have loved you, and regard her howsoever in
that she is my wife; neither being curious nor inquisitive whom I will
chuse, nor disaffected when it is past remedy.
When the company heard him out, and found him so willing to
their satisfaction, they gave him thankes with one heart for his kinde
admission, and answered with one tongue, he should not find them
repugnant; but they would honor his wife as the princesse of the
world, and be morigerous to him as the commander of their soules.
Thus did this new report (like a messenger of glad tidings) fill all the
marquisate with joy, and the palace with delight, when they
understood their lord would marry, and in a manner heard the time
appointed; for presently it was proclaimed through the countrey, and
a day assigned for all commers to come to the court. The nobles
prepared themselves in the best manner: the ladies spared no cost,
either for ornaments of their bodies, or setting out their beauties; the
gentles flocked to please their lord, and were brave to set out their
owne greatnes: the citisens were rich in their neatnes, and handsome
in their attire: the officers were formall in their showes, and
sumptuous in their attendants; the countryman had his variety, and
the verie peasant his bravery; in a word, al sorts gloried in the hope
of that festivall, and every man’s expectation attended the day of
triumph. For never was such a preparation in Saluss before, nor such
a confluence of people seene in that countrey; for besides the novelty,
many forraine princes came to celebrate this mariage, and to shew
their owne greatnes. Savoy was neare, and sent some from her
snowie hills: France as neare, and sent others from her fruitful vines:
Italy not far off, and sent many from her pleasant fields; and the
ilands round about kept none at home that would come. Thus were
his kinred invited, strangers admitted, his owne people entertained,
and all sorts welcommed; but as yet no bride was seene, no woman
named, no lady designed, no maid published, no wife knowne: onely
the preparation was much, and the expectation greater.
All this while the Marquesse continued his hunting, and as he had
accustomed, resorted much to a poore country village not farre from
Salusse, where there dwelt as poore a countriman, named Janicole,
overworne in yeares, and overcomne with distresse. But as it
happens many times that inward graces doe moderate outward
discommodities, and that God seasoneth poverty with contentment
and their sufficient supportation, so had this poore man all his
defects supplied in the admirable comfort of one onely daughter, so
composed, as if nature determined a worke of ostentation. For such
was her beauty in appearance, and vertue in operation, that it put
judicious men to an extasie in the choice by comparison; but both
united did heere grace each other, and when they pretended an
action, it was all to go forward to perfection. And whereas in others
this temporary blessing gave wings to desire to bee seene and
knowne abroad, in her those innated vertues allaied the heat of all
manner of passion, and breakings out of frailty. The viands they had
were but meane, and the diet they kept was to satisfie nature: the
time was over-ruled by their stomachs, and the ceremonies they used
were thanks to God, and moderation in their repasts. The utensiles of
the house were homely, yet handsome in regard of their cleanlinesse:
that bed which they had the ould man lay in, and the sweet daughter
made shift with the ground. No day passed without prayers and
praises to God (for was it not praiseworthy to have such grace in this
disgrace), nor any night without taking account of the day passed.
Her exercise was to helpe her father in the morning, and drive
forth her sheep in the day time: hee was at home making of nets, and
shee abroad looking to her lambs: she was never heard to wish for
any better, but to thank God it was no worse. No word of repining
ever came from her mouth, or the least grudge from her heart: at
night she folded her sheep and dressed her father’s supper, then lay
they downe to rest, and rested as well as in a bed of downe indeed.
This was the glory of their poverty, and memory of their
contentment.
But as fire will not be hid where there is matter combustible, so
vertue will not be obscured where there be tongues and eares: nor
could the Marquesse so hallow after his hawks and hounds, but
report hallowed in his eare as fast this wonderment; insomuch that
when it was confirmed by judicious relation he made it not dainty to
be behoulding to his owne experience: which when he saw
concurring with fame, the miracle brought a kinde of astonishment;
which continuing, the properties of such novelties, increased to
meditation: and so comparing the rest with this rarity, he thought
her a fit woman to make his wife, supposing that if she were vertuous
by nature, she would not prove vicious by education; but rather as a
diamond is a stone of the same value whether set in lead or horne, it
must needs be of more excellency embellished with gold and
enamell. In which resolution hee prepared his heart, and went
forward with his businesse.
In the meane time the Court was daintily furnished, the plate
prepared, the apparell magnificent, the coronet rich, the jewels
precious, the ornaments exceeding, and all things befitting the
magnificence of a prince and the dignities of a queen: only the nobles
wondred, the ladies were amazed, the damsells marvelled, the
gentles disputed, the people flocked, and all sorts attended to see
who should possesse this wealth and bee adorned with these robes.
Till at last the nuptial day came indeed: honour prepared the
sumptuousness; fame divulged the glory; hymen invited the guests;
magnificence adorned the roomes; the officers marshald the state,
and all looked for a bride; but who she was the next chapter must
discover.
 Chap. II.
How, after all this great preparation, the Marquesse of
Saluss demanded Grisell of her poore father Janicola; and,
espousing her, made her Marchionesse of Saluss.

