Pharmacy

Paper-I
1st Term
Introduction
What is pharmacy?
Describe pharmaceutical manufacturing dosages form with an example.
Describe the responsibilities of the head of production.
Describe the responsibilities of the production manager.
Describe the problems of the pharmaceutical industry in Bangladesh.
Describe the advantages and disadvantages of solid oral dosage forms.

Capsule
Define and classify capsules with an example.
Define gelatin.
Write down the difference between hard gelatin and soft gelatin.
Describe the advantages and disadvantages of capsules.
Mention the filling capacity of the empty capsule shell.
Mention some parameters for the in-process checking of capsules.

Flow diagram
Write down the manufacturing flow diagram of the tablet.
Write down the manufacturing flow diagram of the capsule.
Write down the manufacturing flow diagram for liquid.

Suffof

What is the drying process?

Describe the purpose of the drying process.
Describe different mesh sizes for powder preparation.
Describe the precautions that should be taken when making the powder (suffof).
Describe the method of preparation of sufoof with equipment.
Describe the advantages and disadvantages of suffof.
Describe the finished product specification of suffof.

Some definition

Write short notes on: Etrifal, Majun, Jawarish, Joshanda (decoction), Khesanda (infusion),
Khameera, Laooq, and Murabba.
Describe the method of preparation of murabba.
Describe Sikanjbeen. Write down the method of preparation for Sikanjbeen.

DGDA
Write down the details for the registration (recipe) of Unani drugs.

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 2nd Term
Extraction
What is extraction? What types of solvents are used for the extraction of drugs?
Describe the advantages and disadvantages of water as a solvent.
Describe the advantages and disadvantages of alcohol as a solvent.

Tablet

What is dry granulation? What are the advantages, disadvantages, and flow diagrams of dry
granulation?
What is direct compression? Write down the advantages, disadvantages, and flow diagram of
direct compression.
Write down the difference between dry granulation and wet granulation.
Describe the specification variation limit of the tablet.
Write down the name of the equipment required for the wet granulation method.
Describe the causes and overcomes of weight variation in tablets.
Mention some parameters for in-process tablet checks.
Mention the problems and remedies of tablet manufacturing.
Define capping.
Write down the causes and remedies for capping.
Define lamination.
Write down the causes and remedies of lamination.
What is tablet coating? Describe the aspects of tablet coating.
Write down the type of tablet coating. Write down the reason for the film coating.
Write down the names of non-enteric agents.
What is an enteric film coating? Write down the purpose of the enteric film coating.
Describe the aqueous film coating.
Why is film coating more popular than sugar-coating?

Specific foods
Write short notes on: Maul – Laham (Water of meat), Maul Asl (Water of honey), Maul
jaban, Maush shaeer (Water of barley)

Detoxification

Describe the elutriation procedure of - Aahak, Choona (Edible Lime), Roghan Zard (Ghee).
Elutriated Lac (Luk maghsool), Elutriated Aloe (Sibor maghsool),
Describe the aims and objectives of Islah-e-Advia (Detoxification)
Describe the detoxification procedure of Afiun (Papaver somniferum latex), Shahed, Asl
(Honey), Azaraqi (Strychnos nuxvomica Linn fruit), Kibreet or Gandhak (Sulphur), Salajeet
musaffa (Purified Asphaltum), Earthworm (Kharateen), Purified Hen’s egg shell (Post-e-
baiza-e- murgh musaffa)

SOP

What is SOP? Write down the distribution of SOP for the tablet compression machine.

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Write down the operation and cleaning procedure of the SOP for the tablet compression
machine.

Test

BMR

What do you mean by BMR?

In an ideal BMR, which information should it consist of?
What do you mean by BPR?
In an ideal BPR, which information should it consist of?
Write down the reconciliation method for tablet manufacturing (Batch Size: 64 kg).
Write down the names of the machines required for the following process:
CMC dispersing, compression, encapsulation, and blistering
Write down the name and quantity of packing materials for the 350 mg tablet (batch size:
27.45 kg).
Write down the name and quantity of packing materials for the liquid product for 350 ml
(Batch Size: 1800 Lt).
What is the master formula?
In an ideal master formula, which information should it consist of?

Semisolid
Write down the finished product specification of the semi-solid product.
Write down the method of preparation of the semisolid product.
Write down the precautions that should always be observed while mixing ingredients in the
semisolid product.
Write down the method of preparation of qiwam with equipment.

Paper-II

1st Term
Liquid
Write down the name of the liquid production machinery.
Describe the basic requirements of GMP in the manufacturing of liquid products.
Describe the method of preparation of extract with equipment.
Describe the facilities required for liquid production area.
Mention some parameters for in-process checks of liquid products.
Describe the excipients for liquid product manufacturing.

QA

What is quality assurance? Mention the activities of quality assurance.

Write down the part about quality assurance.
What is quality control? Mention the activities of quality control.

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Write down the names of QC instruments and their functions.
What do you mean by IPQC?
Why should IPQC checks be conducted?
How can IPQC be made more effective?
Write down the difference between QA & QC.
Describe the responsibility of quality control head.
Describe the responsibilities of quality control analyst

Tablet

Define & classify tablet.

Write down the advantages and disadvantages of tablet.
Describe the essential qualities of good tablet.
What is granulation? Write down the difference between dry granulation & wet granulation.
Describe the causes of granulation.
Describe the limitation of wet granulation.
Write down the flow diagram for the wet granulation process.
Describe the methods for measuring moisture content.
Describe the excipients of tablet manufacturing.
What is diluent?
Write down the properties of diluents.

2nd Term

Finished product analysis

Describe the finished product analysis of tablet.
Describe the test parameters, specification and result of finished product of capsule.
Describe the test parameters, specification and result of finished product of liquid.
Describe the raw material analysis of animal or its organ.
Describe the raw material analysis of plant materials.

Stability
What is a stability study?
Describe the importance of the stability study.
Write down the procedure for a real-time stability study report.

Validation
Define validation. Write down the importance of validation.
Describe the basic concept of process validation.
Describe the responsibilities of the validation team.
What do you mean by cleaning validation? Describe the cleaning validation methodology.
Define and classify deviations. When must a deviation be raised?

GMP
What is GMP? How can we implement GMP in the factory?
Mention the ten (10) principles of GMP.
Write down the name and country of the GMP guidelines.
What do you mean by MHRA? What is the role of the MHRA?
What do you mean by FDA? What are the roles and responsibilities of the FDA?

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What do you mean by ISO? What are the requirements for a quality management system
(QMS)?
Define and classify a clean room. What are the issues to consider when designing a clean
room?
What do you mean by HVAC system? Write down the parameters and components of an
HVAC system.

Kushta
What is kushta? Write down the method of preparation for kushta.
Describe the point to be considered while making kushta.
Describe the characteristics and advantages of kushta.

Machine
Write down the name of tablet and capsule production machines.
Write down the names of basic processes, utility services, and microbiology machines.
Describe the facilities required for the tablet and capsule production area.

PD
Write down the tasks and responsibilities of the PD plan.

Test

Marham (Ointment)
What is Marham? Write down the method of preparation for Marham.
Describe the general precautions for Marham.
Describe the characteristics of an ideal ointment.
Describe the advantages and disadvantages of ointment.
Write down the difference between cream and ointment.

Compound drug
Aims and objective o compound drug
Write down the details about calibration.