AD–2318
Faculty of Pharmacy
B.Pharm. Semester—VI (New) Examination
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BP604T : BIOPHARMACEUTICS AND PHARMACOKINETICS
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Time : Three Hours] [Maximum Marks : 75
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Note :— (1) All questions are compulsory.
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(3) Illustrate your answer wherever necessary with the help of neat sketches.
(4) Use pen of Blue/Black ink/refill only for writing the answer book.
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1. (A) Solve MCQs :
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(1) Absolute bioavailability is denoted by :
(a) [AUC]oral/[AUC]i.v
(b) [AUC]test/[AUC]std
(c) [AUC]oral.Div/[AUC]iv.Doral
(d) AUC]test.Dstd/[AUC]std. Dtest
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(2) Which of the following is the pharmacodynamics method of studying biovailability ?
(a) Acute pharmacologic response
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(b) Plasma-level time studies
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(d) Urinary excretion studies
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(d) Stool excretion studies
(3) Which of the following is not an important parameter of plasma level time studies ?
(a) Cmax
(b) Tax
(c) The area under the plasma level-time curve
(d) Steady state level
(4) Which of the following will not be a parameter that should be examined for urinary
excretion data ?
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(a) (dXu/dt)max
(b) (tu)max
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(c) Xu
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(d) Cmax
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(5) Filp-Flop phenomenon occurs when : R E
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(b) Ke/Ka>3
(c) Ka=Ke
(d) None
LT—1311 1 (Contd.)
(6) Sigma-Minus method is used to determine the _______.
(a) Rate of absorption
(b) Rate of elimination
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(c) Rate of exertion
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(d) Rate of metabolism
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(7) In the equation X=Vd C, what does X stand for?
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(a) Amount of drug in the blood
A (b) Amount of drug in plasma
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(c) Amount of drug in the tablet
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(d) Amount of drug in the body
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(8) Non-linear pharmacokinetics is also known as :
(a) Dose dependent
(b) Enzyme capacity limited
(c) Saturation pharmacokinetics
(d) All of the above
(9) Causes of nonlinearity in metabolism due to :
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(a) Capacity limited metabolism due to enzyme and/or cofactor saturation
(b) Enzyme induction
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(c) Both (a) and (b)
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(d) None of the above
(10) Method of residuals is also known as :
(a) Feathering technique
(b) Peeling technique
(c) Stripping technique
(d) All of the above 10
(B) Write in short (Solve Any 5) :
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(a) Mention factors affecting absorption.
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(b) Differentiate passive transport and active transports.
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(c) List the factors affecting elimination of drugs.
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(d) What is apparent volume of drug distribution ?
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(e) Explain the biliary excretion of drugs. A
(f) How does diet influence drug metabolism ?
(g) What is protein binding ? 10
LT—1311 2 (Contd.)
2. Long questions (Solve Any Two) :
(a) What are the characteristics of microsomal enzymes ? Explain the phase I reactions.
(b) Explain in brief different methods for enhancement of bioavailability.
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(c) Explain in detail about one compartment open model for the IV bolus administration. 20
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3.
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Write in short (Solve Any Seven) :
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(a) Write in short causes of non linearity.
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(b) Describe in short methods for measurement of biovailability on the basis of 3m plasma
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concentration.
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(c) Explain in short pharmacokinetic models.
(d) Discuss in short about IVIVC.
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(e) Describe about the physiological barriers to the distribution of drugs.
(f) Describe the non per oral route for drug absorption.
(g) Enumerate various factors affecting biotransformation.
(h) Explain the pharmaceutical factors affecting drug absorption process in brief.
(i) Write the factors influencing renal excretion of drugs. 35
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LT—1311 3 25