When all things were extended to this glorious shew, the

Marquesse (as if he went to fetch his wife indeed) tooke with him a
great company of earls, lords, knights, squires, and gentlemen,
ladies, and attendants, and went from the palace into the countrey
toward Janicolas house; where the faire mayd Grisel, knowing
nothing of that which hapned, nor once dreaming of that which was
to come, had made her house and selfe somewhat handsome,
determining (with the rest of her neighbour virgins) to see this
solemnity: at which instant arrived the Marquesse with all his
gracious company, meeting with Grisel as shee was carrying two
pitchers of water to her poore fathers house. Of whom (calling her by
her name) he asked where her father was? She humbly answered, in
the house. Goe then, said hee, and tell him I would speak with him.
So the poore old man (made the poorer by this astonishment) came
forth to the lord somewhat appauled, till the Marquesse, taking him
by the hand, with an extraordinary chearefulnesse said, that he had a
secret to impart unto him, and so, sequestering him from the
company, spake these words:—Janicola, I know that you alwaies
loved me, and am resolved that you doe not now hate me. You have
been glad when I have been pleased, and will not now bee sorrowful
if I bee satisfied: nay, I am sure, if it lie in your power, you will
further my delight, and not bee a contrary to my request. For I intend
to begge your daughter for my wife, and bee your sonne in lawe for
your advancement. What saiest thou, man? wilt thou accept mee for
a friend, as I have appointed thee for a father?
 The poore ould man was so astonished, that he could not looke up
for teares, nor speak a word for joy; but when the extasie had end,
hee thus faintly replied:—My gracious soueraigne, you are my lord,
and therefore I must accord to your will; but you are generous, and
therefore I presume on your vertue; take her a Gods name, and make
mee a glad father; and let that God, which raiseth the humble and
meek, make her a befitting wife, and fruitful mother. Why then,
replied the Marquesse, let us enter your house, for I must ask her a
question before you. So hee went in, the company tarrying without in
great astonishment: the faire maid was busied to make it as
handsome as she could, and proud againe to have such a guest under
her roofe; amazed at nothing but why hee should come so
accompanied, and little conjecturing of so great a blessing
approaching. But, at last, the Marquesse took her by the hand, and
used these speeches:—To tell you this blush becomes you, it were but
a folly; and that your modesty hath graced your comlines, may prove
the deceit of words, and unbefitting my greatnes; but in a word, your
father and I have agreed to make you my wife, and I hope you will
not disagree to take me to your husband. For delay shall not intangle
you with suspicion, nor two daies longer protract the kindnes; onely I
must be satisfied in this, if your heart afford a willing entertainement
to the motion, and your vertue a constancy to this resolution, not to
repine at my pleasure in any thing, nor presume on contradiction,
when I determine to command. For as amongst good souldiers, they
must simply obey without disputing the businesse: so must vertuous
wives dutifully consent withoute reproofe, or the least contraction of
a brow. Therefore be advised how you answer, and I charge you take
heed, that the tongue utter no more then the heart conceits. All this
while Grisel was wondring at the miracle, had not religion told her
that nothing was impossible to the commander of all things; which
reduced her to a better consideration and thus brought forth an
answere.
My gracious lord, I am not ignorant of your greatnesse, and know
mine owne basenesse: there is no worth in me to be your servant,
therefore there can be no desert to be your wife: notwithstanding,
because God will be the author of miraculous accidents, I yeeld to
your pleasure, and praise him for the fortune; onely this I will be
bold to say, that your will shall be my delight, and death shall be
more welcome unto mee then a word of displeasure against you.
 This is sufficient, answered the great lord, and so most lovingly he
took her by the hand, and brought her to the company, even before
all his peeres and great ladies, and told them she should bee his wife,
so that wherein they extended their love, reverence, and obedience
toward her, he could exemplifie his regard, care, and diligence
toward them. And because outward shewes doe sometimes grace
befitting actions (lest her poverty and basenes might too much daunt
their expectation, and seeme disgratious to their noblenes), he
commanded them with a morall livelinesse to adorne her with the
richest robes they had; so that it was a pleasure to see how the ladies
bestird themselves, a delight to behould the severall services
performed, the many hands about her, the jewels and pendants, the
robes and mantles, the ornaments and coronets, the collanaes and
chaines, with all other particulars and accoustrements, but when she
was apparelled indeed, it was a ravishment exceeding report, and
they which stomached her preferment were now delighted with her
glory. Such a benefit hath beauty by nature, and gratiousnesse by
nurture.
 Chap. III.
How the Marquesse and Grisel were married together.

