Antiviral Drugs: Classification,
Uses, Dose, Side Effects,
Mechanism of Action
virus
1. Classification of Antiviral Drugs
1. Anti-Herpes Virus Drugs
2. Anti-Influenza Drugs
3. Anti-Hepatitis Drugs
4. Anti-Retroviral Drugs
1. Anti-Herpes Virus Drugs
1.Acyclovir
2.Valacyclovir
3.Famciclovir
4.Ganciclovir
5.Cidofovir
6.Foscarnet
2. Anti-Influenza Drugs
1.Oseltamivir
2.Zanamivir
3.Peramivir
4.Amantadine
5.Rimantadine
3. Anti-Hepatitis Drugs
A. Hepatitis B (HBV) Drugs
1.Tenofovir disoproxil fumarate (TDF)
2.Entecavir
3.Lamivudine
4.Adefovir dipivoxil
3. Anti-Hepatitis Drugs
B. Hepatitis C (HCV) Drugs
1.Sofosbuvir
2.Ledipasvir
3.Daclatasvir
4.Ribavirin
5.Pegylated Interferon-α
4. Anti-Retroviral Drugs (HIV Treatment)
A. Nucleoside Reverse Transcriptase
Inhibitors (NRTIs)
1.Zidovudine (AZT)
2.Lamivudine (3TC)
3.Abacavir (ABC)
4.Emtricitabine (FTC)
4. Anti-Retroviral Drugs (HIV Treatment)
B. Non-Nucleoside Reverse Transcriptase
Inhibitors (NNRTIs)
1.Nevirapine (NVP)
2.Efavirenz (EFV)
3.Rilpivirine (RPV)
4. Anti-Retroviral Drugs (HIV Treatment)
C. Protease Inhibitors (PIs)
1.Lopinavir/Ritonavir (LPV/r)
2.Atazanavir (ATV)
3.Darunavir (DRV)
4. Anti-Retroviral Drugs (HIV Treatment)
D. Integrase Strand Transfer Inhibitors
(INSTIs)
1.Raltegravir (RAL)
2.Dolutegravir (DTG)
3.Bictegravir (BIC)
Antiviral Drugs Uses
Dose & side effects
1. ACYCLOVIR
• Use: Herpes simplex
(HSV), Varicella-zoster
(VZV)
• Mechanism of Action :
Inhibits viral DNA
polymerase
1. ACYCLOVIR
• Dose:
HSV: 200-400 mg 5 times/day
Shingles: 800 mg 5 times/day
• Side Effects:Nausea, headache, renal
toxicity
• Indian Brands: Acivir, Herpex, Zovirax
2. OSELTAMIVIR
Use: Influenza A & B
echanism: Neuraminidase inhibitor (prevents viral release) |
Common Symptoms of Influenza A & B:
1.Fever (often high, 100°F–104°F or higher, especially in
children)
2. Chills & Sweats
3. Cough (usually dry)
4.Sore Throat
5.Runny or Stuffy Nose
2. OSELTAMIVIR
Common Symptoms of Influenza A & B:
6. Muscle or Body Aches (can be severe)
7. Headache
8.Fatigue (extreme tiredness)
9. Weakness
10. Shortness of Breath(more common in severe
cases)
2. OSELTAMIVIR
Dose: 75 mg twice daily for 5 days
• Side Effects:Nausea, vomiting,
headache
• Indian Brands:Tamiflu, Antiflu
3. SOFOSBUVIR + LEDIPASVIR
Use: Hepatitis C (HCV genotype 1 & 4)
Mechanism: HCV NS5B polymerase
inhibitor |
Dose: 400 mg + 90 mg once daily for
12 weeks
Side Effects: Fatigue, headache,
anemia
Indian Brands: MyHep LV, LediHep
4. REMDESIVIR
Use: COVID-19 (severe cases)
Mechanism : RNA polymerase inhibitor (delays
viral RNA synthesis)
Dose: 200 mg IV on Day 1, then 100 mg/day for
5-10 days
Side Effects: Liver enzyme elevation, nausea
Indian Brands: Cipremi, Covifor
Common Side Effects of Antivirals:
Nausea, vomiting, diarrheaHeadache,
dizziness
Kidney/liver toxicity(Tenofovir,
Acyclovir)
Anemia (Ribavirin)