After the ladies had thus adorned poore Grisel with robes befitting
her estate, the Marquesse and all the noble company returned to
Saluss, and in the Cathedrall Church, in sight of the people,
according to the fulnesse of religious ceremonies, they were espoused
together, and with great solemnitie returned to the palace. Herein yet
consisted the admiration, that no word of reproach was murmured,
nor eie looked unpleasantly upon her; for by her wonderfull
demeanour shee had gained so much of opinion that the basenes of
her birth was not thought upon, and all her graces concurring made
them verely beleeve shee was extracted of princely lineage: no man
once supposed that shee could be Grisel, daughter to poore Janicola,
but rather some creature metamorphosed by the powers of heaven:
for besides the outward statelinesse and majestical carriage of
herselfe, the wonderfull modestie and exact symmetry of her
countenance, the admirable beauty and extraordinary favor of her
visage, her faire demeanour had a kinde of attraction, and her
gratious words a sweet delivery; so that all that came to her were glad
of their accesse, and they which went from her triumphed for their
good speed: yea, report extended so far, that she was not onely
visited by her owne lords and ladies with reverence, but attended on
with strangers, who came from all quarters to see her and to bee
behoulding to their owne judgements; so that if the Marquesse loved
her before for her own worth, he now reverenced her for others
respect; the rather, because he found a blessing attending her
presence, and all people pleased in the contract? For when any
controversie hapned betweene himselfe and his nobles, she was so
nobly minded, that what she could not obtaine by fair intreaty she
yet mitigated by sweet perswasion. When any unkindnes hapned of
forraine prince, shee urged those blessings of peace, and reasoned
Welcome to our website – the ideal destination for book lovers and
knowledge seekers. With a mission to inspire endlessly, we offer a
vast collection of books, ranging from classic literary works to
specialized publications, self-development books, and children's
literature. Each book is a new journey of discovery, expanding
knowledge and enriching the soul of the reade

Our website is not just a platform for buying books, but a bridge
connecting readers to the timeless values of culture and wisdom. With
an elegant, user-friendly interface and an intelligent search system,
we are committed to providing a quick and convenient shopping
experience. Additionally, our special promotions and home delivery
services ensure that you save time and fully enjoy the joy of reading.

Let us accompany you on the journey of exploring knowledge and

personal growth!

ebookultra.com